Article
Medicine, Research & Experimental
Won-Kyung Cho, Jin Yeul Ma
Summary: Epimedium koreanum Nakai (EKN) has shown significant inhibitory effects on influenza A virus infection by directly blocking viral attachment and having a virucidal effect. It can potentially be developed as a natural viral inhibitor against influenza virus infection.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Pin Li, Lin Zhang, Zhaojuan Guo, Qianjun Kang, Cong Chen, Xiaoyao Liu, Quantao Ma, Jingxuan Zhang, Yujie Hu, Ting Wang
Summary: This study investigated the mechanism of hepatotoxicity of Epimedium koreanum Nakai using untargeted metabolomics analysis of serum and liver tissue. The results demonstrated that Epimedium koreanum Nakai caused significant liver damage, possibly through the induction of ferroptosis in hepatocytes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yudan Zhao, Ruiqi Zhang, Lintong Mu, Wanyue Yang, Xin Zhang, Ling Han, Chongning Lv, Jincai Lu
Summary: This study evaluated the pharmacological efficacy of total flavonoids in Epimedium koreanum Nakai against chronic renal failure (CRF) and determined its mechanism of action. Results showed that TFE had a significant effect on CRF at a certain dosage and could alleviate renal fibrosis. Metabolomics revealed potential biomarkers related to energy metabolism pathways, while mechanism studies suggested TFE regulated AMPK and SIRT1 signaling pathways.
Article
Integrative & Complementary Medicine
Muhammad Irfan, Tae-Hyung Kwon, Dong-Ha Lee, Seung-Bok Hong, Jae-Wook Oh, Sung-Dae Kim, Man Hee Rhee
Summary: The study demonstrated that Epimedium koreanum Nakai has antiplatelet and antithrombotic effects by reducing calcium mobilization, ATP secretion, TXB2 formation, and integrin alpha (IIb)beta (3) activation. It may be considered a potential candidate for treating and preventing platelet-related cardiovascular disorders.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Chemistry, Medicinal
Jinqiang Wang, Dandan Feng, Yimin Xiang, Ji Guo, Nianyu Huang, Na Yu, Huishu Yang, Chengxiong Liu, Kun Zou
Summary: The study focused on a natural compound, euparin, derived from a Chinese herb, which showed inhibitory activities against a-glucosidase and PTP1B, two important targets for the treatment of type 2 diabetes. Through efficient transformation reactions, 30 chalcone compounds were obtained and tested for their inhibitory activities. Compounds 12 and 15 exhibited good inhibitory activities against both enzymes and demonstrated strong binding affinities. These findings suggest that compounds 12 and 15 could be potential candidates for the treatment of type 2 diabetes.
Article
Plant Sciences
Jie Xiang, Rifat Nowshin Raka, Luocheng Zhang, Junsong Xiao, Hua Wu, Zhiqian Ding
Summary: Procyanidins from lotus seedpods have inhibitory effects on the activities of α-amylase, α-glucosidase, and PTP1B. The inhibition increases with the degree of polymerization and the existence of galloyl or gallocatechin units.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Article
Chemistry, Applied
Yudan Zhao, Linxuan Teng, Ruiqi Zhang, Chongning Lv, Jincai Lu
Summary: Two new prenylated flavonol glycosides and one unidentified compound were isolated from Epimedium koreanum Nakai. The structures were determined by NMR and HRESIMS analysis, and the sugar moieties were identified through acid hydrolysis and HPLC analysis. One of the compounds showed significant inhibitory effects on A549 cell fibrosis.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Abdul Sadiq, Mater H. Mahnashi, Umer Rashid, Muhammad Saeed Jan, Mohammed Abdulrahman Alshahrani, Mohammed A. Huneif
Summary: This study synthesized a new chiral molecule and evaluated its potential as an antidiabetic drug. The compound showed promising inhibitory effects on multiple antidiabetic targets and exhibited strong binding affinity with enzymes based on molecular docking analysis.
