Article
Clinical Neurology
Benoit Testud, Clara Delacour, Ahmed Ali El Ahmadi, Gilles Brun, Nadine Girard, Guillaume Duhamel, Christoph Heesen, Vivien Haeussler, Christian Thaler, Arzu Ceylan Has Silemek, Jan-Patrick Stellmann
Summary: This study provides a first insight into the evolution of brain perfusion and its association with disability in primary progressive MS (PPMS) over several years. The baseline brain perfusion of patients and controls was comparable, but the perfusion decreased over time in patients and was correlated with disability.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Virginia Meca-Lallana, Leticia Berenguer-Ruiz, Joan Carreres-Polo, Sara Eichau-Madueno, Jaime Ferrer-Lozano, Lucia Forero, Yolanda Higueras, Nieves Tellez Lara, Angela Vidal-Jordana, Francisco Carlos Perez-Miralles
Summary: Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system triggered by unknown environmental factors in patients with genetic risk profiles. Prevention of neurological disability is essential, but mechanisms driving disease progression remain unknown. Lack of markers for early detection and varying definitions of disability progression complicate assessment in clinical practice.
FRONTIERS IN NEUROLOGY
(2021)
Review
Health Care Sciences & Services
Barbara Carletti, Nerisa Banaj, Fabrizio Piras, Paola Bossu
Summary: Schizophrenia is a complex mental illness and its pathophysiology is still unclear. Oxidative stress and glutathione dysregulation play a crucial role in the development of schizophrenia. Glutathione may serve as a biomarker to differentiate different phenotypes of schizophrenia.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Kenneth Hensley, Alexis Danekas, William Farrell, Tiera Garcia, Wafa Mehboob, Matthew White
Summary: The review discusses the interconnections between oxidative stress, dysregulated proteostasis, and neuroinflammation in neurodegenerative diseases, highlighting the importance of oxidative homeostasis in brain metabolism and the potential therapeutic interventions to modulate key elements of this triad.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemical Research Methods
Precious Kwadzo Pomary, Sara Eichau, Nuprimeria Amigo, Laura Barrios, Fuencisla Matesanz, Marta Garcia-Valdecasas, Ioana Hrom, Maria Isabel Garcia Sanchez, Maria Luisa Garcia-Martin
Summary: In this study, H-1 NMR spectroscopy was used to measure metabolites, lipoproteins, glycoproteins, neurodegenerative and inflammatory markers, and metal elements in CSF and serum samples of PPMS, SPMS, and control patients. The findings indicate that the pathogenesis of progressive MS is mainly localized in the CNS. PPMS and SPMS patients with comparable disability status have similar pathological characteristics, but the rapid progression of PPMS may be driven by neurotoxicity induced by heavy metals and diminished CNS antioxidative capacity associated with differential intrathecal ascorbate retention and imbalance of Mg and Cu.
JOURNAL OF PROTEOME RESEARCH
(2023)
Review
Neurosciences
Talia Bergaglio, Antonio Luchicchi, Geert J. Schenk
Summary: Multiple Sclerosis is a complex and chronic disease of the central nervous system characterized by degenerative and inflammatory processes. The dysfunction of axonal mitochondria due to oxidative stress is believed to play a key role in triggering the disease, affecting axonal integrity and communication with glial cells. This mechanism is implicated in the development of primary cytodegeneration and a secondary pro-inflammatory response leading to the onset of MS.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Clinical Neurology
Nik Krajnc, Gabriel Bsteh, Thomas Berger
Summary: Conversion to secondary progressive disease course in multiple sclerosis is a crucial factor for long-term prognosis, with both inflammation and neurodegeneration playing roles in the disease process. The current delay in diagnosing SPMS highlights the need for reliable biomarkers to predict and define this conversion.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Ian J. Tagge, Valerie C. Anderson, Charles S. Springer, Manoj K. Sammi, Dennis M. Bourdette, Rebecca Spain, William D. Rooney
Summary: Transcapillary water exchange is reduced in the normal-appearing gray matter of individuals with progressive multiple sclerosis compared to healthy controls, and is further decreased in white matter lesions, indicating impaired brain metabolism. The k(po) parameter provides a sensitive measure of cerebral metabolic activity and can be mapped at higher spatial resolution than conventional imaging techniques.
