期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 13, 期 7, 页码 2199-2207出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.nano.2017.06.003
关键词
Antimicrobial surface; ZIF coating; Cell rupturing; Surface interaction
资金
- Institute of Bioengineering and Nanotechnology
- Biomedical Research Council
- Joint Council Office
- SERC Personal Care Programme
- Agency for Science, Technology and Research
Cicada wing surfaces are covered with dense patterns of nano-pillar structure that prevent bacterial growth by rupturing adhered microbial cells. To mimic the natural nano-pillar structure, we developed a general and simple method to grow metal organic framework (MOF) nanodagger arrays on a wide range of surfaces. These nano-daggers possess high bactericidal activity, with log reduction >7 for Escherichia coli and Staphylococcus aureus. It was hypothesized that the positively-charged ZIF-L nano-dagger surfaces enhance bacterial cell adhesion, facilitating selective and efficient bacteria killing by the rigid and sharp nano-dagger tips. This research provides a safe and clean antimicrobial surface technology which does not require external chemicals and will not cause drug resistance. (C) 2017 Elsevier Inc. All rights reserved.
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