Article
Biochemistry & Molecular Biology
David G. Mahal
Summary: This study revealed the genetic affinities of Brahmins with foreign populations as well as with domestic non-Brahmin groups in India. By tracing Y-chromosome haplogroups and genetic markers, the deep ancient origins of Brahmins were identified, with their progenitors emerging from at least 12 different geographic regions worldwide. Additionally, the study found that 83% of Brahmins in the dataset belonged to four major haplogroups, two from Central Asia, one from the Fertile Crescent, and one of indigenous Indian origin.
MOLECULAR GENETICS AND GENOMICS
(2021)
Article
Biotechnology & Applied Microbiology
Balnd M. Albarzinji, Farhad M. Abdulkarim, Shaho A. Hussein, Dlshad Rashid, Hayder Lazim
Summary: This study investigates the population relationship of the Sorani Kurdish population in Sulaymaniyah province using DNA samples. The results show that the J2 subclade predominates in this population, and they cluster with Asian populations while being furthest from European and African populations.
Article
Biochemistry & Molecular Biology
Isaac J. Nijman, Benjamin D. Rosen, Philippe Bardou, Thomas Faraut, Tristan Cumer, Kevin G. Daly, Zhuqing Zheng, Yudong Cai, Hojjat Asadollahpour, Bengi Cinar Kul, Wei-Yi Zhang, Guangxin E, A. Ayin, Hayley Baird, Meirat Bakhtin, Valentin A. Balteanu, Diana Barfield, Beate Berger, Thor Blichfeldt, Geert Boink, Sri R. A. Bugiwati, Zexi Cai, Sean Carolan, Emily Clark, Vlatka Cubric-Curik, Muhammad I. A. Dagong, Tashi Dorji, Louise Drew, Jiazhong Guo, Jon Hallsson, Simon Horvat, Juha Kantanen, Fuki Kawaguchi, Polat Kazymbet, Negar Khayatzadeh, Namshin Kim, Manoj Kumar Shah, Yuying Liao, Amparo Martinez, Joseph S. Masangkay, Maho Masaoka, Raffaele Mazza, John McEwan, Marco Milanesi, Faruque Md Omar, Yuto Nomura, Nadjet-Amina Ouchene-Khelifi, Filipe Pereira, Goutam Sahana, Mazdak Salavati, Shinji Sasazaki, Anne Da Silva, Mojca Simcic, Johann Solkner, Alison Sutherland, Johannes Tigchelaar, Hongpin Zhang, Paolo Ajmone-Marsan, Daniel G. Bradley, Licia Colli, Cord Drogemuller, Yu Jiang, Chuzhao Lei, Hideyuki Mannen, Francois Pompanon, Gwenola Tosser-Klopp, Johannes A. Lenstra
Summary: This study analyzed the Y-chromosomal variants in domestic and wild goats, revealing the importance of paternal population history and male-mediated introgression. The findings provide insights into the evolution of goat species and the influence of migrations and crossbreeding on their genetic diversity.
Review
Genetics & Heredity
Peter de Knijff
Summary: This article reviews the history of using Y-chromosome polymorphisms in forensic investigations and discusses several often overlooked factors that influence the proper use and interpretation of Y-chromosome information.
Article
Biochemical Research Methods
Mengyuan Song, Xindi Wang, Chenxi Zhao, Xiaoqin Qian, Min Lang, Yiping Hou, Feng Song
Summary: This study combines four human Y chromosomal datasets and analyzes the genetic relationship between different ethnic groups in China. The results show that the Han and Hui ethnic groups have a strong genetic affinity, while the Hui group is the most admixed. The Li ethnic group is the least admixed. The study provides valuable data for future paternal genetic research and forensic genealogical identification.
Article
Plant Sciences
Cong Feng, Xingwei Wang, Shishi Wu, Weidong Ning, Bo Song, Jianbin Yan, Shifeng Cheng
Summary: Haplotype identification, characterization, and visualization are crucial in population genomics. HAPPE is a user-friendly tool that uses coloring of Excel tables to display genotypes and haplotypes, along with additional information such as phylogenetic trees and GWAS values.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Yeldar Ashirbekov, Madina Seidualy, Arman Abaildayev, Albina Maxutova, Aigul Zhunussova, Ainur Akilzhanova, Kamalidin Sharipov, Zhaxylyk Sabitov, Maxat Zhabagin
Summary: This study expanded the Y-chromosome haplotype reference database of South Kazakhstan and found that the Y-chromosome variability in the region can be divided into four main clusters - south, north, east, and west. In the genetic space of tribal groups, the population of South Kazakhstan clusters with tribes from the same region and shows genetic similarity with the Hazaras of Afghanistan and the Mongols of China.
