期刊
NANOTECHNOLOGY
卷 28, 期 46, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1361-6528/aa8c31
关键词
mitochondria; ABT737; non-small cell lung cancer; anticancer efficacy
资金
- National Research Foundation of Korea [2014R1A2A1A11052615, 2015R1A2A1A15056054]
- Korea Health Technology R&D Project of KHIDI - Ministry of Health Welfare [HI14C1802]
- Korea Health Promotion Institute [HI14C1802000016] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2014R1A2A1A11052615, 2015R1A2A1A15056054] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Although activating apoptosis in cancer cells by targeting the mitochondria is an effective strategy for cancer therapy, insufficient targeting of the mitochondria in cancer cells restricts the availability in clinical treatment. Here, we report on a polyethylene glycol-coated carbon nanotube (CNT)-ABT737 nanodrug that improves the mitochondrial targeting of lung cancer cells. The polyethylene glycol-coated CNT-ABT737 nanodrug internalized into the early endosomes via macropinocytosis and clathrin-mediated endocytosis in advance of early endosomal escape and delivered into the mitochondria. Cytosol release of the nanodrug led to apoptosis of lung cancer cells by abruption of the mitochondrial membrane potential, inducing Bcl-2-mediated apoptosis and generating intracellular reactive oxygen species. As such, this study provides an effective strategy for increasing the anti-lung cancer efficacy by increasing mitochondria accumulation rate of cytosol released anticancer nanodrugs.
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