The Novel Triazolonaphthalimide Derivative LSS-11 Synergizes the Anti-Proliferative Effect of Paclitaxel via STAT3-Dependent MDR1 and MRP1 Downregulation in Chemoresistant Lung Cancer Cells

A novel triazolonaphthalimide induces apoptosis and inhibits tumor growth by targeting DNA and DNA-associated processes

(2017) Liyan Ji et al.   Oncotarget

Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells

(2016) Jingyun Yao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of acquired paclitaxel resistance of breast cancer cells and involvement of ABC transporters

(2016) Vlasta Němcová-Fürstová et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Targeting HDAC with a novel inhibitor effectively reverses paclitaxel resistance in non-small cell lung cancer via multiple mechanisms

(2016) L Wang et al.   Cell Death & Disease

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Changed expression and function of P-gp in peripheral blood CD56 + cells predicting chemoresistance in non-Hodgkin lymphoma patients

(2015) Li Han et al.   Cancer Biomarkers

Nsc23925 prevents the development of paclitaxel resistance by inhibiting the introduction of P-glycoprotein and enhancing apoptosis

(2015) Xiaoqian Yang et al.   INTERNATIONAL JOURNAL OF CANCER

Phase I dose escalation study of amrubicin plus paclitaxel in previously treated advanced non-small cell lung cancer

(2015) Kyoichi Kaira et al.   International Journal of Clinical Oncology

Early responses of the STAT3 pathway to platinum drugs are associated with cisplatin resistance in epithelial ovarian cancer

(2013) W.J. Sheng et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

PARP-1 Regulates Resistance of Pancreatic Cancer to TRAIL Therapy

(2013) K. Yuan et al.   CLINICAL CANCER RESEARCH

7b, a novel naphthalimide derivative, exhibited anti-inflammatory effects via targeted-inhibiting TAK1 following down-regulation of ERK1/2- and p38 MAPK-mediated activation of NF-κB in LPS-stimulated RAW264.7 macrophages

(2013) Jin Shao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Sequential Targeted Delivery of Paclitaxel and Camptothecin Using a Cross-Linked “Nanosponge” Network for Lung Cancer Chemotherapy

(2013) Ghazal Hariri et al.   MOLECULAR PHARMACEUTICS

BRCA1 regulates microtubule dynamics and taxane-induced apoptotic cell signaling

(2013) M Sung et al.   ONCOGENE

3-Nitro-naphthalimide and nitrogen mustard conjugate NNM-25 induces hepatocellular carcinoma apoptosis via PARP-1/p53 pathway

(2012) Song-qiang Xie et al.   APOPTOSIS

Reversal of P-gp and MRP1-mediated multidrug resistance by H6, a gypenoside aglycon from Gynostemma pentaphyllum, in vincristine-resistant human oral cancer (KB/VCR) cells

(2012) Hengrui Zhu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

PLGA nanoparticles codeliver paclitaxel and Stat3 siRNA to overcome cellular resistance in lung cancer cells

(2012) Wu-Chou Su et al.   International Journal of Nanomedicine

Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship

(2012) Julian R. Molina et al.   MAYO CLINIC PROCEEDINGS

Increased cellular accumulation and distribution of amrubicin contribute to its activity in anthracycline-resistant cancer cells

(2011) Vidya Mamidipudi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Deactivation of Signal Transducer and Activator of Transcription 3 Reverses Chemotherapeutics Resistance of Leukemia Cells via Down-Regulating P-gp

(2011) Xulong Zhang et al.   PLoS One

Sulforaphane Inhibits Constitutive and Interleukin-6-Induced Activation of Signal Transducer and Activator of Transcription 3 in Prostate Cancer Cells

(2010) E. R. Hahm et al.   Cancer Prevention Research

Reactive oxygen species involved in sulforaphane-induced STAT3 inactivation and apoptosis in DU145 prostate cancer cells

(2010) Wonil Koh et al.   CHINESE SCIENCE BULLETIN

Overview of Naphthalimide Analogs as Anticancer Agents

(2009) Min Lv et al.   CURRENT MEDICINAL CHEMISTRY

PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM

(2009) Michael J. Carrozza et al.   DNA REPAIR

Substrates and Inhibitors of Human Multidrug Resistance Associated Proteins and the Implications in Drug Development

(2008) Shu-Feng Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Defective activations of STAT3 Ser727 and PKC isoforms lead to oncostatin M resistance in metastatic melanoma cells

(2008) A. Lacreusette et al.   JOURNAL OF PATHOLOGY

Amonafide L-malate is not a substrate for multidrug resistance proteins in secondary acute myeloid leukemia

(2008) M Burcu et al.   LEUKEMIA