Article
Medicine, Research & Experimental
Xuzhuo Chen, Xiankun Cao, Dasheng Zheng, Chang Li, Yan Chen, Keyu Kong, Weifeng Xu, Bin Shi, Xinwei Chen, Fengrong Dai, Shanyong Zhang
Summary: In this study, PtAu2 nanoclusters with nitric oxide-responsive phosphorescence turn-on characteristics and strong binding interactions with cysteine were designed. They showed satisfactory biocompatibility and cellular uptake behavior, with potent anti-inflammatory and anti-osteoclast activities. Furthermore, PtAu2 clusters alleviated lipopolysaccharide-induced calvarial osteolysis in vivo and activated Nrf2 expression.
Article
Nanoscience & Nanotechnology
Yue Gao, Xiangyang Shi, Mingwu Shen
Summary: Advancements in nanotechnology have paved the way for innovative solutions in clinical treatments, particularly in the development of ultrasmall iron oxide nanoparticles (USIO NPs) for intelligent nanoplatforms and imaging-guided therapies to combat diseases. Collaboration with other nanomaterials and the potential future directions of USIO NP-based nanoplatforms hold promise for the field of smart nanomedicines.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Rodrigo Ken Kawassaki, Mariana Romano, Mayara Klimuk Uchiyama, Roberta Mansini Cardoso, Mauriicio S. Baptista, Sandra H. P. Farsky, Khallil Taverna Chaim, Robson Raphael Guimaraes, Koiti Araki
Summary: A novel ultrasmall paramagnetic nanoparticle (UPN), decorated with iron oxide on 3 nm titanium dioxide nanoparticles, has been developed as a potential alternative blood-pool contrast agent to gadoteric acid (GA) for MR angiography. It exhibits comparable relaxometric parameters to GA and has strong and prolonged contrast enhancement before renal excretion.
Article
Chemistry, Analytical
Wei Liu, Shengyan Yin, Yingcai Hu, Ting Deng, Jishan Li
Summary: A pH-responsive T2-T1 switchable MRI nanoprobe was constructed by combining the microemulsion method with the biomineralization principle, which can achieve T1-weighted imaging in tumor environments.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Alexander Omelyanchik, Franciscarlos Gomes da Silva, Guilherme Gomide, Ivan Kozenkov, Jerome Depeyrot, Renata Aquino, Alex Fabiano Cortez Campos, Dino Fiorani, Davide Peddis, Valeria Rodionova, Sonja Jovanovi
Summary: The study investigated the structural and magnetic properties of iron oxide nanoparticles obtained by the precipitation of iron ions in the presence of different amounts of citric acid. It was found that the particle size plays a crucial role in determining the magnetic properties, with smaller particles showing reduced saturation magnetization and increased coercivity due to the increasing role of the disordered surface. The observation of superspin-glass freezing, memory effects, and exchange bias in smaller particles provides evidence of unique magnetic behaviors at the nanoscale.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Chemistry, Physical
Ali M. Abou-Elanwar, Yogita M. Shirke, Cheol Hun Yoo, Soon Jin Kwon, Won-Kil Choi, Jong Suk Lee, Seong Uk Hong, Hyung Keun Lee, Jae-Deok Jeon (Jae-Deok)
Summary: By incorporating iron oxide nanoparticles into a polyamide matrix to form thin film nanocomposite membranes, significant improvements in water vapor permeance and selectivity were achieved.
APPLIED SURFACE SCIENCE
(2021)
Article
Biophysics
Jing Yu, Fangyin Zhu, Ya Yang, Peixia Zhang, Yilin Zheng, Haijun Chen, Yu Gao
Summary: Ultra-small iron-doped zinc oxide nanoparticles were developed for synergistic sono-chemodynamic therapy with low accumulation in vivo. These nanoparticles exhibited enhanced inhibitory effects on proliferation of various cancer cells and murine breast tumor growth with no obvious cumulative toxicity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Pharmacology & Pharmacy
Guan-Ling Lu, Ya-Chi Lin, Ping-Ching Wu, Yen-Chin Liu
Summary: Our study found that USPIO-101 has analgesic effects on mice with inflammatory pain. It reduces pain sensitivity by attenuating long-term potentiation at spinal cord and hippocampal synapses. However, higher doses of USPIO-101 may pose neurotoxicity risks.
Article
Nanoscience & Nanotechnology
Loi Tonthat, Toru Murayama, Nobukiyo Kobayashi, Shin Yabukami, Wakako Ikeda-Ohtsubo, Ken Ichi Arai
Summary: In this study, ultrasmall FeCo nanoparticles with a high magnetic moment were prepared and their antigen-antibody reaction for biodetection was examined. FeCo nanoparticles were obtained by dissolving the FeCo-BaF2 nanogranular film in water. The antigen-antibody reaction showed successful absorption of Candida albicans onto FeCo nanoparticles, and sonication treatment significantly increased the number of Candida albicans bound to FeCo nanoparticles. This study demonstrates the potential of ultrasmall nanoparticles with high magnetic moment for improved detection sensitivity and detection of smaller biomolecules.
