期刊
MOLECULES
卷 22, 期 8, 页码 -出版社
MDPI AG
DOI: 10.3390/molecules22081346
关键词
nucleotides; ADP-ribosylated compounds; divergent synthesis
资金
- National Natural Science Foundation of China [21472036, 21373079, U1604285]
- Excellent Youth Foundation of Henan Scientific Committee [164100510020]
- Program for Science & Technology Innovation Talents in Universities of Henan Province [14HASTIT015]
- Henan Science and Technology Program [162300410022]
Adenosine diphosphate-ribose (ADP-ribose) and its derivatives play important roles in a series of complex physiological procedures. The design and synthesis of artificial ADP-ribosylated compounds is an efficient way to develop valuable chemical biology tools and discover new drug candidates. However, the synthesis of ADP-ribosylated compounds is currently difficult due to structural complexity, easily broken pyrophosphate bond and high hydrophilicity. In this paper, ADP-ribosyl-N-3 was designed and synthesized for the first time. With ADP-ribosyl-N-3 as the key precursor, a divergent post-modification strategy was developed to prepare structurally diverse ADP-ribosylated compounds including novel nucleotides and peptides bearing ADP-ribosyl moieties.
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