Article
Clinical Neurology
Jakub Surkont, Stephen Joza, Richard Camicioli, W. R. Wayne Martin, Marguerite Wieler, Fang Ba
Summary: This study identified microstructural changes in the thalamus, caudate, and MLC in PD patients, which correlated with gait parameters. The findings suggest a characteristic regional pattern of microstructural degradation in PD, indicating a potential subcortical locomotion network failure. DTI ROI analysis could be a useful tool for assessing PD functional status and specific motor domains like gait.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Neurosciences
Chao Wang, Cheng Zhou, Tao Guo, Yeerfan Jiaerken, Siyu Yang, Peiyu Huang, Xiaojun Xu, Minming Zhang
Summary: This study found that chronic coffee consumption is associated with a decrease in striatal volume in patients with Parkinson's disease, but the effects may diminish or compensate after quitting coffee.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Seong Ho Jeong, Chae Jung Park, Hyun-Jae Jeong, Mun Kyung Sunwoo, Sung Soo Ahn, Seung-Koo Lee, Phil Hyu Lee, Yun Joong Kim, Young Ho Sohn, Seok Jong Chung
Summary: This study aimed to investigate the association between choroid plexus volume (CPV), nigrostriatal dopaminergic degeneration, and motor outcomes in Parkinson's disease (PD). The study found that CPV was negatively associated with dopamine transporter availability and motor scores, and was positively associated with the risk of developing freezing of gait and an increase in dopaminergic medication. Therefore, CPV has the potential to serve as a biomarker for baseline and longitudinal motor disabilities in PD.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neurosciences
Jung Bin Kim, Hayom Kim, Chan-Nyung Lee, Kun-Woo Park, Byung-Jo Kim
Summary: Neurodegenerative changes in the central nervous system have been suggested as a mechanism for autonomic dysfunction in PD. The study found that PD patients with OH had more severe autonomic dysfunction and decreased volume in the right inferior temporal cortex. The association between changes in regional GM volume and visuospatial/visuoperceptual function and autonomic severity scores in PD patients with OH was also identified.
Editorial Material
Behavioral Sciences
Matteo Esposito, Marco Tamietto, Giuliano Carlo Geminiani, Alessia Celeghin
Summary: Recent studies indicate a primary role of the basal ganglia in extracting stimulus-value regularities and managing visual stimulus selection once sensory-motor associations are formed. In Parkinson's Disease, visuospatial attention deficits observed since the early stages may result from the cognitive system losing the ability to translate high-level processing into stable sensorimotor memories.
Article
Neurosciences
Luis M. Garcia-Marin, Paula Reyes-Perez, Santiago Diaz-Torres, Alejandra Medina-Rivera, Nicholas G. Martin, Brittany L. Mitchell, Miguel E. Renteria
Summary: This study reveals the genetic correlations between Parkinson's disease (PD) and brain structure volumes, and identifies potential genetic variants and pathways involved. The findings suggest that genetic variations influencing brain structure volumes, possibly during early stages, can affect the risk of developing PD later in life.
NPJ PARKINSONS DISEASE
(2023)
Article
Neurosciences
Sander Lamballais, Philip R. Jansen, Jeremy A. Labrecque, M. Arfan Ikram, Tonya White
Summary: Individual differences in subcortical brain volumes are highly heritable, with previously identified genetic variants affecting both prenatal and postnatal development of these regions. Polygenic scores associated with adult subcortical volumes primarily influenced corresponding volumes at the age of 10, with a moderate relationship to early measurements on cranial ultrasound. The genetic influence on subcortical volumes at 10 years was found to be partially mediated through measurements at 7 weeks of age.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Calogero Edoardo Cicero, Giulia Donzuso, Antonina Luca, Marco Davi, Roberta Baschi, Giovanni Mostile, Loretta Giuliano, Stefano Palmucci, Andrea Salerno, Roberto Monastero, Alessandra Nicoletti, Mario Zappia
Summary: This study found that Parkinson's disease patients with mild cognitive impairment showed midbrain atrophy and thinning of the frontal cortical regions on MRI scans. These findings may serve as structural MRI features of Parkinson's disease patients with cognitive impairment.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Delshad Vaghari, Ehsanollah Kabir, Richard N. Henson
Summary: This study examined the potential of Magnetoencephalography (MEG) in early detection of Alzheimer's disease (AD). The results showed that combining MEG data with structural MRI data improved classification accuracy for Mild Cognitive Impairment (MCI) patients. However, MEG alone performed worse than MRI alone. Other MEG features were found to provide complementary information for classification above MRI.
Article
Neurosciences
Hyeon-Man Baek
Summary: The pathology of Parkinson's disease involves dopaminergic neuron death in the substantia nigra, gradually affecting basal ganglia pathways due to decreased dopamine transport. Diffusion MRI has been used to diagnose PD by evaluating white matter connectivity in certain brain areas. This study employed Lead-DBS to automatically segment subcortical structures in human connectome project data, reducing reliance on manual segmentation for improved consistency. The Lead-connectome pipeline was applied to investigate differences in diffusion measures between 3T and 7T data acquisition protocols, revealing significant variations in fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity values in different regions.
