Article
Toxicology
Xuejin Li, Dongjie Li, Guofang Zhang, Yanqiao Zeng, Nancy A. Monteiro-Riviere, Yan-Zhong Chang, Yang Li
Summary: The functional activities of gold nanoparticles depend on their physical-chemical properties and surface functionalizations. This study shows that primary human epidermal keratinocytes exposed to certain types of gold nanoparticles exhibit increased particle uptake, decreased cell viability, and enhanced production of inflammatory factors. However, the presence of a human plasma-derived biocorona decreases nanoparticle uptake and rescues cells from cell death. The mechanistic study reveals that oxidative stress and an antioxidant response are key factors involved in gold nanoparticle-induced cellular stress and inflammation, with Nrf2 playing a major regulatory role.
TOXICOLOGY LETTERS
(2022)
Review
Biotechnology & Applied Microbiology
Mohammad Azharuddin, Geyunjian Harry Zhu, Anirban Sengupta, Jorma Hinkula, Nigel K. H. Slater, Hirak K. Patra
Summary: Despite the success of conventional vaccines, which are based on attenuated or altered microorganisms, they are not effective for all microbes and may fail to elicit a protective immune response and even pose unexpected safety risks. The expanding field of nanotechnology offers a variety of nanoparticle-based platforms that can overcome these challenges and induce specific immune responses, suggesting exciting and novel solutions for future personalized nanovaccines.
TRENDS IN BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Li Xia, Saeed Alqahtani, Christina R. Ferreira, Uma K. Aryal, Katelyn Biggs, Jonathan H. Shannahan
Summary: Nanoparticles interact with biomolecules by forming a biocorona on their surface, which alters cell interactions and toxicity. Metabolic syndrome may result in distinct interactions between nanoparticles and biomolecules in the lungs, leading to the formation of unique biocoronas and enhanced toxicity.
Review
Engineering, Biomedical
Lucia Abarca-Cabrera, Paula Fraga-Garcia, Sonja Berensmeier
Summary: This paper critically reviews experimental studies on the interactions between low cost IONPs and biomolecules, emphasizing on the driving forces and unique structural characteristics of biomolecular classes at the solid-liquid interface. Future work is needed to improve nanoparticles' targeting capabilities in complex systems and to facilitate multipurpose recognition and bioseparation processes.
BIOMATERIALS RESEARCH
(2021)
Article
Chemistry, Physical
Xuefan Deng, Fengze Yao, Zhengxi Wang, Haixu Zhao, Bin Qi, Yingtang Zhou, Haibo Zhang, Xiaohai Zhou
Summary: By ingeniously combining halloysite nanotubes (HNTs) with the dodecahydro-closo-dodecaborate anion, high catalytic activity and selectivity of Au single-atom catalysts were achieved. The HNT@B12H12@Au catalyst showed excellent photocatalytic selective reduction activity for nitrobenzene compounds, efficiently converting them to corresponding azobenzenes.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Guillermo S. Moreno-Pescador, Dunya S. Aswad, Christoffer D. Florentsen, Azra Bahadori, Mohammad R. Arastoo, Helena Maria D. Danielsen, Anne Sofie B. Heitmann, Theresa L. Boye, Jesper Nylandsted, Lene B. Oddershede, Poul Martin Bendix
Summary: A study demonstrates the creation of nanoscopic holes in the cell plasma membrane using laser-induced heating of gold nanostructures, which allows for the identification of molecular components involved in membrane repair. Annexin V is found to reshape the edges surrounding the membrane holes, as evidenced by experiments using model membranes. The thermoplasmonic method provides new insights into how cells respond to photothermal treatment.
