Article
Chemistry, Multidisciplinary
Ruofei Zhang, Lei Chen, Qian Liang, Juqun Xi, Hanqing Zhao, Yiliang Jin, Xingfa Gao, Xiyun Yan, Lizeng Gao, Kelong Fan
Summary: Nanozymes with catalase-like activity, especially ferrihydrite, show potential in relieving tumor hypoxia for adjuvant radiotherapy. The surface iron-associated hydroxyl groups of ferrihydrite dominantly affect its catalytic activity. Moreover, ferrihydrite constantly catalyzes the decomposition of H2O2 to release O-2 in a specific pH range, enhancing the therapeutic effect of radiotherapy in the physiological environment.
Article
Nanoscience & Nanotechnology
Zi-Yang Liao, Wei-Wei Gao, Ning-Ning Shao, Jia-Min Zuo, Tao Wang, Meng-Zhen Xu, Feng-Xiu Zhang, Ya-Mu Xia
Summary: FePO4-HG, a new antibacterial agent, has demonstrated excellent antibacterial ability against antibiotic-resistant pathogens and can promote wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Zhiwei Wang, Wenlong Wang, Jin Wang, Dingsheng Wang, Milan Liu, Qianyuan Wu, Hongying Hu
Summary: This study demonstrates a regulatory mechanism based on the electron filling and orbital energies of metal active centers and provides a rational catalyst design strategy for achieving ultrahigh H2O2-decomposition activity. Among the investigated platinum-group-metal active centers, Ir-N-4 with partially occupied d(x2-y2) and d(xz) orbitals and the highest d-band center shows the strongest interaction with H2O2 and the lowest energy barrier for its decomposition. The single-atom Ir catalyst (Ir-NC) exhibits an ultrahigh H2O2-decomposition capacity, which is 1614 times higher than that of natural catalase, and surface-adsorbed atomic oxygen is identified as the key intermediate for O2 generation.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Mingchen Liang, Xueluer Mu, Yue Li, Yuanhang Tan, Xiaoying Hao, Ying Tang, Zigeng Wang, Wenbi Feng, Yingxi Lu, Xianfeng Zhou
Summary: A supramolecular strategy is developed to tune the stacking pattern of photosensitizer molecules in their aggregates, optimizing the efficiency of photothermal therapy and photodynamic therapy. The study reveals that BTH-Cy7-TCF, with loose molecular stacks formed by fine-tuning hydrogen bonding and intermolecular pi-pi interactions, exhibits higher singlet oxygen quantum yield and competitive photothermal conversion efficiency compared to IND-Cy7-TCF in their aggregated states, enhancing the synergistic effect of photodynamic therapy/photothermal therapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Hyung Shik Kim, Sieun Lee, Dong Yun Lee
Summary: Aurozyme, a novel nanomedicine composed of gold nanoparticles and glycyrrhizin, shows promise as a therapeutic strategy for colitis. It converts harmful peroxidase-like activity to beneficial catalase-like activity, effectively scavenging reactive oxygen/reactive nitrogen species and damage-associated molecular patterns. It promotes anti-inflammatory effects, restores intestinal function, and increases beneficial probiotics, highlighting its potential for the treatment of inflammatory diseases.
Article
Chemistry, Multidisciplinary
Kaiwei Wan, Chang Long, Bing Jiang, Minmin Liang, Zhiyong Tang, Hui Wang, Xinghua Shi
Summary: The decomposition process of hydrogen peroxide on reductive CoP nanoparticles and the pH-regulated peroxidase and catalase-like activities were studied. OH· radical intermediates complexed with TMB via H-bonds were found to be the main oxidants of TMB. The coverage of O*/OH* from the dissociation of H2O2 on CoP nanoparticles at neutral and alkaline pH conditions enhanced the dehydrogenation of H2O2 to O-2, leading to the transition between peroxidase and catalase-like activities.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Qianqian Qiao, Jinyu Wang, Kai Long, Linwei Li, Jiahao Chen, Yuhao Guo, Ziqiang Xu, Ying Kuang, Tianjiao Ji, Cao Li
Summary: This study developed a catalytic system using titanium-based MXene nanosheets to load enzymes and anticancer drugs. The nanosheets demonstrated catalase-like activity and photothermal capability, enabling enhanced cancer treatment through starvation therapy and alleviation of hypoxia. In vitro and in vivo studies confirmed the effective anticancer capability of this enzyme cascade system.