Article
Clinical Neurology
Haoting Wu, Hui Hong, Chenqing Wu, Jianmei Qin, Cheng Zhou, Sijia Tan, Xiaojie DuanMu, Xiaojun Guan, Xueqin Bai, Tao Guo, Jingjing Wu, Jingwen Chen, Jiaqi Wen, Zhengye Cao, Ting Gao, Luyan Gu, Peiyu Huang, Xiaojun Xu, Baorong Zhang, Minming Zhang
Summary: This study found that patients with Parkinson's disease had significantly increased white matter hyperintensity volumes in the occipital region, and this increase was significantly correlated with the worsening of motor function. However, the increase in white matter hyperintensity volume could not predict the progression of motor function.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jannik Prasuhn, Martin Goettlich, Sinja S. Grosser, Katharina Reuther, Britt Ebeling, Christina Bodemann, Henrike Hanssen, Armin M. Nagel, Norbert Brueggemann
Summary: Progressive supranuclear palsy (PSP) is a debilitating neurodegenerative disease with aggressive disease course, and total and intracellular-weighted sodium imaging (Na-23-MRI) is a promising method for investigating neurodegeneration.
Article
Neurosciences
Venkateswarlu Gonuguntla, Ehwa Yang, Yi Guan, Bang-Bon Koo, Jae-Hun Kim
Summary: This study proposes a framework for constructing a brain network using sMRI data and successfully extracts brain signature patterns and critical regions associated with cognitive impairment and Alzheimer's disease. The results demonstrate the potential applications of this framework in brain mapping and brain network-based applications.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Linbo Wang, Cheng Zhou, Wei Cheng, Edmund T. Rolls, Peiyu Huang, Ningning Ma, Yuchen Liu, Yajuan Zhang, Xiaojun Guan, Tao Guo, Jingjing Wu, Ting Gao, Min Xuan, Quanquan Gu, Xiaojun Xu, Baorong Zhang, Weikang Gong, Jingnan Du, Wei Zhang, Jianfeng Feng, Minming Zhang
Summary: Parkinson's disease is characterized by the loss of dopaminergic cells and atrophy in subcortical regions, which in turn affects cortical synchronization and metastability. The study shows that dopamine depletion leads to decreased cortical synchronization and metastability in PD patients, impacting cognitive performance. Thalamic volume and thalamocortical fiber connectivity play roles in mediating the relationship between subcortical dysfunction, dopamine levels, and cognitive performance in PD.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Nicholas Shaff, Erik Erhardt, Stephanie Nitschke, Kayla Julio, Christopher Wertz, Andrei Vakhtin, Arvind Caprihan, Gerson Suarez-Cedeno, Amanda Deligtisch, Sarah Pirio Richardson, Andrew R. Mayer, Sephira G. Ryman
Summary: Evaluation of quantitative analysis methods using neuromelanin-sensitive magnetic resonance imaging provides promising biomarkers for quantifying degeneration of the substantia nigra in patients with Parkinson's disease. Signal intensity measures outperform spatial and subject specific abnormality measures, and atlas identified metrics perform better than manual tracing metrics.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Han Soo Yoo, Seong Ho Jeong, Kyeong Taek Oh, Sangwon Lee, Young H. Sohn, Byoung Seok Ye, Mijin Yun, Phil Hyu Lee
Summary: Yoo et al. investigated the relationship between striatal dopamine depletion, brain metabolism, and cognition in patients with dementia with Lewy bodies. They found that striatal dopamine loss and brain hypometabolism are closely related, impacting cognition in a specific manner, and predicting cognitive decline. Brain hypometabolism was found to be more relevant to longitudinal cognitive outcomes than striatal dopaminergic degeneration in patients with Lewy body dementia.
