Overview of carbon and nitrogen catabolite metabolism in the virulence of human pathogenic fungi

Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression

(2017) Sarah R. Beattie et al.   PLoS Pathogens

The CreB deubiquitinating enzyme does not directly target the CreA repressor protein in Aspergillus nidulans

(2016) Md Ashiqul Alam et al.   CURRENT GENETICS

Diverse Regulation of the CreA Carbon Catabolite Repressor in Aspergillus nidulans

(2016) Laure N. A. Ries et al.   GENETICS

Carbon regulation of environmental pH by secreted small molecules that modulate pathogenicity in phytopathogenic fungi

(2016) Fangcheng Bi et al.   MOLECULAR PLANT PATHOLOGY

Amino Acid Permeases and Virulence in Cryptococcus neoformans

(2016) Kevin Felipe Cruz Martho et al.   PLoS One

Characterization of gprK Encoding a Putative Hybrid G-Protein-Coupled Receptor in Aspergillus fumigatus

(2016) Mun-Gu Jung et al.   PLoS One

Functional Analysis of the Nitrogen Metabolite Repression Regulator Gene nmrA in Aspergillus flavus

(2016) Xiaoyun Han et al.   Frontiers in Microbiology

Diverse Regulation of the CreA Carbon Catabolite Repressor in Aspergillus nidulans

(2016) Laure N. A. Ries et al.   GENETICS

The Zinc Finger Protein Mig1 Regulates Mitochondrial Function and Azole Drug Susceptibility in the Pathogenic Fungus Cryptococcus neoformans

(2016) Mélissa Caza et al.   mSphere

The Aspergillus fumigatus sitA Phosphatase Homologue Is Important for Adhesion, Cell Wall Integrity, Biofilm Formation, and Virulence

(2015) Vinícius Leite Pedro Bom et al.   EUKARYOTIC CELL

The Role of Amino Acid Permeases and Tryptophan Biosynthesis in Cryptococcus neoformans Survival

(2015) João Daniel Santos Fernandes et al.   PLoS One

Comparative proteomics of atorinducibleAspergillus fumigatusmutant reveals involvement of the Tor kinase in iron regulation

(2015) Clara Baldin et al.   PROTEOMICS

How to bolster the antifungal pipeline

(2015) D. W. Denning et al.   SCIENCE

A fungal protease allergen provokes airway hyper-responsiveness in asthma

(2015) Nariman A. Balenga et al.   Nature Communications

Activation and Alliance of Regulatory Pathways in C. albicans during Mammalian Infection

(2015) Wenjie Xu et al.   PLOS BIOLOGY

The Saccharomyces cerevisiae AMPK, Snf1, Negatively Regulates the Hog1 MAPK Pathway in ER Stress Response

(2015) Tomoaki Mizuno et al.   PLoS Genetics

Direct involvement of the CreA transcription factor in penicillin biosynthesis and expression of the pcbAB gene in Penicillium chrysogenum

(2014) Cristina Cepeda-García et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess

(2014) F. Gsaller et al.   EMBO JOURNAL

Increased permeability of blood–brain barrier is mediated by serine protease during Cryptococcus meningitis

(2014) Chi-Yu Xu et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Regulatory Networks Controlling Nitrogen Sensing and Uptake in Candida albicans

(2014) Shruthi Ramachandra et al.   PLoS One

Invasion of the Central Nervous System by Cryptococcus neoformans Requires a Secreted Fungal Metalloprotease

(2014) K. Vu et al.   mBio

The Cryptococcus neoformans Transcriptome at the Site of Human Meningitis

(2014) Y. Chen et al.   mBio

Modulation of Phagosomal pH by Candida albicans Promotes Hyphal Morphogenesis and Requires Stp2p, a Regulator of Amino Acid Transport

(2014) Slavena Vylkova et al.   PLoS Pathogens

Nitrogen regulation of fungal secondary metabolism in fungi

(2014) Bettina Tudzynski   Frontiers in Microbiology

The glucose signaling network in yeast

(2013) Jeong-Ho Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Functional characterisation of the non-essential protein kinases and phosphatases regulating Aspergillus nidulans hydrolytic enzyme production

