期刊
MOVEMENT DISORDERS
卷 32, 期 3, 页码 414-422出版社
WILEY
DOI: 10.1002/mds.26887
关键词
Lewy body; synuclein; stereology; pulvinar; thalamus; dementia
资金
- UK Medical Research Council [G0400074]
- NIHR Newcastle Biomedical Research Centre
- Newcastle upon Tyne NHS Foundation Trust and Newcastle University
- Alzheimer's Research UK
- Alzheimer's Society
- NHS National Institute of Health Research Biomedical Research Unit
- MRC [G0900652, G0502157, G0400074, G1100540] Funding Source: UKRI
- Alzheimer's Society [181] Funding Source: researchfish
- Medical Research Council [G0900652, G0502157, G1100540, G0400074] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10048] Funding Source: researchfish
Background: Complex visual hallucinations occur in 70%-80% of dementia with Lewy bodies patients and significantly affect well-being. Despite the prevalence of visual hallucinations in dementia with Lewy bodies, the neuropathological basis of this phenomenon is poorly understood. The pulvinar nucleus of the thalamus has not previously been neuropathologically examined, but has been linked to visual hallucinations in dementia with Lewy bodies. The objective of this study was to investigate whether neuropathological or morphometric changes occur in the pulvinar nucleus in dementia with Lewy bodies cases that may contribute to visual hallucinations. Methods: Postmortem pulvinar tissue was acquired from 8 individuals with dementia with Lewy bodies, 8 with Alzheimer's disease, and 8 control cases and was analyzed using stereological and quantitative neuropathological techniques. Results: Lewy body pathology was present throughout the pulvinar in dementia with Lewy bodies but was most severe in the medial pulvinar. Neuronal loss was found in the lateral pulvinar in dementia with Lewy bodies and Alzheimer's disease but was more severe in dementia with Lewy bodies. Conclusions: The pulvinar has an important role in visual attention, visual target selection and affective visual perception. These functions are thought to be deficient in dementia with Lewy bodies and may contribute a vulnerability to visual hallucinations. Therefore, this study has demonstrated neuropathological changes that may promote the manifestation of visual hallucinations in dementia with Lewy bodies. (C) 2017 International Parkinson and Movement Disorder Society
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