Review
Biochemistry & Molecular Biology
Antonella Comitato, Rita Bardoni
Summary: Recent studies have shown that presynaptic GABAergic receptors in the spinal cord dorsal horn play a crucial modulatory role in sensory information processing, particularly in states of sensitization induced by chronic pain. Techniques such as opto- and chemogenetic stimulation have provided valuable insights into this topic, highlighting the importance of regulating neurotransmitter release for integrating postsynaptic responses and coding sensory information.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Caifeng Shao, Jiaxue Dong, Mingwei Zhao, Shenhao Liu, Xue Wang, Yang Yu, Lingyan Fang, Ziying Zhu, Qian Chen, Xu Xiao, Wei-Ning Zhang, Kun Yang
Summary: By combining cell type-specific optogenetics and whole cell recordings on mouse acute hippocampal slices, the study compared the GABA release from cholecystokinin-expressing (CCK) and parvalbumin-expressing (PV) interneurons onto CA1 pyramidal neurons. The results provide direct evidence that GABA(B) receptors differentially modulate GABA release from CCK and PV interneurons.
NEUROSCIENCE LETTERS
(2022)
Article
Anatomy & Morphology
Mingwei Zhao, Caifeng Shao, Jiaxue Dong, Qian Chen, Rui Ma, Ping Jiang, Wei-Ning Zhang, Kun Yang
Summary: This study demonstrates through in vitro experiments that blockade of presynaptic GABA(B)Rs in spinal cord glutamatergic synapses increases the probability of glutamate release, and postsynaptic GABA(B)Rs modulate glutamate-induced postsynaptic potentials.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Biochemical Research Methods
Cristina Rodriguez, Anderson Chen, Jose A. Rivera, Manuel A. Mohr, Yajie Liang, Ryan G. Natan, Wenzhi Sun, Daniel E. Milkie, Thomas G. Bifano, Xiaoke Chen, Na Ji
Summary: The development of a compact adaptive optics module has enabled correction of tissue-induced aberrations in two-photon and three-photon fluorescence microscopes, allowing high-resolution imaging of synaptic structures in deep regions of the mouse brain and spinal cord, as well as somatosensory-evoked calcium responses. This advancement has facilitated structural and functional imaging deep within living organisms such as mice and zebrafish larvae.
Review
Neurosciences
Davide Bassetti
Summary: Gamma-aminobutyric acid (GABA) is the main neurotransmitter in the brain responsible for inhibiting neuronal activity. GABA(B) receptors play a crucial role in regulating proliferation, migration, and cell inhibition. They can shape neuronal activity and contribute to development by modulating the function of cells in response to varying levels of GABA concentration.
Review
Neurosciences
Xianshu Bai, Frank Kirchhoff, Anja Scheller
Summary: This review focuses on the role of GABA as the main inhibitory neurotransmitter in the CNS, particularly in the oligodendrocyte lineage. It discusses the physiological functions of GABA receptors within this lineage and their potential as targets for treatments of CNS diseases.
NEUROSCIENCE BULLETIN
(2021)
Article
Multidisciplinary Sciences
Xiling Li, Chun Chien, Yifu Han, Zihan Sun, Xun Chen, Dion Dickman
Summary: The study revealed that the Glutamate-gated chloride channel (GluCl alpha) in Drosophila neurons plays a critical role in presynaptic homeostatic depression (PHD), driving the process through an activity-dependent anionic conductance.
Article
Multidisciplinary Sciences
Kwabena Boahen
Summary: The study proposes a new learning method for artificial intelligence called dendrocentric learning, which arranges the input signals along dendrites to overcome the thermal constraints of three-dimensional chips. This approach allows for efficient AI computation with low power consumption.
Review
Biochemistry & Molecular Biology
Hanns Ulrich Zeilhofer, Karolina Werynska, Jacinthe Gingras, Gonzalo E. Yevenes
Summary: Restoring proper synaptic inhibition in the spinal cord, particularly through targeting the alpha 3 subtype of glycine receptors, may help reduce deleterious side effects and increase tolerability in chronic pain states. This review provides an update on the physiological properties and functions of alpha 3 subtype GlyRs and related drug discovery programs.
