Goblet cells as mucosal sentinels for immunity

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

(2016) G. M. H. Birchenough et al.   SCIENCE

Antibiotics promote inflammation through the translocation of native commensal colonic bacteria

(2015) Kathryn A Knoop et al.   GUT

New developments in goblet cell mucus secretion and function

(2015) G M H Birchenough et al.   Mucosal Immunology

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

(2014) Marta Wlodarska et al.   CELL

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

(2014) Thaher Pelaseyed et al.   IMMUNOLOGICAL REVIEWS

Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon

(2014) K A Knoop et al.   Mucosal Immunology

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

Ischaemia-induced mucus barrier loss and bacterial penetration are rapidly counteracted by increased goblet cell secretory activity in human and rat colon

(2012) Joep Grootjans et al.   GUT

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

(2012) Jeremiah R. McDole et al.   NATURE

Mucin dynamics and enteric pathogens

(2011) Michael A. McGuckin et al.   NATURE REVIEWS MICROBIOLOGY

Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa

(2010) Kirk S. B. Bergstrom et al.   PLoS Pathogens

Mucins in the mucosal barrier to infection

(2008) S K Linden et al.   Mucosal Immunology

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA