Article
Toxicology
Yajie Wang, Hao Zhao, Fan Wang, Huiming Nong, Yanan Li, Yue Xu, Mingqiang He, Jianfeng Li
Summary: This study aimed to investigate the expression of DJ-1 in auditory cells and its correlation with cisplatin-induced ototoxicity. DJ-1 expression was detected in mouse cochlea hair cells and HEI-OC1 cells, and was reduced by cisplatin treatment. DJ-1 participated in cisplatin-induced cell damage by regulating apoptosis and autophagy. These findings provide a new strategy for the prevention of cisplatin-induced ototoxicity.
TOXICOLOGY LETTERS
(2023)
Article
Pharmacology & Pharmacy
Stefania Magnano, Patricia Hannon Barroeta, Ronan Duffy, Jeff O'Sullivan, Daniela M. Zisterer
Summary: The study evaluated the role of autophagy in mediating cisplatin resistance in oral squamous cell carcinoma (OSCC) cells. Results demonstrated that cisplatin induces both apoptosis and autophagy in OSCC cells through the ROS/JNK pathway. However, autophagy did not play a significant role in acquired resistance to cisplatin or have a pro-survival effect in the cells. This suggests a complex interplay between apoptosis and autophagy pathways in OSCC.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Benyu Nan, Zirui Zhao, Kanglun Jiang, Xi Gu, Huawei Li, Xinsheng Huang
Summary: In this study, it was demonstrated through computer simulation and experimental validation that Astaxanthine (AST) can reduce cisplatin-induced ototoxicity through the NRF2-mediated pathway, reducing overexpression of reactive oxygen species (ROS), improving mitochondrial dysfunction, and reducing cell apoptosis, thereby promoting cell survival.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemistry & Molecular Biology
Dongyang Gao, Runchang Wang, Yuwen Gong, Xiaoquan Yu, Qian Niu, Enguang Yang, Guangrui Fan, Junhai Ma, Chaohu Chen, Yan Tao, Jianzhong Lu, Zhiping Wang
Summary: This study demonstrates that CAB39 enhances autophagy in muscle-invasive bladder cancer cells, protecting mitochondria and other organelles to reduce cell damage caused by cisplatin and other harmful substances, thus influencing cisplatin resistance.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Andrea M. P. Romani
Summary: Cisplatin is a commonly used chemotherapy agent that inhibits the growth of cancer cells by interfering with their DNA repair mechanism. However, its usage is limited due to significant side effects. Recent research has focused on combining cisplatin with other anti-cancer drugs and exploring its immunomodulatory effects.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yinghui Shang, Qinghai Wang, Jian Li, Haiting Liu, Qiangqiang Zhao, Xueyuan Huang, Hang Dong, Wansong Chen, Rong Gui, Xinmin Nie
Summary: ZrO2 NPs induce cell death in HeLa cells through elevation of intracellular ROS, mitochondrial damage, promotion of autophagy and apoptosis.
FRONTIERS IN CHEMISTRY
(2021)
Review
Toxicology
Bingqing Wang, Yue Wang, Jing Zhang, Chang Hu, Jun Jiang, Yiming Li, ZhiYong Peng
Summary: Reactive oxygen species (ROS) play a crucial role in cell death processes such as apoptosis, autophagy, and ferroptosis through lipid peroxidation. The oxidation of phospholipid bilayers can trigger mitochondrial apoptosis and endoplasmic reticulum stress, while also affecting autophagy. Additionally, ROS and lipid peroxides are involved in ferroptosis, and the nuclear factor erythroid 2-related factor 2 regulates ferroptosis under oxidative conditions. This review provides insights into the interplay among apoptosis, autophagy, and ferroptosis mediated by ROS and lipid peroxidation, offering new directions for studying diseases related to pathological cell death.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Oncology
Huynh Diem Thi Ngoc, Yujin Jin, Chang-Seon Myung, Kyung-Sun Heo
Summary: Breast cancer is the most common cause of cancer-related deaths among women globally. Ginsenoside Rh1 exhibits potential anticancer effects on breast cancer cells by inducing cell cycle arrest, apoptosis, and autophagy via inhibition of the ROS-mediated PI3K/Akt pathway.