Article
Nutrition & Dietetics
Marta Sala-Climent, Teresa Lopez de Coca, Maria Dolores Guerrero, Francisco Javier Munoz, Maria Amparo Lopez-Ruiz, Lucrecia Moreno, Monica Alacreu, Maria Auxiliadora Dea-Ayuela
Summary: This article investigates the effects of anti-inflammatory foods on chronic pain caused by rheumatic diseases. The study found that increased intake of anti-inflammatory foods can improve physical characteristics, stress, and pain in patients, while decreased consumption of pro-inflammatory foods is positively correlated with sleep satisfaction. In conclusion, following this anti-inflammatory diet pattern can provide relief from chronic pain, improve stress and depression symptoms, and reduce sleep disturbances.
FRONTIERS IN NUTRITION
(2023)
Article
Biotechnology & Applied Microbiology
Ruru Zhang, Kuan Lu, Li Xiao, Xuelan Hu, Wu Cai, Linjiang Liu, Yan Liu, Weihua Li, Hui Zhou, Zhiyuan Qian, Sixia Wang, Can Chen, Jianfeng Zeng, Mingyuan Gao
Summary: This study utilized ultrasmall iron oxide nanoparticles in combination with magnetic resonance imaging (MRI) to achieve early and noninvasive diagnosis of atherosclerotic plaques. The experiment demonstrated that the nanoparticles could enhance the signal at the plaque sites, providing a means for dynamic evaluation over a specific time frame.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jin Liu, Lu Shi, Xinxin Ma, Sijin Jiang, Xinyao Hou, Pu Li, Yue Cheng, Jia Lv, Shaoru Li, Tianyou Ma, Bei Han
Summary: A patented strain of Bacillus amyloliquefaciens C-1 in our laboratory has been found to produce functional sodium selenite under optimized fermentation conditions. This strain, known as C-1, has the ability to synthesize selenium nanoparticles and has shown potential as selenium-enriched postbiotics. The synthesized selenium nanoparticles exhibited antioxidant activity and C-1 cells enriched with selenium demonstrated anti-inflammatory effects. Transcriptome data analysis revealed differential gene expression in C-1 with and without selenium-enrichment, suggesting the involvement of various genes related to ABC transporter proteins and selenium metabolism. This study provides valuable insights for the development of nano-selenium biomaterials and selenium-enriched postbiotics.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Song Wang, Yonggang Zhang
Summary: A new advanced oxidation process, combining zero-valent iron (ZVI) activated peroxymonosulfate (PMS) process with electro-Fenton (EF) oxidation process, has been designed for the efficient degradation of methylene blue (MB) wastewater. The EF-PMS process can generate more reactive oxygen species (ROS) and reduce the cost of oxidants, leading to a significantly higher degradation rate and mineralization rate of MB. The main ROS involved in the EF-PMS process were identified as OH, SO4-, and O-1(2), and free radical oxidation played a crucial role in MB removal, accounting for 70.39% of the total removal efficiency.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Polymer Science
Huan-Jun Lu, Jian-Ke Cen, Yu Ren, Mei-Xian Li
Summary: This study aimed to design a nanoparticle delivery system using ginsenoside Rh2-conjugated O-carboxymethyl chitosan and explore its anti-nociceptive effects. The results showed that the nanoparticle could effectively reduce inflammatory pain and had a longer analgesic effect, indicating its potential medicinal application.
