Article
Medical Laboratory Technology
Xiaoyan Dong, Junwu Zhang, Fangfang Yang, Jinlin Liu, Yumeng Peng, Yumei Ge
Summary: This study found that serum levels of CXCL8, CXCL9, and CXCL10 were significantly increased in seroresistant syphilitic patients, with CXCL8 showing a strong association with platelets and CXCL10 being significantly positively related to INR levels.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Microbiology
Xin Yu, Ying Chen, Lele Cui, Kaming Yang, Xumeng Wang, Linyuan Lei, Yanping Zhang, Xinyi Kong, Wanwen Lao, Zhenlin Li, Yang Liu, Yuetong Li, Changlong Bi, Chao Wu, Aixia Zhai
Summary: This study found that CXCL8, CXCL9, CXCL10, and CXCL11 can be used as serum biomarkers to forecast liver injury caused by HBV infection, using a combination of bioinformatics, cell experiments, and clinical correlation analysis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Parasitology
Debashis Ghosh, Md Utba Rashid, Soumik Kha Sagar, Md Rasel Uddin, Shomik Maruf, Prakash Ghosh, Rajashree Chowdhury, Md Abu Rahat, Md Nazmul Islam, M. M. Aktaruzzaman, Abu Nayeem Mohammad Sohel, Megha Raj Banjara, Axel Kroeger, Abraham Aseffa, Dinesh Mondal
Summary: The study aimed to explore the epidemiological, serological, and entomological aspects of visceral leishmaniasis (VL) in suspected new VL foci and assess the knowledge, attitude, and practices of the community living in the alleged new VL foci. The study found some areas with VL infection but no new active cases in the suspected new foci, highlighting the need for early detection and community awareness to control the spread of the disease.
Article
Cell Biology
Yuwen Chen, Ying Wang, Jian Xu, Tingting Hou, Jing Zhu, Yingzi Jiang, Liying Sun, Chunling Huang, Lulu Sun, Su Liu
Summary: Chemokines, including CCL2, CCL5, CXCL1, CXCL10, and CXCL13, are found to be significantly elevated following traumatic brain injury (TBI), and their concentrations are negatively correlated with the severity of injury and clinical outcome. CCL2 may serve as an independent predictor for TBI severity and outcome. Combination of GCS score, CCL2, and CXCL10 may offer a better assessment of prognosis for moderate and severe TBI.
Article
Public, Environmental & Occupational Health
Shomik Maruf, Soumik Kha Sagar, Md Utba Rashid, Md Rasel Uddin, Debashis Ghosh, Prakash Ghosh, Rupen Nath, Abu Nayeem Mohammad Sohel, M. M. Aktaruzzaman, Md. Nazmul Islam, Megha Raj Banjara, Axel Kroeger, Abraham Aseffa, Dinesh Mondal
Summary: COVID-19 has impacted the management of Visceral leishmaniasis (VL) in Bangladesh, resulting in extended treatment and reporting times for VL patients, as well as hindrances in indoor residual spraying activities. The study emphasizes the importance of long-term follow-up, effective vector control measures, and capacity development in sustaining the elimination goal in VL endemic regions.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Dermatology
Tangxiele Liu, Ji Li, Zhili Deng, Mengting Chen, Ke Sha, Wenqin Xiao, Hongfu Xie, Zhixiang Zhao
Summary: This study examined the serum levels of various chemokines in rosacea patients and found that the concentrations of CCL3, CXCL8, CXCL9, and CXCL10 were significantly increased. The levels of these chemokines correlated with the severity of rosacea. The expression of their corresponding receptors was also elevated in the skin lesions of rosacea patients and mouse model. These findings may contribute to the clinical diagnosis and treatment of rosacea.
JOURNAL OF DERMATOLOGY
(2022)
Article
Pediatrics
Giulia Baresi, Mauro Giacomelli, Daniele Moratto, Marco Chiarini, Immacolata Claudia Conforti, Rita Padoan, Piercarlo Poli, Silviana Timpano, Francesca Caldarale, Raffaele Badolato
Summary: The study compared inflammatory markers in CF patients with and without COVID-19, aiming to understand the changes in inflammation levels during the pandemic in individuals with cystic fibrosis.
FRONTIERS IN PEDIATRICS
(2021)
Article
Parasitology
Shaila Basnyat, Megha Raj Banjara, Prakash Ghimire, Greg Matlashewski, Anjana Singh
Summary: Visceral leishmaniasis (VL) is a life-threatening disease caused by Leishmania donovani, transmitted by sand flies in Nepal. Seroprevalence study in three endemic districts found asymptomatic individuals as potential reservoirs for VL transmission, with higher infection rates in children under 15. Family members of diagnosed VL cases did not show seropositivity.
PARASITOLOGY INTERNATIONAL
(2021)
Article
Microbiology
Koushik Mondal, Shantanabha Das, Khudiram Naskar, Syamal Roy
Summary: The study found that in antimony-resistant L. donovani infection, there is an increase in Transitional T3 B cells and B1a B cells in the spleen, accompanied by alterations in the Follicular B cell population. Additionally, the drug-resistant strain induced elevated levels of IL-10 from B1a B cells and IL-6 from Transitional T3 B cell subsets in the spleen.
Article
Parasitology
Livia Mendes Carvalho, Miria Rodrigues Gusmao, Ana Flavia Pereira Costa, Rory Cristiane Fortes de Brito, Rodrigo Dian de Oliveira Aguiar-Soares, Jamille Mirelle de Oliveira Cardoso, Alexandre Barbosa Reis, Claudia Martins Carneiro, Bruno Mendes Roatt
Summary: The immunochemotherapy using miltefosine along with LBSapMPL-vaccine showed promising results in controlling Leishmania infection and upregulating immunity, suggesting it as a potential alternative option for human and canine visceral leishmaniasis.
Article
Biochemistry & Molecular Biology
Amir Atapour, Farideh Ghalamfarsa, Samaneh Naderi, Gholamreza Hatam
Summary: Leishmaniasis is a disease caused by a parasitic infection, and the development of vaccines faces challenges. However, a fusion protein designed using bioinformatics methods shows potential for use as a candidate vaccine for the disease.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
N. Shaslinah, P. Sangavi, R. Sangeetha, S. Gowthamkumar, V. Sindhu, K. Langeswaran
Summary: Through computational analysis, we identified a compound from the Specs database as a potential inhibitor for Trypanothione synthetase, a target protein for V. leishmaniasis.
JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY
(2022)