JOURNAL OF NEUROIMAGING
(2021)
Review
Biochemistry & Molecular Biology
Panagiotis Theodosis-Nobelos, Eleni A. A. Rekka
Summary: Multiple sclerosis is a complex neurodegenerative disease characterized by inflammation and oxidative stress. Antioxidant compounds have shown potential in controlling MS progression by reducing oxidative stress. This review analyzes research on the therapeutic effects of natural antioxidant compounds and their derivatives on MS, and discusses the role of reactive oxygen and nitrogen species in the disease. The multitargeting potential of antioxidants and their source of activity are also examined. Further studies are needed to establish these antioxidants as recommended treatments for MS patients.
Review
Neurosciences
Aleksandra Pogoda-Wesolowska, Angela Dziedzic, Karina Maciak, Adam Stepien, Marta Dziaduch, Joanna Saluk
Summary: Approximately 70% of RRMS patients will develop SPMS within 10-15 years, characterized by a decline in neurological functionality and limitations of daily activities. Delay in diagnosing SPMS is caused by retrospective assessment, thus reliable biomarkers are needed to predict and define SPMS conversion.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Sina C. Rosenkranz, Lilija Gutmann, Arzu Ceylan Has Silemek, Michael Dorr, Vivien Haussler, Margareta Lupke, Andrea Monch, Stefanie Reinhardt, Jens Kuhle, Penelope Tilsley, Christoph Heesen, Manuel A. Friese, Alexander Brandt, Friedemann Paul, Hanna Zimmermann, Jan-Patrick Stellmann
Summary: In this study, the long-term changes in visual function, retinal neurodegeneration, and serum NfL levels were assessed in PPMS patients. It was found that visual function remains stable until a certain turning point, while retinal nerve fiber layer thickness gradually decreases. Serum NfL levels remained stable and were not associated with structural or functional impairment in the visual system.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Immunology
Emily Kamma, Wendy Lasisi, Cole Libner, Huah Shin Ng, Jason R. Plemel
Summary: There are limited treatment options available for progressive multiple sclerosis (MS) due to a poor understanding of its pathophysiology. Microglia and macrophages play a vital role in the progressive phase of MS and may contribute to neurodegeneration. However, there is a lack of disease-modifying drugs that target these cells specifically in progressive MS.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Clinical Neurology
Moein Amin, Daniel Ontaneda
Summary: Multiple sclerosis (MS) results in thalamic volume loss, which affects cognitive function such as processing speed and memory. Thalamic atrophy is a significant predictor of cognitive impairment (CI) in MS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Augustine Joshua Devasahayam, Liam Patrick Kelly, John Bradley Williams, Craig Stephen Moore, Michelle Ploughman
Summary: The study found that individuals with higher fitness levels in progressive MS tend to show a shift towards a repair phenotype, with higher levels of IL-6. Progressive MS patients had significantly lower maximal oxygen consumption, and higher (V)over dotO(2max) was associated with a shift in the balance of blood biomarkers towards a repair phenotype from inflammation.
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Angela Trovato Salinaro, Roberta Fusco, Marika Cordaro, Daniela Impellizzeri, Maria Scuto, Maria Laura Ontario, Gianluigi Lo Dico, Salvatore Cuzzocrea, Rosanna Di Paola, Rosalba Siracusa, Vittorio Calabrese
Summary: The study investigated the development of neurodegenerative diseases following traumatic brain injury (TBI) and the potential of Coriolus versicolor and Hericium erinaceus in preventing PD-related pathology. The findings suggest that these nutritional fungi can prevent neuroinflammatory and oxidative processes typical of PD, thus playing a crucial role in preventing the progression of neurodegenerative diseases.