Emerging functions of the EGFR in cancer

Stress-specific p38 MAPK activation is sufficient to drive EGFR endocytosis but not its nuclear translocation

(2017) Alejandra Tomas et al.   JOURNAL OF CELL SCIENCE

EGFR modulates monounsaturated fatty acid synthesis through phosphorylation of SCD1 in lung cancer

(2017) Jiqin Zhang et al.   Molecular Cancer

Reticulon 3–dependent ER-PM contact sites control EGFR nonclathrin endocytosis

(2017) Giusi Caldieri et al.   SCIENCE

A Chimeric Egfr Protein Reporter Mouse Reveals Egfr Localization and Trafficking In Vivo

(2017) Yu-Ping Yang et al.   Cell Reports

An Endosomal NAADP-Sensitive Two-Pore Ca 2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling

(2017) Bethan S. Kilpatrick et al.   Cell Reports

Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin

(2017) Althea N. Waldhart et al.   Cell Reports

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

(2017) Paolo Grumati et al.   eLife

Spatial and Temporal Regulation of Receptor Tyrosine Kinase Activation and Intracellular Signal Transduction

(2016) John J.M. Bergeron et al.   Annual Review of Biochemistry

Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression

(2016) P.-L. Boulay et al.   CANCER RESEARCH

EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape

(2016) S.-O. Lim et al.   CANCER RESEARCH

Oncogenic activation of the PI3K/Akt pathway promotes cellular glucose uptake by downregulating the expression of thioredoxin-interacting protein

(2016) Shin Yee Hong et al.   CELLULAR SIGNALLING

Endocytic control of signaling at the plasma membrane

(2016) Elisa Barbieri et al.   CURRENT OPINION IN CELL BIOLOGY

Signal processing by the endosomal system

(2016) Roberto Villaseñor et al.   CURRENT OPINION IN CELL BIOLOGY

A Tether Is a Tether Is a Tether: Tethering at Membrane Contact Sites

(2016) Michal Eisenberg-Bord et al.   DEVELOPMENTAL CELL

Annexin A1 Tethers Membrane Contact Sites that Mediate ER to Endosome Cholesterol Transport

(2016) Emily R. Eden et al.   DEVELOPMENTAL CELL

RAB2A controls MT1‐MMP endocytic and E‐cadherin polarized Golgi trafficking to promote invasive breast cancer programs

(2016) Hiroaki Kajiho et al.   EMBO REPORTS

Drugging the addict: non‐oncogene addiction as a target for cancer therapy

(2016) Remco Nagel et al.   EMBO REPORTS

The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR

(2016) Sandra Scharaw et al.   JOURNAL OF CELL BIOLOGY

Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2

(2016) Zuzana Kadlecova et al.   JOURNAL OF CELL BIOLOGY

Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment

(2016) Carly C. Barron et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

PtdIns(4,5)P2signaling regulates ATG14 and autophagy

(2016) Xiaojun Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations

(2016) Sabrina Arena et al.   Science Translational Medicine

Mutational and network level mechanisms underlying resistance to anti-cancer kinase inhibitors

(2016) Maicol Mancini et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Right Time, Right Place: Probing the Functions of Organelle Positioning

(2016) Petra van Bergeijk et al.   TRENDS IN CELL BIOLOGY

Stress-Induced EGFR Trafficking: Mechanisms, Functions, and Therapeutic Implications

(2016) Xiaojun Tan et al.   TRENDS IN CELL BIOLOGY

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer

(2016) Beth O. Van Emburgh et al.   Nature Communications

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

A Structural Perspective on the Regulation of the Epidermal Growth Factor Receptor

(2015) Erika Kovacs et al.   Annual Review of Biochemistry

A Kinase-Independent Role for EGF Receptor in Autophagy Initiation

(2015) Xiaojun Tan et al.   CELL

Emergence of Multiple EGFR Extracellular Mutations during Cetuximab Treatment in Colorectal Cancer

(2015) S. Arena et al.   CLINICAL CANCER RESEARCH

CALM Regulates Clathrin-Coated Vesicle Size and Maturation by Directly Sensing and Driving Membrane Curvature

(2015) Sharon E. Miller et al.   DEVELOPMENTAL CELL

Panitumumab in Metastatic Colorectal Cancer: The Importance of Tumour RAS Status

(2015) Marc Peeters et al.   DRUGS

LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation

(2015) X. Tan et al.   EMBO JOURNAL

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma

(2015) Hideki Makinoshima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal growth factor–stimulated Akt phosphorylation requires clathrin or ErbB2 but not receptor endocytosis

