Article
Biochemical Research Methods
Chenrui Liang, Yaqi Yao, Haoran Ding, Xiaomeng Li, Yubo Li, Ting Cai
Summary: This study established a method for rapid classification and identification of flavonoids, saponins, and amino acid compounds in Astragalus. A total of 45 chemical constituents were successfully screened out.
PHYTOCHEMICAL ANALYSIS
(2022)
Article
Pharmacology & Pharmacy
Lei Ren, Hao-Nan Guo, Jun Yang, Xiao-Ying Guo, Ye-Sheng Wei, Zhao Yang
Summary: Taxifolin (TFN) is an important natural compound with antifibrotic activity, but its pharmacological mechanism is unclear. This study used metabolomics to investigate the effects of TFN in a UUO animal model, identifying 32 potential biomarkers related to renal fibrosis. TFN treatment regulated 27 biomarkers and affected eight metabolic pathways, highlighting the potential of metabolomics for studying natural compounds.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jiang-Tao Ke, Heng Zhang, Yan-Hong Bu, Pei-Rong Gan, Fang-Yuan Chen, Xin-Tong Dong, Yan Wang, Hong Wu
Summary: This study investigated the mechanism of Geniposide (GE) in the treatment of rheumatoid arthritis (RA) by analyzing sphingolipid metabolism in RA samples. The results showed that GE could restore the abnormal sphingolipid metabolism related to RA and down-regulated the expression of acid-sphingomyelinase to achieve its effect.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Shiqiang Wang, Wenna Li, Xinfei Zhang, Gang Li, Xiao dong Li, Hui Chang, Junfeng Niu, Zhezhi Wang
Summary: This study employed UPLC-Q-TOF-MS/MS based metabolomics for the first time to discriminate between three Polygonatum species, and identified key compounds suitable for their identification. The results showed that adenosine, sucrose, and pyroglutamic acid can be used to distinguish different Polygonatum species.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Sang Suk Kim, Hyun-Jin Kim, Kyung Jin Park, Seok Beom Kang, YoSup Park, Seong-Gab Han, Misun Kim, Yeong Hun Song, Dong-Shin Kim
Summary: This study analyzed the changes in chemical composition during the fruit development process of Citrus unshiu, revealing the trends in total phenolic content, total carotenoid content, antioxidant activity, and metabolite profiles at different stages, providing important information for understanding these changes.
Article
Chemistry, Medicinal
Min Wang, Na Yang, Xu Wu, Ting Zou, Jiahui Zheng, Huaijun Zhu, Chongbo Zhao, Jing Wang
Summary: This study investigated the metabolic shifts induced by Arisaematis Rhizome (AR) and explored the processing mechanism using metabolomics and network analysis. The results showed that crude AR caused kidney damage, while processing alleviated this damage. Metabolomics analysis identified several metabolic pathways associated with AR nephrotoxicity and the toxic-reducing effect of processing.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Pharmacology & Pharmacy
Ting Yu, Yan-Xin Zhang, Xin-Juan Liu, Dan-Qing Chen, Dan-Dan Wang, Guo-Qin Zhu, Qi Gao
Summary: This study investigates the pharmacological effects and clinical applications of mountain-cultivated ginseng and garden ginseng on cardiovascular diseases, highlighting the differences in metabolites, target genes, and signaling pathways. Both types of ginseng promote angiogenesis and protect damaged blood vessels, showing potential therapeutic effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Applied
Zhuhua Tang, Ying Wei, Dan Wang, Jinni Huang, Na Wan, Jing Wei, Bei Li
Summary: This study evaluated the potential risk of pesticide residues in bananas and investigated the quality and safety situation in Hainan province, China by analyzing 369 pesticides in 123 banana samples. The results showed that most samples contained 1-10 residues, with insecticides and fungicides being the most frequently detected groups. The detected pesticide residues in bananas were found to have acceptable safety risk based on the index of food safety. However, there were some medium-risk pesticides that should be continuously monitored to protect people's health.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Chemistry, Analytical
Jiajin Huang, Lijun Ding, Wenyue Tian, Hui Zhi, Jing Chen, Liangcai Wu, Likang Wang, Juntao Xie, Jingyan Bai, Hongxia Fan, Suqing Zhao, Kun Zhang, Junxia Zheng
Summary: In this study, the polyphenolic profile of Mesona chinensis Benth (MCB) was determined using UPLC-Q-TOF-MS/MS, identifying a total of 57 compounds including 45 polyphenols. Among them, 23 phytochemicals were identified in MCB for the first time. The antioxidant activities were found to be positively correlated with the polyphenolic levels, with MCB produced in Guangdong Raoping showing the best antioxidant activity and strongest inhibitory effect on alpha-glucosidase.
