Article
Biochemistry & Molecular Biology
Tina Gulin-Sarfraz, Georgios N. Kalantzopoulos, John-Erik Haugen, Lars Axelsson, Hilde Raanaas Kolstad, Jawad Sarfraz
Summary: This study presents a mesoporous silica nanocarrier for loading natural active compounds, which can prolong release and protect compounds in real food packaging applications. By simulating drip-loss from food, the nanocarrier system is activated, resulting in antimicrobial effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Min Ji Son, Taelin Kim, Sang-Wha Lee
Summary: Fluorescent mesoporous silica nanoparticles were synthesized as a nanocarrier for the efficient delivery of Die molecules. The release rate of Die was pH-responsive, with the PEG-coated nanoparticles showing the most pronounced difference between pH 4.5 and pH 7.4. The double-layer-coated nanoparticles exhibited significantly delayed release rates compared to the coating-free and single-layer-coated analogs.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Review
Materials Science, Biomaterials
Jun Yong Oh, Gyeongseok Yang, Eunshil Choi, Ja-Hyoung Ryu
Summary: The review highlights the recent research on mesoporous silica nanoparticle-supported nanocarriers for efficient cancer treatment. These nanocarriers possess a high drug loading capacity, encapsulation stability, and targeting capability, making them promising for drug delivery applications.
BIOMATERIALS SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Yameng Zhu, Mengmeng Zhang, Shujie Wei, Boyao Wang, Jun He, Xilong Qiu
Summary: In this study, monodisperse and temperature-responsive hollow mesoporous silica nanoparticles (HMSN@P(NIPAM-co-NHMA)) were successfully synthesized, showing excellent drug loading efficiency and temperature-sensitive release behavior. The nanoparticles also exhibited good biocompatibility and stability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Jing Hu, Peiting Du, Ruoyi Xu, Weijun Deng
Summary: This study fabricated supersmall dendritic mesoporous silica nanospheres (DMSNs) with tunable diameters, serving as nanocarriers for antioxidants and flavoring oils to generate stable emulsions. Gas chromatography-mass spectrometry-olfactometry (GC-MS-O) analysis demonstrated that DMSNs have outstanding protective functionalities for the encapsulated flavoring oil. The research indicates that DMSNs are an ideal platform for stable Pickering emulsions for aromatic compounds, offering a new approach for delivering flavor and sensitive bioactives with excellent stability in various applications such as food, medicine, and cosmetics.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Food Science & Technology
Yingjun Cui, Xiangyou Wang, Meng Cheng, Yanli Guo, Rongfei Zhang
Summary: Mesoporous silica nanoparticles (MSNPs) with different pore structures were developed to carry and release thymol, enhancing its bioavailability. The loading capacity of thymol-loaded MSNPs reached the highest when the ratio of thymol to MSNPs was 3:1. The encapsulation of thymol improved its stability and the release behavior followed Fickian diffusion process. Thymol-loaded MSNPs showed remarkable antimicrobial efficiency against S. aureus.
Article
Crystallography
Melissa Venedicto, Jake Carrier, Ha Na, Chen-Yu Chang, Daniela R. Radu, Cheng-Yu Lai
Summary: Mesoporous silica nanoparticles (MSNs) are utilized as carriers in drug and gene delivery research for biomedical applications due to their high surface area, consistent particle size, and minimal toxicity. By incorporating disulfide (SS) bonds into the walls of MSNs, a dual pathway for drug release is provided. Various characterization methods are employed to study the effect of embedding disulfide bonds into MSNs. The study demonstrates that MSN-SS is a promising nanocarrier for controlled-release drug delivery with efficient pH-responsive drug release behavior.
Review
Chemistry, Multidisciplinary
Ping Huang, Daizheng Lian, Hualin Ma, Nansha Gao, Limin Zhao, Ping Luan, Xiaowei Zeng
Summary: Mesoporous silica nanoparticles, with their simple synthesis, biocompatibility, and high surface area, have been developed as drug carriers for targeted and controlled drug release. By designing gated systems using various materials, these nanoparticles offer a new approach for selective delivery of antitumor drugs. Challenges and future prospects of gated mesoporous silica nanoparticles are discussed for their potential in drug delivery systems.
