Article
Multidisciplinary Sciences
Chi Zhang, Weiyun Li, Xiaobo Lei, Zhenfei Xie, Linlin Qi, Hui Wang, Xia Xiao, Jun Xiao, Yuxiao Zheng, Chen Dong, Xin Zheng, Shiyang Chen, Jianfeng Chen, Bing Sun, Jun Qin, Qiwei Zhai, Jinsong Li, Bin Wei, Jianwei Wang, Hongyan Wang
Summary: The study reveals that in viral infection, LPA suppresses interferon production through the LPA1 receptor, affecting immune responses. Additionally, LPA1 and ROCK1/2 may impact viral infections by promoting vascular leaking or lung fibrosis. Therefore, targeting the LPA1-ROCK module could be beneficial for treating SARS-CoV-2 or other virus infections.
Article
Cell Biology
Cong Hu, Bincheng Wang, Zhigang Liu, Qiling Chen, Masashi Ishikawa, Han Lin, Qingquan Lian, Jun Li, Jia Li, Daqing Ma
Summary: Perioperative risk factors, including the choice of anesthetics, may influence ovarian cancer recurrence after surgery. This study investigated the effects of inhalational anesthetic sevoflurane and intravenous agent propofol on ovarian cancer cell biology and metabolism. The results showed that sevoflurane increased malignancy-related factors while propofol decreased them, suggesting different impacts of the two anesthetics on ovarian cancer cells.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Kaire Ojasalu, Sonja Lieber, Anna M. Sokol, Andrea Nist, Thorsten Stiewe, Imke Bullwinkel, Florian Finkernagel, Silke Reinartz, Sabine Mueller-Bruesselbach, Robert Grosse, Johannes Graumann, Rolf Mueller
Summary: Lysophosphatidic acid (LPA) species accumulate in the ascites of ovarian high-grade serous cancer (HGSC) and are associated with short relapse-free survival. LPA supports metastatic spread of cancer cells by activating multiple signaling pathways. However, a systematic analysis of the LPA-regulated signal transduction network in ovarian cancer cells has not been reported.
Article
Oncology
Yongchang Chen, Lu Liu, Longzheng Xia, Nayiyuan Wu, Ying Wang, He Li, Xue Chen, Xiaoye Zhang, Zhaoyi Liu, Miaochen Zhu, Qianjin Liao, Jing Wang
Summary: TRPM7 silencing enhances AMPK activation and HIF-1 alpha ubiquitination degradation, shifting glycolysis to oxidative phosphorylation, thereby suppressing the proliferation of ovarian cancer cells.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Antonio-Andres, Gustavo U. Martinez-Ruiz, Mario Morales-Martinez, Elva Jimenez-Hernandez, Estefany Martinez-Torres, Tania V. Lopez-Perez, Laura A. Estrada-Abreo, Genaro Patino-Lopez, Sergio Juarez-Mendez, Victor M. Davila-Borja, Sara Huerta-Yepez
Summary: This study reveals that HIF-1 alpha can transcriptionally regulate YY1, and the expression of HIF-1 alpha positively correlates with YY1 in leukemia patients, suggesting that they may serve as therapeutic targets or biomarkers for ALL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ho-Jun Shih, Hsin-Fang Chang, Chi-Ling Chen, Pao-Ling Torng
Summary: Ovarian cancer is often diagnosed at advanced stages, leading to treatment failures and recurrences. HIFs activated by cancer cells in response to hypoxia play a key role in facilitating tumor growth and resistance to treatments. Although IGFBP3 can inhibit tumor angiogenesis, its effects are temporary, and the transition from dormancy to proliferation states in cancer cells may involve the activation of HIF-2 alpha.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Xueyan Huang, Bin Feng, Meihui Liu, Zuyuan Liu, Shi Li, Wenbin Zeng
Summary: Ovarian cancer is a highly metastatic disease and the leading cause of death from gynecological malignancies. Mastery of LPA measurement techniques is beneficial for providing a new diagnostic or prognostic platform for ovarian cancer. This review summarizes various methods for LPA detection, with emphasis on advances in mass spectrometry-based technologies and emerging optical sensor strategies.