Article
Geriatrics & Gerontology
Sakulrat Mankhong, Sujin Kim, Sohee Moon, Seong-Hye Choi, Hyo-Bum Kwak, Dong-Ho Park, Pratik Shah, Phil Hyu Lee, Seong Wook Yang, Ju-Hee Kang
Summary: This study discovered differentially expressed blood miRNAs in Korean AD patients and investigated their role in amyloidogenesis. However, the diagnostic utility of these miRNAs as biomarkers was limited.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Clinical Neurology
Seong Ho Jeong, Hye Sun Lee, Jin Ho Jung, Kyoungwon Baik, Young H. Sohn, Seok Jong Chung, Phil Hyu Lee
Summary: This study revealed the correlation between striatal DAT availability and the severity of WMHs, with different types of WMHs affecting cognitive function in PD patients depending on the cognitive domains.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Sung Hoon Kang, Yunjin Choi, Su Jin Chung, Chi Kyung Kim, Ji Hyun Kim, Kyungmi Oh, Joon Shik Yoon, Geum Joon Cho, Seong-Beom Koh
Summary: This study aimed to investigate the incidence rate of Parkinson's disease dementia (PDD) according to age and disease duration by sex. The results showed that age and disease duration were associated with the incidence of PDD, and hypertension, diabetes, dyslipidemia, and depression independently increased the risk for PDD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Seong Ho Jeong, Chan Wook Park, Hye Sun Lee, Yun Joong Kim, Mijin Yun, Phil Hyu Lee, Young H. Sohn, Seok Jong Chung
Summary: The study investigated whether different patterns of striatal dopamine depletion are associated with motor deficits in Parkinson's disease. A total of 404 drug-naive patients with early-stage PD were enrolled and underwent dopamine transporter imaging. Principal component analysis identified three patterns of dopamine depletion: overall deficiency, selective loss in the sensorimotor striatum, and symmetric loss in the striatum. Linear regression analysis revealed that overall deficiency and selective loss were associated with motor deficits, while symmetric loss was not. Mediation analysis showed that dopamine deficiency in the posterior putamen mediated the association between dopamine depletion patterns and motor deficits. These findings suggest that dopamine deficiency in the posterior putamen plays a crucial role in motor deficits in PD.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Review
Clinical Neurology
Jin Yong Hong, Phil Hyu Lee
Summary: Subjective cognitive complaints (SCCs), self-perceived cognitive decline, are related to objective cognitive decline. SCCs in cognitively normal individuals serve as a preclinical sign of subsequent cognitive impairment due to Alzheimer's disease. This review highlights the current research on SCCs in cognitively normal patients with Parkinson's disease, emphasizing the need for coherence in defining and assessing SCCs, and the value of SCCs in predicting cognitive decline. It also calls for further biomarker studies to establish the underlying pathological basis for these findings.
JOURNAL OF MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Seong Ho Jeong, Jungho Cha, Jin Ho Jung, Mijin Yun, Young H. Sohn, Seok Jong Chung, Phil Hyu Lee
Summary: This study found that additional occipital amyloid-beta deposition is associated with poor baseline language function and rapid cognitive deterioration in patients with Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Sung Hoon Kang, Seok-Joo Moon, Minwoong Kang, Su Jin Chung, Geum Joon Cho, Seong-Beom Koh
Summary: This study aimed to investigate the incidence of Parkinson's disease (PD), including age, sex, and modifiable risk factors. Analysis of data from the Korean National Health Insurance Service revealed that hypertension, diabetes, dyslipidemia, stroke, heart disease, depression, osteoporosis, and obesity were independently associated with a higher risk for PD. These findings are important for informing healthcare policies to prevent the development of PD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Nursing
Juhee Lee, Young H. Sohn, Seok Jong Chung, Eunyoung Kim, Yielin Kim
Summary: This study found that sex and onset age are important factors in determining the clinical features of Parkinson's disease. All participants reported at least one nonmotor symptom, with nocturia and constipation being the most commonly reported. Male participants reported more dribbling of saliva, constipation, and impaired sexual function, while female participants reported more weight change. Young-onset people with Parkinson's disease reported more depression than those with late-onset.
INTERNATIONAL JOURNAL OF NURSING PRACTICE
(2023)
Article
Clinical Neurology
Kyoungwon Baik, Seun Jeon, Mincheol Park, Young-gun Lee, Phil Hyu Lee, Young H. Sohn, Byoung Seok Ye
Summary: This study compared the imaging characteristics and cutoff value of 18F-florapronol (FC119S) and 18F-florbetaben (FBB) positron emission tomography (PET) in detecting 3-amyloid positivity and Alzheimer's disease (AD) in patients with cognitive impairment. The findings showed that quantitative FC119S-PET analysis provided reliable information for detecting 3-amyloid deposition and the presence of AD.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Article
Medicine, General & Internal
Eugene Huh, Jin Gyu Choi, Yujin Choi, In Gyoung Ju, Bora Kim, Yoon-Jung Shin, Jong Min An, Myoung Gyu Park, Sung Vin Yim, Su Jin Chung, Sang-Uk Seo, Dokyoung Kim, Chun Hyung Kim, Dong Hyun Kim, Myung Sook Oh
Summary: This study explores the role of the gut microbiome and the gut-brain axis in central nervous system degeneration. It finds that Proteus mirabilis can induce the aggregation of intestinal alpha-synuclein, resulting in dopaminergic neurodegeneration in the brain. The specific virulence factor haemolysin A is involved in this process by activating the autophagy signaling pathway in intestinal neuroendocrine cells.
Article
Clinical Neurology
Juhee Lee, Young H. Sohn, Seok Jong Chung, Sung Hae Kim, Yujin Suh, Jungah Park, Yielin Kim
Summary: This study translated and validated the Korean version of the Parkinson's Disease Questionnaire-Carer (PDQ-Carer), identified four factors through exploratory factor analysis, and found that a modified model fit the data well in the confirmatory factor analysis.
JOURNAL OF CLINICAL NEUROLOGY
(2023)