CHINESE CHEMICAL LETTERS
(2021)
Article
Engineering, Environmental
Yunhao Gao, Yu Liu, Xueyin Qin, Ziping Guo, Donglin Li, Chenggang Li, Hu Wan, Fuxing Zhu, Jianhong Li, Zhuo Zhang, Shun He
Summary: The study presented controlled-release formulations with pH/cellulase dual stimuli responsiveness for efficient fungicidal activity against Magnaporthe oryzae and reduced genotoxicity of pyraclostrobin. These formulations are promising for sustainable crop disease protection.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Materials Science, Multidisciplinary
Latifah Hamad K. Alfhaid
Summary: Mesoporous silica nanoparticles (MSNs) are considered a highly promising candidate for novel drug delivery systems, with controllable pores, large pore volume, high loading cavities, and biocompatibility; MSNs functionalized with stimuli-responsive polymers can release drugs in response to various stimuli, improving drug stability and extending release period.
Article
Nanoscience & Nanotechnology
Chao-Yi Wang, Xin-Yue Lou, Zhi Cai, Ming-Zhe Zhang, Chengguo Jia, Jian-Chun Qin, Ying-Wei Yang
Summary: A supramolecular fungicide nanoplatform responsive to fungal pathogen microenvironment has been designed, utilizing smart cargo delivery systems for controlled release, offering an eco-friendly alternative to synthetic fungicides for disease control.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Inorganic & Nuclear
Anandhu Mohan, Jerome Peter, Lipeeka Rout, Anju Maria Thomas, Saravanan Nagappan, Wei-Jin Zhang, Surendran Parambadath, Sung Soo Park, Chang-Sik Ha
Summary: This study successfully synthesized a temperature-responsive switchable polymer-silica nanohybrid material with well-defined porosity through free-radical polymerization inside MCM-41 mesopores. The catalyst exhibited high catalytic efficiency and robustness in an aqueous medium, along with enhanced selectivity and activity for carbonyl compound reduction compared to other controlled catalysts.
DALTON TRANSACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Zhongtao Li, Jing Guo, Guiqiang Qi, Meng Zhang, Liguo Hao
Summary: A pH-responsive and imaging nanocarriers system using mesoporous silica nanoparticles (MSNs) doped with gadolinium (Gd) was developed. The system showed pH-responsiveness and high biocompatibility, and the T1 contrast was significantly enhanced by Gd, making it a promising system for cancer diagnosis and treatment.
Review
Chemistry, Physical
Yiyuan Tang, Guojie Wang
Summary: This article reviews strategies for the design and fabrication of nanocarriers for NIR light-controlled release, based on three triggering mechanisms: photore-actions of chromophores, photothermal effect, and photo-oxidation. Challenges and perspectives for the future development of NIR light-sensitive nanocarriers are discussed.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS
(2021)
Article
Fisheries
Xiang Liu, Mao-Sheng He, Ke-Chen Yang, Bin Yang, Fei Ling, Gao-Xue Wang
Summary: This study evaluated the anti-LMBV activity of ribavirin and mesoporous silica nanocarriers loaded with ribavirin (MSNs-R) in vitro and in vivo. Ribavirin efficiently protected EPC cells against LMBV infection, with an IC50 value of 7.16 μM after 48 hours of exposure. It also showed potent anti-LMBV activity in largemouth bass, with a 68.4% inhibition rate after 7 days of continuous treatment. MSNs were used as drug carriers to enhance the anti-LMBV activity of ribavirin, and the results showed promising outcome in zebrafish larvae.