Article
Biochemistry & Molecular Biology
Lei Huang, Xinyu He, Wen Peng, Xueqing He, Bei Xu, Hu Xu, Yaoxing Wang, Wenjun Xu, Wentong Chen, Sheng Wang, Lanlan Zhou, Ning Liu, Youzhi Xu, Wenjie Lu
Summary: The molecular mechanisms of uric acid-induced liver injury have not been fully understood. This study revealed that uric acid directly activates inflammation and apoptosis pathways in liver cells, while inhibiting urea cycle enzymes. The upregulation of hypoxia inducible factor-1α by uric acid plays a role in these processes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Plant Sciences
Mingzhu Yu, Qiaoling Pan, Wenbiao Li, Tingting Du, Fei Huang, Hui Wu, Yixin He, Xiaojun Wu, Hailian Shi
Summary: In this study, the researchers found that ISL has anti-gastric cancer activity by inhibiting the growth of gastric cancer and regulating apoptosis-related and metabolism-related protein expression. ISL blocked glucose uptake and suppressed production and secretion of lactic acid, which was accompanied with suppressed mitochondrial oxidative phosphorylation and glycolysis but increased ROS accumulation. Additionally, ISL inhibited the cell viability of gastric cancer by depressing protein expression of c-Myc and HIF-1α, while inducing energy metabolic collapse mediated by PDHK1/PGC-1α.
Article
Chemistry, Multidisciplinary
Veronica Egas Ortuno, Sunil Pulletikurti, Kollery S. Veena, Ramanarayanan Krishnamurthy
Summary: This study presents a robust synthesis method for cyclic phosphatidic acids (cPAs) and investigates their hydrolytic properties, which could advance the understanding of their biological properties and potential use as components of synthetic cells.
CHEMICAL COMMUNICATIONS
(2022)
Review
Cell Biology
Nasim Kheshtchin, Jamshid Hadjati
Summary: Hypoxia, a common characteristic of solid tumors, contributes to different aspects of tumor progression and limits the efficacy of immunotherapies. Developing new immunotherapy strategies involving therapeutic targeting of HIF-1 molecules associated with hypoxia may enhance the clinical effectiveness of immunotherapy. Targeting hypoxia presents a potential opportunity to improve the clinical benefit of cancer immunotherapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yang Wang, Xinyue Wei, Yachong Jiao, Yingyu Bai, Sam Wilfried Noela, Qiushuang Yan, Xuguo Sun, Guangping Li, Jun Ma, Wei Wei, Derun Tian, Fang Zheng
Summary: The study found that fascin-1 and HIF-1 alpha were highly expressed in the synovium of rheumatoid arthritis (RA), and their expression was associated with p-STAT3. The hypoxic environment activated the migration and invasion of RA synovial cells through the STAT3/HIF-1 alpha/fascin-1 axis.
MOLECULAR IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bo Young Jeong, Kyung Hwa Cho, Se-Hee Yoon, Chang Gyo Park, Hwan-Woo Park, Hoi Young Lee
Summary: LPA induces DDR2 expression through the activation of the PI3K/Akt/mTOR/HIF-1α/Twist1 signaling axes, aggravating ovarian cancer cell invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jacqueline G. Parchem, Huihui Fan, Lovepreet K. Mann, Qiuying Chen, Jong H. Won, Steven S. Gross, Zhongming Zhao, Heinrich Taegtmeyer, Ramesha Papanna
Summary: Monochorionic-diamniotic twin pregnancies, which share a single placenta, can lead to unique complications and disturbances in blood flow, such as twin-twin transfusion syndrome (TTTS). This study used TTTS as a model to investigate fetal metabolic adaptations to cardiovascular stress. Metabolomic analyses of amniotic fluid samples showed alterations in fatty acid, glucose, and steroid hormone metabolism in TTTS cases, suggesting that the fetal heart can adapt to hemodynamic stress by modulating glucose metabolism, with potential differences in individual fetuses' ability to respond to cardiovascular stress.
