Article
Engineering, Manufacturing
Yifei Jin, Ruitong Xiong, Patrick J. Antonelli, Christopher J. Long, Christopher W. McAleer, James J. Hickman, Yong Huang
Summary: This study investigates and demonstrates a nanoclay yield-stress suspension-enabled extrusion-based 3D printing system to overcome solidification rate constraints during printing. Two fabrication approaches, including using nanoclay as a support bath material to fabricate tympanic membrane patches and as an internal scaffold material to print neural chambers, have been proposed. Material stress analysis has been performed to explore the geometric limitation of printable nanoclay-PEGDA neural chambers.
JOURNAL OF MANUFACTURING SCIENCE AND ENGINEERING-TRANSACTIONS OF THE ASME
(2021)
Article
Engineering, Electrical & Electronic
Yue Hui, Yuan Yao, Qilin Qian, Jianhua Luo, Hehao Chen, Zheng Qiao, Yetian Yu, Liang Tao, Nanjia Zhou
Summary: This article introduces a method for manufacturing hydrogel electronics using 3D printing technology. By using a special hydrogel supporting matrix and silver-hydrogel ink, complex 3D circuits can be created within the hydrogel matrix. The resulting hydrogel electronics are soft, stretchable, and exhibit high conductivity.
NATURE ELECTRONICS
(2022)
Article
Materials Science, Multidisciplinary
Soyoung E. Seo, Younghoon Kwon, Neil D. Dolinski, Caitlin S. Sample, Jeffrey L. Self, Christopher M. Bates, Megan T. Valentine, Craig J. Hawker
Summary: A two-step process involving initial 3D photopolymerization and subsequent thermal processing is used to create thermally activated polymer foams with tunable pore size and volume fraction. By adjusting the cross-link density of the matrix network, it is possible to control pore size and material mechanics, achieving customized design of foam with complex geometries and porosity.
ACS APPLIED POLYMER MATERIALS
(2021)
Review
Nanoscience & Nanotechnology
Dan Moldovan, Jaeyoo Choi, Youngwoo Choo, Won-Sik Kim, Yoon Hwa
Summary: Laser 3D manufacturing technologies show great potential in fabricating 3D structured electrochemical rechargeable batteries, offering excellent microstructure controllability, design flexibility, simplicity in process, and high energy and cost efficiencies for battery manufacturing.
Article
Materials Science, Multidisciplinary
Xinran Zhou, Pooi See Lee
Summary: This article discusses the application of 3D printing techniques in the fabrication of tactile sensors commonly used in soft robotics, including four types of sensors, and explores the future potential of printable tactile sensors.
Article
Chemistry, Multidisciplinary
Julian Hengsteler, Barnik Mandal, Cathelijn van Nisselroy, Genevieve P. S. Lau, Tilman Schlotter, Tomaso Zambelli, Dmitry Momotenko
Summary: Electrochemical 3D printing has achieved a new breakthrough at the nanoscale, allowing for layer-by-layer manufacturing of 25 nm diameter conductive structures. By controlling the printing process, real-time adjustments of feature sizes and printing of tilted and overhanging structures are made possible.
Review
Chemistry, Multidisciplinary
Houman Honaryar, Saba Amirfattahi, Zahra Niroobakhsh
Summary: Liquid-in-liquid 3D printing techniques that rely on the interaction or association of two liquid phases have been developed for fabricating complex structures from a wide range of soft materials. This review article provides an overview of these techniques, including their fundamentals, underlying mechanisms, characterization techniques for structural stability assurance, and practical properties of prints. The future paths and potential applications are also discussed.
