Article
Environmental Sciences
Fangyuan Zhou, Qingxia Liang, Xiaoyan Zhao, Xiaoqing Wu, Susu Fan, Xinjian Zhang
Summary: Pesticide resistance causes significant economic losses globally each year. Previous research has mainly focused on investigating the interactions between resistant pests and associated microbes, with a lack of quantification on the individual contributions of the pest host and associated microbes to resistance. This study compares resistant and sensitive strains and uses metaproteomics to analyze protein profiles, revealing contributions by the pest and its gut bacteria to phoxim resistance.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Microbiology
Jiajia Zhu, Yunsheng Chen, Yifan Wu, Yongqiang Wang, Kui Zhu
Summary: Commensal bacteria, especially Gram-positive bacteria, facilitate the survival of multidrug-resistant Avibacterium paragallinarum, exacerbating infections.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Manigandan Krishnan, Joonhyeok Choi, Ahjin Jang, Sungjae Choi, Jiwon Yeon, Mihee Jang, Yeongjoon Lee, Kkabi Son, Soon Young Shin, Myeong Seon Jeong, Yangmee Kim
Summary: This article investigates the molecular mechanism underlying the TLR4-signaling and antibacterial activities of papiliocin and finds that it can inhibit LPS-induced TLR4 signaling by binding to TLR4/MD-2 and causing dissociation of LPS from the complex, thus combating gram-negative bacteria infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Forestry
Dun Jiang, Ruoxuan Lin, Mingtao Tan, Junxin Yan, Shanchun Yan
Summary: This study investigates the growth and resistance of Populus alba x P. berolinensis seedlings colonized by Glomus intraradices against the gypsy moth larvae. The results show that mycorrhizal growth response enhances the growth of seedlings but reduces their resistance against the larvae. Transcriptome and metabolome analysis reveal the regulatory network involved in the positive mycorrhizal growth response and mycorrhizal-induced reduction of insect resistance.
Review
Immunology
Deepak Kumar Mahanta, Tanmaya Kumar Bhoi, J. Komal, Ipsita Samal, R. M. Nikhil, Amit Umesh Paschapur, Gaurav Singh, P. V. Dinesh Kumar, H. R. Desai, Mohammad Abbas Ahmad, P. P. Singh, Prasanta Kumar Majhi, U. Mukherjee, Pushpa Singh, Varun Saini, N. Shahanaz, N. Srinivasa, Yogesh Yele
Summary: Insects lack an adaptive immune system, but they possess highly effective anti-infective mechanisms such as bacterial phagocytosis and parasite encapsulation as cellular responses, as well as the secretion of antimicrobial peptides as a humoral response. Recent research has focused on the immune regulatory function of ncRNAs in insect-pathogen crosstalk.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aaron P. Decker, Abraham F. Mechesso, Guangshun Wang
Summary: Unlike the alpha-helical and beta-sheet antimicrobial peptides (AMPs), amino acid-rich AMPs have limited knowledge. This article conducted a systematic study on rich AMPs (>25%) from different life kingdoms using the Antimicrobial Peptide Database (APD) and program R. Of the 3425 peptides analyzed, 724 rich AMPs were identified. The distribution of rich AMPs differs among animals, bacteria, and plants. Certain amino acids are frequently observed in rich AMPs, while others are occasionally observed or not yet found. These findings can guide peptide design and rich AMPs show promise as future antibiotics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Zhenlong Wang, Na Yang, Da Teng, Ya Hao, Ting Li, Huihui Han, Ruoyu Mao, Jianhua Wang
Summary: This study identified the resistance mechanisms of E. coli to the antimicrobial peptide N6NH(2) as increased biofilm formation capacity, decreased affinity with lipopolysaccharide (LPS), and changed cell membrane permeability and potential. Additionally, a chimeric peptide called G6 showed stronger inhibition against N6NH(2)-resistant mutants through enhanced biofilm formation inhibition, increased affinity with LPS, and greater membrane permeability and depolarization compared to N6NH(2).