(2013) Neil Brown et al.   Biotechnology for Biofuels

Ammonia production by human faecal bacteria, and the enumeration, isolation and characterization of bacteria capable of growth on peptides and amino acids

(2013) Anthony J Richardson et al.   BMC MICROBIOLOGY

Candida albicans secreted aspartic proteases 4–6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism

(2013) Hao Wu et al.   FASEB JOURNAL

Nitrogen regulation of virulence in clinically prevalent fungal pathogens

(2013) I. Russel Lee et al.   FEMS MICROBIOLOGY LETTERS

Reactive Oxygen Species Homeostasis and Virulence of the Fungal Pathogen Cryptococcus neoformans Requires an Intact Proline Catabolism Pathway

(2013) I. R. Lee et al.   GENETICS

Profiling of Candida albicans Gene Expression During Intra-abdominal Candidiasis Identifies Biologic Processes Involved in Pathogenesis

(2013) Shaoji Cheng et al.   JOURNAL OF INFECTIOUS DISEASES

Identification of Metabolic Pathways Influenced by the G-Protein Coupled Receptors GprB and GprD in Aspergillus nidulans

(2013) Wagner R. de Souza et al.   PLoS One

The Glucose Sensor-Like Protein Hxs1 Is a High-Affinity Glucose Transporter and Required for Virulence in Cryptococcus neoformans

(2013) Tong-Bao Liu et al.   PLoS One

Characterization of the Complete Uric Acid Degradation Pathway in the Fungal Pathogen Cryptococcus neoformans

(2013) I. Russel Lee et al.   PLoS One

Candida albicanspathogenicity mechanisms

(2013) François L. Mayer et al.   Virulence

Fungal Immune Evasion in a Model Host–Pathogen Interaction: Candida albicans Versus Macrophages

(2013) Claudia Jiménez-López et al.   PLoS Pathogens

Receptor-mediated signaling in Aspergillus fumigatus

(2013) C. M. Grice et al.   Frontiers in Microbiology

The Composition of the Culture Medium Influences the β-1,3-Glucan Metabolism of Aspergillus fumigatus and the Antifungal Activity of Inhibitors of β-1,3-Glucan Synthesis

(2012) Cécile Clavaud et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Extracellular aspartic protease SAP2 of Candida albicans yeast cleaves human kininogens and releases proinflammatory peptides, Met-Lys-bradykinin and des-Arg9-Met-Lys-bradykinin

(2012) Grazyna Bras et al.   BIOLOGICAL CHEMISTRY

Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen

(2012) Iuliana V. Ene et al.   CELLULAR MICROBIOLOGY

Divergent Targets of Candida albicans Biofilm Regulator Bcr1 In Vitro and In Vivo

(2012) Saranna Fanning et al.   EUKARYOTIC CELL

Expression and secretion of Aspergillus fumigatus proteases are regulated in response to different protein substrates

(2012) Edward Farnell et al.   Fungal Biology

Growth of Candida albicans Cells on the Physiologically Relevant Carbon Source Lactate Affects Their Recognition and Phagocytosis by Immune Cells

(2012) Iuliana V. Ene et al.   INFECTION AND IMMUNITY

Reduced TOR signaling sustains hyphal development in Candida albicans by lowering Hog1 basal activity

(2012) Chang Su et al.   MOLECULAR BIOLOGY OF THE CELL

Involvement of PDK1, PKC and TOR signalling pathways in basal fluconazole tolerance in Cryptococcus neoformans

(2012) Hyeseung Lee et al.   MOLECULAR MICROBIOLOGY

HapX-Mediated Iron Homeostasis Is Essential for Rhizosphere Competence and Virulence of the Soilborne Pathogen Fusarium oxysporum

(2012) M. S. Lopez-Berges et al.   PLANT CELL

Secreted Aspartic Protease Cleavage of Candida albicans Msb2 Activates Cek1 MAPK Signaling Affecting Biofilm Formation and Oropharyngeal Candidiasis

