期刊
NANOMEDICINE
卷 12, 期 13, 页码 1547-1560出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2017-0004
关键词
imaging; inflammatory bowel disease; MAdCAM-1; manganese oxide nanoparticles
资金
- Fondazione Regionale per la Ricerca Biomedica (FRRB)
- Academic Funding Unimib
- 'Assessorato alla Sanita', Regione Lombardia
Aim: We investigate MAdCAM-1 as a reliable target to detect active bowel inflammation for selective noninvasive nanodiagnostics. Materials & methods: We coupled anti-MAdCAM-1 antibodies to manganese oxide nanoparticles, and analyzed nanoconjugate biodistribution and safety in murine model of inflammatory bowel disease by imaging and histology. Results: Nanoparticles were stable and nontoxic. Upon administration in colitic mice, anti-MAdCAM-1 functionalized nanoparticles preferentially localized in the inflamed bowel, whereas untargeted nanoparticles were more rapidly washed out. Nanoparticles did not induce lesions in nontarget organs. Conclusion: Anti-MAdCAM-1 functionalized nanoparticles detected active bowel inflammation foci, accurately following MAdCAM-1 expression pattern. These nanoconjugates could be a promising noninvasive imaging system for an early and accurate follow-up in patients affected by acute colitis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据