The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors

The PI3K/AKT Pathway as a Target for Cancer Treatment

(2016) Ingrid A. Mayer et al.   Annual Review of Medicine

Phase I Study of an AKT Inhibitor (MK-2206) Combined with Lapatinib in Adult Solid Tumors Followed by Dose Expansion in Advanced HER2+ Breast Cancer

(2016) K. B. Wisinski et al.   CLINICAL CANCER RESEARCH

Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using Limited Proteolysis

(2016) Fang Liu et al.   JOURNAL OF PROTEOME RESEARCH

Upregulation of AKT3 Confers Resistance to the AKT Inhibitor MK2206 in Breast Cancer

(2016) C. Stottrup et al.   MOLECULAR CANCER THERAPEUTICS

The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

(2016) Aifu Lin et al.   NATURE CELL BIOLOGY

3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained

(2016) Michele Zanoni et al.   Scientific Reports

Measurement of PIP3 Levels Reveals an Unexpected Role for p110β in Early Adaptive Responses to p110α-Specific Inhibitors in Luminal Breast Cancer

(2015) Carlotta Costa et al.   CANCER CELL

A Cytoplasmic NF-κB Interacting Long Noncoding RNA Blocks IκB Phosphorylation and Suppresses Breast Cancer Metastasis

(2015) Bodu Liu et al.   CANCER CELL

PDK1-mTOR signaling pathway inhibitors reduce cell proliferation in MK2206 resistant neuroblastoma cells

(2015) Lei Qi et al.   Cancer Cell International

Global Analysis of the RNA-Protein Interaction and RNA Secondary Structure Landscapes of the Arabidopsis Nucleus

(2015) Sager J. Gosai et al.   MOLECULAR CELL

lncRNA Directs Cooperative Epigenetic Regulation Downstream of Chemokine Signals

(2014) Zhen Xing et al.   CELL

Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers

(2014) Saurabh V. Laddha et al.   MOLECULAR CANCER RESEARCH

Global analysis of protein structural changes in complex proteomes

(2014) Yuehan Feng et al.   NATURE BIOTECHNOLOGY

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

The STAT3-Binding Long Noncoding RNA lnc-DC Controls Human Dendritic Cell Differentiation

(2014) P. Wang et al.   SCIENCE

The RNA-Binding Protein DDX1 Promotes Primary MicroRNA Maturation and Inhibits Ovarian Tumor Progression

(2014) Cecil Han et al.   Cell Reports

Pressure-assisted sample preparation for proteomic analysis

(2013) Pawel P. Olszowy et al.   ANALYTICAL BIOCHEMISTRY

Structural basis for RNA recognition by a dimeric PPR-protein complex

(2013) Jiyuan Ke et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synaptic PI(3,4,5)P3 Is Required for Syntaxin1A Clustering and Neurotransmitter Release

(2013) Thang Manh Khuong et al.   NEURON

Lipid binding by the Unique and SH3 domains of c-Src suggests a new regulatory mechanism

(2013) Yolanda Pérez et al.   Scientific Reports

Improved proteomic profiling of the cell surface of culture-expanded human bone marrow multipotent stromal cells

(2012) Samuel T. Mindaye et al.   Journal of Proteomics

MS2-TRAP (MS2-tagged RNA affinity purification): Tagging RNA to identify associated miRNAs

(2012) Je-Hyun Yoon et al.   METHODS

mrhl RNA, a Long Noncoding RNA, Negatively Regulates Wnt Signaling through Its Protein Partner Ddx5/p68 in Mouse Spermatogonial Cells

(2012) G. Arun et al.   MOLECULAR AND CELLULAR BIOLOGY

Segregation of PIP2 and PIP3 into distinct nanoscale regions within the plasma membrane

(2012) J. Wang et al.   Biology Open

Development of sulfonamide AKT PH domain inhibitors

(2011) Ali Md. Ahad et al.   BIOORGANIC & MEDICINAL CHEMISTRY

First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors

(2011) Timothy A. Yap et al.   JOURNAL OF CLINICAL ONCOLOGY

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

(2011) Yaoting Gui et al.   NATURE GENETICS

MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo

(2010) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

In vivo detection of RNA-binding protein interactions with cognate RNA sequences by fluorescence resonance energy transfer

(2009) M. Huranova et al.   RNA

Perifosine: Update on a novel Akt inhibitor

(2009) Joell J. Gills et al.   Current Oncology Reports

Comprehensive Identification of PIP3-Regulated PH Domains from C. elegans to H. sapiens by Model Prediction and Live Imaging

(2008) Wei Sun Park et al.   MOLECULAR CELL

Lipid signalling in disease

(2008) Matthias P. Wymann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY