Article
Agriculture, Multidisciplinary
Jian Bao, Zheng Liang, Xiaokang Gong, Yanna Zhao, Mengjuan Wu, Wei Liu, Chenyu Tu, Xiaochuan Wang, Xiji Shu
Summary: This study found that Tangeretin (TAN) exhibits antidementia activity in APPswe/PSEN1dE9 transgenic mice, reducing cognitive impairment, synaptic impairments, and beta-amyloid accumulations. TAN also showed powerful inhibitory activity against beta-secretase, suggesting it as a potential drug for preventing Alzheimer's disease pathology.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Clinical Neurology
Yaqi Wang, Yuting Cui, Jing Liu, Qiao Song, Min Cao, Yuli Hou, Xiaomin Zhang, Peichang Wang
Summary: The upregulation of KLF5 is found to positively regulate BACE1 and accelerate APP amyloidogenic cleavage in Alzheimer's disease (AD) progression. The levels of KLF5 significantly increase in AD patients and APP/PS1 mice, and are closely related to cognitive capacity. KLF5 promotes amyloidogenic metabolism and AP synthesis through BACE1.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Neurosciences
Jonathan Aow, Tzu-Rung Huang, Gopal Thinakaran, Edward H. Koo
Summary: In this study, the researchers found that there was a significant early and aberrant Bace1-mediated APP cleavage in the presence of APP/Bace1 co-expression. This led to disturbances in the trafficking of full-length APP (fl-APP) from the secretory pathway, resulting in a substantial loss of surface fl-APP and a marked reduction in APP internalization. Therefore, caution is needed when interpreting results where APP is detected only with a C-terminal tag in the presence of Bace1 co-expression, and previous findings may need to be reinterpreted if it is unclear whether fl-APP is present in normal physiological levels.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Plant Sciences
Caixia Zang, Hui Liu, Junmei Shang, Hanyu Yang, Lu Wang, Chanjuan Sheng, Zihong Zhang, Xiuqi Bao, Yang Yu, Xinsheng Yao, Dan Zhang
Summary: The study demonstrates that GJ-4 improves cognitive deficits in APP/PS1 transgenic mice by reducing A beta levels, inhibiting tau protein phosphorylation, and suppressing neuroinflammatory responses. These findings provide a basis for further development of GJ-4 as a potential treatment for AD.
Article
Biochemistry & Molecular Biology
Laura Schnoeder, Inge Tomic, Laura Schwindt, Dominic Helm, Mandy Rettel, Walter Schulz-Schaeffer, Elmar Krause, Jens Rettig, Klaus Fassbender, Yang Liu
Summary: Deficiency of p38 alpha-MAPK in neurons leads to increased retrograde transportation of BACE1 in axons, shifting it from axonal terminals to lysosomes in the cell body, which exacerbates amyloid deposition in the brain of Alzheimer's disease.
Article
Cell Biology
Na Li, Ning Bai, Xiong Zhao, Rong Cheng, Xuan Wu, Bo Jiang, Xiaoman Li, Mingli Xue, Hongde Xu, Qiqiang Guo, Wendong Guo, Mengtao Ma, Sunrun Cao, Yanling Feng, Xiaoyu Song, Zhuo Wang, Xiaoyu Zhang, Yu Zou, Difei Wang, Hua Liu, Liu Cao
Summary: Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by amyloid-beta (Aβ) deposition and neurofibrillary tangles. The ratio of SIRT2:SIRT1 is elevated in aging mice and AD mouse models, and SIRT1 overexpression prevents Aβ-induced neurotoxicity. SIRT1 inhibits the binding of SIRT2 to APP, thus reducing amyloidogenic processing of APP and providing a potential avenue for therapeutic intervention of AD.
Article
Chemistry, Multidisciplinary
Meng-dan Wang, Shuo Zhang, Xing-yang Liu, Pan-pan Wang, Yi-fan Zhu, Jun-rong Zhu, Chong-shan Lv, Shi-ying Li, Sui-feng Liu, Lei Wen
Summary: Alzheimer's disease (AD) is a neurodegenerative disease that is difficult to diagnose early. Retinal damage in AD may occur before cognitive impairment and could be used as an indicator for early diagnosis. Salvianolic acid B (Sal B), a compound from Salvia miltiorrhiza, has shown promise in treating AD. This study demonstrated that Sal B treatment ameliorated retinal deficits in early-stage AD, suggesting its potential as a therapeutic intervention for early AD treatment.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Environmental Sciences
Ruike Wang, Zuntao Wu, Rundong Liu, Lin Bai, Yan Lin, Yue Ba, Hui Huang
Summary: Emerging evidence suggests that lead (Pb) exposure contributes to cognitive decline and increases the risk of Alzheimer's disease (AD) dementia. This study investigates the effects of Pb on microRNAs (miRNAs), which play a role in AD pathogenesis. The findings suggest that miR-124-3p/BACE1 pathway modulation is critically involved in Pb-induced AD-like amyloidogenic processing.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Nutrition & Dietetics
Yacoubou Abdoul Razak Mahaman, Jun Feng, Fang Huang, Maibouge Tanko Mahamane Salissou, Jianzhi Wang, Rong Liu, Bin Zhang, Honglian Li, Feiqi Zhu, Xiaochuan Wang
Summary: Alzheimer's disease is a global health problem with no effective single therapy. Nutraceutical agents like Moringa oleifera (MO), which have multiple effects, show promise in treating AD. This study found that MO treatment improved behavioral and cognitive deficits, reduced A beta burden, and improved synaptic plasticity and neurodegeneration in AD mice.
Article
Biochemistry & Molecular Biology
Yan-Li Jia, Wei Wang, Ning Han, Hong-Liang Sun, Fang -Ming Dong, Ya-Xue Song, Rong-Fang Feng, Jian-Hua Wang
Summary: Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by cognitive dysfunction and an impaired ability to carry out daily life functions. Mitochondrial dysfunction and β-amyloid (β-AMY) deposition are the main causes of AD. This study showed that the antioxidant peptide SS31 protected mitochondrial and synaptic function, reduced neuronal apoptosis and ROS levels, and improved behavioral deficits in early-stage AD.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Food Science & Technology
Yue-Qin Zeng, Juan-Hua Gu, Liang Chen, Tao-Tao Zhang, Xin-Fu Zhou
Summary: The study showed that chronic administration of gastrodin can decrease aggregation of A beta 42, prevent A beta 42 induced neurotoxicity, reduce levels of A beta plaques and hyperphosphorylated tau, alleviate activation of glial cells and proinflammatory cytokines, and attenuate oxidative stress in the APP/PS1 transgenic mice. The potential mechanisms involve inhibition of A beta enzymes and prevention of GSK3 beta activity. These results suggest that gastrodin may be a potential treatment agent for AD.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Neurosciences
Bijayani Sahu, Amy R. Mackos, Angela M. Floden, Loren E. Wold, Colin K. Combs
Summary: This study investigated the effects of particulate matter exposure on AD-related brain changes using a transgenic disease model. The results showed that chronic particulate matter exposure exacerbates AD by increasing A beta plaque load, gliosis, and the brain inflammatory status.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Geriatrics & Gerontology
Nicole K. Zhang, Selena K. Zhang, Li I. Zhang, Huizhong W. Tao, Guang-Wei Zhang
Summary: Alzheimer's disease is a progressive neurodegenerative disorder that primarily affects cognitive functions. This literature review examines the sensory deficits and cortical pathological changes observed in AD patients and animal models. Sensory deficits may emerge early in the disease and precede cognitive decline, accompanied by cortical pathological changes. The review highlights the significance of sensory deficits and emphasizes the need for further research to develop reliable early detection and intervention through sensory systems.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Plant Sciences
Kaili Lin, Stephen Cho-Wing Sze, Bin Liu, Zhang Zhang, Zhu Zhang, Peili Zhu, Ying Wang, Qiudi Deng, Ken Kin-Lam Yung, Shiqing Zhang
Summary: Alzheimer's disease (AD) is a prevalent neurodegenerative disorder. Enhancing hippocampal neurogenesis through compounds like 20(S)-protopanaxadiol (PPD) and oleanolic acid (OA) found in ginseng can alleviate cognitive deficits in animal models by activating the Wnt/GSK3 beta/beta-catenin pathway.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Neurosciences
Wenwen Yin, Ke Wan, Wenhao Zhu, Xia Zhou, Yating Tang, Wenhui Zheng, Jing Cao, Yu Song, Han Zhao, Xiaoqun Zhu, Zhongwu Sun
Summary: This study aimed to evaluate the correlations between plasma BACE1 concentration, cognition, and hippocampal volume at different stages of the AD continuum. The results showed that BACE1 concentration was elevated in AD continuum patients and correlated with memory function and hippocampal atrophy. Plasma BACE1 concentration may serve as a potential biomarker at the early stage of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Shuting Zhang, Fang Cai, Yili Wu, Tahereh Bozorgmehr, Zhe Wang, Si Zhang, Daochao Huang, Jifeng Guo, Lu Shen, Catharine Rankin, Beisha Tang, Weihong Song
MOLECULAR PSYCHIATRY
(2020)
Article
Biochemistry & Molecular Biology
Yan Yun, Yun Zhang, Chen Zhang, Liyan Huang, Shichuan Tan, Pin Wang, Carles Vilarino-Guell, Weihong Song, Xiulian Sun
Summary: The study reveals that RCAN1 is a novel RNA-binding protein, and its RNA aptamer can block RCAN1-induced inhibition of NFAT and NF-kappa B signaling pathways, reducing neuronal apoptosis and playing a neuroprotective role.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Yuhang Liu, Juelu Wang, Ging-Yuek Robin Hsiung, Weihong Song
MOLECULAR NEUROBIOLOGY
(2020)
Editorial Material
Neurosciences
Keenan Sterling, Mengen Xing, Weihong Song
NEUROSCIENCE BULLETIN
(2022)
Review
Neurosciences
Lina Gao, Yun Zhang, Keenan Sterling, Weihong Song
Summary: Synaptic abnormalities are a key aspect of Alzheimer's disease, connecting pathological changes to cognitive impairment. Brain-derived neurotrophic factors are crucial in synaptic plasticity for learning and memory, and have potential as diagnostic biomarkers and therapeutic molecules for AD. The exact mechanisms underlying the effects of impaired BDNF signaling on AD are still unclear.