Article
Nanoscience & Nanotechnology
Yuzhu Yao, Puze Li, Junkai He, Dongdong Wang, Jun Hu, Xiangliang Yang
Summary: In this study, Bi2Se3-MnO2@BSA nanocomposites were successfully prepared via biomineralization, with Bi2Se3 and MnO2 acting as radiosensitizers and oxygen enhancers to improve tumor radiosensitivity. BSA templating provided high biocompatibility and stability to the nanocomposites, enhancing the efficacy of radiotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
H. Wang, Y. Shen, L. Chen, K. Li, Y. Shi, Z. Xu, D. Li, H. Chen, W. Wang, L. Gao
Summary: In this study, Gd-doped PBzyme with enhanced catalase-like activity is constructed by screening metal dopants on small-sized hollow mesoporous silica nanoparticles. Theoretical calculation shows that Gd regulates the state density population of Fe in PBzyme and reduces the Gibbs free energy of the catalytic cycle, thus improving its catalytic activity. The Gd-doped PBzyme exhibits approximately 4 times higher catalytic activity than pure PBzyme. In addition, the nanoplatform, when conjugated with photosensitizer Ce6 and tumor-targeted molecule folic acid and loaded with chemotherapy drug doxorubicin, shows dual-enhanced T1 and T2 imaging capacity. It demonstrates augmented antitumor effects by combining enhanced photodynamic therapy and doxorubicin-mediated chemotherapy in vitro and in vivo. This work highlights the effectiveness of integrating Gd into PBzyme in improving its catalytic activity and enhancing tumor theranostics.
MATERIALS TODAY NANO
(2023)
Article
Nanoscience & Nanotechnology
Mahsa Nikookar, Abdolreza Rezaeifard, Kirill V. Grzhegorzhevskii, Maasoumeh Jafarpour, Rouhollah Khani
Summary: In this study, a new heterojunction-like photocatalyst (M/K nanohybrid) was developed by combining the as-prepared 2,5,8-triamino-tri-striazine (Melem) with the Keplerate {Mo72Fe30} nanocapsule. The M/K nanohybrid demonstrated efficient photocatalytic activity towards hydrogen peroxide (H2O2) dismutation under visible-light irradiation.
ACS APPLIED NANO MATERIALS
(2022)
Article
Materials Science, Ceramics
Rong Dai, Xiaoning Tang, Xingkun Liang, Bin Zhang, Hao Ma, Jiahui Sun
Summary: In this study, a V doping method was used to obtain rod-like MgO crystals decorated with a nanoflake layer. The effect of V doping on the crystal structure and particle morphology of MgO was investigated. It was found that V doping significantly increased the specific surface area and pore size of MgO, and also dramatically improved its antibacterial properties. The results suggest that 7 mol% V doping induced the best antibacterial activity.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Nemanja Cvjetan, Lukas D. Schuler, Takashi Ishikawa, Peter Walde
Summary: Iron porphyrins, such as hemin, play important roles in biological systems and may have existed in early life forms. Hemin acts as a prosthetic group in heme peroxidases and catalyzes the oxidation of reducing substrates. The active site of heme peroxidases consists of a hydrophobic pocket in which hemin is embedded noncovalently. Experiments showed that certain additives can enhance the catalytic activity of hemin.