Article
Biochemistry & Molecular Biology
Mohammed A. Huneif, Mater H. Mahnashi, Muhammad Saeed Jan, Muhammad Shah, Sultan A. Almedhesh, Seham M. Alqahtani, Mohammad Jamaan Alzahrani, Muhammad Ayaz, Farhat Ullah, Umer Rashid, Abdul Sadiq
Summary: Diabetes mellitus (DM) is a metabolic disorder resulting from pancreatic dysfunction, characterized by reduced insulin production or insulin resistance. In this study, we designed and synthesized new succinimide-thiazolidinedione hybrids for the treatment of DM. We successfully synthesized five new derivatives (10a-e) with different substitution patterns on the N-atom of the succinimide ring. Compound 10d showed the most potential as an antidiabetic agent in in vitro assays. Further investigations in experimental animals confirmed its promising antidiabetic activity. Molecular docking studies also demonstrated the interaction of compound 10d with target enzymes involved in diabetes. Overall, we have identified a new class of compounds with potential as antidiabetic agents.
Article
Biochemistry & Molecular Biology
Manh Tuan Ha, Tae Hyun Lee, Chung Sub Kim, Ritu Prajapati, Jeong Ah Kim, Jae Sue Choi, Byung Sun Min
Summary: This study investigated the Hedera rhombea Bean fruit and isolated several compounds, including two megastigmane glucosides, two rare 1,4-dioxane neolignanes, and two quinic acid derivatives. These compounds showed significant inhibitory activity against PTP1B and α-glucosidase, indicating their potential for the treatment of type 2 diabetes.
Article
Plant Sciences
Aamir Niaz, Ahmad Adnan, Rashida Bashir, Muhammad Waseem Mumtaz, Syed Ali Raza, Umer Rashid, Chin Ping Tan, Tai Boon Tan
Summary: The ethyl acetate fraction of Tamarix dioica extract showed strong antioxidant activity and anti-diabetic potential, possibly due to the presence of metabolites such as quercetin and catechin. This study confirmed the ethnopharmacological use of T. dioica in managing diabetes mellitus and suggested a natural approach for anti-hyperglycemia.
Article
Biochemical Research Methods
Ning Li, Lijuan Xie, Na Yang, Guijiang Sun, Hui Liu, Chenghao Bi, Jingyi Duan, Yu Yuan, Hongxin Yu, Yanyan Xu, Yubo Li
Summary: A method for rapid classification and identification of the main components of flavonoids, organic acids, and alkaloids in Epimedium koreanum Nakai (EKN) was established using UPLC-Q-TOF-MS. 51 chemical components, including 40 flavonoids, nine organic acids, and two alkaloids, were successfully screened out. This method not only comprehensively analyzed the chemical compositions of EKN, solved the difficult problems of analysis and identification of the complex chemical compositions of traditional Chinese medicine, but also further promoted the development of the application of chemical compositions of TCM.
PHYTOCHEMICAL ANALYSIS
(2021)
Article
Chemistry, Medicinal
Yi-Ming Zhao, Meng-Xue Xiu, Jian Song, Yue Zhang, Xiao-Jing Shao, Xue-Hui Wang, Hyun-Sun Lee, Long Cui
Summary: This study confirmed that the crude extracts of Psoralea corylifolia seeds (PCE34) can reduce serum lipids and sugar levels, increase insulin, and decrease body weight in hyperlipidemic rats. Several new compounds were isolated from PCE34, and some showed inhibitory activity against specific enzymes.
Article
Biochemistry & Molecular Biology
Qingchen Cui, Cuicui Wang, Liping Zhou, Yanjun Wei, Zongtao Liu, Xianggen Wu
Summary: A novel functional food for hyperlipidemia, named icariin pro-glycymicelles (ICA-PGs), was easily prepared using glycyrrhizin as a phytonanomaterial. ICA-PGs showed improved stability and encapsulation efficiency, easily dissolved in water to form glycymicelle solution, and exhibited enhanced in vitro and in vivo activities against hyperlipidemia.
Article
Biotechnology & Applied Microbiology
Yu Lin, Wen-wen Chen, Bo Ding, Man Guo, Meng Liang, Hao Pang, Yu-tuo Wei, Ri-bo Huang, Li-qin Du
Summary: In this study, a highly efficient whole-cell catalytic method was developed for the production of icaritin, a potential treatment for hepatocellular carcinoma. The combination of a-L-rhamnosidase SPRHA2 and ss-glucosidase PBGL successfully hydrolyzed icariin to icaritin in a one-pot reaction with a yield of 95.23%. Furthermore, recombinant E. coli strains co-expressing SPRHA2 and PBGL were constructed, allowing for efficient hydrolysis of crude icariin extracts. These findings provide a promising approach for the industrial production of icaritin.
MICROBIAL CELL FACTORIES
(2023)