Article
Chemistry, Applied
Jaime Faria, Bruno Dionisio, Iris Soares, Ana Catarina Baptista, Ana Marques, Lidia Goncalves, Ana Bettencourt, Carlos Baleizao, Isabel Ferreira
Summary: Multifunctional polymeric coatings with drug delivery capabilities are crucial in preventing/reducing biofilm formation on implant surfaces. Cellulose acetate (CA) films and membranes are being explored for use as protective coatings and drug delivery vehicles for metal implants. Improving adhesion to stainless steel substrates is key, with methods such as grinding and intermediate layers being successfully employed. Incorporating PMMA microcapsules containing daptomycin into CA films and fibers has shown promising drug release capabilities under UV radiation in simulated body fluid.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Laurinda R. P. Areias, Jose Paulo S. Farinha
Summary: Structural color is a non-fading pigment that is obtained from materials with periodic variation of refractive index. It has low environmental impact and toxicity and can cover the full visible spectrum by tuning the size and arrangement of nanoparticles. The optical properties of these pigments are directly related to the arrangement of nanoparticles within the pigment.
Article
Biochemistry & Molecular Biology
Quinn A. Besford, Simon Schubotz, Soosang Chae, Ayse B. Ozdabak Sert, Alessia C. G. Weiss, Gunter K. Auernhammer, Petra Uhlmann, Jose Paulo S. Farinha, Andreas Fery
Summary: This article introduces a brush system for studying molecular transport from droplets to external polymer brushes. The study finds that molecular transport is influenced by relative humidity.
Article
Pharmacology & Pharmacy
Leonor Corte-Real, Ana Rita Bras, Adhan Pilon, Nuno Mendes, Ana Sofia Ribeiro, Tiago D. Martins, Jose Paulo S. Farinha, M. Conceicao Oliveira, Fatima Gartner, M. Helena Garcia, Ana Preto, Andreia Valente
Summary: The need for new therapeutic approaches for triple-negative breast cancer is clinically relevant. A new family of ruthenium(II) organometallic complexes was synthesized with the aim of enhancing cancer cell uptake through a multi-targeting approach. These compounds showed promising anti-cancer effects against triple-negative breast cancer cells in experimental conditions.
Article
Chemistry, Multidisciplinary
Iris Soares, Jaime Faria, Ana Marques, Isabel A. C. Ribeiro, Carlos Baleizao, Ana Bettencourt, Isabel M. M. Ferreira, Ana Catarina Baptista
Summary: This study presents a novel dual polymeric film coating for the treatment of implant-related infections. The coating allows local antibiotic-controlled delivery and enhances adhesion to the metal substrate through mechanical abrasion. The release rate depends on the drug type, solution pH, and whether the drug is freestanding or encapsulated.
Article
Chemistry, Physical
Barbara Casteleiro, Tania Ribeiro, Ines Mariz, Jose Manuel Gaspar Martinho, Jose Paulo Sequeira Farinha
Summary: This study presents a method to encapsulate NIR emitting AuNC in polymer nanoparticles (PNPs). The AuNC were successfully encapsulated in PNPs obtained by miniemulsion polymerization, resulting in PNPs with high brightness in the NIR.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Biophysics
Ritu Raj, Sandra N. Pinto, Carina I. C. Crucho, Surajit Das, Carlos Baleizao, Jose Paulo S. Farinha
Summary: Fluorescent silica nanoparticles with a polymer shell can traceably deliver anticancer drugs, protecting them during delivery and releasing them intracellularly. These nanoparticles can accommodate a large drug payload and efficiently release the drug inside cells, showing excellent prospects for controlled drug delivery.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Physical
Barbara Casteleiro, Jose Manuel Gaspar Martinho, Jose Paulo Sequeira Farinha
Summary: In this study, we encapsulated Au25(MHA)18 nanoclusters into methacrylate polymer nanoparticles (PNPs) with a diameter of approximately 50 nm. The time evolution of these structures in aqueous dispersion showed the formation of gold nanoparticles (AuNPs) with a diameter of approximately 4 nm, resulting in a 2-fold emission amplification of the AuNCs due to the plasmon's field enhancement effect. The optical properties of the PNPs were unchanged upon drying due to negligible diffusion of AuNCs inside the PNPs in the absence of solvent.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Giorgia Figari, Jose L. M. Goncalves, Herminio P. Diogo, Madalena Dionisio, Jose Paulo Farinha, Maria Teresa Viciosa
Summary: The impact of surface functionalization on mesoporous silica nanoparticle (MSN) carriers and the release of Fenofibrate (FNB) was investigated. The MSNs were modified with either (3-aminopropyl) triethoxysilane (APTES) or trimethoxy(phenyl)silane (TMPS), and the density of the functional groups was measured. The FNB loaded in the MSNs with ordered cylindrical pores showed amorphization, and the glass transition temperature slightly changed depending on the surface modification. Dielectric studies revealed multiple relaxations associated with different FNB populations and correlated their mobility with drug release profiles.
