Article
Oncology
Cheng Zhang, Bin Shen, Xinwei Chen, Shang Gao, Xinjiang Ying, Pin Dong
Summary: This study identified a four-mRNA signature that could serve as a biomarker for predicting prognosis in LSCC, especially in the long term. The gene signature was validated and shown to stratify patients into high- and low-risk groups with significantly different overall survival rates.
Article
Oncology
Yan Huang, Min Gu, Qi Wu, Juanfen Zhu, Jian Wu, Peipei Wang, Meihua Wang, Judong Luo
Summary: This study conducted a systematic review and meta-analysis to investigate the association between Helicobacter pylori infection in the larynx and laryngeal cancer. The results showed that Helicobacter pylori infection significantly increased the risk of malignant tumors in the larynx, even when controlling for smoking factors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Su-Mei Yang, Meng Wu, Feng-Yan Han, Yu-Man Sun, Jun-Quan Yang, Hong-Xia Liu
Summary: This study found that HPV positivity and PD-L1 expression positivity are correlated with better overall survival in patients with laryngeal squamous cell carcinoma, serving as useful prognostic biomarkers. Smoking and late stage were associated with poor survival outcomes.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2021)
Article
Oncology
Leonardo Franz, Lorenzo Nicole, Anna Chiara Frigo, Giancarlo Ottaviano, Piergiorgio Gaudioso, Tommaso Saccardo, Francesca Visconti, Rocco Cappellesso, Stella Blandamura, Ambrogio Fassina, Gino Marioni
Summary: The mechanism of epithelial-mesenchymal transition (EMT) plays a crucial role in cancer development, tumor progression, and therapy resistance. In laryngeal carcinoma, the predictive value of pN+ status and Slug expression on disease-free survival was identified, supporting the hypothesis of a mutual concurrence of EMT and angiogenesis in driving aggressive phenotype in LSCC. Further studies are needed to characterize the predictive performance of prognostic models based on EMT and angiogenesis.
Article
Biochemistry & Molecular Biology
Lara Alessandrini, Leonardo Franz, Marta Sbaraglia, Tommaso Saccardo, Filippo Cappello, Alessandro Drigo, Anna Chiara Frigo, Gino Marioni
Summary: PD-L1 expression in the tumor microenvironment depends on the interaction between neoplastic and immune cells. The tumor to stroma ratio (TSR) is associated with prognosis in laryngeal squamous cell carcinoma (LSCC). This study analyzed the association between TSR, PD-L1 expression, and other clinical-pathological features in LSCC biopsies and surgical specimens. The findings suggest that low TSR and high PD-L1 expression are associated with poor prognosis in LSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Hui-Ching Lau, Yujie Shen, Qiang Huang, Hui-Ying Huang, Liang Zhou
Summary: Research identified and validated two novel glycolytic gene signatures, DDIT4 and PLOD2, as potential independent risk factors for predicting overall survival in laryngeal squamous cell carcinoma (LSCC). These findings may provide a therapeutic target and survival prediction marker for LSCC patients.
Article
Oncology
Ching-Mei Chen, Tian-Huei Chu, Chih-Chi Chou, Chih-Yen Chien, Jian-Shiang Wang, Chao-Cheng Huang
Summary: The study indicates that exosomal miR-155 and miR-21 are upregulated in OSCC patients, while miR-126 is downregulated. MiR-155 and miR-21 promote cell proliferation and invasion by suppressing PTEN and Bcl-6 tumor suppressors, while miR-126 inhibits oncogenic behaviors and EGFL7 expression. Exosomal miRNAs in blood may serve as biomarkers for the diagnosis and prognosis of OSCC.
