期刊
MOLECULAR IMMUNOLOGY
卷 88, 期 -, 页码 106-115出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2017.06.023
关键词
BmHDD1; 20E; Insect immunity; Bacterial response; Bombyx mori
资金
- National Natural Science Foundation of China [31672496]
- Natural Science Foundation of Chongqing [cstc2016jcyjA0425]
- Chongqing University Innovation Team Building Program funded projects [CXTDX201601010]
- Graduate Scientific Research Foundation of Chongqing [CYB2015067]
- Fundamental Research Funds for the Central Universities [XDJK2015D021]
Insects have evolved an effective immune system to respond to various challenges. In this study, a novel immune-related gene, called BmHDDI, was first charactered in silkworm, Bombyx mori. BmHDD1 contained an ORF of 837 bp and encoding a deduced protein of 278 amino acids. BmHDD1 was specifically expressed in hemocytes, and highly expressed at the molting and metamorphosis stages under normal physiological conditions. Our results suggested that BmHDD1 was mainly generated by hemocytes and secreted into hemolymph. Our results also showed that the expression level of BmHDDI was significantly increased after 20E injection, which indicated that BmHDD1 might be regulated by ecdysone. More importantly, BmHDD1 was dramatically induced after injected with different types of PAMPs or bacteria, either in hemocytes or fat body. Those results suggested that BmHDD1 plays a role in developing and immunity system in silkworm, Bombyx mori.
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