Review
Endocrinology & Metabolism
Nadine Mundt, Lina Kenzler, Marc Spehr
Summary: Adenosine triphosphate (ATP) is not only the essential source of cellular energy, but also functions as an extracellular signal that activates purinergic receptors. Purinergic signaling plays a crucial role in male reproductive system functions, particularly in spermatogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Ophthalmology
Asuka Takeyama, Yutaka Imamura, Masaki Shibata, Yuko Komiya, Masahiro Ishida
Summary: This study demonstrates that using BBG-assisted ERM surgery can lead to better visual improvement and fewer structural changes in the inner retinal layers. BBG-assisted ILM peeling is safe both functionally and anatomically.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Anatomy & Morphology
Takuya Yokoyama, Hiroki Saito, Nobuaki Nakamuta, Yoshio Yamamoto
Summary: The study found VNUT in SIF cells in the rat superior cervical ganglion, suggesting these cells modulate the excitability of sensory nerve endings and postganglionic neurons through ATP release.
Article
Ophthalmology
Ru Zhao, Tao He, Yiqiao Xing, Jinyuan Luo
Summary: This study finds that COG1410 regulates the state of microglia and protects retinal ganglion cells in retinal ischemia-reperfusion injury, showing promising potential for the treatment of eye diseases.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Immunology
Miao Wei, Guowei Zhang, Zeyu Huang, Xuemeng Ding, Qing Sun, Yujian Zhang, Rongrong Zhu, Huaijin Guan, Min Ji
Summary: This study investigates the role of ATP-P2X(7)R in mediating microglial senescence and glaucoma progression. The results suggest that ATP-P2X(7)R induces microglial senescence by inhibiting the PINK1-mediated mitophagy pathway, leading to retinal ganglion cell damage. Specifically inhibiting ATP-P2X(7)R may be a fundamental approach for targeted therapy of RGC injury in microglial aging-related glaucoma.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Ophthalmology
Kaku Itoh
Summary: This study evaluated the stainability of several acrylic intraocular lenses (IOLs) with Brilliant Blue G (BBG) in vitro. The results showed that all acrylic IOLs can be stained with BBG, with hydrophilic IOLs being more susceptible to staining. Precautions should be taken in surgeries requiring the use of BBG staining, and efforts should be made to ensure sufficient intraoperative washing of the dye.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ranit Pariary, Sandip Dolui, Gourav Shome, Sk Abdul Mohid, Achintya Saha, Bhisma N. Ratha, Amaravadhi Harikishore, Kuladip Jana, Atin K. Mandal, Anirban Bhunia, Nakul C. Maiti
Summary: Our studies demonstrate that Coomassie Brilliant Blue G-250 shows promise as a chemical chaperone for stabilising the alpha-helical native human insulin conformers, preventing their aggregation and increasing insulin secretion. This multipolar effect, along with its non-toxic nature, could be valuable for the development of highly bioactive, targeted, and biostable therapeutic insulin.
CHEMICAL COMMUNICATIONS
(2023)
Article
Cell Biology
Yayi Wang, Shida Chen, Jiawei Wang, Yaoming Liu, Yang Chen, Tao Wen, Xiuli Fang, Manuel Vidal-Sanz, Jost B. Jonas, Xiulan Zhang
Summary: The study identified the key role of miR-93 in retinal microglial cells' reaction, showing that its overexpression can significantly reduce microglial functions, cytokine release, and subsequent RGCs death, while inhibiting the STAT3 pathway for neuroprotection.
CELL DEATH & DISEASE
(2021)
Article
Medicine, General & Internal
Gaku Terauchi, Kei Shinoda, Kazuma Yagura, Makoto Kawashima, Soiti Celso Matsumoto, Atsushi Mizota, Yozo Miyake
Summary: This study aimed to determine the effect of brilliant blue G (BBG) staining on macular function. The results showed that intravitreal injection of BBG did not alter the physiology of the macula, indicating that it is safe. Additionally, iFMERGs can be used to monitor macular function during intraocular surgery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Razvan-Geo Antemie, Ovidiu Ciprian Samoila, Simona Valeria Clichici
Summary: Light plays a fundamental role in regulating numerous processes in our body. With the increasing use of electronic devices emitting blue light, the human retina has been exposed to higher levels of it. This study aims to gather recent data and suggest future directions for studies on the potential harmful effects of blue light on the human retina and body.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Yuko Komiya, Asuka Takeyama, Masaki Shibata, Yutaka Imamura, Masahiro Ishida
Summary: This study compared the outcomes of idiopathic macular hole (MH) surgery with and without the use of Brilliant Blue G (BBG) staining. It found that patients who underwent BBG-assisted surgery had faster recovery of outer retinal structures and greater visual improvement compared to those without BBG.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Cell Biology
Todd McLaughlin, Jinli Wang, Liyun Jia, Fuguo Wu, Yaqin Wang, Joshua J. Wang, Xiuqian Mu, Sarah X. Zhang
Summary: The chaperone p58(IPK) plays a protective role in the retina by reducing retinal ganglion cell (RGC) injury, which is mediated through its expression in retinal neurons. This finding provides a new direction and strategy for the treatment of neurodegenerative retinal diseases.
Article
Ophthalmology
Ramesh Venkatesh, Rubble Mangla, Shama Sharief, Jay Chhablani
Summary: This study aimed to investigate the long-term effects of retinal phototoxicity after macular hole repair surgery with xenon endolight illumination and Brilliant blue G dye. An elderly man underwent vitrectomy with BBG dye for idiopathic full-thickness macular hole repair. The patient experienced progressive damage to the outer retinal layers and retinal pigment epithelium over a 4-year period.
Article
Materials Science, Multidisciplinary
Omer Gullu
Summary: In this study, an aluminum/Coomassie Brilliant Blue G-250/p-Si photovoltaic diode was produced using solution-processing method. Admittance analysis was performed to analyze the interface and dielectric parameters. The results showed that frequency and applied bias voltage had a strong influence on the real and imaginary parts of dielectric constant, electric modulus, and electrical conductivity.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2022)
Review
Biochemistry & Molecular Biology
Daniel Jamrozik, Radoslaw Dutczak, Joanna Machowicz, Alicja Wojtyniak, Adrian Smedowski, Marita Pietrucha-Dutczak
Summary: Metallothioneins are metal-rich proteins that play important roles in metal homeostasis and detoxification, as well as protecting cells against oxidative stress and promoting cell survival and differentiation. In the eye, these proteins are vital for protecting neuronal retinal cells and disruption in their expression may contribute to age-related eye diseases. This review emphasizes the potential of metallothioneins as a key component of the retinal neurons' endogenous protection system and discusses their expression changes in common eye diseases, as well as their potential as biomarkers for cancer diagnosis.