(2015) Camilo Garay et al.   MOLECULAR BIOLOGY OF THE CELL

Structure and function of ER membrane contact sites with other organelles

(2015) Melissa J. Phillips et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

The EGFR-HER2 module: a stem cell approach to understanding a prime target and driver of solid tumors

(2015) M R Schneider et al.   ONCOGENE

Identification of an oncogenic RAB protein

(2015) D. B. Wheeler et al.   SCIENCE

The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking

(2015) Leila Belle et al.   Science Signaling

Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer

(2015) Nir Ben-Chetrit et al.   Science Signaling

WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway

(2015) Alejandra Tomas et al.   Nature Communications

Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells

(2015) Fabrizio Capuani et al.   Nature Communications

Mitochondrial translocation of EGFR regulates mitochondria dynamics and promotes metastasis in NSCLC

(2015) Ting-Fang Che et al.   Oncotarget

EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling

(2015) Martin Baumdick et al.   eLife

Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes

(2015) Roberto Villaseñor et al.   eLife

The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking

(2015) Leila Belle et al.   Science Signaling

Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer

(2015) Nir Ben-Chetrit et al.   Science Signaling

Single Particle Tracking Reveals that EGFR Signaling Activity Is Amplified in Clathrin-Coated Pits

(2015) Jenny Ibach et al.   PLoS One

ER Contact Sites Define the Position and Timing of Endosome Fission

(2014) Ashley A. Rowland et al.   CELL

Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells

(2014) Lakshmi Reddy Bollu et al.   CELL CYCLE

Epidermal Growth Factor Receptor (EGFR) Signaling Regulates Global Metabolic Pathways in EGFR-mutated Lung Adenocarcinoma

(2014) Hideki Makinoshima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination

(2014) Emanuela Frittoli et al.   JOURNAL OF CELL BIOLOGY

Proteomic Analysis of the Epidermal Growth Factor Receptor (EGFR) Interactome and Post-translational Modifications Associated with Receptor Endocytosis in Response to EGF and Stress

(2014) Jiefei Tong et al.   MOLECULAR & CELLULAR PROTEOMICS

Endophilin marks and controls a clathrin-independent endocytic pathway

(2014) Emmanuel Boucrot et al.   NATURE

A polarized Ca2+, diacylglycerol and STIM1 signalling system regulates directed cell migration

(2014) Feng-Chiao Tsai et al.   NATURE CELL BIOLOGY

mTORC2 in the center of cancer metabolic reprogramming

(2014) Kenta Masui et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Receptor Tyrosine Kinases: Legacy of the First Two Decades

(2014) J. Schlessinger   Cold Spring Harbor Perspectives in Biology

Molecular Structure, Function, and Dynamics of Clathrin-Mediated Membrane Traffic

(2014) T. Kirchhausen et al.   Cold Spring Harbor Perspectives in Biology

The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases

(2014) M. A. Lemmon et al.   Cold Spring Harbor Perspectives in Biology

Rab Proteins and the Compartmentalization of the Endosomal System

(2014) A. Wandinger-Ness et al.   Cold Spring Harbor Perspectives in Biology

EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance

(2013) Yongjie Wei et al.   CELL

EGFR Mutation-Induced Alternative Splicing of Max Contributes to Growth of Glycolytic Tumors in Brain Cancer

(2013) Ivan Babic et al.   Cell Metabolism

Membrane and actin dynamics interplay at lamellipodia leading edge

(2013) Sara Bisi et al.   CURRENT OPINION IN CELL BIOLOGY

Advances in Analysis of Low Signal-to-Noise Images Link Dynamin and AP2 to the Functions of an Endocytic Checkpoint

(2013) François Aguet et al.   DEVELOPMENTAL CELL

Threshold-controlled ubiquitination of the EGFR directs receptor fate

(2013) Sara Sigismund et al.   EMBO JOURNAL

Epidermal Growth Factor Receptor Inhibition in Lung Cancer: Status 2012

(2013) Fred R. Hirsch et al.   Journal of Thoracic Oncology

Endoplasmic reticulum–endosome contact increases as endosomes traffic and mature

(2013) Jonathan R. Friedman et al.   MOLECULAR BIOLOGY OF THE CELL

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2

(2013) Jia Shen et al.   NATURE

The ErbB/HER family of protein-tyrosine kinases and cancer

(2013) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Inhibition of triple-negative breast cancer models by combinations of antibodies to EGFR

