Article
Chemistry, Multidisciplinary
Shuo Lu, Tianyu Zheng, Jiawei Ma, Zhangming Deng, Shengmeng Qin, Yu Chen, Yong Liang
Summary: In this study, a new ionic ligand is developed and successfully used for the para-selective functionalization of aromatic salts. The reaction shows great potential in gram-scale transformation, late-stage elaboration for drug molecules, and diversification of products.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Liqiu Chu, Zhiyu Zhou, Zhipan Feng, Xinqi Zhao, Huimin Tan, Yu Chen
Summary: In this study, HTCC/Fe3O4/CdTe magnetic fluorescent nanoparticles (MFCNPs) that can be well dispersed in water were prepared via electrostatic interaction. The nanoparticles showed good biocompatibility and their properties were mainly influenced by the relative ratios of different components. The chitosan-based magnetic fluorescent composite may be a promising delivery carrier candidate.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Applied
Yingqi Mi, Yuan Chen, Wenqiang Tan, Jingjing Zhang, Qing Li, Zhanyong Guo
Summary: In this study, different chitosan derivatives were synthesized by ion exchange of glyoxylate bearing Schiff base with chitosan quaternary ammonium salts. The results showed that glyoxylate bearing Schiff base significantly improved the bioactivity of chitosan derivatives, with good antioxidant and antifungal activities.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Mark P. Walsh, Matthew O. Kitching
Summary: The modes of supramolecular recognition of quaternary phosphonium cations mediated by BINOL have been identified and characterized. X-ray crystallography and surface analysis were used to analyze the solid state structures of the ternary complexes, confirming the presence of characteristic intermolecular interactions. These findings provide valuable insights for the future design of agents capable of recognizing and separating phosphonium cations.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Wanjing Zou, Jingwei Gu, Jianna Li, Yuanfang Wang, Shiguo Chen
Summary: The study successfully synthesized IQAS and ISB derivatives and systematically investigated the effects of their substitution degree, carbon chain length, and content ratio on water solubility, antibacterial activity, and cytotoxicity of CS derivatives, suggesting that the properties of CS derivatives can be tailored by adjusting the amount of grafted antibacterial agents.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Li Zhang, Xue-Zhen Feng, Zhuan-Quan Xiao, Guo-Rong Fan, Shang-Xing Chen, Sheng-Liang Liao, Hai Luo, Zong-De Wang
Summary: Beta-pinene quaternary ammonium salts were synthesized and evaluated for their antifungal, antibacterial, and anticancer activities, with compound 4a showing remarkable effectiveness. These findings suggest the potential of beta-PQA salts as novel antimicrobial and anticancer agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Fruzsina Demeter, Patrik Toeroek, Alexandra Kiss, Richard Kovasznai-Olah, Zsuzsa Mathene Szigeti, Viktoria Baksa, Fruzsina Kovacs, Noemi Balla, Ferenc Fenyvesi, Judit Varadi, Aniko Borbas, Mihaly Herczeg
Summary: The emergence of drug-resistant bacteria and fungi is a serious global health issue. Cationic compounds can inhibit the growth of microorganisms by disrupting their cell membrane, and their use avoids the development of resistance. Researchers have designed novel carbohydrate-derived amidinium salts with quaternary ammonium groups, which can potentially disrupt the cell walls of bacteria and fungi. These compounds showed promising antimicrobial activity, particularly against Candida albicans, and their efficacy was influenced by the type of protecting groups and sugar configuration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Alejandro Torres-Rodriguez, Luc Averous, Eric Pollet, Gerardo de Jesus Sosa-Santillan, Alejandro Zugasti-Cruz, Crystel Aleyvick Sierra-Rivera, Nancy Veronica Perez-Aguilar, Marco Antonio Garcia-Lobato, Ernesto Oyervides-Munoz
Summary: Three novel polyaspartate derivatives with antibacterial properties and low hemolytic effects were synthesized and tested, showing potential as antimicrobial agents.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Chemistry, Medicinal
Kyle J. Sommers, Marina E. Michaud, Cody E. Hogue, Amber M. Scharnow, Lauren E. Amoo, Ashley A. Petersen, Robert G. Carden, Kevin P. C. Minbiole, William M. Wuest
Summary: Quaternary ammonium compounds are important in disinfectants and antiseptics, but overuse can lead to resistance. Research into quaternary phosphonium compounds found bicatioinc QPCs to have improved antimicrobial activity against a range of bacteria.
