Article
Dermatology
Shiqi Wang, Jianjian Zhu, Ping Wang, Jing Dong, Yanling Li, Dongmei Shi, Huiping Wang, Xi Huang, Xibao Zhang, Bo Yu, Ziliang Yang, Rixin Chen, Xiaopeng Wang, Fuqiu Li, Kunpeng Bian, Yuping Huo, Nan Yu, Chen Li, Xiujuan Xia, Jiejie Lu, Junjie Li, Yonghong Lu, Yonghao Xu, Yuan Ding, Yuzhen Li, Xiaojing Kang, Ruoyu Li
Summary: This study investigated the epidemiological characteristics, clinical manifestations, fungal infections, arthritic symptoms, and treatments of nail psoriasis patients in China. The results showed that nail psoriasis had distinct manifestations in the toenails and fingernails, and toenail psoriasis combined with onychomycosis required special attention. Articular symptoms in psoriatic patients were associated with specific nail changes.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Microbiology
Marta Elisabetta Eleonora Temporiti, Marta Guerini, Rebecca Michela Baiguera, Simone Buratti, Anthea Desiderio, Lorenzo Goppa, Paola Perugini, Elena Savino
Summary: Different Trichophyton species had varying effects on the mechanical properties of bovine membranes, with potential for a new diagnostic test for onychomycosis. Mechanical analysis of membranes can evaluate changes in thickness and structural integrity following fungal colonization.
Article
Microbiology
Aikaterini Kyriakou, Sofia-Chrysovalantou Zagalioti, Myrto-Georgia Trakatelli, Christina Fotiadou, Zoe Apalla, Elizabeth Lazaridou, Aikaterini Patsatsi
Summary: The relationship between psoriasis and onychomycosis is still controversial, but nail involvement and abnormal blood vessels in psoriasis may weaken the natural defense against fungal infection. Treatment with immunosuppressive drugs may also increase the risk of onychomycosis.
Article
Infectious Diseases
Anne Landreau, Loic Simon, Pascal Delaunay, Christelle Pomares, Lilia Hasseine
Summary: We conducted an epidemiological assessment of superficial fungal infections in the Laboratory of Parasitology-Mycology of the Hospital of Nice over a 2-year period. Dermatophytes, particularly Trichophyton rubrum, remain the predominant fungal species. Our study also revealed an increasing number of non-dermatophytic mould infections. This research provides important insights into the epidemiological profile of superficial fungal infections in our patient population.
Article
Dermatology
Maura Di Vito, Claudia Scafuro, Melinda Mariotti, Stefania Garzoli, Riccardo Torelli, Abdesselam Zhiri, Maurizio Sanguinetti, Francesca Bugli
Summary: This study evaluated the antifungal efficacy of seven essential oils and a commercial mixture against dermatophytes causing onychomycosis, and selected the most effective ones for the production of a preventive or curative green natural nail polish. The data showed that the modified-GNNP with the commercial mixture had preventive activity, while the modified-GNNP with essential oils showed cytocidal activity.
Article
Mycology
Ge Song, Meijie Zhang, Weida Liu, Guanzhao Liang
Summary: Onychomycosis is a common nail disease caused by dermatophytes, yeasts, or molds. This study investigated the epidemiology of onychomycosis in Chinese mainland over the past 30 years and found that fungi, especially Trichophyton rubrum, were the most common pathogens. The study revealed differences in gender, clinical types, infection sites, and geographical distribution of fungal pathogens.
Article
Dermatology
Shiqi Wang, Yinggai Song, Zhe Wan, Wei Chen, Ruojun Wang, Ruoyu Li
Summary: The nail microbiome in psoriatic patients with OM has distinct bacterial and fungal signatures, suggesting that different dysbiosis is associated with the pathogenesis of OM in psoriatic and nonpsoriatic patients.
Article
Dermatology
Shiqi Wang, Ruojun Wang, Yinggai Song, Zhe Wan, Wei Chen, Hang Li, Ruoyu Li
Summary: This study found significant changes in the bacterial and fungal microbiome of patients with nail psoriasis. The unaffected nails in psoriatic patients were associated with higher bacterial diversity and a higher relative abundance of Enhydrobacter, while nail psoriasis was correlated with a decreased relative abundance of Anaerococcus. There was a higher proportion of Malassezia in the unaffected nails of psoriatic patients and an increased proportion of Candida in psoriatic nails.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
Gergana Vazheva, Liliya Zisova, Tsonka Miteva-Katrandzhieva, Valentin Dichev, Veselin Chonov
Summary: This study evaluates the application of real-time PCR in diagnosing fungal infections, and finds that it has higher sensitivity, specificity, and efficacy compared to conventional methods.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Rachel Grynszpan, Maria Barreiros, Marilene do Nascimento Paixao, Mariana Frasnelli Fernandes, Felipe Aguinaga, Claudia Camargo, Marcia Ramos-e-Silva, Sueli Carneiro
Summary: The study evaluated the prevalence of fungi in nails of patients with psoriasis, finding that 33.83% of nails showed fungal elements in direct mycological examination, mainly yeast. Candida was the most common fungus in positive mycological cultures, with no growth of dermatophytes observed. Patients on systemic treatment showed a higher frequency of positive fungal tests compared to topical treatment.