(2013) D. A. Ferraro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival

(2013) Barry Jutten et al.   RADIOTHERAPY AND ONCOLOGY

EGF receptor trafficking: consequences for signaling and cancer

(2013) Alejandra Tomas et al.   TRENDS IN CELL BIOLOGY

Endocytosis and Cancer

(2013) I. Mellman et al.   Cold Spring Harbor Perspectives in Biology

Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locations

(2012) Woody Han et al.   CANCER LETTERS

Predictive value of epidermal growth factor receptor expression for first-line chemotherapy plus cetuximab in patients with head and neck and colorectal cancer: Analysis of data from the EXTREME and CRYSTAL studies

(2012) Lisa Licitra et al.   EUROPEAN JOURNAL OF CANCER

EGFR ligands exhibit functional differences in models of paracrine and autocrine signaling

(2012) Kristy J. Wilson et al.   GROWTH FACTORS

Identification of a mutation in the extracellular domain of the Epidermal Growth Factor Receptor conferring cetuximab resistance in colorectal cancer

(2012) Clara Montagut et al.   NATURE MEDICINE

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Endocytosis and Signaling: Cell Logistics Shape the Eukaryotic Cell Plan

(2012) Sara Sigismund et al.   PHYSIOLOGICAL REVIEWS

EGFR Nuclear Translocation Modulates DNA Repair following Cisplatin and Ionizing Radiation Treatment

(2011) G. Liccardi et al.   CANCER RESEARCH

EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: A potential mechanism of EGFR-driven antagonism of apoptosis

(2011) Xinyu Cao et al.   Molecular Cancer

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma

(2011) R D Eppinga et al.   ONCOGENE

EGF Receptor Exposed to Oxidative Stress Acquires Abnormal Phosphorylation and Aberrant Activated Conformation That Impairs Canonical Dimerization

(2011) Simone Filosto et al.   PLoS One

An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway

(2011) D. Guo et al.   Cancer Discovery

Cetuximab (Erbitux)

(2010) W. Bou-Assaly et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity

(2010) Hu Zhu et al.   CANCER LETTERS

Sym004: A Novel Synergistic Anti-Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy

(2010) M. W. Pedersen et al.   CANCER RESEARCH

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor

(2010) Lai Kuan Goh et al.   JOURNAL OF CELL BIOLOGY

Spatial control of EGF receptor activation by reversible dimerization on living cells

(2010) Inhee Chung et al.   NATURE

Panitumumab

(2009) Eline A. Dubois et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Epidermal Growth Factor Receptor Translocation to the Mitochondria

(2009) Michelle L. Demory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ESCRT machinery at a glance

(2009) T. Wollert et al.   JOURNAL OF CELL SCIENCE

Targeted Therapies: The Rare Cancer Paradigm

(2009) Marco A. Pierotti et al.   Molecular Oncology

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

(2009) D. Guo et al.   Science Signaling

Differential Effects of EGFR Ligands on Endocytic Sorting of the Receptor

(2009) Kirstine Roepstorff et al.   TRAFFIC

Cargo and Dynamin Regulate Clathrin-Coated Pit Maturation

(2009) Dinah Loerke et al.   PLOS BIOLOGY

Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity

(2008) Zhang Weihua et al.   CANCER CELL

The biological properties of cetuximab

(2008) Bruno Vincenzi et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Clathrin-Mediated Internalization Is Essential for Sustained EGFR Signaling but Dispensable for Degradation

(2008) Sara Sigismund et al.   DEVELOPMENTAL CELL

Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments

(2008) Patrick T. Caswell et al.   JOURNAL OF CELL BIOLOGY

Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK

(2008) Klaus Dittmann et al.   Molecular Cancer

Functional selectivity of EGF family peptide growth factors: Implications for cancer

(2008) Kristy J. Wilson et al.   PHARMACOLOGY & THERAPEUTICS

Activation of protein kinase Cε stimulates DNA-repair via epidermal growth factor receptor nuclear accumulation

(2007) Gabriele Wanner et al.   RADIOTHERAPY AND ONCOLOGY