Article
Multidisciplinary Sciences
Nan Wang, Xuanyu Huang, Jinsheng Cheng
Summary: The study found that BIRC5 was strongly correlated with higher tumor grade and differentiation in Laryngeal squamous cell carcinoma (LSCC), and increased expression of BIRC5 was associated with overall survival in LSCC patients. Suppression of BIRC5 induced cell apoptosis and cell cycle arrest, inhibiting proliferation of LSCC cells. Higher level of BIRC5 expression predicted poor prognosis of LSCC patients, suggesting BIRC5 as a promising prognostic biomarker for LSCC.
Article
Oncology
Yong Shi, Dongli Yang, Yixiao Qin
Summary: This study revealed a ceRNA regulatory network in LSCC and identified four lncRNAs associated with patient prognosis. These lncRNAs play a significant role in the progress of LSCC by affecting the proliferation and metastasis of tumor cells.
Article
Oncology
Zhendong Yang, Jinxin Wang, Chun Chen, Peng Sun, Yafeng Yu
Summary: The study found that PD-L1 expression in CAFs of advanced LSCC was higher than that in NFs, and downregulation of PD-L1 can reduce the proliferation and migration capacities of CAFs and HEP-2 cells while enhancing the proliferation and pro-inflammatory function of T cells.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Review
Biochemistry & Molecular Biology
Juan P. Rodrigo, Mario Sanchez-Canteli, Fernando Lopez, Gregory T. Wolf, Juan C. Hernandez-Prera, Michelle D. Williams, Stefan M. Willems, Alessandro Franchi, Andres Coca-Pelaz, Alfio Ferlito
Summary: Tumor-infiltrating lymphocytes (TIL) have been shown to be prognostically significant in Laryngeal Squamous Cell Carcinoma (LSCC), with high stromal TIL, CD8+ TIL, and CD3+/CD4+ TIL associated with better clinical outcomes. Evaluation of TIL in HE sections and assessment of CD3+, CD4+, and/or CD8+ TIL levels may serve as predictive markers for patient prognosis in LSCC.
Article
Oncology
Yan Li, Kunlun Wang, Erjiang Zhao, Bingxu Li, Shenglei Li, Xiaotao Dong, Ling Yuan, Hui Yang
Summary: Serum LDH is a powerful independent predictor for PFS and OS in advanced ESCC patients treated with anti-PD-1 therapy.
PATHOLOGY & ONCOLOGY RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Bin-Yu Mo, Guo-Sheng Li, Su-Ning Huang, Wei-Ying He, Li-Yuan Xie, Zhu-Xin Wei, Ya-Si Su, Yue Liang, Li Yang, Cheng Ye, Wen-Bin Dai, Lin Ruan
Summary: This research explored the molecular mechanisms of laryngeal squamous cell carcinoma (LSCC) using high-throughput datasets and identified key genes associated with LSCC. It also revealed that HOXB13 expression and gender are independently associated with LSCC prognosis for the first time, suggesting HOXB13 may be a novel marker for clinical screening and treatment of LSCC.
Article
Oncology
Jiangyue Lu, Lehui Du, Xiao Lei, Zhibo Zhang
Summary: This study aimed to determine whether the immune prognostic index (ECIPI), based on hemoglobin (Hb) and neutrophil-to-lymphocyte ratio (NLR), could predict the prognosis in patients with advanced esophageal squamous cell carcinoma (ESCC) receiving programmed cell death-1 (PD-1) inhibitor treatment. The results showed that pretreatment ECIPI was associated with the prognosis in advanced ESCC patients with anti-PD-1 therapy, suggesting that ECIPI may be a useful tool to identify patients likely sensitive to PD-1 inhibitors.
Article
Dentistry, Oral Surgery & Medicine
Yingying Zhu, Xiaoli Zhu, Wenwen Diao, Zhiyong Liang, Zhiqiang Gao, Xingming Chen
Summary: This study aims to investigate the association of immune markers with high risk HPV 16 infection and PD-L1 expression in OPSCC patients. The results showed that patients with HPV positive OPSCC had better prognosis and higher PD-L1 expression compared to HPV negative patients.
CLINICAL ORAL INVESTIGATIONS
(2023)