Review
Mycology
Ariel Fernando Florez-Riano, Isabel Cristina Ramirez-Sanchez
Summary: Breakthrough invasive infections can occur during the use of antifungals, leading to the emergence of new pathogens in the fungal landscape. Hormographiella aspergillata is considered as a rare but emerging pathogen in patients with hematological malignancies under broad-spectrum antifungal treatment. This case report presents a breakthrough infection of invasive sinusitis caused by Hormographiella aspergillata in a patient with severe aplastic anemia receiving voriconazole treatment for invasive pulmonary aspergillosis, and includes a review of published literature on H. aspergillata breakthrough infections.
Review
Pharmacology & Pharmacy
Hideharu Hagiya, Yoshito Nishimura, Fumio Otsuka
Summary: This article summarizes the study findings on the safety and clinical utility of nebulized liposomal amphotericin B therapy. The results showed that nebulized liposomal amphotericin B treatment appeared to be safe and without severe adverse effects. Increasing evidence supports the effectiveness of inhalation therapy in patients after lung transplantation and with hemato-oncological diseases.
PULMONARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Dermatology
Tugba Erat, Isa An
Summary: The efficacy and safety of liposomal amphotericin B (L-AmB) in pediatric cutaneous leishmaniasis patients were evaluated in this study. The results showed a low treatment success rate with the L-AmB dose used in the study.
DERMATOLOGIC THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Daniela Peruzzu, Katia Fecchi, Giulietta Venturi, Maria Cristina Gagliardi
Summary: Mpox, caused by the mpox virus (MPXV), has sparked great concern with a multi-country outbreak in 2022. The majority of cases are observed in Europe and are unrelated to travel or contact with infected individuals. Close sexual contact plays an important role in MPXV transmission, particularly in people with multiple sexual partners and men who have sex with men. Vaccines based on Vaccinia virus (VACV) have shown cross-reactive and protective immune response, but their efficacy against the 2022 Mpox outbreak is limited. There are currently no specific antiviral drugs for Mpox. However, the antifungal drug Amphotericin B (AmphB) has the potential to inhibit MPXV infection by disrupting lipid rafts and altering receptor/co-receptor distribution, providing an alternative therapeutic approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Maria Ubals, Pau Bosch-Nicolau, Adrian Sanchez-Montalva, Fernando Salvador, Gloria Aparicio-Espanol, Elena Sulleiro, Aroa Silgado, Antoni Soriano-Arandes, Maria Espiau, Berta Ferrer, Diana Pou, Begona Trevino, Israel Molina, Vicente Garcia-Patos
Summary: The study described a cohort of patients with complex cutaneous leishmaniasis (CL), with a focus on the treatment outcome of liposomal amphotericin B (L-AmB). Results showed that all patients were considered cured within the first year post-treatment, and there were no treatment failures with L-AmB for complex CL.
Article
Microbiology
Suresh Ambati, Tuyetnhu Pham, Zachary A. Lewis, Xiaorong Li, Richard B. Meagher
Summary: This study found that targeting antifungal drugs to fungal glycans can improve drug efficacy and reduce drug dosage, which is of great significance for various invasive fungal infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Frederic Frezard, Marta M. G. Aguiar, Lucas A. M. Ferreira, Guilherme S. Ramos, Thais T. Santos, Gabriel S. M. Borges, Virginia M. R. Vallejos, Helane L. O. De Morais
Summary: This review discusses the use of liposomal amphotericin B (AmBisome) as the best therapeutic option for leishmaniasis, but its efficacy is influenced by patient immunological status, clinical manifestation, and endemic region. The need for parenteral administration, side effects, and cost limit its use in developing countries. Recent advances in understanding the mechanism responsible for reduced toxicity and the development of more effective liposomal AmB formulations, including topical and oral options, are highlighted. The critical role of AmB aggregation state and release rate in reducing toxicity and improving efficacy by non-invasive routes is emphasized.
