Article
Pharmacology & Pharmacy
YuJie Liu, Ke Pei, LiYing He, MeiBian Hu
Summary: This study successfully established the spectrum-effect relationship between HPLC fingerprints and the inhibitory effect of PRPCA on MUC5AC mucin. The findings reveal the material basis of PRPCA and provide an effective method for quality control.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Agriculture, Multidisciplinary
Junwen Liu, Jingwen Bai, Chuntian Shao, Shengnan Yao, Ran Xu, Suyang Duan, Libo Wang, Yaqin Xu, Yu Yang
Summary: The study successfully extracted polysaccharides from seabuckthorn fruits using ultrasound-assisted aqueous two-phase extraction method and investigated the extraction conditions and polysaccharide characteristics. The results showed that seabuckthorn polysaccharides have diverse bioactivities, such as antioxidant properties, and have potential applications in the pharmaceutical and food industries.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Ezzouhra El Maaiden, Nagib Qarah, Amine Ezzariai, Adil Mazar, Boubker Nasser, Khadija Moustaid, Hassan Boukcim, Abdelaziz Hirich, Lamfeddal Kouisni, Youssef El Kharrassi
Summary: Isoquercetin (ISQ) was extracted from Ephedra alata Decne using ultrasound-assisted extraction, and the optimal conditions were determined. The results showed that ultrasound-assisted extraction method was efficient and rapid, and it had potential applications in the pharmaceutical and cosmetics industries.
Article
Nutrition & Dietetics
Xu Pan, Lijing Xu, Junlong Meng, Mingchang Chang, Yanfen Cheng, Xueran Geng, Dongdong Guo, Rongzhu Liu
Summary: In this study, a high-efficiency and non-pollution extraction procedure using deep eutectic solvents (DESs) was applied to extract polysaccharides from Morchella importuna. The results showed that the DES system with a mole ratio of choline chloride and oxalic acid of 2:1 and a water content of 90% produced the highest extraction yield. The extracted polysaccharides had higher carbohydrate and sulfate contents compared to those extracted using hot water extraction method. Chemical analysis revealed that the polysaccharides were composed of glucosamine, galactose, glucose, and mannose, with a lower molecular weight compared to polysaccharides extracted using hot water extraction method.
FRONTIERS IN NUTRITION
(2022)
Article
Acoustics
Yijie Wang, Xiong Xiong, Gangliang Huang
Summary: The extraction, purification, structure, derivatization, and biological activities of maidenhair tree polysaccharides were discussed. Collaborative extraction methods such as ultrasound-assisted extraction and microwave-assisted extraction were used for polysaccharide extraction, with ultrasound-assisted extraction showing higher content and efficiency. The structural characteristics and structure-activity relationship of maidenhair tree polysaccharides were studied to support the further development and utilization of these polysaccharides.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Plant Sciences
Xingbao Tao, Hongbo Liu, Jie Xia, Ping Zeng, Hepeng Wang, Yuwei Xie, Caixia Wang, Yanqiu Cheng, Jiayun Li, Xingde Zhang, Ping Zhang, Shengjun Chen, Hongli Yu, Hao Wu
Summary: This study aimed to investigate the core active constituents and pharmacological mechanism of Pinelliae Rhizoma Praeparatum (PRP) against cold asthma (CA). The results showed that PRP suppressed the allergic airway inflammation of CA by regulating the balance of Th1 and Th2 cytokines and possibly involving the PKC/EGFR/MAPK/PI3KAkt signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Hongjiao Zhang, Huizhen Li, Zhijun Zhang, Tianyu Hou
Summary: Response surface methodology was used to optimize the ultrasound-assisted extraction process of perilla seed meal polysaccharides in this study, leading to the identification of optimal conditions. The extracted PSMP showed potential as a source of antioxidants for medicine and functional foods. The study provides valuable insights for further research on other medicine-food dual-use resources.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Acoustics
Zhenjie Tang, Yanrong Wang, Gangliang Huang, Hualiang Huang
Summary: According to the response surface methodology, the optimized conditions for ultrasound-assisted extraction of polysaccharide from Garcinia mangostana L. rinds were determined. Acetylation significantly improved the antioxidant activity of the polysaccharide. Chemical modification is an effective method to improve the properties of polysaccharides, indicating the great research value and potential of Garcinia mangostana L. polysaccharide.
ULTRASONICS SONOCHEMISTRY
(2023)
Review
Food Science & Technology
Genglan Lin, Yanying Li, Xiaohua Chen, Fuming Zhang, Robert J. Linhardt, Anqiang Zhang
Summary: This paper reviews the research progress in the extraction, structural analysis, and biological activities of Sanghuangporus spp. Polysaccharides (SSP), providing a theoretical basis for the further study of SSP and the expansion of its application in medical and other related fields.
