Article
Nanoscience & Nanotechnology
Guowei Shen, Shichang Yan, Siyuan Shen, Feng Liang, Shouyun Xiao, Yunpeng Zhang, Yongtao Zhang, Huimin Ding
Summary: This study found that curculigoside has the potential to aid cartilage restoration in osteoarthritis patients by inhibiting the NLRP3 pathway.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Immunology
Yu-Wei Chang, Ling-Chien Hung, Yu-Cheng Chen, Wen-Hung Wang, Chun-Yu Lin, Hsin-Han Tzeng, Jau-Ling Suen, Yen-Hsu Chen
Summary: Insulin may reduce inflammation by regulating the NLRP3 inflammasome, as demonstrated in in vivo models, providing evidence for its potential immunomodulatory role in anti-inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Cai-Song Chen, Yao-Gang Zhang, Hai-Jiu Wang, Hai-Ning Fan
Summary: This study investigated the role and activation mechanism of the NLRP3 inflammasome in hepatic alveolar echinococcosis (HAE). The results showed that the activation of the inflammasome is associated with reactive oxygen species (ROS), and inhibition of ROS production can decrease the activation of the NLRP3-caspase-1-IL-1 beta pathway, thereby mitigating hepatocyte damage and inflammation.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Haosheng Zhang, Liang Ding, Xiaoqing Shi, Wei Mei, Zhengquan Huang, Li Zhang, Xiaochen Li, Bo Xu, Peimin Wang
Summary: The study demonstrated that imperatorin can reduce synovial inflammation and fibrosis, inhibit production of inflammatory mediators and cytokines, and decrease expressions of factors promoting synovial fibrosis.
Article
Cell Biology
Christina F. Budden, Linden J. Gearing, Romina Kaiser, Lena Standke, Paul J. Hertzog, Eicke Latz
Summary: The text explains that activation of inflammasomes can lead to inflammation and immune pathology, but EVs released by inflammasome-activated cells also contain specific RNA, which can induce interferon beta in bystander cells to suppress NLRP3 inflammasome responses.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Gastroenterology & Hepatology
Akinobu Nakata, Yuji Nadatani, Toshio Watanabe, Yuji Matsumoto, Satoshi Kosaka, Akira Higashimori, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Koichi Taira, Yasuaki Nagami, Tetsuya Tanigawa, Yasuhiro Fujiwara
Summary: The study revealed that NLRP3 inflammasome plays a crucial role in 5-FU-induced small intestinal mucositis, possibly exacerbating the disease through IL-1 beta maturation.
Article
Immunology
Leying Zhang, Yuanjing Li, Zhenyang Zhao, Jiabao Cai, Shuxin Zhao, Ling Yang
Summary: This study found that the expression of NLR family in the maternal thymus is changed during pregnancy stages, which may be related to the modulation of maternal thymic immune responses and beneficial for normal pregnancy in sheep.
Article
Immunology
Lucia de Almeida, Savita Devi, Mohanalaxmi Indramohan, Qi-Quan Huang, Rojo A. Ratsimandresy, Richard M. Pope, Andrea Dorfleutner, Christian Stehlik
Summary: Canonical inflammasomes are innate immune protein scaffolds that activate inflammatory responses. Excessive activation of inflammasomes is associated with inflammatory diseases. This study found that the protein POP1 regulates the inflammatory response in gout and functions by interfering with crucial interactions within the inflammasome complex.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
John Le, Yathushigan Kulatheepan, Samithamby Jeyaseelan
Summary: The respiratory system has various innate immune mechanisms to cope with microbial infections and limit tissue damage. Macrophages, neutrophils, dendritic cells, epithelial cells, and endothelial cells play key roles in this immune response. Recognition of invading microorganisms by the myeloid and structural cells of the respiratory system triggers a signaling cascade that leads to the activation of transcription factors, induction of cytokines/chemokines, recruitment of immune cells, and subsequent clearance of microbes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Lei Wang, Jiangwei Ding, Changliang Zhu, Baorui Guo, Wu Yang, Wenxin He, Xinxiao Li, Yangyang Wang, Wenchao Li, Feng Wang, Tao Sun
Summary: Semaglutide shows inhibitory effects on NLRP3 inflammasome activation and inflammatory cytokine secretion in both in vitro and in vivo inflammation models. It also reduces seizure severity, improves cognitive function, and decreases neuronal apoptosis, possibly through inhibition of NLRP3 inflammasome activation and inflammatory cytokine secretion. Semaglutide may be a novel and promising adjuvant therapeutic for epilepsy and its associated comorbidities.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Nan Xiang, Ting Yin, Tao Chen
Summary: The study suggests that Gardnerella vaginalis can induce bacterial vaginosis by promoting NLRP3 inflammasome-mediated pyroptosis, providing insights into one of the molecular mechanisms through which G. vaginalis induces BV.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Immunology
Hua Bai, Qifang Zhang
Summary: NLRP3 inflammasome activation plays a crucial role in the pathogenesis of Alzheimer's disease, through mechanisms involving cytokine production and protein deposition. Studying the activation mechanisms of NLRP3 may offer new insights into the pathogenesis of AD and provide novel approaches for its prevention and treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Yan-zhao Wei, Shuang Yang, Wei Li, Yan-hong Tang
Summary: In this study, the potential of gefapixant to inhibit cardiac sympathetic hypersensitivity and protect against cardiac remodeling after myocardial infarction was investigated. It was found that treatment with gefapixant at a dosage of 10 mg/kg per day improved cardiac function, decreased collagen expression, and suppressed cardiac inflammation.
CURRENT MEDICAL SCIENCE
(2023)
Article
Oncology
Yu Gao, Min Zhou, Wen Zhang, Jinxing Jiang, Zhibin Ouyang, Yuanfan Zhu, Nini Li
Summary: This study found that trophoblast cells express the NLRP3 inflammasome and can activate inflammasome, promote the production and release of IL-113 in response to L. monocytogenes infection. In mouse experiments, L. monocytogenes infection resulted in fetal resorption and IL-113 processing. Additionally, mice lacking NLRP3 were more susceptible to miscarriage at a lower infective dose compared to the wild-type group.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Sarah E. Corcoran, Reena Halai, Matthew A. Cooper
Summary: Activation of the NLRP3 inflammasome can lead to inflammatory responses and cell death, and is associated with various diseases. Inhibitors of NLRP3 have potential clinical value in preventing the harmful effects of NLRP3 activation on human diseases.
PHARMACOLOGICAL REVIEWS
(2021)