Article
Agriculture, Dairy & Animal Science
Bolin Zhang, Huilei Sun, Zewei Sun, Ning Liu, Rujie Liu, Qingzhen Zhong
Summary: Glutamine (Gln) addition protects porcine epithelial cells (IPEC-J2) from apoptosis and damage to the mucosal barrier induced by heat stress (HS), potentially through the mitochondrial apoptosis pathway mediated by heat shock protein 70 (HSP70). These findings provide a possible theoretical basis for mitigating HS-induced damage to porcine intestinal epithelium and offer insights for developing nutritional strategies to alleviate the negative effects of HS on farmed animals.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Mingzu Guo, Wenxi Xu, Yoshinari Yamamoto, Takuya Suzuki
Summary: The study found that curcumin can increase the expression of HSP70 in intestinal Caco-2 cells through transcriptional activation, possibly enhancing cell integrity. The effects of curcumin are regulated by various signaling pathways. This discovery is expected to contribute to a deeper understanding of the regulation of intestinal HSP70 by dietary components.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Neurosciences
Zhongting Zhao, Zheng Li, Fangning Du, Yixin Wang, Yue Wu, Kah-leong Lim, Lin Li, Naidi Yang, Changmin Yu, Chengwu Zhang
Summary: Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Misfolding, aggregation, and abnormal degradation of proteins are believed to be key factors in the pathogenesis of PD. Heat shock protein 70 (Hsp70) and Parkin, an E3 ubiquitin ligase, have been found to play important roles in PD pathogenesis. This review focuses on the dysregulation of Hsp70 and Parkin, their interaction, and their potential therapeutic applications in PD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zifei Han, Shelli R. McAlpine, Robert Chapman
Summary: This study demonstrates the successful delivery of inhibitors to block the interaction between Hsp70 and HOP using polymer nanogels. The results show the effectiveness of these inhibitors in inhibiting Hsp70 and inducing cancer cell death.
BIOORGANIC CHEMISTRY
(2022)
Article
Agronomy
Chuanbei Tian, Yaying Li, Yixia Wu, Wenqiang Chu, Huai Liu
Summary: In fluctuating climatic environments, heat acclimation in predatory mites is a superior adaptation strategy for effective agricultural pest management. The sustained accumulation of HSP70 proteins results in predatory mites with thermotolerance advantage, promoting their biological control function to pests. The divergent constitutive regulation of HSP70 to a thermal environment allows predators to adapt flexibly to extreme stress.
PEST MANAGEMENT SCIENCE
(2021)
Review
Biology
Xun Fu, Jiang Liu, Xin Yan, Michael E. DiSanto, Xinhua Zhang
Summary: Prostate cancer is the second most common cancer in aging men globally, but its exact pathogenesis is not fully understood. The heat shock protein (HSP) family plays a significant role in promoting tumor growth and protecting cancer cells from death. HSP molecules are closely involved in important biological processes such as cell differentiation, epithelial-mesenchymal transition, and fibrosis. Agents and inhibitors targeting the critical structure of HSP molecules have been developed for their potent antitumor effects. However, only a small number of them have been clinically tested. Further clinical studies are needed to establish the relationship between HSP70 family, HSP90 molecule, and prostate cancer treatment.
Article
Pediatrics
Chien-Chou Hsiao, Cheng-Han Lee, Rei-Cheng Yang, Jia-Yuh Chen, Tzu-Cheng Su, Yu-Jun Chang, Ching-Yuang Lin, Yi-Giien Tsai
Summary: This study revealed that Hsp-70 levels are associated with oxidative injury in the development of BPD. The development of BPD was significantly correlated with gestational age, respiratory distress syndrome, and TA Hsp-70 and 8-OHdG levels on post-natal Day 28. Further, the TA Hsp-70 level positively correlated with TA 8-OHdG level on both Day 1 and Day 28 of life.
FRONTIERS IN PEDIATRICS
(2021)
Correction
Biotechnology & Applied Microbiology
Xin Tang, Cheng Chang, Michelle Hao, Mei Chen, David T. Woodley, Axel H. Schonthal, Wei Li
Summary: A correction to the paper has been published at the given DOI link.
