期刊
MOLECULES
卷 22, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/molecules22122208
关键词
manganese oxide nanoparticles; fluorescence imaging; magnetic resonance imaging; lymph node; dual-modality
资金
- National Natural Science Foundation of China [81227901, 81627807, 81571725, 81530058, 81230033, 31371006, 61405149, 81660505]
- Natural Science Basic Research Plan in Shaanxi Province of China [2017JM8057]
- Natural Science Basic Research Plan in Ningxia Province of China [NZ17156]
- Natural Science Basic Research Plan in Ningbo of China [2017A610144]
- Fundamental Research Funds for the Central Universities [JB171204]
Multifunctional manganese oxide nanoparticles (NPs) with impressive enhanced T-1 contrast ability show great promise in biomedical diagnosis. Herein, we developed a dual-modality imaging agent system based on polyethylene glycol (PEG)-coated manganese oxide NPs conjugated with organic dye (Cy-7.5), which functions as a fluorescence imaging (FI) agent as well as a magnetic resonance imaging (MRI) imaging agent. The formed Mn3O4@PEG-Cy-7.5 NPs with the size of similar to 10 nm exhibit good colloidal stability in different physiological media. Serial FI and MRI studies that non-invasively assessed the bio-distribution pattern and the feasibility for in vivo dual-modality imaging-guided lymph node mapping have been investigated. In addition, histological and biochemical analyses exhibited low toxicity even at a dose of 20 mg/kg in vivo. Since Mn3O4@PEG-Cy-7.5 NPs exhibited desirable properties as imaging agents and good biocompatibility, this work offers a robust, safe, and accurate diagnostic platform based on manganese oxide NPs for tumor metastasis diagnosis.
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