期刊
NANOMEDICINE
卷 12, 期 8, 页码 941-952出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0393
关键词
cytosolic delivery; nanoparticle-stabilized nanocapsules; nuclear targeting; protein; punctate fluorescence
资金
- NSF [CHE1506725]
- FIRC (Italian Foundation for Cancer Research) [18116]
- Young Faculty Study Abroad Program of Northwest AF University
- [GM077173]
Intracellular delivery of proteins is potentially a game-changing approach for therapeutics. However, for most applications, the protein needs to access the cytosol to be effective. A wide variety of strategies have been developed for protein delivery, however access of delivered protein to the cytosol without acute cytotoxicity remains a critical issue. In this review we discuss recent trends in protein delivery using nanocarriers, focusing on the ability of these strategies to deliver protein into the cytosol.
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