Article
Pharmacology & Pharmacy
Yucong Xue, Muqing Zhang, Miaomiao Liu, Yu Liu, Li Li, Xue Han, Zhenqing Sun, Li Chu
Summary: 8-gingerol (8-Gin) is a phenolic substance extracted from ginger that has been shown to have multiple pharmacological properties. This study found that 8-Gin can reduce J-point elevation and heart rate, decrease cardiac weight index and left ventricle weight index, suppress ROS generation, attenuate ISO-induced heart damage, lower collagen levels, inhibit autophagosome formation, modulate protein activities related to apoptosis, and increase expressions of the PI3K/Akt/mTOR signaling pathway. These findings suggest that 8-Gin may exert cardioprotective effects against myocardial fibrosis by inhibiting ROS generation, apoptosis, and autophagy through modulation of the PI3K/Akt/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fei Li, Jingyao Li, Pei-Hui Wang, Nanyan Yang, Junyu Huang, Jinxin Ou, Ting Xu, Xin Zhao, Taoshu Liu, Xueying Huang, Qinghuan Wang, Miao Li, Le Yang, Yunchen Lin, Ying Cai, Haisheng Chen, Qing Zhang
Summary: The study found that SARS-CoV-2 infection induces autophagy and apoptosis in cells by upregulating intracellular reactive oxygen species (ROS) levels, inhibiting the PI3K/AKT/mTOR pathway, and ultimately triggering inflammatory responses and cell apoptosis. These findings are crucial for understanding the pathogenic inflammation mechanism induced by SARS-CoV-2 infection and developing anti-inflammatory therapies for COVID-19 patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Medicine, Research & Experimental
Zhi-Hong Wen, Hsiao-Mei Kuo, Po-Chang Shih, Ling-Chen Hsu, Jimmy Ming-Jung Chuang, Nan-Fu Chen, Hsi-Wen Sun, Hsin-Tzu Liu, Chun-Sung Sung, Wu-Fu Chen
Summary: This study evaluated the effects of isoaaptamine and aaptamine on cell viability in glioblastoma multiforme (GBM) cell lines. The results showed that isoaaptamine was more potent than aaptamine in these cell lines, with GBM 8401 being the most sensitive. The study also found that isoaaptamine could induce apoptosis, increase oxidative stress, disrupt mitochondrial function, and trigger autophagy in GBM cells.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Medicinal
Liqun Qu, Jianhui Wu, Yong Tang, Xiaoyun Yun, Hang Hong Lo, Lu Yu, Wenhua Li, Anguo Wu, Betty Yuen Kwan Law
Summary: The study found that Licochalcone B (LCB) has neuroprotective effects against oxidative stress-induced damage in neuronal cells. It reduces cell cytotoxicity and apoptosis, lowers the level of oxidative stress markers, and induces autophagy and signaling pathways to protect against damage.
Article
Biotechnology & Applied Microbiology
Jiamen Shen, Jiatian Dong, Feng Shao, Jiaying Zhao, Lifeng Gong, Huipeng Wang, Wenjie Chen, Yafei Zhang, Yuankun Cai
Summary: This study found that graphene oxide (GO) exhibits anticancer effects against colorectal cancer. GO activates the AMPK/mTOR/ULK1 signaling pathway through the production of reactive oxygen species (ROS), leading to apoptosis and autophagy, thereby inhibiting tumor growth.
Article
Neurosciences
Yunzhu Yang, Jiafa Zhang, Canhong Yang, Bo Dong, Yanhong Fu, Yuanyuan Wang, Ming Gong, Tao Liu, Pingming Qiu, Weibing Xie, Tianming Lu
Summary: The study showed that sulforaphane played a protective role on neurons by inhibiting autophagy initiation, autophagic lysosomal membrane permeability, and NLRP3/caspase-1 inflammasomes activation in Aβ-activated microglia. It also inhibited M1 phenotype polarization. These findings provide new insights into the potential role of sulforaphane in AD therapy.
Article
Biotechnology & Applied Microbiology
yingBai Ying, meiCheng Yue, Wenhua Wang, Lijuan Yang, Yongxiu Yang
Summary: This study demonstrates that Alloimperatorin induces autophagy in cervical cancer cells through the reactive oxygen species pathway, inhibiting cell proliferation and increasing apoptosis rate. In vivo experiments on nude mice show that Alloimperatorin effectively inhibits tumor growth, suggesting it as a potential new drug for cervical cancer treatment.