Review
Medicine, Research & Experimental
Jonathan Tschopp, Jean Yannis Perentes, Catherine Beigelman-Aubry, Sabina Berezowska, Alban Lovis, Olivier Spertini, Pierre-Yves Bochud, Frederic Lamoth
Summary: Hormographiella aspergillata is a rare cause of invasive mold infection, but can be successfully managed through complete surgical resection of lesions and antifungal therapy.
MEDICAL MYCOLOGY CASE REPORTS
(2021)
Review
Immunology
Qian Wang, Yinggai Song, Dongmei Han, Hong Cai, Qiuhong Yan, Wei Liu, Hengxiang Wang, Xiaoli Zheng, Li Ding, Xiaoying Yuan
Summary: We report the first suspected case of disseminated H. aspergillata infection in China. Metagenomic next-generation sequencing and panfungal polymerase chain reaction analysis confirmed the presence of H. aspergillata in the patient. Despite combined antifungal therapy, the patient died due to disease progression.
EMERGING MICROBES & INFECTIONS
(2023)
Editorial Material
Ophthalmology
David Lamas-Francis, Jose Llovo-Taboada, Daniel Navarro, Rosario Tourino, Teresa Rodriguez-Ares
Summary: This case report highlights the management and outcome of a rare case of necrotizing scleritis caused by Hormographiella aspergillata. Successful control of the disease was achieved through a combination of medical and surgical treatment.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Dermatology
Valliappan Muthu, Ratnakara Rao Gogineni, Ritesh Agarwal, Kuruswamy Thurai Prasad, Inderpaul Singh Sehgal, Sahajal Dhooria, Ashutosh N. Aggarwal, Shivaprakash Mandya Rudramurthy, Harkant Singh, Mandeep Garg, Arunaloke Chakrabarti
Summary: In this open-label trial, we compared the efficacy and safety of nebulized amphotericin B (NAB) in combination with intravenous liposomal amphotericin B to intravenous liposomal amphotericin B alone for the treatment of pulmonary mucormycosis (PM). The results showed that the addition of NAB did not significantly improve overall response at 6 weeks or reduce 90-day mortality. Further research is needed to explore alternative treatment options for PM.
Article
Infectious Diseases
Andrew A. Voak, Andy Harris, Jose Miguel Coteron-Lopez, Inigo Angulo-Barturen, Santiago Ferrer-Bazaga, Simon L. Croft, Karin Seifert
Summary: This study characterized the pharmacokinetic and pharmacodynamic properties of anti-leishmanial drugs AmBisome and miltefosine in a mouse model of visceral leishmaniasis. Optimal dosing strategies for AmBisome were proposed, demonstrating a wider therapeutic range compared to miltefosine. The study also highlighted the importance of using animal models in drug development for visceral leishmaniasis.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Immunology
Alessandro C. Pasqualotto, Daiane Dalla Lana, Cassia S. M. Godoy, Terezinha do Menino Jesus Silva Leitao, Monica B. Bay, Lisandra Serra Damasceno, Renata B. A. Soares, Roger Kist, Larissa R. Silva, Denusa Wiltgen, Marineide Melo, Taiguara F. Guimaraes, Marilia R. Guimaraes, Hareton T. Vechi, Jaco R. L. de Mesquita, Gloria Regina de G. Monteiro, Antoine Adenis, Nathan C. Bahr, Andrej Spec, David R. Boulware, Dennis Israelski, Tom Chiller, Diego R. Falci
Summary: This is the first trial to show that AIDS patients with disseminated histoplasmosis can be safely and effectively treated with a single high dose of liposomal amphotericin B (10 mg/kg).
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Masato Tashiro, Hotaka Namie, Yuya Ito, Takahiro Takazono, Hiroshi Kakeya, Yoshitsugu Miyazaki, Hiroshi Mukae, Hiroshige Mikamo, Fukuda Tomoo, Kazutoshi Shibuya, Koichi Izumikawa
Summary: This study provides important insights into the precise epidemiology and treatment practices of mucormycosis. The study found that treatment with liposomal amphotericin B at doses higher than 5 mg/kg/d did not improve outcomes relative to 5 mg/kg/d.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Danfeng Ren, Wenya Cao, Xiaojing Liu, Qunying Han, Wanhu Fan, Guoliang Li, Han Xia, Xi Zhang
Summary: This study presented four cases of visceral leishmaniasis treated with low-dose L-AmB therapy, demonstrating the safety and efficacy of this novel treatment protocol for VL patients. The treatment resulted in high cure rates without severe complications.