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Orathai Kamsoi, Alba Ventos-Alfonso, Fernando Casares, Isabel Almudi, Xavier Belles
Summary: In the Paleozoic era, certain insect groups continued molting after forming functional wings, while modern flying insects generally stop molting after metamorphosis. Mayflies are an exception, molting during the subimago stage. The identity and purpose of the subimago remain a topic of debate.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Pharmacology & Pharmacy
Deborah A. O'Neil
Summary: Antimicrobial therapies derived from immunology, utilizing the immune system's defense mechanisms, offer innovative approaches in drug design and development to combat infectious diseases. Immune system holds potential for novel interventions in infection control with non-antibiotic, directly antimicrobial strategies.
DRUG DISCOVERY TODAY
(2021)
Article
Microbiology
Quentin Nicoud, Quentin Barriere, Nicolas Busset, Sara Dendene, Dmitrii Travin, Mickael Bourge, Romain Le Bars, Claire Boulogne, Marie Lecroel, Sandor Jenei, Atilla Kereszt, Eva Kondorosi, Emanuele G. Biondi, Tatiana Timchenko, Benoit Alunni, Peter Mergaert
Summary: Various functions in Sinorhizobium meliloti are involved in protecting endosymbionts, including peptide transporters, bacterial envelope structures, and stress response regulators.
Article
Engineering, Biomedical
Leman Buzoglu Kurnaz, Swagatam Barman, Xiaoming Yang, Claire Fisher, F. Wayne Outten, Prakash Nagarkatti, Mitzi Nagarkatti, Chuanbing Tang
Summary: Inspired by the facial amphiphilic nature and antimicrobial efficacy of antimicrobial peptides, this study developed a new class of facial amphiphilic bicyclic naphthoic acid derivatives that were attached to poly(glycidyl methacrylate). These polymers exhibited potent antibacterial activity against multi-drug resistant gram-negative pathogens and showed low hemolysis and high antimicrobial selectivity. They were also effective in eradicating biofilms and killing dormant cells, suggesting a mechanism of action through membrane disruption. Overall, these facial amphiphiles have the potential to address antimicrobial resistance in both planktonic and biofilm-related infections.
Article
Biochemistry & Molecular Biology
Miray Tonk, James J. Valdes, Alejandro Cabezas-Cruz, Andreas Vilcinskas
Summary: Arthropod antimicrobial peptides (AMPs) provide a potential source for new antibiotics with potent activity against multidrug-resistant bacterial pathogens. Synergistic effects can be achieved by combining AMPs from different sources. Hybrid peptides linked by glycine spacers show enhanced antibacterial activity, but can also exhibit increased cytotoxic activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Paolo Stincone, Flavio Fonseca Veras, Giuseppe Micalizzi, Danilo Donnarumma, Gaetano Vitale Celano, Daniel Petras, Maria de Angelis, Luigi Mondello, Adriano Brandelli
Summary: This study investigated the effect of antimicrobial peptides on L. monocytogenes using mass spectrometry-based lipidomics and proteomics. The results showed that the treatment with antimicrobial peptides caused changes in lipid and protein profiles, affecting the biofilm formation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Kai Hilpert, Jurnorain Gani, Christoph Rumancev, Nathan Simpson, Paula Matilde Lopez-Perez, Vasil M. Garamus, Andreas Robert von Gundlach, Petar Markov, Marco Scocchi, Ralf Mikut, Axel Rosenhahn
Summary: This study investigates the antimicrobial activity of different types of antimicrobial peptides, analyzes the impact of peptides on the ultrastructure of E. coli using BioSAXS technology, and identifies a hybrid peptide that exhibits a different mode of action compared to parental peptides.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Microbiology
Ruben Cebrian, Marta Martinez-Garcia, Matilde Fernandez, Federico Garcia, Manuel Martinez-Bueno, Eva Valdivia, Oscar. P. P. Kuipers, Manuel Montalban-Lopez, Mercedes Maqueda
Summary: Antimicrobial resistance is a serious threat to global public health and economy. Antimicrobial peptides, such as AS-48, offer a promising solution due to their unique mechanisms of action and stability. AS-48 has demonstrated potential against a wide range of pathogens and could be a valuable tool in the fight against antimicrobial resistance.
FRONTIERS IN MICROBIOLOGY
(2023)