期刊
MOLECULES
卷 22, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/molecules22081329
关键词
pre-clinical studies; clinical studies; absorption; toxicity; diabetes mellitus; obesity; cardiovascular diseases; cancer; aging
资金
- National Natural Science Foundation of China [81403468, 81674050, 81522051]
- Beijing Nova Program [xx2014B049, xx2013032]
Resveratrol could be beneficial to health and provides protection against a wide array of pathologies and age-associated problems, as evident from preclinical studies. However, a comparison of animal and human studies reveals that this dietary polyphenol cannot protect against metabolic diseases and their associated complications. The clinical outcomes are affected by many factors such as sample size. This article not only presents a comprehensive review of the current advances concerning the dose, the extent of absorption, interaction and toxicity of resveratrol in human studies, but also describes its therapeutic effects against several chronic diseases such as diabetes mellitus, obesity, cardiovascular diseases, cancer and aging and the related diseases.
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