4.7 Editorial Material

Overcoming the tumor microenvironment: the role of nanohyperthermia

期刊

NANOMEDICINE
卷 12, 期 11, 页码 1213-1215

出版社

FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0096

关键词

drug resistance; mechanobiology; nanohyperthermia; tumor microenvironment; tumor stiffening

资金

  1. European Union [685795]
  2. Institute thematique multi-organismes (ITMO) Cancer
  3. doctoral school Frontieres du Vivant (FdV) - Programme Bettencourt

向作者/读者索取更多资源

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Chemistry, Multidisciplinary

Self-Assemblies of Fe3O4Nanocrystals: Toward Nanoscale Precision of Photothermal Effects in the Tumor Microenvironment

Alba Nicolas-Boluda, Zhijie Yang, Thomas Guilbert, Laura Fouassier, Florent Carn, Florence Gazeau, Marie Paule Pileni

Summary: Fe(3)O(4) nanocrystals self-assemble into colloidosomes and supraballs, which exhibit different interactions within the tumor microenvironment compared to their individual building blocks. These hybrid self-assemblies target distinct compartments in the tumor microenvironment, leading to local photothermal damages that are not observed with isolated nanocrystals.

ADVANCED FUNCTIONAL MATERIALS (2021)

Article Chemistry, Multidisciplinary

Immune Reprogramming Precision Photodynamic Therapy of Peritoneal Metastasis by Scalable Stem-Cell-Derived Extracellular Vesicles

Amandine Pinto, Iris Marangon, Julie Mereaux, Alba Nicolas-Boluda, Gregory Lavieu, Claire Wilhelm, Laure Sarda-Mantel, Amanda K. A. Silva, Marc Pocard, Florence Gazeau

Summary: Extracellular nanovesicles derived from mesenchymal stem/stromal cells offer a promising approach for targeted photodynamic therapy, providing superior selectivity in tumor targeting, potentiation of cytotoxicity, modulation of the tumor microenvironment, and promotion of antitumor immune response. This fourth-generation PDT vehicle shows significant enhancement in tumor selectivity and efficacy compared to traditional forms of PS delivery, presenting a potential solution to the current limitations of PDT in treating peritoneal metastasis.

ACS NANO (2021)

Article Chemistry, Multidisciplinary

Tumor-Selective Immune-Active Mild Hyperthermia Associated with Chemotherapy in Colon Peritoneal Metastasis by Photoactivation of Fluorouracil-Gold Nanoparticle Complexes

Vladimir Mulens-Arias, Alba Nicolas-Boluda, Amandine Pinto, Alice Balfourier, Florent Carn, Amanda K. A. Silva, Marc Pocard, Florence Gazeau

Summary: A strategy using near-infrared photoactivated gold nanoparticles coupled with chemotherapy drug was proposed to achieve precise treatment of tumor nodules within the peritoneal cavity, providing potential to overcome the off-target toxicity and high morbidity of traditional HIPEC. The combined photothermal and chemotherapy mediated by the AuNP-drug complex showed efficient antitumor effects and activation of immune response while leaving healthy tissues undamaged.

ACS NANO (2021)

Article Biology

Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

Alba Nicolas-Boluda, Javier Vaquero, Lene Vimeux, Thomas Guilbert, Sarah Barrin, Chahrazade Kantari-Mimoun, Matteo Ponzo, Gilles Renault, Piotr Deptula, Katarzyna Pogoda, Robert Bucki, Ilaria Cascone, Jose Courty, Laura Fouassier, Florence Gazeau, Emmanuel Donnadieu

Summary: The study found that tumor stiffness is strongly correlated with tumor growth and ECM crosslinking, but negatively correlated with T cell migration. Interfering with collagen stabilization can reduce ECM content and tumor stiffness, improving T cell migration and the efficacy of anti-PD-1 blockade.
Review Pharmacology & Pharmacy

Engineering and loading therapeutic extracellular vesicles for clinical translation: A data reporting frame for comparability

Max Piffoux, Jeanne Volatron, Kondareddy Cherukula, Kelly Aubertin, Claire Wilhelm, Amanda K. A. Silva, Florence Gazeau

Summary: Extracellular vesicles (EVs) have emerged as new drug delivery systems and regenerative cell-free effectors, with intrinsic biocompatibility and targeting capabilities, but clinical translation is still hindered by difficulties in production and loading of EVs.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Review Pharmacology & Pharmacy