(2012) Sumant Puri et al.   PLoS One

The Evolutionary Rewiring of Ubiquitination Targets Has Reprogrammed the Regulation of Carbon Assimilation in the Pathogenic Yeast Candida albicans

(2012) D. Sandai et al.   mBio

The CRE1 carbon catabolite repressor of the fungus Trichoderma reesei: a master regulator of carbon assimilation

(2011) Thomas Portnoy et al.   BMC GENOMICS

An Iron Homeostasis Regulatory Circuit with Reciprocal Roles in Candida albicans Commensalism and Pathogenesis

(2011) Changbin Chen et al.   Cell Host & Microbe

The Candida albicans GAP Gene Family Encodes Permeases Involved in General and Specific Amino Acid Uptake and Sensing

(2011) Lucie Kraidlova et al.   EUKARYOTIC CELL

Adaptation of Cryptococcus neoformans to Mammalian Hosts: Integrated Regulation of Metabolism and Virulence

(2011) Jim Kronstad et al.   EUKARYOTIC CELL

Contribution of the glycolytic flux and hypoxia adaptation to efficient biofilm formation by Candida albicans

(2011) Julie Bonhomme et al.   MOLECULAR MICROBIOLOGY

Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box

(2011) James W. Kronstad et al.   NATURE REVIEWS MICROBIOLOGY

The Temporal Dynamics of Differential Gene Expression in Aspergillus fumigatus Interacting with Human Immature Dendritic Cells In Vitro

(2011) Charles O. Morton et al.   PLoS One

Dual Organism Transcriptomics of Airway Epithelial Cells Interacting with Conidia of Aspergillus fumigatus

(2011) Jean L. Oosthuizen et al.   PLoS One

Identification of the CRE-1 Cellulolytic Regulon in Neurospora crassa

(2011) Jianping Sun et al.   PLoS One

Cryptococcus neoformans Requires a Functional Glycolytic Pathway for Disease but Not Persistence in the Host

(2011) M. S. Price et al.   mBio

In vivo Hypoxia and a Fungal Alcohol Dehydrogenase Influence the Pathogenesis of Invasive Pulmonary Aspergillosis

(2011) Nora Grahl et al.   PLoS Pathogens

Heptahelical Receptors GprC and GprD of Aspergillus fumigatus Are Essential Regulators of Colony Growth, Hyphal Morphogenesis, and Virulence

(2010) A. Gehrke et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Aspergillus fumigatus Catalytic Glucokinase and Hexokinase: Expression Analysis and Importance for Germination, Growth, and Conidiation

(2010) Christian B. Fleck et al.   EUKARYOTIC CELL

Regulation of virulence factors, carbon utilization and virulence by SNF1 in Cryptococcus neoformans JEC21 and divergent actions of SNF1 between cryptococcal strains

(2010) Jiao Yang et al.   FUNGAL GENETICS AND BIOLOGY

The GATA-type transcriptional activator Gat1 regulates nitrogen uptake and metabolism in the human pathogen Cryptococcus neoformans

(2010) Lívia Kmetzsch et al.   FUNGAL GENETICS AND BIOLOGY

Secreted Aspergillus fumigatus Protease Alp1 Degrades Human Complement Proteins C3, C4, and C5

(2010) J. Behnsen et al.   INFECTION AND IMMUNITY

Integration of General Amino Acid Control and Target of Rapamycin (TOR) Regulatory Pathways in Nitrogen Assimilation in Yeast

(2010) Kirk A. Staschke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain

(2010) Meiqing Shi et al.   JOURNAL OF CLINICAL INVESTIGATION

What makes Aspergillus fumigatus a successful pathogen? Genes and molecules involved in invasive aspergillosis

(2010) Ana Abad et al.   REVISTA IBEROAMERICANA DE MICOLOGIA

HapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus

(2010) Markus Schrettl et al.   PLoS Pathogens

HapX Positively and Negatively Regulates the Transcriptional Response to Iron Deprivation in Cryptococcus neoformans

