Article
Cell Biology
Jose Lucas Santos, Evlalia Petsidou, Pallavi Saraogi, Ullrich Bartsch, Andre P. Gerber, Julie Seibt
Summary: Brain plasticity is induced by learning during wakefulness and is consolidated during sleep. Sleep enhances the phosphorylation of 4E-BPs at synapses, especially after exposure to an enriched environment in rats. Exploratory activity in an enriched environment and NREM sleep theta activity are correlated with the phosphorylation level of 4E-BPs at synapses.
Article
Ecology
Nina Toudal Jessen, Bo Fritzboger
Summary: This paper argues that land use management should take into account the production of scientific knowledge, and that landscape ecology will benefit from attention to the historical legacy of typologization and land cover representations. Using archival material, the paper analyzes the negotiations on the typology of a salt meadow in a nature protection case in 1980s Denmark, showing the importance of how the material, physical landscape reality and various kinds of representation interact in attempts to designate areas worthy of nature protection. The research demonstrates the power of categorization and mapping in land use management.
Review
Biochemistry & Molecular Biology
Xiangang Huang, Na Kong, Xingcai Zhang, Yihai Cao, Robert Langer, Wei Tao
Summary: mRNA is an emerging therapeutic agent with great potential for revolutionizing life science and medical research. Recent progress in mRNA engineering and delivery has addressed the challenges related to stability, immunogenicity, and in vivo delivery. The success of mRNA vaccines against COVID-19 has transformed the field and opened up possibilities for treating other diseases.
Review
Biochemistry & Molecular Biology
Oriol Barcenas, Carlos Pintado-Grima, Katarzyna Sidorczuk, Felix Teufel, Henrik Nielsen, Salvador Ventura, Michal Burdukiewicz
Summary: This minireview provides a systematic and accessible analysis of the complex ecosystem of peptide activity prediction, showcasing the variability and popularity of existing models. The reproducibility of bioinformatics tools and their development trends are also evaluated.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Oriol Barcenas, Carlos Pintado-Grima, Katarzyna Sidorczuk, Felix Teufel, Henrik Nielsen, Salvador Ventura, Michal Burdukiewicz
Summary: This article reviews the complex ecosystem of peptide activity prediction, showcasing the variability and popularity of existing peptide assessment models. It also evaluates the reproducibility of such bioinformatics tools and describes the trends observed in their development.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Multidisciplinary Sciences
Chetana Baliga, Tyler J. Brown, Tanja Florin, Sarah Colon, Vallari Shah, Kornelia J. Skowron, Amira Kefi, Teresa Szal, Dorota Klepacki, Terry W. Moore, Nora Vazquez-Laslop, Alexander S. Mankin
Summary: Apidaecin is an 18-amino-acid proline-rich antibacterial peptide produced by bees that inhibits translation termination by invading the ribosome's nascent peptide exit tunnel. By analyzing the activity of different mutants with single-amino-acid substitutions, researchers were able to map critical interactions with the ribosome, tRNA, and release factors, as well as identify a segment of Api that tolerates amino acid substitutions for potential pharmacological improvement.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Gustavo Burin, Travis Park, Tamora D. James, Graham J. Slater, Natalie Cooper
Summary: This study characterizes the adaptive landscape of cetacean body length and finds that the global landscape is relatively flat, but there are numerous local peaks linked to specific adaptations.
Editorial Material
Genetics & Heredity
Walter Steiner
Summary: Steiner highlights a study by Protacio et al., which has identified the molecular mechanisms underlying the plasticity of meiotic recombination in Schizosaccharomyces pombe.
NATURE REVIEWS GENETICS
(2022)
Article
Cell Biology
Xiangxiang Jiang, Jingle Zhai, Zhenyu Xiao, Xulun Wu, Dan Zhang, Haifeng Wan, Yanhong Xu, Luqing Qi, Meijiao Wang, Dainan Yu, Yawei Liu, Hao Wu, Run Sun, Shuwei Xia, Kunyuan Yu, Jingtao Guo, Hongmei Wang
Summary: This study provides a comprehensive understanding of the cellular hierarchy and molecular mechanisms in the cynomolgus macaque placenta throughout gestation using single-cell transcriptomics. The findings highlight stage-specific differences in placental trophoblast cells and their interactions with decidual cells. Comparative analysis with human placentas reveals conserved features of primate placentation and differences in extravillous trophoblast cells.