Article
Neurosciences
Benjamin Leonardon, Lou Cathenaut, Louise Vial-Markiewicz, Sylvain Hugel, Remy Schlichter, Perrine Inquimbert
Summary: The dorsal horn of the spinal cord is involved in the integration of nociceptive messages. Plastic changes in the neuronal networks in the dorsal horn play a role in the development of analgesia, hyperalgesia, and allodynia in acute and chronic pain states. This study investigated the role of NMDA receptors in the modulation of GABAergic synaptic transmission in the dorsal horn network. The results showed that NMDA receptor activation facilitated spontaneous and miniature GABAergic synaptic transmission through a presynaptic mechanism of action, with a target specificity on GABAergic interneurons.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jeremy Signoret-Genest, Maxime Barnet, Francois Gabrielli, Youssef Aissouni, Alain Artola, Radhouane Dallel, Myriam Antri, Philip Tovote, Lenaic Monconduit
Summary: This study found that the basal modulation of trigeminal sensory processing is shifted towards facilitation in migraineurs, and the prophylactic action of propranolol may be attributed to its direct action in the locus coeruleus (LC) through beta-2 adrenergic receptors. These findings reveal new mechanistic aspects of LC control over sensory processing.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Neurosciences
Guillaume Caron, Jadwiga Bilchak, Marie-Pascale Cote
Summary: Current anti-spastic medication impairs motor recovery after SCI. We investigated the effect of bumetanide, an FDA-approved NKCC1 antagonist, on synaptic inhibition. Bumetanide increased postsynaptic inhibition but not presynaptic inhibition of the H-reflex in SCI rats. However, acute delivery of bumetanide decreased presynaptic inhibition in step-trained SCI rats.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Chemistry, Multidisciplinary
Jun Wu, Miao Zhao, Yu-chen Jin, Min Li, Ke-xin Yu, Hai-bo Yu
Summary: This study investigated the antiseizure effect of Schisandrin B (SchB) in mouse models of seizure and explored its underlying mechanisms. The results showed that SchB exhibited therapeutic potential in various mouse models of seizure and acted as a positive allosteric modulator of GABA(A)Rs and GlyRs.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Multidisciplinary Sciences
Saeka Tomatsu, Geehee Kim, Shinji Kubota, Kazuhiko Seki
Summary: This article investigates the role of presynaptic inhibition in proprioceptive signals and finds that it can modulate proprioceptive input based on muscle length. This presynaptic inhibition may be initiated by cortical signals and has an impact on stable motor output.
NATURE COMMUNICATIONS
(2023)
Review
Neurosciences
Annemarie Dedek, Michael E. Hildebrand
Summary: NMDA receptors play a critical role in both acute and chronic pain, particularly in the superficial dorsal horn of the spinal cord. Recent advances have uncovered the plasticity mechanisms of presynaptic NMDA receptors in the spinal cord. Understanding the physiology and modulation of presynaptic NMDA receptors across pain states can lead to potential new therapeutic treatments for chronic pain.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Editorial Material
Neurosciences
Gabriella D'Arcangelo, Laura Lossi, Adalberto Merighi
FRONTIERS IN CELLULAR NEUROSCIENCE
(2017)
Review
Neurosciences
Adalberto Merighi
PROGRESS IN NEUROBIOLOGY
(2018)
Article
Neurosciences
Adalberto Merighi
FRONTIERS IN CELLULAR NEUROSCIENCE
(2018)
Review
Biochemistry & Molecular Biology
Laura Lossi, Claudia Castagna, Adalberto Merighi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Cell Biology
Claudia Castagna, Adalberto Merighi, Laura Lossi
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2019)
Review
Medicine, General & Internal
Laura Lossi, Claudia Castagna, Alberto Granato, Adalberto Merighi
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Cell Biology
Chiara Salio, Patrizia Aimar, Pascale Malapert, Aziz Moqrich, Adalberto Merighi
Summary: The study investigated the immunocytochemistry of murine C-type DRG neurons, revealing the expression patterns of specific markers in different subpopulations. Using transgenic mice, the researchers examined the effects of selective ablation of certain neurons on the distribution and density of glomerular terminals, providing insights into interspecies differences and functional relevance.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura Lossi, Adalberto Merighi, Vittorino Novello, Alessandra Ferrandino
Article
Cell Biology
Alberto Granato, Adalberto Merighi
Summary: Pyramidal neurons are the most abundant cells in the neocortex and their dendrites play a crucial role in various neurological and mental disorders. Different types of intellectual disabilities may be sustained by different parts of the pyramidal neuron dendritic tree or by dysregulation of their interaction.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Adalberto Merighi, Nadia Gionchiglia, Alberto Granato, Laura Lossi
Summary: The gamma phosphorylated form of histone H2AX, known as gamma H2AX, was discovered over 40 years ago and has been found to play a crucial role in the cellular response to DNA damage. It is involved in various cellular functions in both normal and pathological cells. Particularly, its involvement in the central nervous system, from immature to mature neurons, highlights its importance in neurogenesis and neuronal cell death, showcasing its pleiotropic nature with diverse functions from embryonic life to old age.
Review
Biochemistry & Molecular Biology
Adalberto Merighi, Laura Lossi
Summary: In addition to protein processing, the endoplasmic reticulum (ER) also plays roles in lipid synthesis, molecular transfers, and Ca2+ homeostasis. Proper protein folding and modification in the ER require molecular chaperones and a favorable environment. Disruption in ER conditions or chaperone capacity can lead to the unfolded protein response (UPR), triggering autophagy and potentially causing cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chelsea R. Wood, Esri H. Juarez, Francesco Ferrini, Peter Myint, John Innes, Laura Lossi, Adalberto Merighi, William E. B. Johnson
Summary: This study found that MSC conditioned medium had significant effects on spinal cord tissue in ex vivo slice cultures, enhancing viability and promoting GFAP immunoreactivity, contradicting previous findings.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2021)
Article
Clinical Neurology
A. Wallin, E. Kapaki, M. Boban, S. Engelborghs, D. M. Hermann, B. Huisa, M. Jonsson, M. G. Kramberger, L. Lossi, B. Malojcic, S. Mehrabian, A. Merighi, E. B. Mukaetova-Ladinska, G. P. Paraskevas, B. O. Popescu, R. Ravid, L. Traykov, G. Tsivgoulis, G. Weinstein, A. Korczyn, M. Bjerke, G. Rosenberg
Review
Veterinary Sciences
Laura Lossi, Adalberto Merighi
FRONTIERS IN VETERINARY SCIENCE
(2018)