FRONTIERS IN MEDICINE
(2021)
Article
Infectious Diseases
Amine Benadji, Xavier Duval, Kostas Danis, Bruno Hoen, Bernard Page, Guillaume Beraud, Veronique Vernet-Garnier, Christophe Strady, Nathalie Brieu, Laurence Maulin, Carine Roy, Marie-Cecile Pioy, Jacques Gaillat, Emmanuelle Varon, Sarah Tubiana
Summary: This study found that both host factors and pneumococcal serotypes have an impact on 30-day mortality in invasive pneumococcal disease patients, emphasizing the need for a targeted vaccination strategy for high-risk populations.
Article
Infectious Diseases
Agathe Metais, Jose Miguel Torregrosa Diaz, Maria Pilar Gallego Hernanz, Maxime Pichon, Deborah Desmier, France Roblot, Blandine Rammaert
Summary: This study compared the efficacy of short versus prolonged antibiotic treatment for bloodstream infection (BSI) in acute myeloid leukemia (AML) patients. The findings suggest that short-term antibiotic treatment is as effective as prolonged treatment, with very few relapses within 30 days of discontinuation.
JOURNAL OF INFECTION
(2022)
Article
Multidisciplinary Sciences
Guillaume Beraud, Jean-Francois Timsit, Henri Leleu
Summary: Remdesivir and dexamethasone are the only drugs proven to reduce the length of hospital stays for COVID-19 patients. The use of remdesivir can significantly decrease hospital bed occupancy, leading to potential cost savings and improved hospital capacity management.
Article
Infectious Diseases
Guillaume Beraud, Jean-Claude Maupetit, Audric Darras, Alexandre Vimont, Martin Blachier
Summary: Our study compared real-life data from French hospitals and identified that patients treated with dalbavancin often had shorter lengths of stay and generated savings, particularly with early switching within 11 days of hospitalization. The budget impact of dalbavancin was heterogeneous but frequently led to cost savings, especially with earlier administration within 7 days of hospitalization. Patients requiring a deep venous catheter and those with more severe conditions benefited the most from dalbavancin.
INFECTIOUS DISEASES AND THERAPY
(2022)
Article
Oncology
Sebastien Petit, Mathieu Puyade, Maxime Pichon, Marc Wangermez, Stephane Velasco, France Roblot, Nicolas Isambert, Camille Evrard, Blandine Rammaert
Summary: The study aimed to assess the risk factors for biliary stent infection (BI) after stenting procedure and its impact on patient survival. The results showed that transpapillary stenting and a higher WHO score were significant risk factors for BI occurrence.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Mycology
Dorian Loubet, Benjamine Sarton, Lucie Lelievre, Gaspard Grouteau, Xavier Iriart, Pamela Chauvin, Judith Fillaux, Alexis Valentin, Antoine Berry, Stein Silva, Fabrice Bonneville, Sophie Cassaing, Emilie Guemas
Summary: This article reports an uncommon coinfection of mucormycosis and aspergillosis with HLH, highlighting the significance of screening for mould infections in HLH patients.
