Review
Infectious Diseases
Huilin Su, Weiwei Jiang, Paul E. Verweij, Li Li, Junhao Zhu, Jiande Han, Min Zhu, Shuwen Deng
Summary: The emergence of resistance in Trichophyton rubrum to azoles and terbinafine has led to the need for the development of new antifungal drugs. In this study, the in vitro antifungal activity of 3 echinocandins against clinical isolates of T. rubrum was evaluated. The results showed that micafungin and anidulafungin exhibited greater potency than caspofungin, suggesting that echinocandins could be potential treatment options for managing recalcitrant dermatophytoses resulting from resistance.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Connie F. Canete-Gibas, James Mele, Hoja P. Patterson, Carmita J. Sanders, Dora Ferrer, Victor Garcia, Hongxin Fan, Marjorie David, Nathan P. Wiederhold
Summary: Dermatophytes are common pathogens causing skin, hair, and nail infections in humans. A study evaluated the antifungal susceptibility profiles and species identification of dermatophytes received from North America, revealing relatively common terbinafine resistance and the presence of Trichophyton indotineae in multiple areas. Continued surveillance is necessary.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Polymer Science
Muhammad Abdullah Akram, Barkat Ali Khan, Muhammad Khalid Khan, Ali Alqahtani, Sultan M. Alshahrani, Khaled M. Hosny
Summary: The study successfully developed a polymeric emulgel of eugenol and linalool for the treatment of Trichophyton rubrum infections. The emulgel showed good physical properties and demonstrated significant effects in treating the infections both in vitro and in vivo, making it a promising topical treatment option.
Article
Pharmacology & Pharmacy
Carolina Orlando Vaso, Fabiana Pandolfi, Niura Madalena Bila, Daniela De Vita, Martina Bortolami, Maria Jose Soares Mendes-Giannini, Valeria Tudino, Roberta Costi, Caroline Barcelos Costa-Orlandi, Ana Marisa Fusco-Almeida, Luigi Scipione
Summary: This article introduces a synthetic nitrofuran derivative that was tested for inhibitory activity against different fungal species. The results showed that most of the compounds exhibited inhibitory and fungicidal activity, with low toxicity and high selectivity. These compounds have the potential to be promising for the treatment of fungal diseases.
Article
Microbiology
Nicole L. van der Weerden, Kathy Parisi, James A. Mckenna, Brigitte M. Hayes, Peta J. Harvey, Pedro Quimbar, Sean R. Wevrett, Prem K. Veneer, Owen Mccorkelle, Shaily Vasa, Rosemary Guarino, Simon Poon, Yolanda M. Gaspar, Michael J. Baker, David J. Craik, Rob B. Turner, Marc B. Brown, Mark R. Bleackley, Marilyn A. Anderson
Summary: Onychomycosis, or fungal nail infection, can cause pain, discomfort, and psychological and social consequences. Current treatments are limited by poor nail penetration or potential toxicity. Plant defensins, such as Ppdef1, have stable structures and potent antifungal activity, making them promising treatments. Ppdef1 shows excellent activity against a range of fungal pathogens, including Trichophyton rubrum, the major cause of onychomycosis.
Article
Immunology
Caroline Barcelos Costa-Orlandi, Luis R. Martinez, Niura Madalena Bila, Joel M. Friedman, Adam J. Friedman, Maria Jose S. Mendes-Giannini, Joshua D. Nosanchuk
Summary: This study evaluated the anti-T. rubrum biofilm potential of NO-np and compared it to commonly used antifungal drugs. The results showed that NO-np and efinaconazole severely damaged established biofilms, reducing the density and thickness of the biofilms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Dermatology
Junichiro Hiruma, Hiromitsu Noguchi, Midori Hase, Yumie Tokuhisa, Tatsuya Shimizu, Takasuke Ogawa, Masataro Hiruma, Kazutoshi Harada, Rui Kano
Summary: Research investigated TRF-resistant Trichophyton interdigitale and T. rubrum strains isolated from Japanese patients, identifying some TRF-resistant strains and revealing genetic mutations in these strains.