Article
Pharmacology & Pharmacy
Aleph M. S. Souza, Renato C. A. Ribeiro, Gleyse K. L. O. Pinheiro, Francisco I. Pinheiro, Wogenes N. Oliveira, Luanda B. F. C. Souza, Andre L. Silva, Lucas Amaral-Machado, Everton N. Alencar, Guilherme M. Chaves, Eryvaldo S. T. Egito
Summary: The study successfully produced a nail lacquer loaded with Amphotericin B and evaluated its performance, showing good stability, drug release, and antifungal activity. The results suggest that the AmB-loaded nail lacquer has the potential to be a promising treatment for onychomycosis induced by Candida spp.
Article
Microbiology
Gabriella da Rosa Monte Machado, Bruna Pippi, Simone Berlitz, Denise Diedrich, Diego Defferrari, William Lopes, Simone Cristina Baggio Gnoatto, Irene Clemes Kulkamp-Guerreiro, Marilene Henning Vainstein, Mickael Jean, Pierre Van de Weghe, Saulo Fernandes de Andrade, Alexandre Meneghello Fuentefria
Summary: The study evaluated the effectiveness of a nail lacquer containing a quinoline derivative on an ex vivo onychomycosis model using porcine hooves, showing significant inhibitory effects on dermatophytes and damage to fungal cell morphology. The quinoline derivative demonstrated a time-dependent fungicidal effect, suggesting high potential for use as a treatment for dermatophytic onychomycosis.
JOURNAL OF MEDICAL MICROBIOLOGY
(2021)
Article
Geriatrics & Gerontology
Aditya K. Gupta, Maanasa Venkataraman, Mesbah Talukder
Summary: The risk of onychomycosis increases with age, especially in older males. Proper clinical assessment and mycological examination are recommended to exclude other conditions. Treatment options include systemic and topical antifungals, with recent approval of fosravuconazole in Japan. Clinicians should consider age-related factors and possible drug interactions when making treatment decisions. Older patients should practice sanitization techniques and consider long-term maintenance therapy to prevent recurrence.
Article
Dermatology
FangYuan Long, ZhiQin Zhang, Fang He, Jie Tu, Zhi Yin, JiPing Xia, Yan Lu, ZhiQiang Yin
Summary: Dermoscopy plays a significant role in the diagnosis of nail psoriasis, with specific features of the nail correlating with disease severity. By observing dermoscopic features of the nails, a better understanding of psoriasis can be obtained.
JOURNAL OF DERMATOLOGY
(2021)
Review
Microbiology
Narges Maskan Bermudez, Giselle Rodriguez-Tamez, Sofia Perez, Antonella Tosti
Summary: Onychomycosis is a common fungal infection of the nail that causes discoloration and thickening. Oral agents are the preferred treatment, especially for mild toenail infections. Terbinafine and itraconazole are approved oral therapies, but fluconazole is commonly used off-label. However, cure rates are limited and terbinafine resistance is increasing globally. This review discusses current and potential oral treatment options for onychomycosis.
Letter
Infectious Diseases
P. Lewis White, Rosemary A. Barnes, Rebecca Gorton, Mario Cruciani, Juergen Loeffler, Alexandre Alanio, Ralf Bialek, Stephane Bretagne, Dieter Buchheidt, Maria Jose Buitrago Serna, Angie Caliendo, Sharon Chen, Neil Clancy, Massimo Cogliati, Catherine Cordonnier, Brendan Crowley, J. Peter Donnelly, Malcolm Guiver, Ferry Hagen, Catriona Halliday, Petr Hamal, Werner Heinz, Katja Jaton, Elizabeth Johnson, Brian Jones, Lena Klingspor, Rasmus Kroger Hare, Michaela Lackner, Katrien Lagrou, Frederic Lamoth, Martina Lengerova, Chris Linton, Deborah Lockhart, Johan Maertens, Willem Melchers, Carlo Mengoli, Laurence Millon, Oliver Morton, Minh Hong Nguyen, Lily Novak-Frazer, Melinda Paholcsek, Tom Patterson, Wilfried Posch, Riina Richardson, Volker Rickerts, Tom Rogers, Markus Ruhnke, Boualem Sendid, Eveline Snelders, Timoleon-Achilleas Vyzantiadis, Peter Warn, Adilia Warris, Barbora Weinbergerova, Birgit Willinger
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2019)
Article
Microbiology
Anthi-Marina Markantonatou, Konstantinos Samaras, Evangelia Yannaki, Evaggelia Zachrou, Timoleon-Achilleas Vyzantiadis
CURRENT MICROBIOLOGY
(2019)
Article
Biophysics
Anastasia Papadopoulou, Maria Alvanou, Kiriakos Koukoulias, Evangelia Athanasiou, Andriana Lazaridou, Nikolaos Savvopoulos, Panayotis Kaloyannidis, Anthi-Marina Markantonatou, Timoleon-Achilleas Vyzantiadis, Minas Yiangou, Achilles Anagnostopoulos, Evangelia Yannaki
BONE MARROW TRANSPLANTATION
(2019)
Article
Neurosciences
Stella Bouziana, Konstantinos Tziomalos, Antonis Goulas, Timoleon-Achilleas Vyzantiadis, Maria Papadopoulou, Athanasia Panderi, Apostolos Hatzitolios
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2019)
Article
Dentistry, Oral Surgery & Medicine
Konstantinos Chatzivasileiou, Eleni Kotsiomiti, Timoleon-Achilleas Vyzantiadis
INTERNATIONAL JOURNAL OF PROSTHODONTICS
(2019)
Article
Oncology
Stamatia Theodoridou, Angeliki Balassopoulou, Effrossyni Boutou, Evangelia-Eleni Delaki, Eleni Yfanti, Timoleon-Achilleas Vyzantiadis, Evangelia Vetsiou, Ersi Voskaridou, Efthymia Vlachaki
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2020)
Article
Microbiology
Anthi-Marina Markantonatou, Konstantinos Samaras, Evaggelia Zachrou, Timoleon-Achilleas Vyzantiadis
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Microbiology
Valentina Arsic Arsenijevic, Timoleon-Achilleas Vyzantiadis, Mihai Mares, Suzana Otasevic, Athanasios Tragiannidis, Dragana Janic
Article
Microbiology
Ioannis Ventoulis, Theopisti Sarmourli, Pinelopi Amoiridou, Paraskevi Mantzana, Maria Exindari, Georgia Gioula, Timoleon-Achilleas Vyzantiadis
Editorial Material
Microbiology
Athanasios Tragiannidis, Antonios Kattamis, Timoleon-Achilleas Vyzantiadis
Article
Health Care Sciences & Services
Christodoula Kourtidou, Vasileios Rafailidis, Garyfallia Varouktsi, Efthimios Kanakis, Vassilios Liakopoulos, Timoleon-Achilleas Vyzantiadis, Maria Stangou, Smaragdi Marinaki, Konstantinos Tziomalos
Summary: Patients with diabetic kidney disease (DKD) have a higher risk of cardiovascular events, which may be related to subclinical vascular disease that is not fully explained by traditional risk factors. Evaluating the presence of subclinical vascular disease could improve risk stratification and management of these patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Microbiology
Panagiotis Siasios, Kostoula Arvaniti, Evangelia Zachrou, Aikaterini Poulopoulou, Pinelopi Pisanidou, Georgia Vasileiadou, Evangelos Kaimakamis, Athina Georgopoulou, Foteini Renta, Dimitrios Lathyris, Foteini Veroniki, Eleni Geka, Ioanna Soultati, Eleni Argiriadou, Eleni Apostolidou, Pinelopi Amoiridou, Konstantinos Ioannou, Leonidas Kouras, Ioanna Mimitou, Konstantinos Stokkos, Elliniki Flioni, Evangelos Pertsas, Maria Sileli, Christina Iasonidou, Evdokia Sourla, Georgia Pitsiou, Timoleon-Achilleas Vyzantiadis
Summary: COVID-19-associated pulmonary aspergillosis (CAPA) is a significant complication in patients with acute respiratory failure due to SARS-CoV-2 infection. The diagnosis and management of CAPA remain challenging, contributing to increased mortality. This study examines the experience in diagnosing CAPA and presents different classifications of clinical cases based on existing diagnostic criteria and definitions.
Review
Microbiology
Anthi-Marina Markantonatou, Konstantinos Samaras, Timoleon-Achilleas Vyzantiadis
Summary: Microbes can form biofilms as a protective mechanism against external agents, including antifungals, leading to treatment failure and recurrent infections. Evaluating the inhibition or eradication ability of biofilm formation can help assess susceptibility and develop effective treatment methods.
Article
Health Care Sciences & Services
Christodoula Kourtidou, Vasileios Rafailidis, Garyfallia Varouktsi, Efthimios Kanakis, Vassilios Liakopoulos, Timoleon-Achilleas Vyzantiadis, Christos Savopoulos, Smaragdi Marinaki, Maria Stangou, Konstantinos Tziomalos
Summary: SGLT2 inhibitors reduce arterial stiffness and have potential cardiovascular benefits for both high-risk and low-risk patients with type 2 diabetes mellitus.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Pediatrics
Ioannis Kyriakidis, Maria Palabougiouki, Eleni Vasileiou, Athanasios Tragiannidis, Maria Stamou, Tatiani Moudiou, Timoleon Vyzantiadis, Nikolaos Gombakis, Maria Hatzistilianou
TURK PEDIATRI ARSIVI-TURKISH ARCHIVES OF PEDIATRICS
(2019)