Review
Food Science & Technology
Yongshuai Jing, Shilin Zhang, Mingsong Li, Yunfeng Ma, Yuguang Zheng, Danshen Zhang, Lanfang Wu
Summary: This paper summarizes the research status of Coriolus versicolor polysaccharide (CVP) in terms of extraction technology, separation and purification, structural characterization, and pharmacological activity in recent years, and points out the existing problems and research gaps.
Article
Acoustics
Zongyan Song, Xiong Xiong, Gangliang Huang
Summary: Maize polysaccharides exhibit antitumor, antioxidant, hypoglycemic, and immunomodulatory properties. The enzymatic method for extracting polysaccharides from maize has advanced and is often combined with ultrasound or microwave, or different enzymes. Ultrasound has a good effect on breaking cell walls, making it easier to remove lignin and hemicellulose from the cellulose surface of maize husks. The water extraction and alcohol precipitation method is simple but time-consuming, while ultrasound-assisted extraction and microwave-assisted extraction methods not only compensate for this drawback but also increase the extraction rate. This article analyzes and discusses the preparation, structural analysis, and activities of maize polysaccharides.
ULTRASONICS SONOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Kanika Sharma, Manoj Kumar, Roji Waghmare, Rajat Suhag, Om Prakash Gupta, Jose M. Lorenzo, Suraj Prakash, Radha, Nadeem Rais, Vellaikumar Sampathrajan, Chandan Thappa, T. Anitha, Ali A. S. Sayed, Basel A. Abdel-Wahab, Marisennayya Senapathy, R. Pandiselvam, Abhijit Dey, Sangram Dhumal, Ryszard Amarowicz, John F. Kennedy
Summary: Moringa oleifera Lam. is a plant with various bioactivities, including polysaccharides and gums. Polysaccharides have been found to possess antihyperlipidemic, anti-diabetic, immunomodulatory, antihypertensive, and gastrointestinal protection functions. The extraction methods can influence the structure and bioactivity of polysaccharides. This review provides updated information on the extraction, purification, structural characterization, bioactivities, and potential applications of moringa polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Xiaopeng Ai, Peiling Yu, Xiangyu Li, Xianrong Lai, Ming Yang, Fu Liu, Fei Luan, Xianli Meng
Summary: This review comprehensively outlines the extraction and purification methods, structural features, biological activities, underlying mechanisms, and toxicities of Spirulina platensis polysaccharides (SPPs), aiming to support their potential utilization value in pharmaceuticals fields and functional foods. New insights for future research with SPPs are also proposed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Applied
Hai-Yang Li, Yan-Ling Yi, Sheng Guo, Fang Zhang, Hui Yan, Zhi-Lai Zhan, Yue Zhu, Jin-Ao Duan
Summary: This review provides a comprehensive summary of the extraction, purification, structural characterization, and biological activities of Laminaria japonica polysaccharides, offering valuable insights for further research, production, and application in functional foods and therapeutic agents.
Article
Chemistry, Analytical
Marjan Mazrouei Sebdani, Hajar Abbasi
Summary: This study aimed to extract carotenoids from pumpkin using ultrasound and sunflower oil as a green solvent. The optimal extraction conditions were found to be a solid-solvent ratio of 0.08 g/mL, a temperature of 30°C, and an extraction time of 55 min. These conditions resulted in the highest carotenoid content, 8 -carotene, phenolic content, and antioxidant activity.
MICROCHEMICAL JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Wei Peng, Yunhui Chen, Steve Tumilty, Lizhou Liu, Ling Luo, Haiyan Yin, Yongmei Xie
Summary: Neurodegenerative diseases (NDDs) are neurological disorders characterized by neuronal degeneration and apoptosis. Paeoniflorin, a natural compound extracted from the root of Paeonia lactiflora pall, has been found to have potential therapeutic effects on NDDs by modulating cellular Ca2+/ROS homeostasis.
CURRENT OPINION IN PHARMACOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Ruolan Li, Feng Lu, Xue Sun, Liying He, HuXinyue Duan, Wei Peng, ChunJie Wu
Summary: The study successfully developed hydroxy-alpha-sanshool liposomes (HAS-LPs) that can improve learning and memory disorders in an Alzheimer's disease (AD) model, suggesting potential clinical applications for these nanoparticles.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Cell Biology
Dandan Tang, Qing Zhang, Huxinyue Duan, Xun Ye, Jia Liu, Wei Peng, Chunjie Wu
Summary: This article comprehensively summarizes the pharmacological effects and potential molecular mechanisms of polydatin in protecting and treating liver disorders through regulation of oxidative stress. Polydatin has shown significant protective and curative effects on liver diseases associated with oxidative stress through various molecular mechanisms. However, further clinical investigations are needed to confirm the clinical treatment effect of polydatin in liver diseases related to regulation of oxidative stress.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Editorial Material
Pharmacology & Pharmacy
Wei Peng, Xin Luan, Hong Zhang
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Bingke Bai, Chang Liu, Chengzhong Zhang, Xuhui He, Hongrui Wang, Wei Peng, Chengjian Zheng
Summary: This review summarizes the structural diversities, biological activities, and promising biosynthetic potentials of terpenoids isolated from Trichoderma species. Trichoderma terpenoids exhibit important antibacterial, antifungal, inhibitory, and cytotoxic activities, making Trichoderma species valuable microbial resources for drug discovery and environmentally friendly agrochemicals development. The abundance of novel skeletons, bioactivities, and biosynthetic potentials present new opportunities for drug and agrochemicals discovery, genome mining, and enzymology exploration from Trichoderma species.