Article
Pharmacology & Pharmacy
Shuyuan Guan, Lingbin Sun, Xihua Wang, Xirui Huang, Tao Luo
Summary: Propofol can alleviate neuroinflammation and cell damage induced by lipopolysaccharide, and improve lipopolysaccharide-induced cognitive dysfunction. It exerts anti-inflammatory effects by inhibiting the metabolic reprogramming of cells via the suppression of the ROS/PI3K/Akt/mTOR/HIF-1α signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Upasana Ray, Sib Sankar Roy
Review
Oncology
Derek B. Oien, Christopher L. Pathoulas, Upasana Ray, Prabhu Thirusangu, Eleftheria Kalogera, Viji Shridhar
Summary: Quinacrine, originally an antimalarial drug, has been rediscovered as an anticancer agent due to its multiple mechanisms including inhibition of cancer cell growth and DNA repair processes. Its potential in treating aggressive tumors such as high grade serous ovarian cancer has been highlighted in recent studies.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Karthikeyan Thirugnanam, Stephanie M. Cossette, Qiulun Lu, Shreya R. Chowdhury, Leanne M. Harmann, Ankan Gupta, Andrew D. Spearman, Dmitry L. Sonin, Michelle Bordas, Suresh N. Kumar, Amy Y. Pan, Pippa M. Simpson, Jennifer L. Strande, Erin Bishop, Ming-Hui Zou, Ramani Ramchandran
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2019)
Article
Biochemistry & Molecular Biology
Yinan Xiao, Ling Jin, Chaolin Deng, Ye Guan, Eleftheria Kalogera, Upasana Ray, Prabhu Thirusangu, Julie Staub, Sayantani Sarkar Bhattacharya, Haotian Xu, Xiaoling Fang, Viji Shridhar
Summary: The inhibition of PFKFB3 with PFK158 can reduce chemoresistance in endometrial cancer cell lines by lowering cell proliferation, increasing sensitivity to chemotherapy, inhibiting glucose metabolism, and promoting apoptosis and autophagy-induced cell death. The combination of PFK158 with chemotherapy drugs can enhance chemosensitivity by affecting cell signaling pathways, ultimately leading to suppressed tumor growth.
Article
Oncology
Prabhu Thirusangu, Christopher L. Pathoulas, Upasana Ray, Yinan Xiao, Julie Staub, Ling Jin, Ashwani Khurana, Viji Shridhar
Summary: Ovarian cancer is a common and deadly cancer among women worldwide, with drug repurposing providing a potential strategy for treatment. Quinacrine has shown promise in ovarian cancer treatment by upregulating CTSL and promoting cell death. This study suggests that Quinacrine-induced autophagy and CTSL upregulation create a positive feedback loop leading to cell death in ovarian cancer.
Article
Oncology
Upasana Ray, Debarshi Roy, Ling Jin, Prabhu Thirusangu, Julie Staub, Yinan Xiao, Eleftheria Kalogera, Andrea E. Wahner Hendrickson, Grace D. Cullen, Krista Goergen, Ann L. Oberg, Viji Shridhar
Summary: The study demonstrates that downregulation of PLA2G3 inhibits lipid droplet biogenesis, reduces cell growth, and increases sensitivity to platinum drugs in ovarian cancer cells.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Derek B. Oien, Upasana Ray, Christopher L. Pathoulas, Ling Jin, Prabhu Thirusangu, Deokbeom Jung, Joseph E. Kumka, Yinan Xiao, Sayantani Sarkar Bhattacharya, Dennis Montoya, Jeremy Chien, Viji Shridhar
Summary: This study investigates the mechanism of action of quinacrine in chemoresistant ovarian cancer cells, finding that it increases DNA damage by inhibiting the ribosomal biogenesis pathway and inducing nucleolar stress, ultimately sensitizing cells to PARP inhibitors. This supports new therapeutic strategies for treating refractory ovarian cancer.
Article
Oncology
Upasana Ray, Deok-Beom Jung, Ling Jin, Yinan Xiao, Subramanyam Dasari, Sayantani Sarkar Bhattacharya, Prabhu Thirusangu, Julie K. Staub, Debarshi Roy, Bhaskar Roy, S. John Weroha, Xiaonan Hou, James W. Purcell, Jamie N. Bakkum-Gamez, Scott H. Kaufmann, Nagarajan Kannan, Anirban K. Mitra, Viji Shridhar
Summary: This study identifies the role of LRRC15 in promoting ovarian cancer metastasis and demonstrates that the LRRC15-targeted antibody-drug conjugate can suppress ovarian cancer metastasis.
Review
Oncology
Upasana Ray, Christopher L. Pathoulas, Prabhu Thirusangu, James W. Purcell, Nagarajan Kannan, Viji Shridhar
Summary: Abundant fibrotic stroma is a common feature in solid tumors, and targeting the tumor stroma, including the overexpressed LRRC15 protein, has become a promising therapeutic strategy. Effective LRRC15-targeted therapy may improve outcomes for patients with LRRC15-positive tumors, offering personalized clinical benefits and predictive biomarkers for preclinical assessment.
Article
Biochemistry & Molecular Biology
Prabhu Thirusangu, Upasana Ray, Sayantani Sarkar Bhattacharya, Derek B. Oien, Ling Jin, Julie Staub, Nagarajan Kannan, Julian R. Molina, Viji Shridhar
Summary: PFKFB3 is an important enzyme in glycolysis that is overexpressed in many human cancers. Its high expression promotes glycolysis and survival in cancer stem cells, while inhibition of PFKFB3 can reduce proliferation, spheroid formation, chemotherapy resistance, and invasion/migration in SCLC cells.