Review
Biotechnology & Applied Microbiology
Siavash Shariatzadeh, Negin Moghimi, Farima Khalafi, Sepehr Shafiee, Mohsen Mehrabi, Saba Ilkhani, Foad Tosan, Pooria Nakhaei, Ali Alizadeh, Rajender S. Varma, Mohammad Taheri
Summary: Cancer, a life-threatening disease with high costs and side effects in traditional treatments, has led researchers to explore the use of metal nanoparticles for more effective and targeted therapy. Metal nanoparticles, which can easily penetrate cells and deliver drugs, show promise in photodynamic therapy and sonodynamic therapy for cancer treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Yuxiang Xue, Xinyao Ma, Xue Feng, Sam Roberts, Guangyu Zhu, Yi Huang, Xianfeng Fan, Jun Fan, Xianfeng Chen
Summary: Gold nanostructures, especially gold nanobipyramids, have gained significant attention due to their unique physical and optical properties. However, synthesizing and purifying homogeneous gold nanobipyramids is a challenging task.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Physical
Prashant Gupta, Priya Rathi, Rohit Gupta, Harsh Baldi, Quentin Coquerel, Avishek Debnath, Hamed Gholami Derami, Baranidharan Raman, Srikanth Singamaneni
Summary: Nanotechnology-enabled neuromodulation is a promising minimally-invasive tool that can be used in neuroscience and engineering for both fundamental studies and clinical applications. This study reveals the transformation of neuromodulation from heterogeneous to homogeneous in a progressively maturing neural network, and the selective nano-neuro interaction between nanoparticles and neurons based on their surface charge. The density of nanoparticles bound to neurons in a developing neural network leads to heterogeneous optical neuromodulation, which simultaneously excites and inhibits neural network activity.
NANOSCALE HORIZONS
(2023)
Review
Pharmacology & Pharmacy
Dylan A. Hendy, Eva A. Amouzougan, Isabella C. Young, Eric M. Bachelder, Kristy M. Ainslie
Summary: Influenza is a global disease affecting millions of people, and vaccination is the best prevention method. However, due to viral mutations, seasonal influenza vaccines often have low efficacy and require yearly vaccination. To increase the antigenicity of universal influenza vaccines, nano/microparticles have been utilized as carriers, showing promising results in animal models.
Article
Chemistry, Physical
Jong Min An, Sangrim Kang, Chang Woo Koh, Sungnam Park, Myung Sook Oh, Dokyoung Kim
Summary: A new nano-antibiotic formulation based on sceptrin-Au nano-aggregates (SANA) has been developed to combat drug-resistant bacterial infections. SANA showed superior antibiotic/antibiofilm activity with low toxicity to red blood cells and endothelial cells. The feasibility of SANA as a new nano-antibiotic was demonstrated in CRPA-contaminated medical supplies.
NANOSCALE HORIZONS
(2022)
Article
Cell Biology
Huey-Shan Hung, Wei-Chien Kao, Chiung-Chyi Shen, Kai-Bo Chang, Cheng-Ming Tang, Meng-Yin Yang, Yi-Chin Yang, Chun-An Yeh, Jia-Jhan Li, Hsien-Hsu Hsieh
Summary: The study created a nanocomposite of PEG with various concentrations of Au nanoparticles, with PEG-Au 43.5 ppm showing superior biocompatibility and biological properties for MSCs, especially in neuronal differentiation. This nanocomposite enhanced cell adhesion, proliferation, and migration in MSCs, prevented apoptosis, inhibited inflammation, and promoted differentiation into various cell types, including nerve cells.
Article
Multidisciplinary Sciences
Can Xiao, Bernat Mir-Simon, Pilar Rivera-Gil
Summary: This article reports a synthetic procedure to obtain stable, reproducible, and robust highly-SERS performing nanocomposites for labeling. The biosensing performance was validated by designing a SERS-based detection assay model for SARS-CoV-2, with a detection limit below 10 ng/mL.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Multidisciplinary
Fenglian Qi, Ki-Jae Jeong, Jianxiao Gong, Zhiyong Tang
Summary: Self-assembly plays a crucial role in the research of nanomaterials, allowing for the spontaneous arrangement of nanoparticles. By balancing nanoscale interactions, highly controllable and efficient nanoparticle superstructures have been successfully built. Proper arrangement of nanoparticles inside the superstructures is essential for showcasing their functionalities. Constructing superstructures from optical nano units, such as noble metal nanostructures and semiconductor nanoparticles, is critical for achieving unique optical properties and exploring practical applications. This article provides guidelines for self-assembly strategies and discusses the optical properties of superstructures, as well as future directions in this field.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Li Tang, Zhengmao Yin, Ru Wang, Bin Wang, Kefan Jiang, Mei Ding, Shuxin Wang
Summary: In this study, two compounds Cd12Ag32-1 and Cd12Ag32-2 were synthesized and structurally determined by single-crystal X-ray diffraction. The selective adsorption of phosphine ligands caused by different types of thiol ligands was found. Additionally, Cd12Ag32-1 exhibited a unique stacking pattern in a superlattice with multiple inter-cluster channels. This study contributes to a deeper understanding of the effect of mixed ligands on nanocluster formation and the correlation between structure and properties.