(2010) Won Hee Jung et al.   PLoS Pathogens

Regulatory Diversity ofTUP1inCryptococcus neoformans

(2009) Hyeseung Lee et al.   EUKARYOTIC CELL

A Regulator of Aspergillus fumigatus Extracellular Proteolytic Activity Is Dispensable for Virulence

(2009) A. Bergmann et al.   INFECTION AND IMMUNITY

Transcription Factor PrtT Controls Expression of Multiple Secreted Proteases in the Human Pathogenic Mold Aspergillus fumigatus

(2009) H. Sharon et al.   INFECTION AND IMMUNITY

Time Course Global Gene Expression Analysis of an In VivoCandidaBiofilm

(2009) Jeniel E. Nett et al.   JOURNAL OF INFECTIOUS DISEASES

Deletion and overexpression of the Aspergillus nidulans GATA factor AreB reveals unexpected pleiotropy

(2009) K. H. Wong et al.   MICROBIOLOGY-SGM

The yeast Candida albicans evades human complement attack by secretion of aspartic proteases

(2009) Katharina Gropp et al.   MOLECULAR IMMUNOLOGY

Mutation ofCRE1inFusarium oxysporumreverts the pathogenicity defects of theFRP1deletion mutant

(2009) Wilfried Jonkers et al.   MOLECULAR MICROBIOLOGY

Cryptococcus neoformansSite-2 protease is required for virulence and survival in the presence of azole drugs

(2009) Clara M. Bien et al.   MOLECULAR MICROBIOLOGY

A Phenotypic Profile of the Candida albicans Regulatory Network

(2009) Oliver R. Homann et al.   PLoS Genetics

The Protein Kinase Tor1 Regulates Adhesin Gene Expression in Candida albicans

(2009) Robert J. Bastidas et al.   PLoS Pathogens

Nutritional control via Tor signaling in Saccharomyces cerevisiae

(2008) John R Rohde et al.   CURRENT OPINION IN MICROBIOLOGY

Mutational Analysis of theCandida albicansAmmonium Permease Mep2p Reveals Residues Required for Ammonium Transport and Signaling

(2008) Neelam Dabas et al.   EUKARYOTIC CELL

Recent Advances in Nitrogen Regulation: a Comparison betweenSaccharomyces cerevisiaeand Filamentous Fungi

(2008) Koon Ho Wong et al.   EUKARYOTIC CELL

Roles of theAspergillus nidulanshomologues of Tup1 and Ssn6 in chromatin structure and cell viability

(2008) Irene García et al.   FEMS MICROBIOLOGY LETTERS

CreA mediates repression of the regulatory gene xlnR which controls the production of xylanolytic enzymes in Aspergillus nidulans

(2008) Elsy N. Tamayo et al.   FUNGAL GENETICS AND BIOLOGY

A small G protein Rhb1 and a GTPase-activating protein Tsc2 involved in nitrogen starvation-induced morphogenesis and cell wall integrity of Candida albicans

(2008) Chang-Chih Tsao et al.   FUNGAL GENETICS AND BIOLOGY

Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis

(2008) Julian R. Naglik et al.   MICROBIOLOGY-SGM

Metabolic adaptation inCryptococcus neoformansduring early murine pulmonary infection

(2008) Guanggan Hu et al.   MOLECULAR MICROBIOLOGY

Genes Differentially Expressed in Conidia and Hyphae of Aspergillus fumigatus upon Exposure to Human Neutrophils

(2008) Janyce A. Sugui et al.   PLoS One

Metabolomics in Lung Inflammation:A High-Resolution1H NMR Study of Mice Exposedto Silica Dust

(2008) Jian Zhi Hu et al.   TOXICOLOGY MECHANISMS AND METHODS

Sub-Telomere Directed Gene Expression during Initiation of Invasive Aspergillosis

(2008) Andrew McDonagh et al.   PLoS Pathogens

GLN3 encodes a global regulator of nitrogen metabolism and virulence of C. albicans

(2007) Wei-Li Liao et al.   FUNGAL GENETICS AND BIOLOGY