Article
Nanoscience & Nanotechnology
Amar M. Kamat, Yutao Pei, Bayu Jayawardhana, Ajay Giri Prakash Kottapalli
Summary: The study introduces a novel processing method for fabricating complex, bioinspired PDMS structures, including two flexible piezoresistive microelectromechanical (MEMS) sensors integrated into an electric shaver. This method involves 3D printing a thin-walled sacrificial metallic mold, soft polymer casting, and acidic etching of the mold, allowing for the creation of intricate structures that are challenging to achieve with current techniques.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Manufacturing
Bjorn Sparrman, Cosima du Pasquier, Charles Thomsen, Shokofeh Darbari, Rami Rustom, Jared Laucks, Kristina Shea, Skylar Tibbits
Summary: Rapid Liquid Printing (RLP) is a silicone-based embedded additive manufacturing method applied to the fabrication of soft pneumatic actuators for soft robotics. RLP offers complete design freedom at high speed and surpasses traditional methods in terms of performance. Tests have shown RLP to be comparable or superior to existing methods, indicating its potential for further implementation in soft robotics and manufacturing of soft pneumatic actuators.
ADDITIVE MANUFACTURING
(2021)
Review
Chemistry, Analytical
Joao B. M. Rocha Neto, Juliana Coatrini Soares, Guilherme A. Longhitano, Andrey Coatrini-Soares, Hernandes F. Carvalho, Osvaldo N. Oliveira, Marisa M. Beppu, Jorge V. L. da Silva
Summary: This paper reviews the recent applications of 3D printing in biosensors for cancer diagnosis, highlighting the main advantages it brings. Additionally, the challenges in mass production of high-performance biosensors using 3D printing technology for cancer diagnosis are discussed.
Article
Engineering, Manufacturing
Ketan Thakare, Laura Jerpseth, Zhijian Pei, Bryan Tomlin, Hongmin Qin
Summary: The biological approach of using algae for copper removal offers advantages of low cost and environmental friendliness, but currently faces technological barriers. Experimental results demonstrate that hydrogel filters containing algae cells outperform those without algae cells in removing copper.
JOURNAL OF MANUFACTURING SCIENCE AND ENGINEERING-TRANSACTIONS OF THE ASME
(2021)
Article
Nanoscience & Nanotechnology
Yuejiao Wang, Xiang Li, Sufeng Fan, Xiaobin Feng, Ke Cao, Qi Ge, Libo Gao, Yang Lu
Summary: This study introduces a versatile microfabrication process using PμSL-based 3D printing to achieve high-resolution 3D stretchable electronic structures with exceptional stretchability and stable electrical conductivity. The fabrication process can also create complex 3D interconnect networks, as demonstrated with a stretchable capacitive pressure sensor array.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Manufacturing
Yeowon Yoon, Yang Xu, Yong Chen
Summary: Inspired by natural porous morphology, a novel additive manufacturing process is proposed to fabricate porosity-embedded structures by integrating stereolithography and inkjet printing. Water droplets are dispensed onto a layer of liquid resin, which is then photocured to define the layer profile and capture the deposited water droplets. By varying inkjet printing parameters, the size and distribution of micropores in the 3D-printed part can be modulated.
JOURNAL OF MANUFACTURING SCIENCE AND ENGINEERING-TRANSACTIONS OF THE ASME
(2023)
Review
Engineering, Biomedical
Jessica Mancilla-De-la-Cruz, Marisela Rodriguez-Salvador, Jia An, Chee Kai Chua
Summary: This paper presents the use of 3D printing technology in drug delivery applications. The different variations of the technique according to characteristics, materials, and dosage forms are discussed. The seven main categories of 3D printing and the most frequent materials used are introduced. The paper also explores different forms of drug dosage and provides insights for those interested in the advancement of drug delivery and the development of 3D printing applications in this area.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2022)
Article
Materials Science, Multidisciplinary
D. M. Correia, L. C. Fernandes, N. Pereira, J. C. Barbosa, J. P. Serra, R. S. Pinto, C. M. Costa, S. Lanceros-Mendez
Summary: This study developed printable materials for soft actuators based on ionic liquids and fluorinated polymers, demonstrating high ionic conductivity and large displacement, indicating their potential for applications.
