Review
Mycology
Xuhua Tang, Penghao Guo, Hioteng Wong, Jiahui Xie, Jiande Han, Yingbin Xu, Hui Zhou
Summary: Cutaneous mucormycosis caused by Mucor irregularis is a rare condition that typically occurs in immunocompetent patients. A successful treatment of a cutaneous M. irregularis infection in an immunocompromised patient was described, involving surgical debridement and negative pressure technique. The patient's skin ulcers healed after extensive surgical treatment, with no signs of recurrence at 36-month follow-up.
Article
Environmental Sciences
Paul Olusegun Bankole, Kirk Taylor Semple, Byong-Hun Jeon, Sanjay Prabhu Govindwar
Summary: This study demonstrated the efficient fluorene degradation capability of marine-derived filamentous fungus Mucor irregularis strain bpo1, with optimization using Response Surface Methodology resulting in a degradation rate of 81.50%. Enhanced degradation efficiencies were achieved through growth-linked validation experiments, showing promising potentials for PAH degradation and green remediation technology.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Microbiology
Teclegiorgis Gebremariam, Sondus Alkhazraji, Abdullah Alqarihi, Nathan P. Wiederhold, Laura K. Najvar, Thomas E. Patterson, Scott G. Filler, Ashraf S. Ibrahim
Summary: Biomedical research shows some differences between male and female mice infected with invasive pulmonary mucormycosis, but these differences have no impact on the outcome of treatment or host immune response.
Article
Microbiology
Cecilia G. G. Carvalhaes, Paul R. R. Rhomberg, Michael D. D. Huband, Michael A. A. Pfaller, Mariana Castanheira
Summary: Isavuconazole is the only FDA-approved antifungal for treating invasive mucormycosis. A global collection of Mucorales isolates was evaluated, and it was found that Isavuconazole displayed good inhibitory activity against most isolates, although there was variation among different species.
Article
Chemistry, Multidisciplinary
Paul Olusegun Bankole, Victor Taghoghor Omoni, Sikandar Imamsab Mulla, Seun Owolabi Adebajo, Adedotun Adeyinka Adekunle
Summary: The present study investigated the potential of marine-derived fungal co-culture in the mycoremediation of polycyclic aromatic hydrocarbons (PAHs). The results demonstrated the efficiency of the co-culture in degrading fluoranthene, a PAH, with the induction of various enzymes. The analysis of metabolites provided insights into the metabolic pathway. These findings highlight the significance of marine-derived fungal co-biomass in the eco-friendly remediation of PAHs.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Review
Microbiology
Ghizlane Tahiri, Carlos Lax, Jose Tomas Canovas-Marquez, Pablo Carrillo-Marin, Marta Sanchis, Eusebio Navarro, Victoriano Garre, Francisco Esteban Nicolas
Summary: The classification of Mucorales, a group of basal fungi, has been limited due to their aversion to genetic manipulation techniques. The emergence of mucormycosis has drawn attention to Mucorales biology and spurred recent efforts to uncover their mysteries. Genetic advances have revealed virulence factors and mechanisms controlling the pathogenic potential of Mucorales, leading to new strategies against mucormycosis. New study models are enabling further research on the virulence of Mucorales, indicating a promising future for the field.
Article
Microbiology
Courtney Smith, Soo Chan Lee
Summary: Mucormycosis is a serious fungal infection that mainly affects immunocompromised individuals. It manifests in various clinical forms including sinusitis, cutaneous, gastrointestinal, pulmonary, and disseminate infections. The treatment options for mucormycosis currently involve the use of lipid formulations of amphotericin B and surgical excision of infected tissue.
Article
Dermatology
Guanzhao Liang, Meijie Zhang, Wenqi Xu, Xiaowen Wang, Hailin Zheng, Huan Mei, Weida Liu
Summary: This study revealed the differences in pathogenicity among the four Mucorales species and their relationship with mitogenomic features. The sequencing and comparison of the mitogenomes of these species uncovered structural and functional variations, indicating potential differences in pathogenicity mechanisms. Future research should focus on the spatial structure of mitochondrial genomes and comprehensive analysis of transcription regulation for a deeper understanding.
Article
Immunology
Lingyue Sun, Shuzhen Zhang, Zhe Wan, Ruoyu Li, Jin Yu
Summary: Deficiency in Card9 increases susceptibility to Mucor irregularis infection, affecting local cytokine production, NF-kappa B activation, and neutrophil-dependent antifungal immunity.
