期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 13, 期 8, 页码 2523-2531出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2017.07.001
关键词
Chitosan; Nanoparticles; Lidocaine; Water-based system; Chitosan-poly(lactic acid) nanoparticles; Tropical drug delivery
资金
- PETROMAT: Center of Excellence on Petrochemical and Materials Technology
- Integrated Innovation Academic Center: IIAC, Chulalongkorn University Centenary Academic Development Project
- PTT Public Company Limited under the PTT - NSTDA [FDA-CO-2558-1309-TH]
Chitosan whisker (CSWK) grafted with oligo(lactic acid) (OLA) nanoparticles (NPs) in water is developed to aid transferring therapeutic agents through the skin in a transdermal drug delivery system. Although several works in the past have shown grafting of poly(lactic acid) onto chitosan, the present work shows a green grafting system for the first time. The nano-sized CSWK provided effective conjugation of lactic acid even in a heterogeneous water-based system followed by polycondensation to form OLA. The OLA chain length is controlled by the lactic acid content and modulates the lipophilicity of CSWK-OLA. This fine tunes not only the size of the NPs but also the encapsulation efficiency of the hydrophobic drug lidocaine. A detailed chemical structure analysis, including the factors related to the development of NPs, is presented and extends the studies to the model drug encapsulation and delivery. (C) 2017 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据