期刊
MOLECULES
卷 22, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/molecules22040654
关键词
Flos Lonicerae Japonicae-Fructus forsythiae herb couple; integral pharmacokinetics; multiple caffeic acid derivatives; chito-oligosaccharide; tight junction; anti-viral activity
资金
- National Natural Science Foundation of China [81273655]
- Qing Lan Project from Jiangsu Provincial Technology Innovation Team Support Scheme
- priority Academic Program Development of Jiangsu Higher Education Institution [ysxk-2010]
- Fourth Phase of the 333 Project from Jiangsu Province [BRA2013201]
In the present study, the rationality for the antiviral effect (H1N1 virus) of Flos Lonicerae Japonicae (FLJ, named JinYinHua)-Fructus forsythiae (FF, named LianQiao) herb couple preparations improved by chito-oligosaccharide (COS) was investigated. We found that the improvement of antiviral activity for four preparations attributed to the enhancement of bioavailability for the FLJ-FF herb couple in vivo, and that caffeic acid derivatives are the most important type of components for antiviral activity. The anti-Influenza virus activity-half maximal inhibitory concentration (IC50), not area under concentration (AUC) was considered as the weighting factor for integrating the pharmacokinetics of caffeic acid derivatives. It was found that the integral absorption, both in vitro and in vivo, especially that in Shuang-Huang-Lian, can be improved significantly by COS, an absorption enhancer based on tight junction. The results indicated that the antiviral activity in four preparations improved by COS was mainly attributed to the integral absorption enhancement of caffeic acid derivatives.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据