APPLIED MATERIALS TODAY
(2021)
Article
Medicine, Research & Experimental
Matthew A. Schaller, Yamini Sharma, Zadia Dupee, Duy Nguyen, Juan Uruena, Ryan Smolchek, Julia C. Loeb, Tiago N. Machuca, John A. Lednicky, David J. Odde, Robert F. Campbell, W. Gregory Sawyer, Borna Mehrad
Summary: The researchers developed a system for ex vivo study of human SARS-CoV-2 infection using primary human lung tissue from a library of donor tissues. They found significant donor-dependent heterogeneity in the host response to SARS-CoV-2, and some drugs were effective in suppressing viral replication in the tissues.
Article
Engineering, Chemical
D. I. Pedro, D. T. Nguyen, J. G. Rosa, N. Diodati, J. Kim, J. I. Bowman, R. A. Olson, J. M. Uruena, B. S. Sumerlin, W. G. Sawyer
Summary: The gel-forming mucins in the tear film are critical for lubricity, while glycocalyces show high friction in Gemini contacts and result in cell damage.
Article
Biology
Tapomoy Bhattacharjee, Daniel B. Amchin, Ricard Alert, Jenna Anne Ott, Sujit Sankar Datta, Irene Giardina
Summary: Collective migration, a fascinating behavior in active matter, has functional implications for biological systems. This study investigates how bacterial populations persist in migration despite perturbations. The researchers discover that the bacteria autonomously smooth out large-scale perturbations by adjusting their ability to sense and respond to the local nutrient gradient, enabling them to continue migrating together.
Article
Cell Biology
Duy T. Nguyen, Jack E. Famiglietti, Ryan A. Smolchek, Zadia Dupee, Nickolas Diodati, Diego Pedro, Juan M. Uruena, Matthew A. Schaller, W. Gregory Sawyer
Summary: A new cell culture platform has been developed, which utilizes a pump-free suction device for controlled perfusion of cell culture media, leading to more physiologically relevant cell culture models. This platform has demonstrated versatile applications, including the culture of cellular spheroids and the maintenance of tissue microexplants with high viability and prolonged contractility.
Review
Cell Biology
Duy T. Nguyen, Elizabeth Ogando-Rivas, Ruixuan Liu, Theodore Wang, Jacob Rubin, Linchun Jin, Haipeng Tao, William W. Sawyer, Hector R. Mendez-Gomez, Matthew Cascio, Duane A. Mitchell, Jianping Huang, W. Gregory Sawyer, Elias J. Sayour, Paul Castillo
Summary: This article discusses the important role of the tumor microenvironment in CAR-T cell therapy and explains the advantages and limitations of preclinical models.
Article
Polymer Science
Rebecca A. Olson, Megan E. Lott, John B. Garrison, Cullen L. G. Davidson, Lucca Trachsel, Diego I. Pedro, W. Gregory Sawyer, Brent S. Sumerlin
Summary: This paper describes the synthesis of ultrahigh molecular weight water-soluble polymers via photoiniferter polymerization under inverse miniemulsion conditions. The process utilizes low-intensity UV irradiation and offers rapid polymerization rates, excellent molecular weight control, and viscosity control. By optimizing the polymerization conditions, acrylamido homopolymers and block copolymers with molecular weights exceeding 1,000,000 Da have been successfully synthesized at ambient temperature.
Article
Biophysics
D. T. Nguyen, D. I. Pedro, A. Pepe, J. G. Rosa, J. I. Bowman, L. Trachsel, G. R. Golde, I. Suzuki, J. M. Lavrador, N. T. Y. Nguyen, M. A. Kis, R. A. Smolchek, N. Diodati, R. Liu, S. R. Phillpot, A. R. Webber, P. Castillo, E. J. Sayour, B. S. Sumerlin, W. G. Sawyer
Summary: Tumor invasion is driven by intrinsic and extrinsic stresses, reduced intercellular adhesion, and interactions with the extracellular matrix. This study investigates nonenzymatic mechanisms of invasion using a bioconjugated liquid-like solid (LLS) medium to mimic a loose capillary-like network. The LLS is made of soft granular microgels and allows for the exploration of 3D tumor invasion using confocal microscopy. The study reveals that tumor invasion is guided by the interstitial space and geometrical cues, independent of proteolytic ability.