Article
Toxicology
Lin Wu, Wen Wen, Xiaofeng Wang, Danhua Huang, Jin Cao, Xueyong Qi, Song Shen
Summary: The study found that ultrasmall Fe3O4 nanoparticles have high toxicity, especially on the heart. The toxicity is related to both the iron element and particle size, providing new insights into the toxicology of ultrasmall Fe3O4 nanoparticles.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yuan-Yuarn Liu, Hung-Tsung Hsiao, Jeffrey Chi-Fei Wang, Yen-Chin Liu, Sheng-Nan Wu
EUROPEAN JOURNAL OF PHARMACOLOGY
(2019)
Article
Neurosciences
Hung-Tsung Hsiao, Yen-Chin Liu, Ping-Yen Liu, Sheng-Nan Wu
BRAIN RESEARCH BULLETIN
(2019)
Article
Biochemistry & Molecular Biology
Ping-Chung Kuo, Yen-Chin Liu, Yi-Ching Lo, Sheng-Nan Wu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Neurosciences
Yun Fan, Mei-Chuan Chou, Yen-Chin Liu, Ching-Kuan Liu, Chu-Huang Chen, Shiou-Lan Chen
Summary: Sleep apnea disrupts physiological homeostasis and can lead to neuronal dysfunction and anxiety, without significant impact on cognitive function. Chronic intermittent hypoxia alters synaptic plasticity in the brain, resulting in anxiety-like behaviors in mice. Treatment with NMDA receptor antagonist attenuates anxiety-like behavior induced by chronic IH, suggesting early intervention is important in managing anxiety-related complications in sleep apnea patients.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Patrick Szu-Ying Yen, Yen-Chin Liu, Chun-Hsien Chu, Shiou-Lan Chen
Summary: Chronic hypertension may lead to abnormal neuronal function and an increase in the expression of glutamatergic receptors, affecting the locomotor activity of rodents.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Environmental Sciences
Shung-Tai Ho, Tso-Chou Lin, Chun-Chang Yeh, Kuang- Cheng, Wei-Zen Sun, Chun-Sung Sung, Yeong-Ray Wen, Yi-Jer Hsieh, Po-Kai Wang, Yen-Chin Liu, Yu-Chuan Tsai
Summary: This study investigated the effects of long-term opioid treatment on sex hormone disturbances, sexual function, and depression in patients with chronic noncancer pain in Taiwan. The results showed a high prevalence of depression diagnosis, low sex hormone levels, and reduced sexual function among patients, highlighting the importance of regular screenings for further management.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Hung-Tsung Hsiao, Guan-Ling Lu, Yen-Chin Liu, Sheng-Nan Wu
Summary: PT-2385 has a significant impact on the ionic currents of pituitary tumor cells and glioma cells, potentially acting through alterations in cell membrane ion channels.
Article
Cell Biology
Mei-Chuan Chou, Hsiang-Chun Lee, Yen-Chin Liu, Patrick Szu-Ying Yen, Ching-Kuan Liu, Chu-Huang Chen, Tzu-Han Hsieh, Shiou-Lan Chen
Summary: This study found that long-term consumption of a high-fat diet may cause lipid metabolism overload in the brain and damage to glial cells. This may affect the protection of the brain and the survival of specific neurons.
Review
Anesthesiology
Yu -Lien Hsieh, Chung-Ren Lin, Yen -Chin Liu, Chi -Jane Wang, Wei-Teng Weng
Summary: Meta-analysis of 40 randomized controlled trials showed that sugammadex is associated with a lower risk of postoperative nausea and vomiting compared to neostigmine, especially in patients receiving volatile anesthetics.
MINERVA ANESTESIOLOGICA
(2023)
Article
Health Care Sciences & Services
Jia-Lin Chen, Shung-Tai Ho, Wei-Zen Sun, Yu-Chuan Tsai, Kuang- Cheng, Yen-Chin Liu, Yi-Jer Hsieh, Yeong-Ray Wen, Po-Kai Wang, Chun-Sung Sung, Chun-Chang Yeh, Tso-Chou Lin
Summary: The study found that the COVID-19 outbreak in 2020 did not interrupt access to long-term opioid prescriptions for most registered patients with chronic pain in Taiwan, but some patients experienced an increase in opioid dosage. 60% of patients reported experiencing constipation.
Article
Multidisciplinary Sciences
Yen-Chin Liu, Hung-Tsung Hsiao, Jeffrey Chi-Fei Wang, Tzu-Cheng Wen, Shiou-Lan Chen
Summary: The study suggests that TGF-beta 1 may be an important biological indicator for chronic pain in osteoarthritis patients in the CSF, while BDNF, TNF-alpha, and IL-8 show no significant correlations with pain scores in both the CSF and plasma.
Article
Health Care Sciences & Services
Po-Feng Lee, Chung-Yi Li, Yen-Chin Liu, Chang-Ta Chiu, Wen-Hsuan Hou
Summary: This study investigated the risk of mortality among long-term opioid analgesics users without cancer in Taiwan. Findings showed a significantly increased risk of all-cause mortality in this population, especially in younger adults. Strategies to reduce long-term opioid analgesics use, particularly their overuse or misuse, are urgently needed.
Article
Anesthesiology
Wei-Teng Weng, Chi-Jane Wang, Chung-Yi Li, Huai-Wei Wen, Yen-Chin Liu
Summary: This study found that erector spinae plane block is more effective than systemic analgesic within 24 hours after breast surgery and can serve as an alternative with similar analgesic effects to paravertebral block. However, no significant differences were observed between erector spinae plane block and paravertebral block in various outcome measures.
Article
Neurosciences
Yuan-Yuarn Liu, Jeffrey Chi-Fei Wang, Ya-Chi Lin, Hung-Tsung Hsiao, Yen-Chin Liu
Article
Cell Biology
Hung-Tsung Hsiao, Yuan-Yuarn Liu, Jeffrey Chi-Fei Wang, Ya-Chi Lin, Yen-Chin Liu
JOURNAL OF BIOMEDICAL SCIENCE
(2019)
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
