Antisense oligonucleotide therapy for spinocerebellar ataxia type 2

The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper

(2016) Eric J. Lang et al.   CEREBELLUM

Cellular and circuit mechanisms underlying spinocerebellar ataxias

(2016) Pratap Meera et al.   JOURNAL OF PHYSIOLOGY-LONDON

Degenerative ataxias, from genes to therapies

(2016) Stefan M. Pulst   NEUROLOGY

Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways

(2016) Melissa Ingram et al.   NEURON

Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate

(2015) M. Fittschen et al.   NEUROGENETICS

Circuit Mechanisms Underlying Motor Memory Formation in the Cerebellum

(2015) Ka Hung Lee et al.   NEURON

Ataxin-2 Regulates RGS8 Translation in a New BAC-SCA2 Transgenic Mouse Model

(2015) Warunee Dansithong et al.   PLoS Genetics

Repeat Associated Non-AUG Translation (RAN Translation) Dependent on Sequence Downstream of the ATXN2 CAG Repeat

(2015) Daniel R. Scoles et al.   PLoS One

Broad Therapeutic Benefit After RNAi Expression Vector Delivery to Deep Cerebellar Nuclei: Implications for Spinocerebellar Ataxia Type 1 Therapy

(2014) Megan S Keiser et al.   MOLECULAR THERAPY

Allele-Specific Suppression of Mutant Huntingtin Using Antisense Oligonucleotides: Providing a Therapeutic Option for All Huntington Disease Patients

(2014) Niels H. Skotte et al.   PLoS One

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

(2013) Timothy M Miller et al.   LANCET NEUROLOGY

Altered Purkinje cell miRNA expression and SCA1 pathogenesis

(2013) Edgardo Rodriguez-Lebron et al.   NEUROBIOLOGY OF DISEASE

The genetics and neuropathology of Parkinson’s disease

(2012) Henry Houlden et al.   ACTA NEUROPATHOLOGICA

Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2

(2012) S. T. Hansen et al.   HUMAN MOLECULAR GENETICS

Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABAA receptors

(2011) Pratap Meera et al.   JOURNAL OF NEUROPHYSIOLOGY

Impaired Locomotor Learning and Altered Cerebellar Synaptic Plasticity in pep-19/pcp4-Null Mice

(2011) P. Wei et al.   MOLECULAR AND CELLULAR BIOLOGY

Potent and Selective Antisense Oligonucleotides Targeting Single-Nucleotide Polymorphisms in the Huntington Disease Gene / Allele-Specific Silencing of Mutant Huntingtin

(2011) Jeffrey B Carroll et al.   MOLECULAR THERAPY

Cep76, a Centrosomal Protein that Specifically Restrains Centriole Reduplication

(2009) William Y. Tsang et al.   DEVELOPMENTAL CELL

Deranged Calcium Signaling and Neurodegeneration in Spinocerebellar Ataxia Type 2

(2009) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Dissociated Fear and Spatial Learning in Mice with Deficiency of Ataxin-2

(2009) Duong P. Huynh et al.   PLoS One

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Phosphorylation of Homer3 by Calcium/Calmodulin-Dependent Kinase II Regulates a Coupling State of Its Target Molecules in Purkinje Cells

(2008) A. Mizutani et al.   JOURNAL OF NEUROSCIENCE

Sensorimotor enhancement in mouse mutants lacking the Purkinje cell-specific Gi/o modulator, Pcp2(L7)

(2008) Emilia Iscru et al.   MOLECULAR AND CELLULAR NEUROSCIENCE