ACS INFECTIOUS DISEASES
(2022)
Article
Biotechnology & Applied Microbiology
Karol Sikora, Jakub Jedrzejczak, Marta Bauer, Damian Neubauer, Maciej Jaskiewicz, Magdalena Szarynska
Summary: This study investigated the influence of quaternization of the amino group of lysine side chain in ultrashort cationic lipopeptides (USCLs) on their antimicrobial, hemolytic, and cytotoxic activities. The results showed that quaternization can enhance the antimicrobial activity of lipopeptides but usually decreases their activity. Furthermore, the quaternized analogues demonstrated lower toxicity to human cells and higher selectivity to pathogens. Quaternization also improved the solubility of the peptides, increasing their bioavailability.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Biochemistry & Molecular Biology
Lin Wang, Meihua Xin, Mingchun Li, Wenfeng Liu, Yangfan Mao
Summary: In this study, three new chitosan quaternary phosphonium compounds were synthesized and characterized. Their antibacterial activities against Escherichia coli and Staphylococcus aureus, as well as their antibiofilm activities, were investigated. The results showed that the chitosan quaternary phosphonium salts exhibited stronger antibacterial and antibiofilm activities compared to chitosan quaternary ammonium salt.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Nikita A. Frolov, Ksenia A. Fedoseeva, Karl A. Hansford, Anatoly N. Vereshchagin
Summary: Novel phenyl-based bis-quaternary ammonium compounds showed potent broad-spectrum biocidal activity against bacterial and fungal pathogens and have the potential to replace existing household sanitizers.
Article
Chemistry, Physical
Yujiao Hao, Shun Liu, Hongtan Cai, Qiaoyi Zhang, Ge Gao, Xiufeng Hao
Summary: A silicone material with one cationic quaternary ammonium salt (QAS) and three N-halamine sites was developed for enhanced antibacterial performance. The material showed higher deactivation abilities against E. coli and S. aureus compared to materials with only one cationic center or one N-halamine. This research has theoretical and practical value for the development of new antibacterial materials.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2023)
Article
Chemistry, Applied
Yaoyao Chang, Weiqiang Zhong, Jiaqi Liang, Anqiang Zhang, Yaling Lin
Summary: The study showed that Si(x)Q(5) has a good inhibitory effect on Foc4, is easily adsorbed by soil and relatively immobile. Additionally, Si(x)Q(5) can increase the total fungal and bacterial populations in soil while decreasing the actinobacterial population.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Engineering, Chemical
Michael Lu, Gonela Vijaykumar, Prashanth Wilfred Menezes, Matthias Driess, Reinhard Schomaecker
Summary: Triphenylphosphine is a crucial reagent in Wittig olefination reactions. Researchers have optimized an indirect electrochemical reduction method to recycle triphenylphosphine oxide to triphenylphosphine, achieving high current efficiency and chemical selectivity.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Computer Science, Artificial Intelligence
He Zhang, Qiuhong Chen, Pengbo Ni, Haibo Liang, Min Mao, Jialing Zou
Summary: This paper proposes a method for identifying the lithology of a drilled formation using element and gamma spectrum measurement, as well as establish an intelligent identification model. The field application shows that the accuracy of the proposed method can reach 90.9%, verifying the feasibility of using this approach for intelligent identification of formation lithology during drilling.
NEURAL COMPUTING & APPLICATIONS
(2022)
Article
Cell Biology
Huanjia Gao, Jeremy Bigalke, Enshe Jiang, Yuanyuan Fan, Bojun Chen, Qing-Hui Chen, Zhiying Shan
Summary: The study revealed that TNF alpha can induce inflammatory response in brain neurons and PVN of rats, with Dahl-S rats showing a more significant response to TNF alpha compared to SD rats. This increased inflammatory response in Dahl-S rats may indicate an underlying mechanism for enhanced pressor reactivity to salt intake in the Dahl-S rat model.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Abdelmoneim Bakur, Hongyun Lu, Tarig Elshaarani, Dafaallah Albashir, Anas Mohammed, Qihe Chen
Summary: This study introduces a green method for fabricating biocomposites using microbial glycolipids, showing strong antioxidant properties and effectiveness in inhibiting the growth of liver cancer cells.
JOURNAL OF CLUSTER SCIENCE
(2022)
Article
Architecture
Biao Zhou, Jiazhi Sun, Xukun Sun, Kai Wang, Chen Qingqing, Xuan Wang, Yajun Han
Summary: Chinese historic buildings with wooden structures are prone to fire disasters. The effects of hydrogen fluoride (HF) released during fire suppression on these buildings are unclear. Experimental results show that flame enhancement occurs at the early stage of fire suppression with various types of fire agents.