Article
Biochemistry & Molecular Biology
Shreya Bandopadhyay, Parash Prasad, Upasana Ray, Damayanti Das Ghosh, Sib Sankar Roy
Summary: SIRT6 plays a crucial oncogenic role in ovarian cancer by enhancing glycolysis and oxidative phosphorylation in cancer cells, promoting migration and invasion. Its mechanism involves promoting ERK1/2-driven activatory phosphorylation of DRP1 at serine-616, inducing mitochondrial fission and facilitating cell movement important for metastasis. The downregulation of SIRT6 leads to decreased cellular invasion through compromised mitochondrial fragmentation and reduction in stress fiber formation in ovarian cancer cells.
Review
Chemistry, Medicinal
Upasana Ray, Robert Z. Orlowski
Summary: Multiple myeloma is often treated with monoclonal antibodies targeting specific markers or as antibody-drug conjugates. There are several approved antibodies for treatment, such as daratumumab and isatuximab targeting CD38, elotuzumab targeting Signaling lymphocytic activation molecule family member 7, and teclistamab targeting BCMA. Belantamab mafodotin is an ADC that gained attention but faced withdrawal due to negative Phase III results. Despite this setback, there are other ADCs in development targeting BCMA or other plasma cell surface markers. Overall, ADCs have potential as part of chemotherapy against myeloma.
Article
Biochemistry & Molecular Biology
Syed Mohammed Musheer Aalam, Xiaojia Tang, Jianning Song, Upasana Ray, Stephen J. Russell, S. John Weroha, Jamie Bakkum-Gamez, Viji Shridhar, Mark E. Sherman, Connie J. Eaves, David J. H. F. Knapp, Krishna R. Kalari, Nagarajan Kannan
Summary: A lack of understanding of mechanisms controlling organ-specific patterns of metastasis is a problematic feature of many human cancers. In this study, the researchers developed a methodology that comprehensively characterizes different aspects of the metastatic process at a clonal resolution. They demonstrated the effectiveness of this methodology by discriminating the metastatic behavior of a well-established human metastatic cancer cell line and its derivative using computational analysis and machine learning. The findings highlight the potential of combined genomic and computational methodologies to identify new drivers of site-specific patterns of metastasis.
Article
Cell Biology
Upasana Ray, Shreya Roy Chowdhury, Sib Sankar Roy
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2017)
Article
Oncology
Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannick P. Kok, Shibo Yu, Jana Dobrovolna, Pavel Janscak, Marcel van Vugt, Libor Macurek
Summary: Oncogene-induced replication stress is a major cause of genome instability in cancer cells. This study reveals that increased activity of PPM1D exacerbates replication stress caused by cyclin E1 overexpression, leading to abnormal cell cycle progression and accumulation of DNA copy number alterations. Pharmacological inhibition of PPM1D can alleviate replication stress-induced genome instability.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Alamelu G. Bharadwaj, Meghan E. McLean, Margaret L. Dahn, Hannah F. Cahill, Marie-Claire D. Wasson, Raj Pranap Arun, Olivia L. Walker, Brianne M. Cruickshank, Wasundara Fernando, Jaganathan Venkatesh, Penelope J. Barnes, Gillian Bethune, Gregory Knapp, Lucy K. Helyer, Carman A. Giacomantonio, David M. Waisman, Paola Marcato
Summary: ALDH1A3 regulates the plasminogen activation pathway to promote breast cancer metastasis. Co-expression of ALDH1A3 and tPA is associated with TNBC subtype, high tumor grade, and recurrent metastatic disease.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas de Laat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. Primary fibrinolytic protease plasminogen promotes PDAC tumor growth and metastatic potential through engaging plasminogen receptors on tumor cells.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nuria Gendrau-Sanclemente, Agnes Figueras, Kristina Gracova, Alvaro Lahiguera, Elisenda Alsina-Sanchis, Juan A. Marin-Jimenez, August Vidal, Xavier Matias-Guiu, Sergi Fernandez-Gonzalez, Marc Barahona, Lola Marti, Jordi Ponce, Francesc Vinals
Summary: High-grade serous ovarian cancer (HGSOC), the deadliest gynecological malignancy, spreads through transcoelomic dissemination. This study reveals that platelet-derived growth factor receptor beta (PDGFRβ) is essential for the formation of tumorspheres in HGSOC. Inhibition of PDGFRβ blocks the clustering of ovarian cancer cells and prevents peritoneal dissemination.
MOLECULAR ONCOLOGY
(2024)