JOURNAL DE MYCOLOGIE MEDICALE
(2023)
Article
Microbiology
Laurene Tardieu, Gillian Divard, Olivier Lortholary, Anne Scemla, Eric Rondeau, Isabelle Accoceberry, Remi Agbonon, Alexandre Alanio, Adela Angoulvant, Laetitia Albano, Philippe Attias, Anne Pauline Bellanger, Dominique Bertrand, Julie Bonhomme, Francoise Botterel, Nicolas Bouvier, Matthias Buchler, Taieb Chouaki, Thomas Crepin, Marie-Fleur Durieux, Guillaume Desoubeaux, Gary Doppelt, Loic Favennec, Arnaud Fekkar, Ophelie Fourdinier, Marie Frimat, Jean-Pierre Gangneux, Claire Garandeau, Lilia Hasseine, Christophe Hennequin, Xavier Iriart, Nassim Kamar, Hannah Kaminski, Raphael Kormann, Laurence Lachaud, Christophe Legendre, Moglie Le Quintrec Donnette, Jordan Leroy, Charlene Levi, Marie Machouart, David Marx, Jean Menotti, Valerie Moal, Florent Morio, Natacha Mrozek, Muriel Nicolas, Philippe Poirier, Marie-Noelle Peraldi, Benjamin Poussot, Stephane Ranque, Jean-Philippe Rerolle, Boualem Sendid, Renaud Snanoudj, Jerome Tourret, Marc Vasse, Cecile Vigneau, Odile Villard, Laurent Mesnard, Fanny Lanternier, Cedric Rafat
Summary: This study analyzed the clinical characteristics of cryptococcosis in kidney transplant recipients in France. The incidence of cryptococcal meningitis (CM) was relatively high, and the prognosis was poor. Hyponatremia and neurological symptoms were associated with CM.
Article
Infectious Diseases
Gregoire Pasquier, Magalie Demar, Patrick Lami, Asma Zribi, Pierre Marty, Pierre Buffet, Nicole Desbois-Nogard, Jean Pierre Gangneux, Stephane Simon, Romain Blaizot, Pierre Couppie, Louis Thiebaut, Francine Pratlong, Jean-Pierre Dedet, Patrick Bastien, Yvon Sterkers, Christophe Ravel, Laurence Lachaud
Summary: Leishmaniasis shows different epidemiology in metropolitan France and its overseas territories. Autochthonous cases have decreased while imported cases have increased over time. French Guiana has a high incidence, while sporadic cases are reported in the French West Indies. Continued monitoring and active surveillance are necessary.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Immunology
Peggy Blanc, Fabrice Bonnet, Olivier Leleux, Adelaide Perrier, Emilie Bessede, Sabine Pereyre, Charles Cazanave, Didier Neau, Marc-Olivier Vareil, Estibaliz Lazaro, Pierre Duffau, Aurelie Saunier, Katell Andre, Linda Wittkop, Marie-Anne Vandenhende
Summary: This large prospective cohort study examined the types of severe non-AIDS bacterial infections (SBIs) among people with HIV, as well as the bacterial documentation and antibiotic resistance patterns over an 18-year period. The study found that the proportion of Streptococcus pneumoniae infections in HIV patients decreased over time, as did resistance of Staphylococcus aureus and Streptococcus pneumoniae, while resistance of Enterobacteriaceae increased. The use of cotrimoxazole as prophylaxis was associated with an increased risk of antibiotic resistance.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Guillaume Beraud, Laura Bouetard, Rok Civljak, Jocelyn Michon, Necla Tulek, Sophie Lejeune, Romain Millot, Aurelie Garchet-Beaudron, Maeva Lefebvre, Petar Velikov, Benjamin Festou, Sophie Abgrall, Ivan K. Lizatovic, Aurelie Boldolli, Huseyin Esmer, Sophie Blanchi, Gabrielle Froidevaux, Nikol Kapincheva, Jean-Francois Faucher, Mario Duvnjak, Elcin Afsar, Luka Svitek, Saliha Yarimoglu, Rafet Yarimoglu, Cecile Janssen, Olivier Epaulard
Summary: This study aimed to assess the association between vaccine status and the severity of Omicron SARS-CoV-2 infection in hospitalized patients. The results showed that vaccination was associated with lower 28-day mortality, intensive care unit admission, and oxygen requirement. Additionally, compared to Delta infection, Omicron infection was associated with lower mortality, intensive care unit admission, and oxygen requirements.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Microbiology
Maria N. Gamaletsou, Blandine Rammaert, Barry Brause, Marimelle A. Bueno, Sanjeet S. Dadwal, Michael W. Henry, Aspasia Katragkou, Dimitrios P. Kontoyiannis, Matthew W. McCarthy, Andy O. Miller, Brad Moriyama, Zoi Dorothea Pana, Ruta Petraitiene, Vidmantas Petraitis, Emmanuel Roilides, Jean-Pierre Sarkis, Maria Simitsopoulou, Nikolaos V. Sipsas, Saad J. Taj-Aldeen, Valerie Zeller, Olivier Lortholary, Thomas J. Walsh, Int Consortium Osteoarticular Mycoses
Summary: Osteoarticular mycoses are chronic debilitating infections that require extended courses of antifungal therapy and may warrant expert surgical intervention. This review provides a comprehensive analysis of the etiologies, clinical manifestations, diagnostic approaches, treatments, and outcomes of these infections. Candida osteomyelitis and Candida arthritis are associated with greater events of hematogenous dissemination than other osteoarticular mycoses, while traumatic inoculation is more commonly linked with Aspergillus and non-Aspergillus molds.
