期刊
NANOMEDICINE
卷 12, 期 12, 页码 1491-1510出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0055
关键词
antibacterial; chitosan; drug delivery; fucoidan; H. pylori; nanogels; nanoparticles
资金
- Ministry of Science and Technology, Taiwan, ROC [NSC101-2221-E-038-016-MY3]
Aim: This study aims to validate the anti-Helicobacter pylori efficacy of amoxicillinloaded nanoparticles and nanogels with pH-responsive and site-specific drug release properties against H. pylori infection. Materials & methods: Genipin-crosslinked low molecular weight fucoidan/chitosan-N-arginine nanogels (FCSA) were prepared for targeted delivery of amoxicillin to the site of H. pylori infected AGS gastric epithelial cells. Results: The negatively charged nanogels (n-FCSA) adhered to H. pylori and exhibited pH-responsive drug release property to reduce cytotoxic effects in H. pylori infected AGS cells. Conclusion: These in vitro findings suggest that n-FCSA nanogels are potential carriers for H. pylori specific delivery of antibacterial agents, and provide the basis for further studies on the clinical use of the nanogels.
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