Article
Nanoscience & Nanotechnology
Barbara Casteleiro, Fernande Da Cruz-Boisson, Pierre Alcouffe, Sandra N. Pinto, Jose M. Gaspar Martinho, Marie-Therese Charreyre, Jose Paulo Sequeira Farinha, Arnaud Favier
Summary: This study reports the synthesis of biocompatible poly(N-acryloyl morpholine) (PNAM) surface-modified gold nanoclusters (AuNCs) with a diameter under 2 nm and near-infrared photoluminescence. Compared with AuNCs stabilized by small ligands, the PNAM-AuNCs exhibit better colloidal stability, increased photoluminescence lifetimes, and enhanced quantum yields. Furthermore, the properties of these PNAM-AuNCs can be successfully tuned using PNAM chains with different molecular weights. These PNAM-AuNCs provide an excellent platform for the development of bioimaging probes without organic dyes.
ACS APPLIED NANO MATERIALS
(2023)
Review
Polymer Science
Jose Paulo Sequeira Farinha
Summary: This review discusses strategies for preparing high-performance emissive polymer nanomaterials with high brightness and photostability, including designing polymer nanomaterials carrying multiple fluorescent dyes and increasing the brightness of each individual dye.
Article
Polymer Science
Barbara Casteleiro, Mariana Rocha, Ana R. Sousa, Andre M. Pereira, Jose M. G. Martinho, Clara Pereira, Jose P. S. Farinha
Summary: Gold nanoclusters (AuNCs) with fluorescence in the Near Infrared (NIR) were incorporated in mesoporous silica nanoparticles (MSNs) using a one-pot synthesis procedure, resulting in nanocomposite particles with simultaneous NIR fluorescence and superparamagnetic properties, which have high potential for application in multimodal bioimaging.
Review
Chemistry, Multidisciplinary
Barbara Casteleiro, Jose Manuel Gaspar Martinho, Jose Paulo Sequeira Farinha
Summary: Gold nanoclusters (AuNCs) have unique properties but lack colloidal stability, encapsulation can provide stronger protection and improve performance. This review focuses on encapsulating AuNCs in polymers, silica and metal organic frameworks (MOFs) for applications in bioimaging, sensing and catalysis.
Article
Chemistry, Multidisciplinary
Laetitia Bardet, Herve Roussel, Stefano Saroglia, Masoud Akbari, David Munoz-Rojas, Carmen Jimenez, Aurore Denneulin, Daniel Bellet
Summary: The thermal instability of silver nanowires leads to increased electrical resistance in AgNW networks. Understanding the relationship between structural and electrical properties of AgNW networks is crucial for their integration as transparent electrodes in flexible optoelectronics. In situ X-ray diffraction measurements were used to study the crystallographic evolution of Ag-specific Bragg peaks during thermal ramping, revealing differences in thermal and structural transitions between bare and SnO2-coated AgNW networks.