TRANSLATIONAL NEURODEGENERATION
(2022)
Review
Biochemistry & Molecular Biology
Lin Peng, Isabel Bestard-Lorigados, Weihong Song
Summary: Alzheimer's disease is a neurodegenerative disorder that severely impairs memory and cognition. It is characterized by Aβ deposition, tau tangles, synaptic abnormalities, and dysfunctions. Targeting the synapse and early treatment windows hold promise for finding effective treatments for AD patients.
MOLECULAR PSYCHIATRY
(2022)
Article
Environmental Sciences
Zhengkang Su, Kaiyu Guan, Yunbin Liu, Hai Zhang, Zhengwei Huang, Miaomiao Zheng, Ya Zhu, He Zhang, Weihong Song, Xi Li
Summary: The use of clinical psychoactive drugs can pose unpredictable threats to fetal development. Opicapone, a newly effective peripheral COMT inhibitor, is used for the treatment of Parkinson's disease and other dopamine-related disorders. However, the impact of opicapone on embryonic development is still unknown.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Juelu Wang, Peiye Chen, Bolang Hu, Fang Cai, Qin Xu, Sipei Pan, Yili Wu, Weihong Song
Summary: Alzheimer's disease (AD) and Parkinson's disease (PD) are age-related neurodegenerative disorders that cause specific neuronal loss in the cholinergic and dopaminergic systems, respectively. The mutations in APP(SWE) and SNCA(A53T) have been implicated in the pathology of AD and PD, promoting the generation of A beta and the aggregation of alpha-synuclein, respectively. We found that SDC3 and FGFRL1 genes were differentially expressed in cells carrying these mutations and their knockdown attenuated cell death induced by oxidative stress.
Review
Biochemistry & Molecular Biology
Jing Yao, Zhe Wang, Weihong Song, Yun Zhang
Summary: Neuroinflammation is a crucial pathological feature in neurological diseases, including Alzheimer's disease (AD). NLRP3, a member of the NLRs family, is primarily expressed in microglia and plays a significant role in inflammation by activating the NLRP3 inflammasome to release proinflammatory cytokines and cause pyroptosis. Recent studies have also highlighted the importance of neuronal NLRP3 in the pathogenesis of neurological disorders.
MOLECULAR PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Yun Zhang, Huaqiu Chen, Ran Li, Keenan Sterling, Weihong Song
Summary: Amyloid & beta; protein (A & beta;) is the main component of neuritic plaques in Alzheimer's disease. It has been considered as the molecular driver of Alzheimer's pathogenesis. The failures of A & beta;-targeted clinical trials have raised doubts about the amyloid cascade hypothesis, but recent successes have alleviated those doubts. This review discusses the evolution of the hypothesis, its application in Alzheimer's diagnosis and treatment, and the prospects for future research and development of A & beta;-targeted approaches.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
Review
Biochemistry & Molecular Biology
Yan Lian, Yu-Juan Jia, Joelyn Wong, Xin-Fu Zhou, Weihong Song, Junhong Guo, Colin L. Masters, Yan-Jiang Wang
Summary: This article analyzes key questions regarding the efficacy of Aβ targeting therapies and provides perspectives on early intervention, adequate Aβ removal, sufficient treatment period, and combinatory therapeutics. The success of recent clinical trials and lessons from previous trials provide critical evidence supporting the role of Aβ in AD pathogenesis.
MOLECULAR PSYCHIATRY
(2023)
Letter
Biochemistry & Molecular Biology
Xi Liu, Rongbo Che, Wenping Liang, Yun Zhang, Liyong Wu, Chao Han, Hong Lu, Weihong Song, Yili Wu, Zhe Wang
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Yun Zhang, Lin Peng, Weihong Song
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2020)
Article
Medicine, Research & Experimental
Qing Zhang, Weihong Song