Development of extracellular vesicle-based medicinal products: A position paper of the group Extracellular Vesicle translatiOn to clinicaL perspectiVEs-EVOLVE France

Amanda K. A. Silva, Marie Morille, Max Piffoux, Surendar Arumugam, Phlippe Mauduit, Jerome Larghero, Arnaud Bianchi, Kelly Aubertin, Olivier Blanc-Brude, Daniele Noel, Emilie Velot, Celia Ravel, Celine Elie-Caille, Anna Sebbagh, Chantal Boulanger, Claire Wilhelm, Gabriel Rahmi, Isabelle Raymond-Letron, Kondareddy Cherukula, Tristan Montier, Christophe Martinaud, Jean-Marie Bach, Olivier Favre-Bulle, Jolanda Spadavecchia, Christian Jorgensen, Philippe Menasche, Clotilde Aussel, Joel Chopineau, Mathilde Mosser, Matti Ullah, Nicolas Sailliet, Nathalie Luciani, Noelle Mathieu, Pierre-Emmanuel Rautou, Sophie Brouard, Wilfrid Boireau, Sebastien Jauliac, Marianne Dedier, Jean-Hugues Trouvin, Florence Gazeau, Marina Trouillas, Juliette Peltzer, Antoine Monsel, Sebastien Banzet

Summary: The translation of EV research into medicinal products presents an exciting and challenging perspective, requiring fulfillment of quality, safety, and efficacy criteria. Active contributions from regulatory agencies, expert networks, and the newly established EVOLVE group in France play important roles in this translation process.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Review Pharmacology & Pharmacy

Genetic alterations shaping tumor response to anti-EGFR therapies

Javier Vaquero, Allan Pavy, Ester Gonzalez-Sanchez, Mark Meredith, Ander Arbelaiz, Laura Fouassier

Summary: EGFR can be targeted through selective tyrosine kinase inhibitors and monoclonal antibodies, but the majority of patients do not benefit due to the presence of drug resistance mechanisms. Extensive research is being conducted to find novel approaches to overcome resistance.

DRUG RESISTANCE UPDATES (2022)

Article Physics, Applied

Cold plasma endoscopy applied to biliary ducts: feasibility risk assessment on human-like and porcine models for the treatment of cholangiocarcinoma

Henri Decauchy, Allan Pavy, Marine Camus, Laura Fouassier, Thierry Dufour

Summary: In recent years, cold plasmas have emerged as a breakthrough technology for cancer treatment. This study focuses on the innovation of catheters and endoscopic devices to enable cold plasma treatment for biliary tract cancer. The researchers examined the safety and therapeutic efficacy of cold plasma endoscopy using a transferred plasma catheter. The study validated the technical feasibility of the technology and demonstrated its potential as a local treatment for biliary tract cancer.

JOURNAL OF PHYSICS D-APPLIED PHYSICS (2022)

Article Pharmacology & Pharmacy

Cationic Polyethyleneimine (PEI)-Gold Nanocomposites Modulate Macrophage Activation and Reprogram Mouse Breast Triple-Negative MET-1 Tumor Immunological Microenvironment

Vladimir Mulens-Arias, Alba Nicolas-Boluda, Florent Carn, Florence Gazeau

Summary: Nanomedicines based on inorganic nanoparticles have shown promise in the field of medicine due to their versatile properties. However, concerns exist regarding the immunological effects of nanoparticles. This study investigated the effects of AuPEI nanocomposites on the tumor microenvironment and found differential effects in vitro and in vivo, suggesting the importance of testing nanomaterials in relevant immunocompetent mouse tumor models.

PHARMACEUTICS (2022)

Review Oncology

Unraveling the actin cytoskeleton in the malignant transformation of cholangiocyte biology

Lea Duwe, Laura Fouassier, Juan Lafuente-Barquero, Jesper B. Andersen

Summary: The correct organization of actin cytoskeleton is crucial for liver organ homeostasis and disease control. Rearrangements of actin cytoskeleton in bile duct cells may play a key role in the development of cholangiocarcinoma (CCA) and cancer cell dissemination. Actin rearrangements not only occur due to signaling pathways, but also regulate and modify cellular signaling, promoting tumorigenic phenotypes. The specific mechanisms of CCA are still not fully understood, and future research should focus on how actin affects and regulates other signaling pathways to unravel the mechanisms of CCA development, progression, and metastasis.