JOURNAL OF ADVANCED RESEARCH
(2023)
Editorial Material
Pharmacology & Pharmacy
Yunhui Chen, Charles Hsu, Xiuping Chen, Heng Zhang, Wei Peng
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Lijie Wang, Xiaoling Gou, Yin Ding, Jingye Liu, Yue Wang, Yaqian Wang, Jing Zhang, Leilei Du, Wei Peng, Gang Fan
Summary: Globally, metabolic diseases are a significant public health issue, and herbal medicines derived from plants are widely used in their treatment due to their efficacy and minimal side effects. Recent research has shown that the gut microbiota plays a key role in the therapeutic effects of herbal medicines on metabolic diseases. Mechanisms involved include effects on gut microbial composition, intestinal barrier, inflammation, and microbial metabolites. These findings highlight the importance of the interaction between herbal medicines and gut microbiota in the treatment of metabolic diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qi Liang, Jing-Wen Wang, Yu-Ru Bai, Ruo-Lan Li, Chun-Jie Wu, Wei Peng
Summary: TRPV1 and TRPA1 channels have beneficial effects in ameliorating postoperative ileus, making natural herbs a potential therapeutic option. Activation of these channels enhances gastrointestinal motility and relieves pain.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Ruo-Lan Li, Hu-Xinyue Duan, Ling-Yu Wang, Qi Liang, Chunjie Wu, Wei Peng
Summary: Neurodegenerative diseases are a global threat and burden on the social economy due to neuronal degeneration and apoptosis. The current drugs for these diseases have side effects, necessitating the urgent discovery of safe and effective alternatives. Zanthoxylum bungeanum Maxim. (ZBM) has a long medicinal history in China and is rich in amides. This review highlights the potential therapeutic role of amides from ZBM in neurodegenerative diseases, specifically in Alzheimer's, Parkinson's, and depression, through antioxidant and anti-inflammatory effects on the TRPV1, TRPA1, and PI3K/AKT signaling pathways. The review also discusses the physical and chemical properties of these amides.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Review
Integrative & Complementary Medicine
Lian Zhong, Qing Zhang, Wei Peng, Yongxiang Gao, Daneng Wei, Xufeng Pu, Huan Xu, Chunjie Wu
Summary: This systematic review and meta-analysis evaluated the effect and safety of Guizhi-Shaoyao-Zhimu decoction (GSZD) for treating rheumatoid arthritis (RA). The results showed that GSZD was more likely to achieve clinical efficacy and significantly improve physical signs compared to conventional drugs. Additionally, GSZD exhibited a reduced incidence of adverse events compared to the control group.
JOURNAL OF HERBAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Chengxun He, Ke Wang, Jun Xia, Die Qian, Juan Guo, Lian Zhong, Dandan Tang, Xiuping Chen, Wei Peng, Yunhui Chen, Yong Tang
Summary: MELNs can mitigate the progression of type 2 diabetes in the HFD/STZ mouse model. The underlying molecular mechanism is related to the PI3K/Akt/GLUT4/GSK-3 beta signaling pathway.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Editorial Material
Pharmacology & Pharmacy
Yunhui Chen, Yongmei Xie, Cailu Lin, Wei Peng
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Qi Liang, Ruo-Lan Li, Dan-Dan Tang, Ting Zhang, Lian Zhong, Chun-Jie Wu, Wei Peng
Summary: This review summarizes the potential roles of targeting T2Rs with bitter compounds for the treatment of respiratory diseases. It also discusses the potential of ABC transmembrane transporter proteins in delivering bitter compounds to combat drug resistance. The findings provide a reference for future studies on bitter receptor therapy for respiratory diseases.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Biochemical Research Methods
Meiyan Li, Dandan Tang, Runchun Xu, Sirong Zhang, Yu Chen, Wei Peng
Summary: This study aims to investigate the quality markers of Yiqi Tongluo capsule (YTC) and optimize its extraction process based on these markers. The results identified 8 compounds with protective effects on cardiomyocytes, which were considered as the quality markers of YTC. The optimized extraction process was established and the HPLC fingerprint of optimized YTC was successfully developed.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Plant Sciences
Qing Zhang, Cheng-Xun He, Ling-Yu Wang, Die Qian, Dan-Dan Tang, Sheng-Nan Jiang, Wen-Wen Chen, Chun-Jie Wu, Wei Peng
Summary: The study found that hydroxy-alpha-sanshool (HAS) can promote browning of white adipose tissue (WAT) through the regulation of the AMPK/SIRT-1/PPAR gamma signaling pathway, which helps combat obesity.