Article
Chemistry, Multidisciplinary
Nathalia Cancino-Fuentes, Arnau Manasanch, Joana Covelo, Alex Suarez-Perez, Enrique Fernandez, Stratis Matsoukis, Christoph Guger, Xavi Illa, Anton Guimera-Brunet, Maria V. Sanchez-Vives
Summary: This study provides a comprehensive characterization of graphene-based solution-gated field-effect transistors (gSGFETs) for brain recordings, highlighting their potential clinical applications.
Article
Chemistry, Multidisciplinary
Sikandar Aftab, Hailiang Liu, Dhanasekaran Vikraman, Sajjad Hussain, Jungwon Kang, Abdullah A. Al-Kahtani
Summary: This study examines the effects of hybrid nanoparticles made of NiO@rGO and NiO@CNT on the active layers of polymer solar cells and X-ray photodetectors. The findings show that these hybrid nanoparticles can enhance the charge carrier capacities and exciton dissociation properties of the active layers. Among the tested configurations, the NiO@CNT device demonstrates superior performance in converting sunlight into electricity, and achieves the best sensitivity for X-ray detection.
Article
Chemistry, Multidisciplinary
Hyo Jung Shin, Seung Gyu Choi, Fengrui Qu, Min-Hee Yi, Choong-Hyun Lee, Sang Ryong Kim, Hyeong-Geug Kim, Jaewon Beom, Yoonyoung Yi, Do Kyung Kim, Eun-Hye Joe, Hee-Jung Song, Yonghyun Kim, Dong Woon Kim
Summary: This study investigates the role of SOX9 in reactive astrocytes following ischemic brain damage using a PLGA nanoparticle plasmid delivery system. The results demonstrate that PLGA nanoparticles can reduce ischemia-induced neurological deficits and infarct volume, providing a potential opportunity for stroke treatment.
Article
Chemistry, Multidisciplinary
Anurag Chaudhury, Koushik Debnath, Nikhil R. Jana, Jaydeep K. Basu
Summary: The study investigates the interaction between nanoparticles and cell membranes, and identifies key parameters, including charge, crowding, and membrane fluidity, that determine the adsorbed concentration and unbinding transition of nanoparticles.
Article
Chemistry, Multidisciplinary
Sina Sadeghi, Fazel Bateni, Taekhoon Kim, Dae Yong Son, Jeffrey A. Bennett, Negin Orouji, Venkat S. Punati, Christine Stark, Teagan D. Cerra, Rami Awad, Fernando Delgado-Licona, Jinge Xu, Nikolai Mukhin, Hannah Dickerson, Kristofer G. Reyes, Milad Abolhasani
Summary: In this study, an autonomous approach for the development of lead-free metal halide perovskite nanocrystals is presented, which integrates a modular microfluidic platform with machine learning-assisted synthesis modeling. This approach enables rapid and optimized synthesis of copper-based lead-free nanocrystals.
Article
Chemistry, Multidisciplinary
Zahir Abbas, Nissar Hussain, Surender Kumar, Shaikh M. Mobin
Summary: The rational construction of free-standing and flexible electrodes for electrochemical energy storage devices is an emerging research focus. In this study, a redox-active metal-organic framework (MOF) was prepared on carbon nanofibers using an in situ approach, resulting in a flexible electrode with high redox-active behavior and unique properties such as high flexibility and lightweight. The prepared electrode showed excellent cyclic retention and rate capability in supercapacitor applications. Additionally, it could be used as a freestanding electrode in flexible devices at different bending angles.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Xiaoting Zhang, Hui Ran, Ze Chen, Yicheng Ye, Jiamiao Jiang, Ziwei Hu, Miral Azechi, Fei Peng, Hao Tian, Zhili Xu, Yingfeng Tu
Summary: Photodynamic therapy (PDT) is a promising local treatment modality in cancer therapy, but its therapeutic efficacy is restricted by ineffective delivery of photosensitizers and tumor hypoxia. In this study, a phototactic Chlorella-based near-infrared (NIR) driven green affording-oxygen microrobot system was developed for enhanced PDT. The system exhibited desirable phototaxis and continuous oxygen generation, leading to the inhibition of tumor growth in mice. This study demonstrates the potential of using a light-driven green affording-oxygen microrobot to enhance photodynamic therapy.