TRANSLATIONAL ONCOLOGY (2022)

Article Gastroenterology & Hepatology

Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance

Diego Calvisi, Luke Boulter, Javier Vaquero, Anna Saborowski, Luca M. Fabris, Pedro Rodrigues, Cedric E. Coulouarn, Rui Castro, Oreste Segatto, Chiara Raggi, Luc J. W. van der Laan, Guido Carpino, Benjamin Goeppert, Stephanie J. Roessler, Timothy Kendall, Matthias Evert, Ester W. Gonzalez-Sanchez, Juan Valle, Arndt Vogel, John J. Bridgewater, Mitesh J. Borad, Gregory R. Gores, Lewis Roberts, Jose J. G. B. Marin, Jesper Andersen, Domenico Alvaro, Alejandro M. Forner, Jesus Banales, Vincenzo Cardinale, Rocio I. R. Macias, Silve Vicent, Xin Chen, Chiara Braconi, Monique M. A. Verstegen, Laura Fouassier, Lewis Roberts, Alexander Scheiter, Florin M. Selaru, Katja Evert, Kirsten Utpatel, Laura Broutier, Massimiliano Cadamuro, Meritxell Huch, Robert Goldin, Sergio A. Gradilone, Yoshimasa Saito

Summary: In this Consensus Statement, experts provide recommendations on the criteria for preclinical models of cholangiocarcinoma (CCA) to increase disease understanding and develop novel therapeutic approaches.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2023)

Review Oncology

Cancer-Associated Fibroblasts and Extracellular Matrix: Therapeutical Strategies for Modulating the Cholangiocarcinoma Microenvironment

Mirko Minini, Laura Fouassier

Summary: Immunotherapy has greatly impacted anti-tumor treatments, but solid tumor treatment has fallen short of expectations. Cholangiocarcinoma (CCA) is a leading cause of hepatic cancer-related deaths due to drug inefficacy and chemo-resistance. Research is ongoing to understand the mechanisms of chemo-resistance and the role of the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) and the excess production of aberrant extracellular matrix (ECM) by these cells may limit drug access and contribute to immune exclusion. This article summarizes the features, functions, and interactions of CAFs, tumor-associated ECM, and immune cells in the TME, and discusses strategies to target CAFs and remodel the ECM for improved immunotherapy and drug therapies.

CURRENT ONCOLOGY (2023)

Review Nanoscience & Nanotechnology

Hybrid nano- and microgels doped with photoacoustic contrast agents for cancer theranostics

Yu Xiao, Jerome Gateau, Amanda K. A. Silva, Xiangyang Shi, Florence Gazeau, Claire Mangeney, Yun Luo

Summary: Photoacoustic imaging (PAI) is an emerging noninvasive bioimaging modality for cancer theranostics, where hybrid nano- and microgels serve as protective carriers for PAI contrast agents due to their biocompatibility and high loading capacity. The development of photoacoustic active nano- and microgels has opened up new opportunities for innovative cancer theranostic agents. The chemical nature of gels, PAI contrast agents, and hybrid matrices, as well as their applications in multimodal cancer theranostics, are discussed.
Article Chemistry, Multidisciplinary

Local administration of stem cell-derived extracellular vesicles in a thermoresponsive hydrogel promotes a pro-healing effect in a rat model of colo-cutaneous post-surgical fistula

Arthur Berger, Irami Araujo-Filho, Max Piffoux, Alba Nicolas-Boluda, Alice Grangier, Imane Boucenna, Caroline Cristiano Real, Fabio Luiz Navarro Marques, Daniele de Paula Faria, Amalia Cinthia Meneses do Rego, Chloe Broudin, Florence Gazeau, Claire Wilhelm, Olivier Clement, Christophe Cellier, Carlos Alberto Buchpiguel, Gabriel Rahmi, Amanda K. A. Silva

Summary: Extracellular vesicles from stem/stromal cells, when administered locally in a thermoresponsive gel, show therapeutic potential for managing challenging post-surgical colon fistulas.

NANOSCALE (2021)

暂无数据