Article
Genetics & Heredity
Caiyong Yin, Ziwei He, Yi Wang, Xi He, Xiao Zhang, Mingying Xia, Dian Zhai, Kaichuang Chang, Xueyun Chen, Xingneng Chen, Feng Chen, Li Jin, Shilin Li
Summary: This study focused on improving the resolution of the Y-STR dataset by utilizing a Y-SNP Pedigree Tagging System in a regional Y-DNA database. Results indicated the critical role of haplogroups in enhancing regional Y-STR haplotype resolution and the ability of Y-SNPs to correct misclassifications from Y-STRs, ultimately improving prediction accuracy.
FORENSIC SCIENCE INTERNATIONAL-GENETICS
(2022)
Article
Cell Biology
Lomous Kumar, Bhavna Ahlawat, Sachin Kumar, Veena Mushrif-Tripathy, Niraj Rai
Summary: The rich cultural and genetic diversity of South Asia is the result of multiple migrations and cultural assimilations. The Parsi community of North-western India, who migrated from West Eurasia in the 7th century CE, has both Middle Eastern and South Asian genetic components. In this study, we analyzed the complete mitogenome of 19 ancient Parsi settlers and found that their maternal ancestry includes both South Asian and Middle Eastern genetic composition.
Article
Genetics & Heredity
Milica Mihajlovic, Vanja Tanasic, Milica Keckarevic Markovic, Miljana Kecmanovic, Dusan Keckarevic
Summary: The study analyzed Y chromosome flow in 1200 Serbian males from three geographical regions, showing highest haplotype diversity and discrimination capacity in samples from present-day Serbia. The haplogroup composition was similar across datasets, with I-M170, E-P170, and R-M198 being dominant. Within the historical dataset, I2a1-P37.2 was the most prevalent haplogroup.
FORENSIC SCIENCE INTERNATIONAL-GENETICS
(2022)
Article
Anthropology
Zheng Ren, Yuhang Feng, Hongling Zhang, Qiyan Wang, Meiqing Yang, Yubo Liu, Cuiyun Le, Jie Wang, Jiang Huang
Summary: This study analyzed the sequences and haplogroups of the mitochondrial DNA control region in a typical Dong population in Guizhou, China. The findings revealed 180 haplotypes assigned to 97 different haplogroups. The Guizhou Dong showed the closest genetic relationship with the Han and Miao populations in China, as well as with the Punjab and Kashmiri populations in Pakistan and other world populations.
ANNALS OF HUMAN BIOLOGY
(2022)
Article
Anthropology
Dana Kristjansson, Jon Bohlin, Astanand Jugessur, Theodore G. Schurr
Summary: The study analyzed 1174 partial modern Norwegian mtDNA sequences, revealing that modern Norwegian mtDNAs fall into eight West Eurasian, five East Eurasian, and one African haplogroups. Pairwise analysis showed that Norwegians were differentiated from each other at 1.68%, and certain mtDNA lineages were also found among prehistoric and historic period populations, suggesting genetic continuity over hundreds to many thousands of years.
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY
(2021)
Article
Multidisciplinary Sciences
Chuan-Chao Wang, Cosimo Posth, Anja Furtwangler, Katalin Sumegi, Zsolt Banfai, Miklos Kasler, Johannes Krause, Bela Melegh
Summary: The study revealed that Bela III of the early Hungarian dynasty had a Central Asian Y-chromosome, but his autosomal and maternal DNA showed European East ancestry, possibly due to intermarriage with local European ruling families.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
C. Escouflaire, A. Capitan
Summary: This article analyzed pedigree information and whole-genome sequence data of males from 12 bovine breeds in France, highlighting differences in paternal lineages and the presence of major male founder effects. The results pave the way for future studies on the effects of Y-chromosome haplotypes on male reproductive performances and the conservation of Y-chromosome diversity.
Article
Medicine, Legal
Guang-Yao Fan
Summary: This study examined the factors and issues of using a k-nearest neighbor classifier for haplogroup prediction, and identified the prerequisites for effective and accurate haplogroup assignment.