INFECTION AND IMMUNITY
(2021)
Article
Public, Environmental & Occupational Health
Ahmet Dilek, Resat Ozaras, Sevket Ozkaya, Mustafa Sunbul, Elif Itir Sen, Hakan Leblebicioglu
Summary: A patient with COVID-19-associated mucormycosis was described, with most cases reported from India and main risk factors including steroid use, diabetes, and hypertension. The most common sites of involvement were rhino-orbital, and mortality rate was high.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Medicine, General & Internal
Ruhui Zhang, Ge Jin, Yasheng Zhan, Lisha Shen, Yake Yao, Qiqi Gao, Qing Yang, Jianying Zhou, Hua Zhou
Summary: This article reports a rare case of invasive pulmonary mucormycosis with overlapping allergic diseases, which was successfully treated with systemic corticosteroids and antifungal therapy.
FRONTIERS IN MEDICINE
(2022)
Article
Dermatology
Meijie Zhang, Guanzhao Liang, Jiacheng Dong, Hailin Zheng, Huan Mei, Fuxing Zha, Weida Liu
Summary: This study aimed to investigate the thermal adaptation and virulence-related genes in Mucor irregularis strains under high temperature. The research identified key genes essential for thermal adaptation and virulence of M. irregularis. RNA-seq analysis revealed a large number of differentially expressed genes, providing valuable insights for future research on antifungal development targeting M. irregularis.
Article
Microbiology
Verena Harpf, Guenter Rambach, Nadia Parth, Magdalena Neurauter, Verena Fleischer, Michaela Lackner, Cornelia Lass-Floerl, Reinhard Wuerzner, Cornelia Speth
Summary: Mucormycetes, a heterogeneous group of fungi, induce a life-threatening disease called mucormycosis. Immune deficiencies represent a major risk factor; hence, we wanted to illuminate the role of complement and platelets in the defense against mucormycetes. In vitro experiments showed significant differences in complement deposition between mucormycetes.
Article
Microbiology
Alexis Garcia, Eun Young Huh, Soo Chan Lee
Summary: Procedures such as solid-organ transplants and cancer treatments can weaken the immune system, making patients more susceptible to opportunistic diseases like fungal infections. Mucormycosis infections, caused by Mucorales fungi, have been increasing, particularly in patients with SARS-CoV-2 infections. These fungi are resistant to most antifungal drugs, including echinocandins, which are currently the most effective. The study found that the resistance to echinocandins in Mucorales fungi is due to the overexpression of fks genes and the role of calcineurin.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Dermatology
Hirotaka Kato, Corey M. Foster, Kishore Karri
Summary: This study utilized National Inpatient Sample data to describe the incidence, predisposing factors, and inpatient outcomes of cutaneous mucormycosis in the United States between 2016 and 2017. The findings revealed that the majority of patients were severely immunocompromised hosts, with hematologic malignancies and solid organ transplantations being the most common predisposing factors.
Letter
Orthopedics
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2023)
Letter
Critical Care Medicine
Pathum Sookaromdee, Viroj Wiwanitkit
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Medicine, General & Internal
Pathum Sookaromdee, Viroj Wiwanitkit
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Letter
Immunology
Pathum Sookaromdee, Viroj Wiwanitkit
Letter
Gastroenterology & Hepatology
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit
Letter
Cardiac & Cardiovascular Systems
Amnuay Kleebayoon, Viroj Wiwanitkit
CLINICAL CARDIOLOGY
(2023)
Letter
Obstetrics & Gynecology
Amnuay Kleebayoon, Viroj Wiwanitkit
FERTILITY AND STERILITY
(2023)
Letter
Rheumatology
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit
Letter
Clinical Neurology
Rujittika Mungmunpuntipatip, Viroj Wiwanitkit
OTOLOGY & NEUROTOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit
REVISTA PORTUGUESA DE CARDIOLOGIA
(2023)
Letter
Hematology
Amnuay Kleebayoon, Viroj Wiwanitkit
THROMBOSIS RESEARCH
(2023)
Letter
Medicine, General & Internal
Sim Sai Tin, Viroj Wiwanitkit
INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
(2023)
Letter
Geriatrics & Gerontology
Amnuay Kleebayoon, Viroj Wiwanitkit
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Letter
Medicine, General & Internal
Won Sriwijitalai, Viroj Wiwanitkit
Letter
Infectious Diseases
Pathum Sookaromdee, Viroj Wiwanitkit
INFECTION AND CHEMOTHERAPY
(2023)