Article
Chemistry, Multidisciplinary
Yujin Li, Jing Xu, Xinqi Luo, Futing Wang, Zhong Dong, Ke-Jing Huang, Chengjie Hu, Mengyi Hou, Ren Cai
Summary: In this study, hollow heterostructured materials were constructed using an innovative template-engaged method as cathodes for zinc-ion batteries. The materials exhibited fast Zn2+ transport channels, improved electrical conductivity, and controlled volume expansion during cycling. The designed structure allowed for an admirable reversible capacity and high coulombic efficiency.
Article
Chemistry, Multidisciplinary
Paritosh Mahato, Shashi Shekhar, Rahul Yadav, Saptarshi Mukherjee
Summary: This study comprehensively elucidates the role of the core and electrostatic surface of metal nanoclusters in catalytic reduction reactions. The electrostatic surface dramatically modulates the reactivity of metal nanoclusters.
Article
Chemistry, Multidisciplinary
Pei Liu, Mengdi Liang, Zhengwei Liu, Haiyu Long, Han Cheng, Jiahe Su, Zhongbiao Tan, Xuewen He, Min Sun, Xiangqian Li, Shuai He
Summary: This study demonstrates a simple and environmentally-friendly method for the synthesis of zinc oxide nanozymes (ZnO NZs) using wasted hop extract (WHE). The WHE-ZnO NZs exhibit exceptional peroxidase-like activity and serve as effective catalysts for the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2). In addition, a straightforward colorimetric technique for detecting both H2O2 and glucose was developed using the WHE-ZnO NZs as peroxidase-like catalysts.
Article
Chemistry, Multidisciplinary
Hyunkyu Oh, Young Jun Lee, Eun Ji Kim, Jinseok Park, Hee-Eun Kim, Hyunsoo Lee, Hyunjoo Lee, Bumjoon J. Kim
Summary: Mesoporous carbon particles have unique structural properties that make them suitable as support materials for catalytic applications. This study investigates the impact of channel nanostructures on the catalytic activity of porous carbon particles (PCPs) by fabricating PCPs with controlled channel exposure on the carbon surface. The results show that PCPs with highly open channel nanostructures exhibit significantly higher catalytic activity compared to those with closed channel nanostructures.
Article
Chemistry, Multidisciplinary
Yunjie Lu, Zhaohui Li, Zewei Li, Shihao Zhou, Ning Zhang, Jianming Zhang, Lu Zong
Summary: A tough, long-lasting adhesive and highly conductive nanocomposite hydrogel (PACPH) was fabricated via the synergy of interfacial entanglement and adhesion group densification. PACPH possesses excellent mechanical properties, interfacial adhesion strength, and conductivity, making it a promising material for long-term monitoring of human activities and electrocardiogram signals.
Article
Chemistry, Multidisciplinary
Zichao Wei, Audrey Vandergriff, Chung-Hao Liu, Maham Liaqat, Mu-Ping Nieh, Yu Lei, Jie He
Summary: We have developed a simple method to prepare polymer-grafted plasmonic metal nanoparticles with pH-responsive surface-enhanced Raman scattering. By using pH-responsive polymers as ligands, the aggregation of nanoparticles can be controlled, leading to enhanced SERS. The pH-responsive polymer-grafted nanoparticles show high reproducibility and sensitivity in solution, providing a novel approach for SERS without the need for sample pre-concentration.
Article
Chemistry, Multidisciplinary
Melis Ozge Alas Colak, Ahmet Gungor, Merve Buldu Akturk, Emre Erdem, Rukan Genc
Summary: This research investigates the effect of functionalizing carbon dots with hydroxyl polymers on their performance as electrode materials in a supercapacitor. The results show that the functionalized carbon dots exhibit excellent electrochemical performance and improved stability.