CLINICAL MICROBIOLOGY REVIEWS
(2022)
Article
Microbiology
Mohammed Benlaassri, Florine Ecale, Alexandre Crepin, Marie-Helene Rodier, Nicolas Venisse, Estelle Cateau
Summary: In this study, the reciprocal interactions between three parabens and yeasts from the human cutaneous mycobiota were explored in vitro. The results showed that ethylparaben completely inhibited the growth of Cryptococcus uniguttulatus and Rhodotorula mucilaginosa, while methylparaben and propylparaben had no effect on these two fungi. Candida parapsilosis and R. mucilaginosa were found to degrade propylparaben, while C. uniguttulatus did not degrade any paraben.
FEMS MICROBIOLOGY LETTERS
(2023)
Article
Infectious Diseases
Damien Blez, Didier Bronnimann, Blandine Rammaert, Valerie Zeller, Laurence Delhaes, Laurent Hustache, Frederic Grenouillet, Nicolas Traversier, Julie Bonhomme, Taieb Chouaki, Thomas Perpoint, Florence Persat, Marie Elisabeth Bougnoux, Sophie Bayle, Luc Quaesaet, Gilles Nevez, David Boutoille, Florent Morio, Laurence Pougnet, Viviane Queyrel-Moranne, Beate Heym, Romain Guillemain, Eric Dannaoui, Antoine Roux, Dea Garcia-Hermoso, Fanny Lanternier
Summary: This study describes 15 cases of localized osteoarticular Scedosporiosis (LOS) from the nationwide French Scedosporiosis Observational Study. LOS mainly presents as arthritis, osteitis, and thoracic wall infection, with non-specific clinical manifestations. The analysis shows that these patients have a good prognosis, as long as they receive a prolonged course of antifungal therapy and adequate surgical management.
Article
Infectious Diseases
Macha Tetart, Priscila Passecountrin, Anais Lesourd, Diane Sanderink, Gwenael Le Moal, Laure Surgers, Guillaume Beraud, Christine Katlama, Olivier Robineau, Jean-Jacques Parienti, COMEDWEEK Study Group
Summary: This study aimed to investigate the presence of declared and undeclared co-medications among people living with HIV (PLHIV) and assess their potential burden. The results showed that the issue of drug-drug interactions remains significant in PLHIV and emphasizes the importance of identifying co-medications and over-the-counter treatment in all PLHIV.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Parasitology
Nicolas Argy, Celine Nourrisson, Ahmed Aboubacar, Philippe Poirier, Stephane Valot, Adrien Laude, Guillaume Desoubeaux, Christelle Pomares, Marie Machouart, Yohann Le Govic, Frederic Dalle, Francoise Botterel, Nathalie Bourgeois, Estelle Cateau, Marion Leterrier, Patrice Le Pape, Florent Morio, Sandrine Houze
Summary: Commercial multiplex PCR assay panels show high sensitivity and specificity for parasitological diagnosis, serving as a complement to traditional microscopic examination methods. However, the PCR procedure and analytical performance for each specific protist may vary depending on the multiplex PCR assay, which should be considered when implementing a PCR-based diagnostic approach.