FORENSIC SCIENCE INTERNATIONAL
(2022)
Article
Genetics & Heredity
Orsolya Biro, Abel Fothi, Balint Alasztics, Balint Nagy, Tamas I. Orban, Janos Rigo
Article
Pharmacology & Pharmacy
Daniella Kovacsics, Anna Brozik, Borbala Tihanyi, Zsolt Matula, Adrienn Borsy, Nikolett Meszaros, Edit Szabo, Eszter Nemeth, Abel Fothi, Boglarka Zambo, David Szuts, Gyorgy Varady, Tamas Orban, Agota Apati, Balazs Sarkadi
BIOCHEMICAL PHARMACOLOGY
(2020)
Article
Anthropology
Erzsebet Fothi, Angela Gonzalez, Tibor Feher, Ariana Gugora, Abel Fothi, Orsolya Biro, Christine Keyser
ARCHAEOLOGICAL AND ANTHROPOLOGICAL SCIENCES
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Daniella Kovacsics, Anna Brozik, Borbala Tihanyi, Zsolt Matula, Adrienn Borsy, Nikolett Meszaros, Edit Szabo, Eszter Nemeth, Abel Fothi, Boglarka Zambo, David Szuts, Gyorgy Varady, Tamas Orban, Agota Apati, Balazs Sarkadi
Article
Biochemistry & Molecular Biology
Mi Yang, Francesca Petralia, Zhi Li, Hongyang Li, Weiping Ma, Xiaoyu Song, Sunkyu Kim, Heewon Lee, Han Yu, Bora Lee, Seohui Bae, Eunji Heo, Jan Kaczmarczyk, Piotr Stepniak, Michal Warchol, Thomas Yu, Anna P. Calinawan, Paul C. Boutros, Samuel H. Payne, Boris Reva, Emily Boja, Henry Rodriguez, Gustavo Stolovitzky, Yuanfang Guan, Jaewoo Kang, Pei Wang, David Fenyo, Julio Saez-Rodriguez
Article
Biochemistry & Molecular Biology
Abel Fothi, Orsolya Biro, Zsuzsa Erdei, Agota Apati, Tamas I. Orban
Summary: The study reveals tissue-specific and position-dependent differences in expression levels of C19MC miRNA cluster in embryonic stem cells and placenta, possibly due to differences in posttranscriptional processing. In placenta, there are enhancer regions associated with the Microprocessor complex, leading to more efficient processing of pri-miRNA.
Article
Psychiatry
Ab Fothi, Latha Soorya, Andras Lorincz
FRONTIERS IN PSYCHIATRY
(2020)
Article
Genetics & Heredity
Anita Schamberger, Gyorgy Varady, Abel Fothi, Tamas Orban
Summary: ABCG2 is a membrane transporter protein associated with multidrug resistance and tumor development. By designing artificial mirtrons, researchers were able to posttranscriptionally regulate ABCG2 expression, with mismatch at the first position resulting in better silencing. Additionally, a mismatch in the seed region did not impair efficient silencing at the protein level.
Article
Cell Biology
Luca Pagliaroli, Abel Fothi, Ester Nespoli, Istvan Liko, Borbala Veto, Piroska Devay, Flora Szeri, Bastian Hengerer, Csaba Barta, Tamas Aranyi
Summary: Dyskinesias are abnormal repetitive involuntary movements caused by dysfunctional neuronal activity. While levodopa-induced dyskinesia has no clinical treatment for Parkinson's disease patients, Riluzole shows potential to improve the phenotype by affecting DNA methylation. The study suggests that Riluzole co-treatment may pinpoint specific methylation targets for potential new druggable targets in Levodopa-Induced Dyskinesia.
Article
Mathematical & Computational Biology
Abel Fothi, Csaba Pinter, Peter Pollner, Andras Lorincz
Summary: The omnigenic theory suggests that all expressed genes are involved in complex disorders like autism. Research shows that autism-related genes have stronger connections in brain-related tissues compared to non-neuronal tissues.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2022)
Article
Genetics & Heredity
Dora Ree, Abel Fothi, Nora Varga, Orsolya Kolacsek, Tamas Orban, Agota Apati
Summary: Studies have shown that DGCR8 heterozygous mutation has a modest effect on mRNA level but a significant decrease at the protein level, while not affecting self-renewal and trilineage differentiation capacity of hESCs.
Meeting Abstract
Oncology
Daniella Kovacsics, Nikolett Meszaros, Borbala Tihanyi, Zsolt Matula, Adrienn Borsy, Edit Szabo, Gyorgy Varady, Tamas Orban, Agota Apati, Abel Fothi, Anna Brozik, Balazs Sarkadi
Meeting Abstract
Clinical Neurology
Luca Pagliaroli, Ester Nespoli, Abel Fothi, Piroska Devay, Istvan Liko, Borbala Veto, Tamas Orban, Bastian Hengerer, Csaba Barta, Tamas Aranyi
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)
Meeting Abstract
Physiology
A. Fothi, A. Schamberger, Zs Erdei, A. Apati, T. I. Orban