DEVELOPMENTAL CELL
(2023)
Article
Physics, Fluids & Plasmas
M. Rahimi-Majd, M. A. Seifi, L. de Arcangelis, M. N. Najafi
Summary: Local anaxonic neurons with graded potential release play a crucial role in spontaneous activity of the neural system. By adjusting the fraction of local neurons, researchers have identified two transition lines in the system's behavior: a critical line separating subcritical and supercritical regions, and a bifurcation line. The relevance of local neuron transmission, relative to axonal transmission, is shown to significantly impact the statistical properties of spontaneous activity.
Review
Endocrinology & Metabolism
Shengyu Wu, Han Xie, Yao Su, Xinrui Jia, Yabing Mi, Yuanhui Jia, Hao Ying
Summary: This article discusses the importance of RNA methylation at the maternal-fetal interface during normal and pathological implantation and placentation in pregnancy. It affects early embryo development, embryo implantation, endometrium receptivity, immune microenvironment, and complications such as miscarriage and preeclampsia. The study finds that the role of dynamic RNA methylation at the maternal-fetal interface has been underappreciated, but it could offer a novel approach to treating related complications.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Physics, Applied
Ujjal Das, Pranab Sarkar, Bappi Paul, Asim Roy
Summary: The study presented a two-terminal artificial synapse based on organic-inorganic hybrid perovskite, which can emulate important synaptic characteristics including analog memory switching, short-term plasticity, and long-term plasticity. The device modifies synaptic plasticity through voltage pulses and light illumination, achieving emulation of synaptic functions.
APPLIED PHYSICS LETTERS
(2021)
Article
Multidisciplinary Sciences
Joao A. A. Ascensao, Kelly M. M. Wetmore, Benjamin H. H. Good, Adam P. P. Arkin, Oskar Hallatschek
Summary: Ascensao et al. engineered knockout libraries of a nascent bacterial community and found that ecological and epistatic patterns combine to shape adaptive landscapes, despite idiosyncratic behavior of individual knockouts. The study also revealed that fitness effects are correlated with evolutionary outcomes for certain conditions, indicating shifting patterns of adaptation.
NATURE COMMUNICATIONS
(2023)
Editorial Material
Biochemistry & Molecular Biology
Erin M. Schuman
Summary: This paper describes how Calcium-calmodulin protein kinase 2, an important synaptic molecule, is concentrated at synapses and how its local synthesis is crucial for memory in fruit flies.
Article
Multidisciplinary Sciences
Michael A. Willcockson, Sean E. Healton, Cary N. Weiss, Boris A. Bartholdy, Yair Botbol, Laxmi N. Mishra, Dhruv S. Sidhwani, Tommy J. Wilson, Hugo B. Pinto, Maxim I. Maron, Karin A. Skalina, Laura Norwood Toro, Jie Zhao, Chul-Hwan Lee, Harry Hou, Nevin Yusufova, Cem Meydan, Adewola Osunsade, Yael David, Ethel Cesarman, Ari M. Melnick, Simone Sidoli, Benjamin A. Garcia, Winfried Edelmann, Fernando Macian, Arthur I. Skoultchi
Summary: Histone H1 functions as a critical regulator of gene silencing by controlling chromatin compaction, genome organization, and histone methylation. Experimental evidence using a conditional triple-knockout mouse strain demonstrates that H1 plays a key role in regulating the activity of chromatin domains.
Article
Biochemical Research Methods
Vitaly A. Likhoshvai, Vladislav V. Kogai, Stanislav I. Fadeev, Tamara M. Khlebodarova
JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY
(2015)
Article
Multidisciplinary Sciences
Vitaly A. Likhoshvai, Vladislav V. Kogai, Stanislav I. Fadeev, Tamara M. Khlebodarova
SCIENTIFIC REPORTS
(2016)
Article
Mathematics, Interdisciplinary Applications
Vladislav V. Kogai, Vitaly A. Likhoshvai, Stanislav I. Fadeev, Tamara M. Khlebodarova
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS
(2017)
Article
Biochemical Research Methods
Tamara M. Khlebodarova, Vladislav V. Kogai, Stanislav I. Fadeev, Vitaly A. Likhoshvai
JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY
(2017)
Article
Biochemical Research Methods
Vitaly A. Likhoshvai, Stanislav I. Fadeev, Vladislav V. Kogai, Tamara M. Khlebodarova
JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY
(2013)
Article
Mathematics, Applied
S. I. Fadeev, V. V. Kogai, V. V. Mironova, N. A. Omelyanchuk, V. A. Likhoshvai
NUMERICAL ANALYSIS AND APPLICATIONS
(2013)
Article
Biochemical Research Methods
Konstantin V. Gunbin, Leonid V. Omelyanchuk, Vladislav V. Kogai, Stanislav I. Fadeev, Nikolay A. Kolchanov
JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY
(2007)