Article
Chemistry, Multidisciplinary
Lei Zhang, Qi Wang, Rutong Si, Zhongxin Song, Xiaoting Lin, Mohammad Norouzi Banis, Keegan Adair, Junjie Li, Kieran Doyle-Davis, Ruying Li, Li-Min Liu, Meng Gu, Xueliang Sun
Summary: This study investigates the enhanced mechanisms between Pt single atoms and different types of nitrogen-doped support materials. The Pt catalyst shows improved hydrogen evolution reaction activity with an increase in pyrrole-like nitrogen content in the carbon nanotube support. The superior performance of the Pt single atom catalysts is attributed to the interaction between dyz and s orbitals of hydrogen and sp(3) hybrid orbital of nitrogen.
Article
Nanoscience & Nanotechnology
Jie Chen, Linlin He, Bo Shen, Hongwei Yang, Huaming Mao, Yu Ren, Jungang Yin, Wei Dai, Shuanglong Zhao, Leihao Chen, Yiwei Dong
Summary: In this work, ethanolamine (ETA) was used to synthesize sesame cake-like Cu/Ag core-shell nanosheets (Cu/AgNSs) for the first time. It was found that ETA molecules played a role in the formation of Cu/AgNSs by binding to CuNSs and forming silver-amine complexes. The resulting Cu/AgNSs showed excellent catalytic activity in the reduction of p-nitrophenol.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
Lihong Wu, Xuechun Zhou, Gengping Wan, Yulin Tang, Shaohua Shi, Xuefei Xu, Guizhen Wang
Summary: Novel hierarchical CuNiAl layered double hydroxide nanotubes were prepared with in-situ transformation of Al2O3, displaying a high catalytic performance due to the unique tube-like structure. The developed label-free method enables the sensitive detection of glucose, with potential applications in juice samples.
DALTON TRANSACTIONS
(2021)
Article
Neurosciences
Nanfang Pan, Song Wang, Kun Qin, Lei Li, Ying Chen, Xun Zhang, Han Lai, Xueling Suo, Yajing Long, Yifan Yu, Shiyu Ji, Joaquim Radua, John A. Sweeney, Qiyong Gong
Summary: This study found overlapping neural abnormalities in temporoparietal circuitry in patients with ADHD and BPD, which may contribute to shared behavioral control problems. It also identified disorder-specific neural substrates in frontostriatal circuitry, which could explain the distinguishing features of motor and emotion domains in ADHD and BPD, respectively.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Chemistry, Multidisciplinary
Xiaoqin Zhang, Xiaoming Wang, Zhiqian Li, Jun Du, Xueyang Xiao, Dayi Pan, Hu Zhang, Xiaohe Tian, Qiyong Gong, Zhongwei Gu, Kui Luo
Summary: A macromolecular contrast agent BLDCGd was developed for targeted liver cancer imaging. The contrast agent had a high molecular weight and small particle size, and exhibited significant signal enhancement at the tumor site. The study demonstrated the potential of BLDCGd as an effective and bio-safe MRI contrast agent for clinical diagnosis of liver cancer.
Article
Neurosciences
Chengmin Yang, Wenjing Zhang, Jiajun Liu, Li Yao, Jeffrey R. R. Bishop, Rebekka Lencer, Qiyong Gong, Zhipeng Yang, Su Lui
Summary: By introducing functional gradient, this study found that the functional connectivity of subcortical systems in schizophrenia patients was disrupted before treatment and normalized after treatment. The changes in gradient were associated with symptom improvement.
NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Psychiatry
Huibing Guo, Bin Feng, Yingqiao Ma, Xueyi Zhang, Huiyong Fan, Zaiquan Dong, Taolin Chen, Qiyong Gong
Summary: This study aims to integrate drawing indicators into the process of screening for or classifying mental disorders by conducting a systematic review and meta-analysis of the application of the HTP test. The results revealed that drawing characteristics can predict mental disorders, with the whole being the strongest predictor, followed by the house, tree, and person. Valid predictors can be categorized into four types: item absence, bizarre or twisted, excessive details, and small or simplified. These findings can promote the standardization of the HTP test and provide a theoretical reference for the screening and clinical diagnosis of mental disorders.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Nanoscience & Nanotechnology
Shengxiang Fu, Zhongyuan Cai, Li Liu, Xiaomin Fu, Changqiang Wu, Liang Du, Chunchao Xia, Su Lui, Qiyong Gong, Bin Song, Hua Ai
Summary: Compared to traditional branched polymers, branched polymers with Gd(III) chelates as the internal skeleton show higher kinetic stability and better relaxivity enhancement for MRI contrast agents. Different poly-DOTA branched polymers were synthesized and the Gd(III) chelates displayed excellent stability and high T1 relaxivities. In vivo studies showed that P4-Gd had the best performance in terms of MRA effect, vascular stenosis detection, and longer observation window compared to Gd-DOTA. Overall, poly-DOTA branched polymers with Gd(III) chelates are promising candidates for MRI probes with improved relaxivity enhancement.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Clinical Neurology
Lei Wang, Qing Ma, Xiaoyi Sun, Zhilei Xu, Jiaying Zhang, Xuhong Liao, Xiaoqin Wang, Dongtao Wei, Yuan Chen, Bangshan Liu, Chu-Chung Huang, Yanting Zheng, Yankun Wu, Taolin Chen, Yuqi Cheng, Xiufeng Xu, Qiyong Gong, Tianmei Si, Shijun Qiu, Ching-Po Lin, Jingliang Cheng, Yanqing Tang, Fei Wang, Jiang Qiu, Peng Xie, Lingjiang Li, Yong He, Mingrui Xia, Yihe Zhang
Summary: This study conducted frequency-resolved connectome analysis on a large sample of MDD patients and healthy controls, revealing significant frequency-dependent connectome alterations in MDD. These alterations mainly occur in the left parietal, temporal, precentral, and fusiform cortices, as well as bilateral precuneus. Additionally, the connectome alteration in the high frequency band (0.16-0.24 Hz) is significantly associated with illness duration.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Behavioral Sciences
Jinping Lin, Lei Li, Nanfang Pan, Xiqin Liu, Xun Zhang, Xueling Suo, Graham J. Kemp, Song Wang, Qiyong Gong
Summary: A meta-analysis of resting-state functional neuroimaging studies showed that neuroticism is positively correlated with brain activity in the left middle temporal gyrus, left striatum, and right hippocampus, but negatively correlated with brain activity in the left superior temporal gyrus and right supramarginal gyrus. Sex and age were found to moderate the link between spontaneous brain activity and neuroticism.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Oncology
Shuang Li, Xiaorui Su, Youquan Ning, Simin Zhang, Hanbing Shao, Xinyue Wan, Qiaoyue Tan, Xibiao Yang, Juan Peng, Qiyong Gong, Qiang Yue
Summary: This study aimed to develop and validate CT-based radiomics models to differentiate between parotid pleomorphic adenoma (PA) with and without complete capsule. The results showed that models based on radiomics features from the tumor and peritumor achieved higher AUCs compared to models based on features from the tumor alone. The best performing model was Linear discriminant analysis, achieving an AUC of 0.86 in cross-validation and 0.869 in the test set.