INTERNATIONAL JOURNAL OF ARCHITECTURAL HERITAGE
(2023)
Article
Biochemistry & Molecular Biology
Yingqi Mi, Qin Miao, Jingmin Cui, Wenqiang Tan, Zhanyong Guo
Summary: This study investigated the moisture absorption and retention properties of 2-hydroxypropyltrimethyl ammonium chitosan derivatives modified by anionic compounds via ion exchange. Results showed enhanced moisture absorption and retention properties in all target products, with HACBA exhibiting the most significant improvement.
Article
Biochemical Research Methods
Ping Yu, Xinxin Wang, Jian Ma, Qili Zhang, Qingwei Chen
Summary: This study investigated the chaperone-assisted soluble expression of high molecular weight chitinase chiZJ408 in Escherichia coli BL21 and its optimal conditions for activity. Results showed that introduction of the chaperone GroELS improved the correct folding and solubility of chitinase chiZJ408. Additionally, Mg(2+) and Ca2+ were found to significantly impact the activity of chitinase chiZJ408.
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
(2022)
Article
Biochemical Research Methods
Min He, Jian Ma, Qingwei Chen, Qili Zhang, Ping Yu
Summary: The study successfully enhanced the production of PLP in E. coli by constructing a recombinant strain, and determined the optimal conditions for production, laying a good foundation for the efficient production of PLP.
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
(2022)
Article
Emergency Medicine
Hua-ling Wang, Jun Shao, Wei-li Liu, Fei Wu, Han-bing Chen, Rui-Qiang Zheng, Qi-hong Chen
Summary: A multicenter prospective observational study found that an initial fluid resuscitation rate of 20-30 ml/kg may be associated with reduced 28-day mortality in patients with septic shock, highlighting the need for further high-quality randomized controlled clinical trials to confirm these findings.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Chemistry, Applied
Yixin Wu, Yu Li, Yang Wang, Qian Liu, Qingguo Chen, Minghua Chen
Summary: Developing highly foldable batteries with no safety hazard is crucial for portable, wearable, and implantable electric devices. Solid-state batteries, particularly those based on PVDF electrolytes, show great potential, but also face challenges such as lower ionic conductivity and lack of reactive groups. Recent research has focused on gel polymer electrolytes and all solid polymer electrolytes based on PVDF to address these issues.
JOURNAL OF ENERGY CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Yan Sun, Xia Ji, Jingmin Cui, Yingqi Mi, Jingjing Zhang, Zhanyong Guo
Summary: This study presents a series of phenolic acid chitooligosaccharide (COS) derivatives synthesized using two mild and green methods. The synthesized derivatives exhibited enhanced antioxidant activity and low cytotoxicity, making them potential candidates for non-toxic antioxidant agents in the food and cosmetics industry.
Article
Chemistry, Medicinal
Qin Miao, Qing Li, Wenqiang Tan, Yingqi Mi, Bing Ma, Jingjing Zhang, Zhanyong Guo
Summary: This study primarily synthesized glucosamine-heparin salt (GHS) and characterized its structure. The results showed that the salt exhibited enhanced antioxidant and anticoagulant activities.
Article
Chemistry, Medicinal
Jingmin Cui, Yan Sun, Linqing Wang, Qin Miao, Wenqiang Tan, Zhanyong Guo
Summary: A series of l-arginine Schiff base acylated chitosan derivatives were successfully prepared to enhance the antioxidant and antimicrobial activities. Some compounds showed promising activities, indicating potential for further development and utilization as antioxidants and antimicrobial agents.
Article
Chemistry, Medicinal
Yan Sun, Jingmin Cui, Liguang Tian, Yingqi Mi, Zhanyong Guo
Summary: Fourteen novel phenolic acid functional chitooligosaccharide derivatives were successfully prepared and characterized in this study. The derivatives showed strong antioxidant and antimicrobial activities, making them potentially useful in various industries.
Article
Education & Educational Research
Guangtian Zhu, Xiaoling Su, Juan Du, Qingwei Chen, Bolong Xiong, Feng-Kuang Chiang
Summary: The study explored the effects of different scaffolds on students' physics problem solving, with MAPS scaffold showing more effective results. Future research will focus on the application of dynamic figures in physics problem-solving.
INTERACTIVE LEARNING ENVIRONMENTS
(2023)
Article
Computer Science, Information Systems
Xuan Hua, Jungang Han, Chen Zhao, Haipeng Tang, Zhuo He, Qinghui Chen, Shaojie Tang, Jinshan Tang, Weihua Zhou
Summary: This paper presents a novel end-to-end ECG signal classification algorithm using a segmentation strategy and 1D Convolutional Neural Networks (CNN). The proposed method achieves high accuracy in classifying different types of heartbeats, reducing the workload of physicians. Experimental results demonstrate better performance compared to state-of-the-art methods.
MULTIMEDIA SYSTEMS
(2022)