MICROCHEMICAL JOURNAL
(2021)
Article
Plant Sciences
Ya-Li Zhang, Qiang Yin, Hui-Ming Peng, Rong Huang, Jie-Wen Zhou, Lin-Hui Liu, Han-Qi Gao, Chuan-Peng Zhao, Xin-Hang Peng, Ling Xiao, Jing Nie, Quan-Cheng Yang, Chun-Ye He, Gao-Sheng Hu, Jia-Chun Chen, Jing-Ming Jia, Jin-Bo Fang
Summary: The study explored the molecular mechanism of HCZP in treating asthma through network pharmacology methods and in vivo experiments, revealing potential pathways and chemical composition. Results showed that HCZP significantly inhibited the inflammatory response via the PI3K-Akt and Fc epsilon RI signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Food Science & Technology
Jie Peng, Jinhua Gan, Ting Liu, Xiaoqian Ju, Jianwu Chen, Li He
Summary: Quality and safety issues in fishery products due to herbicide residues are a growing concern. A modified QuEChERS approach utilizing UPLC-Q-Tof-MS/MS was validated for screening and quantification of 158 herbicide residues in fishery products. An efficient lipid-removing sorbent, EMR-Lipid, was used instead of conventional dispersive sorbents, and the method demonstrated good linearity, sensitivity, recovery, and reproducibility. The technique was applied for identification of fragment ions and analysis of herbicides in crustacean and shellfish samples from China.
Article
Plant Sciences
Jiajia Wang, Liang Cao, Xia Gao, Huifang Gao, Xialin Chen, Zhenzhong Wang, Wei Xiao
Summary: This study investigated the chemical composition and pharmacokinetics of Jiuwei Xifeng granules (JWXF) and found that it contains 75 components, including alkaloids, terpenes, and organic acids. The main compounds, gastrodin, gentiopicroside, and sweroside, showed rapid absorption, elimination, and dose-dependent pharmacokinetics in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jun Rao, Xianghui Wan, Fangfang Tou, Qinsi He, Aihua Xiong, Xinyi Chen, Wenhao Cui, Zhi Zheng
Summary: This study used proteomics and metabolomics techniques to analyze serum samples from patients with advanced CRC, identifying potential biomarkers and pathways associated with cancer cell metabolism. The results suggest the conservation role of lipids in the regulatory network of advanced CRC and discovered novel biomarkers that can improve diagnosis and monitoring of advanced CRC.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Pharmacology & Pharmacy
Wenxiang Deng, Qinghu He, Wenan Zhang
Summary: Curcumin, a polyphenolic compound derived from the turmeric plant, has shown potential in treating osteoarthritis by targeting key proteins and pathways involved in inflammation and metabolism. This study used metabolomics and transcriptomics to reveal the mechanism of curcumin in osteoarthritis treatment. Results showed that curcumin decreased inflammatory markers and influenced important metabolic pathways and gene expression.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Chemistry, Applied
Ajay Anand, Anusha Komati, Kumar Katragunta, Hussain Shaik, Narendra Kumar Nagendla, Madhusudana Kuncha, Mohana Krishna Reddy Mudiam, Katragadda Suresh Babu, Ashok Kumar Tiwari
Summary: Boiled rhizome of Nymphaea nouchali shows significant antihyperglycemic and antioxidative stress potentials, making it a promising food material for managing hyperglycemia and oxidative stress.