Article
Neurosciences
Simin Zhang, Fei Zhao, Xibiao Yang, Qiaoyue Tan, Shuang Li, Hanbin Shao, Xiaorui Su, Qiyong Gong, Qiang Yue
Summary: This study aims to investigate the reorganization of white matter tracts and changes in structural networks in patients with glioma-related epilepsy. The results show complex WM reorganization in patients, primarily in the language, frontal-parietal, and limbic networks. Additionally, preserved integrity in contralateral corticospinal tract and decreased nodal betweenness in the paracentral lobule may serve as potential neuroimaging markers for the occurrence of seizures in glioma-related epilepsy.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Du Lei, Kun Qin, Wenbin Li, Ziyu Zhu, Maxwell J. Tallman, L. Rodrigo Patino, David E. Fleck, Veronica Aghera, Qiyong Gong, John A. Sweeney, Melissa P. DelBello, Robert K. McNamara
Summary: This study compared the brain microstructure differences in ADHD youth with and without a family history of bipolar disorder (BD). The high-risk ADHD group showed higher FA and lower MD in certain brain regions compared to the low-risk ADHD group. Both ADHD groups exhibited higher FA compared to healthy controls. Significant correlations were found between microstructure metrics and clinical ratings in ADHD groups.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Behavioral Sciences
Lei Li, Jing Jiang, Baolin Wu, Jinping Lin, Neil Roberts, John A. Sweeney, Qiyong Gong, Zhiyun Jia
Summary: Previous studies have found gray matter abnormalities in individuals with histories of childhood maltreatment. This study compared the effects in youth and adulthood and identified different patterns of gray matter changes. Adolescents closer to the maltreatment events showed more gray matter alterations in the developmental trajectory of brain structure.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Neurosciences
Qingyuan Li, Xun Zhang, Xun Yang, Nanfang Pan, Xiao Li, Graham J. Kemp, Song Wang, Qiyong Gong
Summary: This study aims to investigate the neurobiological mechanisms underlying social anxiety changes during the COVID-19 pandemic. The findings suggest that social anxiety alterations are related to the network properties of the brain, both at the global and nodal levels. These findings remain robust even after controlling for other factors.
NEUROBIOLOGY OF STRESS
(2023)
Article
Materials Science, Biomaterials
Kai Chen, Zhongyuan Cai, Yingzi Cao, Lingling Jiang, Yuting Jiang, Haojie Gu, Shengxiang Fu, Chunchao Xia, Su Lui, Qiyong Gong, Bin Song, Hua Ai
Summary: In this study, kinetically inert manganese-based hybrid micellar complexes (MnCs) were developed for magnetic resonance imaging (MRI) to localize and differentially diagnose sentinel lymph nodes (SLNs). The MnC MnC-20, composed of C18E20 and C18-PhDTA-Mn at a hydrodynamic particle size of 5.5 nm, showed significant signal intensity brightening effect and shortened T-1 relaxation time, which favored the discrimination of normal lymph nodes from SLN. This strategy of developing manganese-based MR nanoprobes was proven to be useful in lymph node imaging.
REGENERATIVE BIOMATERIALS
(2023)
Article
Neuroimaging
Yajuan Zhang, Chu-Chung Huang, Jiajia Zhao, Yuchen Liu, Mingrui Xia, Xiaoqin Wang, Dongtao Wei, Yuan Chen, Bangshan Liu, Yanting Zheng, Yankun Wu, Taolin Chen, Yuqi Cheng, Xiufeng Xu, Qiyong Gong, Tianmei Si, Shijun Qiu, Jingliang Cheng, Yanqing Tang, Fei Wang, Jiang Qiu, Peng Xie, Lingjiang Li, Yong He, Ching-Po Lin, Chun-Yi Zac Lo
Summary: Through analysis of a large dataset, it has been found that there are abnormal functional connections between the brainstem nuclei and other brain regions in patients with major depressive disorder (MDD). These findings improve our understanding of the pathophysiology of depression and provide a theoretical foundation for the development of new pharmacotherapies.
NEUROIMAGE-CLINICAL
(2023)
Article
Materials Science, Biomaterials
Yuting Jiang, Haojie Gu, Zhongyuan Cai, Shengxiang Fu, Yingzi Cao, Lingling Jiang, Changqiang Wu, Wei Chen, Chunchao Xia, Su Lui, Bin Song, Qiyong Gong, Hua Ai
Summary: Researchers developed a facile method to synthesize poly(acrylic acid)-coated manganese oxide nanoparticles (MnO2/PAA NPs), which exhibited good biocompatibility and high longitudinal relaxivity. The MnO2/PAA NPs with a particle size of 4.9 nm showed higher longitudinal relaxivity. In vivo magnetic resonance angiography experiments demonstrated that MnO2/PAA NPs had better angiographic performance and rapid clearance compared to Gadovist (Gd-DO3A-Butrol).
BIOMATERIALS SCIENCE
(2023)