CANCER GENE THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Precious Adedayo Adesina, Itsuki Saeki, Yoshinari Yamamoto, Takuya Suzuki
Summary: Impaired integrity of the intestinal epithelium can lead to intestinal and extraintestinal diseases. Heat shock protein 70 (HSP70) plays a crucial role in maintaining intestinal homeostasis. This study investigates the molecular mechanisms behind the upregulation of HSP70 by n-butyrate, a major metabolite of the intestinal microbiota. The findings suggest that n-butyrate enhances HSP70 expression through the activation of heat shock factor 1 (HSF1) and AMP-activated protein kinase (AMPK) pathways.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Environmental Sciences
Tian Zhang, Wenhua Yan, Cong Liu, Weixia Duan, Yu Duan, Yuanyuan Li, Qin Yu, Yapei Sun, Jiacheng Tian, Jie Zhou, Zhiqin Xia, Guixue Wang, Shangcheng Xu
Summary: Cadmium (Cd) exposure induces ferroptosis of vascular endothelial cells (ECs), resulting in endothelial dysfunction and cardiovascular disease. Cd accumulates in ECs, leading to increased lipid peroxidation and disrupted oxidoreductase system. Cd decreases Gpx4 expression and alters mitochondrial morphology, causing reduced ECs and caudal venous plexus in zebrafish embryos, as well as decreased survival rate of HUVECs. Inhibition of Hsp70 ameliorates Cd-induced ferroptosis by targeting multiple factors, including Gpx4, Fth1, Nrf2, and Acsl4. Regulation of Hsp70 is therefore a promising approach for alleviating Cd-induced endothelial damage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Parasitology
Desmond O. Agwunobi, Tongxuan Wang, Meng Zhang, Tianhong Wang, Qingying Jia, Miao Zhang, Xinyue Shi, Zhijun Yu, Jingze Liu
Summary: In this study, genes of hsp70 and hsp90 cDNA were cloned and characterized from the tick Dermacentor silvarum, and their functions in cold stress were evaluated. Results showed that Dshsp70 and Dshsp90 play essential roles in the low-temperature adaptation of ticks. This study contributes to understanding the survival and acclimatization of overwintering ticks.
PARASITES & VECTORS
(2021)
Article
Biochemistry & Molecular Biology
Chang-Li Yang, Jian-Yu Meng, Lv Zhou, Chang-Yu Zhang
Summary: UV-B radiation directly affects insect growth, development, and reproduction. Heat shock protein 70s (Hsp70s) plays a crucial role in insect adaptation to the environment. This study identified seven complete complementary DNA sequences of MpHsp70s in Myzus persicae and found that they were expressed ubiquitously during different developmental stages. Exposure to UV-B stress significantly upregulated the expression of MpHsp70s. Suppression of MpHsp70 expression using dsMpHsp70 nanocarriers reduced the body size, weight, survival rate, and fecundity of M. persicae under UV-B exposure. Combining RNAi approaches showed greater effects on survival rate and fecundity under UV-B stress, except for MpHsc70-4.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Entomology
Shou-Min Fang, Qian Zhang, Yu-Li Zhang, Gui-Zheng Zhang, Ze Zhang, Quan-You Yu
Summary: The heat shock protein 70 family was identified in the whole genome of the silkworm, showing important roles in protecting against environmental stresses. The stress-inducible forms were found to play more crucial roles in adaptation to various stresses compared to the heat shock cognates.
Article
Biochemistry & Molecular Biology
Tong Wu, Yanan Sheng, Yu Tian, Changyuan Wang
Summary: The study found that vitexin can alleviate heat stress and reduce cell apoptosis. Vitexin protects cells from heat stress-induced apoptosis by inhibiting intracellular reactive oxygen species levels and modulating the expression of heat shock proteins. This study provides a theoretical basis for the prevention and amelioration of heat stress using vitexin.
Article
Veterinary Sciences
Jae-Yeon Park, Jihoon Ryu, Jung-Eun Park, Eui-Ju Hong, Hyun-Jin Shin
Summary: This study found that HSP70 plays an important role in PEDV replication, with its overexpression increasing the speed of viral replication, while knockout significantly reduces PEDV protein expression and replication. Furthermore, the study confirmed the crucial role of the PEDV membrane (M) protein in collaboration with HSP70 in viral replication in infected cells.
VETERINARY RESEARCH
(2021)