Article
Chemistry, Multidisciplinary
Anna Badia, Anna Duarri, Anna Salas, Jordi Rosell, Joana Ramis, Muriel Freixanet Gusta, Eudald Casals, Miguel A. Zapata, Victor Puntes, Josep Garcia-Arumi
Summary: A formulation for ocular topical delivery containing small biocompatible cerium oxide nanoparticles (CeO(2)NPs) has shown antioxidant and neuroprotective effects, reducing oxidative stress and inhibiting neovascularization related to AMD disease.
Article
Biology
Diana Boraschi, Laura Canesi, Damjana Drobne, Birgit Kemmerling, Annalisa Pinsino, Petra Prochazkova
Summary: The interaction of engineered nanomaterials (ENMs) with the immune system primarily occurs in the interface tissues of living organisms, mainly involving cells and molecules of the innate immunity. Immuno-nanotoxicological studies aim to understand the consequences of this interaction, whether it is insignificant or potentially causes irreversible damage. This review focuses on the effector cells of innate immunity, the phagocytes, and their major sensing receptors, Toll-like receptors (TLRs), to evaluate the modes of interaction between ENMs and host defenses, comparing responses in various organisms.
BIOLOGICAL REVIEWS
(2023)
Editorial Material
Materials Science, Multidisciplinary
Qiang Cao, Na Liu, Yushi Xiao, Rong Huang, Yang Li, Lidong Wu
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Long Yuan, Qiran Chen, Jim E. Riviere, Zhoumeng Lin
Summary: Nanoparticles (NPs) are widely used but the clinical translation rate is low. Understanding the pharmacokinetics of NPs, especially in tumor delivery efficiency, is important for designing effective nanomedicines. This review focuses on the pharmacokinetics of NPs, discussing factors affecting NP pharmacokinetics and tumor delivery efficiency, as well as challenges and perspectives in the field.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Multidisciplinary Sciences
Mengyu Guo, Muya Xiong, Jinying Peng, Tong Guan, Haixia Su, Yanyi Huang, Cai-Guang Yang, Yang Li, Diana Boraschi, Thanigaimalai Pillaiyar, Guanbo Wang, Chengqi Yi, Yechun Xu, Chunying Chen
Summary: The ongoing COVID-19 pandemic has caused global concerns in public health and economy, leading to continuous development in therapeutics and vaccines. The use of multi-omics approaches has been instrumental in understanding the virus and its molecular features, aiding in the design of potential treatments and expediting vaccine development. This overview highlights the latest applications of multi-omics technologies in addressing COVID-19, providing suggestions for the development of effective therapeutics and vaccines based on comprehensive knowledge.
NATIONAL SCIENCE REVIEW
(2023)
Article
Materials Science, Biomaterials
Zhengjiang Xu, Yuan Zhang, Danping Lu, Guofang Zhang, Yang Li, Zufu Lu, Fei Wang, Guocheng Wang
Summary: Accumulation of senescent cells in the elderly has a negative impact on bone homeostasis, and it is important to mitigate cell senescence and reduce oxidative stress for improved bone fracture healing in elderly patients. This study developed a nanoformulation of resveratrol (RSV) using a biocompatible zeolitic imidazolate framework-8 (ZIF-8) nanoparticle, which effectively addressed the issues of oxidation and bioavailability. The ZIF-8/RSV nanoformulation showed promising results in alleviating cellular senescence and enhancing cell functions, suggesting its potential for bone fracture treatment in the elderly.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Veterinary Sciences
Scott A. Fritz, Steve M. Ensley, Jay R. Lawrence, Nicholas Van Engen, Zhoumeng Lin, Michael D. Kleinhenz, Larry W. Wulf, Somchai Rice, Patrick J. Gorden, Jackie Peterson, Johann F. Coetzee
Summary: Pain control is a major concern in dairy cattle. NSAIDs are approved for use in other species but their safety profile in cattle is not well studied. This study investigated the safety and pharmacokinetics of a high dose of meloxicam in lactating dairy cows.
VETERINARY SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Qiran Chen, Long Yuan, Wei-Chun Chou, Yi-Hsien Cheng, Chunla He, Nancy A. Monteiro-Riviere, Jim E. Riviere, Zhoumeng Lin
Summary: This study presents an updated version of Nano-Tumor Database, which includes more concentration data sets for nanoparticles in tumors and provides data on nanoparticle accumulation in healthy organs. The results reveal a low tumor delivery efficiency, but consistent with previous studies. By employing the best regression model, hypothetical scenarios with potential higher delivery efficiency are generated by varying the nanoparticle factors.