Article
Engineering, Biomedical
M. Sreepadmanabh, Meenakshi Ganesh, Ramray Bhat, Tapomoy Bhattacharjee
Summary: Although traditional 2D culturing approaches are widely adopted, there is a need for a broadly biocompatible, high-throughput, and easily accessible manufacturing process for 3D cell culture. Researchers introduce a rapid, high-throughput method to synthesize jammed microgels composed of agarose granules directly in a culture medium. These microgels are optically transparent, porous, and compatible with standard techniques, making them versatile for 3D cell culture and bioprinting.
BIOMEDICAL MATERIALS
(2023)
Article
Chemistry, Physical
Ligesh Theeyancheri, Subhasish Chaki, Tapomoy Bhattacharjee, Rajarshi Chakrabarti
Summary: To study the behavior of deformable active agents in porous media, we computationally investigate the dynamics of linear chains and rings made of active Brownian monomers. We find that flexible linear chains and rings migrate smoothly and undergo swelling, while semiflexible linear chains shrink at lower activities and swell at higher activities. Semiflexible rings, on the other hand, shrink and get trapped at lower activities, but escape at higher activities. This demonstrates the interplay between activity and topology in controlling the structure and dynamics of linear chains and rings in porous media.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Meeting Abstract
Oncology
W. Gregory Sawyer, Duy Nguyen, Ryan Smolchek, Jack Famiglietti, Stephanie Warrington
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Chemistry, Physical
Katie A. Rose, Emanuele Marino, Christopher S. O'Bryan, Christopher B. Murray, Daeyeon Lee, Russell J. Composto
Summary: The effect of nanoscale defects on nanoparticle dynamics in defective tetra-PEG hydrogels was investigated using single particle tracking. The study found that the percentage of mobile nanoparticles and the size of displacements increased with the number and size of defects, suggesting that nanoparticle mobility is influenced by the size of the defects. The study also indicated that different sized nanoparticles probe different length scales of the defects, indicating that confinement ratios alone cannot predict bulk dynamics in these systems.
Article
Physics, Fluids & Plasmas
Ligesh Theeyancheri, Subhasish Chaki, Tapomoy Bhattacharjee, Rajarshi Chakrabarti
Summary: Inspired by how the shape deformations in active organisms help them migrate through disordered porous environments, this study simulated active ring polymers in two-dimensional random porous media. It was found that flexible and inextensible active ring polymers navigate smoothly through the disordered media, while semiflexible rings undergo transient trapping inside the pore space, which is inversely correlated with the increase in activity. Moreover, it was discovered that flexible rings swell while inextensible and semiflexible rings shrink upon increasing the activity.
Review
Biophysics
Senthilkumar Duraivel, Vignesh Subramaniam, Steven Chisolm, Georg M. Scheutz, Brent. S. Sumerlin, Tapomoy Bhattacharjee, Thomas E. Angelini
Summary: In recent developments in 3D bioprinting, the physics of interfaces has been relatively neglected. However, the discovery of liquid-liquid phase separation (LLPS) in living cells has sparked increased interest in the study of complex fluid interfaces. Researchers believe that many new insights from LLPS research can be applied to develop improved materials and methods for 3D bioprinting that leverage LLPS.
BIOPHYSICS REVIEWS
(2022)
Meeting Abstract
Immunology
Matthew Schaller, Yamini Sharma, Zadia Dupee, Duy Nguyen, Juan Uruena, Ryan Smolchek, Tiago Machuca, W. Gregory Sawyer, Borna Mehrad
JOURNAL OF IMMUNOLOGY
(2021)
Article
Physics, Fluids & Plasmas
Lazaro J. Perez, Tapomoy Bhattacharjee, Sujit S. Datta, Rishi Parashar, Nicole L. Sund
Summary: The study utilized a random walk particle-tracking approach to simulate bacterial transport in porous media, finding that the model efficiently captured the dynamics of bacterial spreading, including the impact of cell-cell interactions and pore confinement. The model is able to qualitatively reproduce observed directional persistence and provides a basis for studying bacterial dispersal in complex environments on a multiscale level.