JOURNAL OF DERMATOLOGY
(2021)
Article
Microbiology
Annabel Guttentag, Krishothman Krishnakumar, Nural Cokcetin, Steven Hainsworth, Elizabeth Harry, Dee Carter
Summary: Jarrah honey exhibits potent antifungal activity against dermatophyte species, primarily through high levels of H2O2 production. It inhibits fungal growth effectively, acts mainly on the surface of fungal cells, relies not only on H2O2 but also contains other components that enhance its antifungal activity.
Article
Infectious Diseases
Manuela Gil-Gonzalez, Juan C. Gomez-Velasquez, Natalia Loaiza-Diaz, Sindy Florez-Munoz, Gilma N. Hernandez-Herrera, Ana Cecilia Mesa-Arango
Summary: The study compared cases of onychomycosis caused by Neoscytalidium dimidiatum and Trichophyton rubrum, finding that the clinical characteristics were similar, but N. dimidiatum has lower sensitivity to itraconazole and higher sensitivity to terbinafine.
Article
Dermatology
Keita Takeda, Junko Suzuki, Akira Watanabe, Ryo Sekiguchi, Tomoya Sano, Masato Watanabe, Osamu Narumoto, Masahiro Kawashima, Takeshi Fukami, Yuka Sasaki, Atsuhisa Tamura, Hideaki Nagai, Hirotoshi Matsui, Katsuhiko Kamei
Summary: The study shows that morphological identification of Aspergillus spp. is accurate at the species level in over 95% of cases, but there is low concordance in cases with low detection rates. Cryptic species exist within the A. fumigatus and A. niger complexes, showing higher resistance to antifungal drugs.
Article
Integrative & Complementary Medicine
S. Aliabasi, M. Shams-Ghahfarokhi, M. Razzaghi-Abyaneh
Summary: The study investigated the effect of eugenol on Trichophyton rubrum pathogenicity and SUB3 gene expression. Eugenol effectively inhibited T. rubrum growth, reduced ergosterol content, and inhibited keratinase activity. The expression of SUB3 gene was significantly downregulated in eugenol-treated T. rubrum. These findings suggest that eugenol may be a good alternative for treating chronic dermatophytosis caused by T. rubrum.
JOURNAL OF HERBAL MEDICINE
(2023)
Article
Microbiology
Marcos E. R. Lopes, Tamires A. Bitencourt, Pablo R. Sanches, Maira P. Martins, Vanderci M. Oliveira, Antonio Rossi, Nilce M. Martinez-Rossi
Summary: Dermatophytes are difficult to treat due to their ability to neutralize the stress caused by antifungal drugs. This resistance is achieved through mechanisms such as drug efflux and biofilm formation. Alternative splicing has also been identified as a mechanism that enhances fungal adaptive responses. This study used RNA-seq data to investigate alternative splicing in genes encoding efflux pumps in the dermatophyte Trichophyton rubrum. The findings suggest that alternative splicing plays a role in drug tolerance and antifungal resistance, particularly in biofilms.
Article
Biochemistry & Molecular Biology
Katya M. Aguilar-Perez, Dora Medina, Roberto Parra-Saldivar, Hafiz M. N. Iqbal
Summary: Nanoliposomes, bilayer vesicles at the nanoscale, have gained popularity for their safety, patient compliance, high entrapment efficiency, and prompt action. In this study, multi-compositional nanoliposomes loaded with clove essential oil (CEO) and tea tree oil (TTO) were characterized to understand their nano-size distribution. The CEO-loaded nanoliposomes showed a maximum entrapment efficacy and exhibited high antifungal activity.
Article
Chemistry, Multidisciplinary
Paola Perugini, Margherita Bonetti, Marta Guerini, Giorgio Musitelli, Pietro Grisoli
Summary: Nail fungal infection has a negative impact on social life, leading to a need for exploring new antifungal treatments. Bovine hoof membranes were used as a model in this study to evaluate the antiadhesive capability of a product.
APPLIED SCIENCES-BASEL
(2021)
Article
Microbiology
Carlos H. Lopes Rocha, Flaviane M. Galvao Rocha, Tamires A. Bitencourt, Maira P. Martins, Pablo R. Sanches, Antonio Rossi, Nilce M. Martinez-Rossi
Summary: The antidepressant sertraline (SRT) alone or in combination with caspofungin (CASP) exhibits antifungal activity against Trichophyton rubrum, targeting genes involved in cell wall and ergosterol biosynthesis. This combination shows potential in minimizing resistance and reducing virulence of the pathogen.