Article
Environmental Sciences
Shiyu Chen, Zhenzhen Shi, Qiang Zhang
Summary: In this study, a human physiologically based pharmacokinetic (PBPK) model of diethyl phthalate (DEP) was developed to assess its toxicity. The model considers the distribution and metabolism of DEP and its active metabolite monoethyl phthalate (MEP) in different tissue compartments. Sensitivity analysis and Bayesian Markov chain Monte Carlo (MCMC) simulations were performed to evaluate the uncertainty and variability of the model parameters. The results suggest that dermal absorption is an important route of exposure to DEP in the environment.
ENVIRONMENTAL POLLUTION
(2024)
Article
Food Science & Technology
Xue Wu, Zhoumeng Lin, Emily Toney, Maaike O. Clapham, Scott E. Wetzlich, jennifer L. Davis, Qiran Chen, Lisa A. Tell
Summary: This study aimed to determine the depletion profiles and withdrawal intervals (WDIs) for florfenicol and its metabolite in goats. The plasma half-life for florfenicol was 101.80 hours and for its metabolite was 207.69 hours. The calculated WDIs using different pharmacostatistical methods were 202 and 101 days.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alexandra C. Fux, Cristiane Casonato Melo, Sara Michelini, Benjamin J. Swartzwelter, Andreas Neusch, Paola Italiani, Martin Himly
Summary: Lipopolysaccharide (LPS), a major component of Gram-negative bacteria's outer cell wall, elicits severe immune reactions and requires accurate detection in medical devices and injectable pharmaceuticals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Wei-Chun Chou, Qiran Chen, Long Yuan, Yi-Hsien Cheng, Chunla He, Nancy A. Monteiro-Riviere, Jim E. Riviere, Zhoumeng Lin
Summary: An AI-assisted PBPK model was established to simulate the delivery efficiency and biodistribution of nanoparticles (NPs) in tumor-targeted therapy. The AI-based QSAR model, developed with machine learning and deep neural network algorithms, predicted critical input parameters of the PBPK model. The predictions of the AI-PBPK model correlated well with experimentally-measured pharmacokinetic profiles of NPs in tumor.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Ana Garcia, Juan Antonio Camara, Ana Maria Boullosa, Muriel F. Gusta, Laura Mondragon, Simo Schwartz Jr, Eudald Casals, Ibane Abasolo, Neus G. Bastus, Victor Puntes
Summary: Injection of albumin-stabilised 5 nm CeO(2)NPs into mice enhances X-ray contrast significantly, with prolonged residence time in target organs.
Article
Biochemistry & Molecular Biology
Wenjie Yang, Yang Li, Diana Boraschi
Summary: Plastic pollution is a global problem that poses risks to the environment and human health. Discarded plastic degrades into microplastics (MPs) in the environment, which can interact with microorganisms and biomolecules. These interactions can modify the characteristics of microbes and biomolecules, potentially affecting the immune response and leading to risks to human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Yuping Zhang, Shijie Ju, Gregori Casals, Jie Tang, Yichao Lin, Xiaofang Li, Lihua Liang, Zhiyu Jia, Muling Zeng, Eudald Casals
Summary: Advanced oxidation processes using TiO2-based nanomaterials are sustainable and promising technologies for the degradation of various pollutants, including pharmaceutical residues. However, a systematic comparison of heterostructures coupling TiO2 with visible-light active nanomaterials is lacking. The complex synthesis processes and wide variety of proposed nanostructures hinder the commercialization and effectiveness of these materials for environmental remediation. In this study, we successfully synthesized two heterostructured photocatalysts representative of two main families of novel structures, hybrids of TiO2 with metal (Au) and semiconductor (CeO2) nanomaterials, using a facile and cost-effective method. The photocatalytic degradation of ciprofloxacin and sulfamethoxazole, two antibiotics polluting water sources, was evaluated, and CeO2/TiO2 exhibited the highest activity, achieving complete antibiotic degradation at very low photocatalyst concentrations. The study provides new insights into the development of inexpensive heterostructured photocatalysts and highlights the enhanced role of CeO2 in the photocatalytic reaction.
