期刊
NANOMEDICINE
卷 12, 期 11, 页码 1231-1242出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0410
关键词
autoimmunity; experimental autoimmune encephalomyelitis; immunotherapy; liposomes; multiple sclerosis
资金
- Spanish Government [FIS PI15/00198]
- European Regional Development funds (FEDER)
- CERCA Programme, Generalitat de Catalunya
- A FACTT network [BM1305]
- EU
- AGAUR, Generalitat de Catalunya
Aim: Based on the ability of apoptosis to induce immunological tolerance, liposomes were generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our aim was to validate the immunotherapy in other autoimmune disease: multiple sclerosis. Materials & methods: Phosphatidylserine-rich liposomes were loaded with disease-specific autoantigen. Therapeutic capability of liposomes was assessed in vitro and in vivo. Results: Liposomes induced a tolerogenic phenotype in dendritic cells, and arrested autoimmunity, thus decreasing the incidence, delaying the onset and reducing the severity of experimental disease, correlating with an increase in a probably regulatory CD25(+) FoxP3(-) CD4(+) T-cell subset. Conclusion: This is the first work that confirms phosphatidylserine-liposomes as a powerful tool to arrest multiple sclerosis, demonstrating its relevance for clinical application.
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