Article
Immunology
Yongjin Lia, Chao Kong, Wei Wang, Feng Hu, Xiaolong Chen, Baoshan Xu, Shibao Lu
Summary: Low back pain (LBP) is a common clinical condition with significant economic burdens. Intervertebral disc degeneration (IVDD) is a major contributing factor to LBP, and recent studies have highlighted the role of microRNAs (miRNAs) in regulating IVDD. Understanding the involvement of miRNAs in IVDD can expand our knowledge of the underlying mechanisms and potentially identify new therapeutic targets for managing LBP.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Kai Guo, Di Qi, Bo Huang
Summary: The study revealed that lncRNA MEG8 plays a critical role in the development of NSCLC by modulating the miR-15a/b-5p/PSAT1 axis, indicating that lncRNA MEG8, miR-15a-5p, miR-15b-5p, and PSAT1 may serve as potential targets for NSCLC therapy.
CANCER CELL INTERNATIONAL
(2021)
Article
Virology
Shaw M. M. Akula, John F. F. Williams, Lok R. R. Pokhrel, Anais N. N. Bauer, Smit Rajput, Paul P. P. Cook
Summary: The study suggests that circulatory miR-6741-5p may serve as a prognostic biomarker for predicting mortality risk and length of stay in hospitalized COVID-19 patients.
Article
Chemistry, Multidisciplinary
Anupama Ninawe, Sameer Ahmad Guru, Prasant Yadav, Mirza Masroor, Amit Samadhiya, Namrata Bhutani, Naresh Gupta, Richa Gupta, Alpana Saxena
Summary: The study reveals alterations in the expression levels of miR-486-5p in CML patients, suggesting its potential as a biomarker for diagnosis and prognosis. The findings indicate a critical role of miR-486-5p in the treatment and prognosis of CML patients.
Article
Medicine, General & Internal
Yuan Yuan, Weimin Ren, Jinchao Zhu, Saiyan Ji, Qingyuan Yang
Summary: Lymph node metastasis, perineural/venous invasion, TNM stage, local recurrence or distant metastasis after surgery, and the expression of Ki-67 and KRAS mutation are independent prognostic biomarkers for predicting the 2-year survival rate of CRC patients. These markers show differential prognosis in different subgroups based on age, tumor site, differentiation, histological type, lymph node metastasis, TNM stage, and recurrence/metastasis.
ANNALS OF MEDICINE
(2023)
Article
Clinical Neurology
Rukiye Tekdemir, Yavuz Selvi, Kursat Altinbas, Nadir Kocak
Summary: This study found that miRNAs play an important role in the pathogenesis of bipolar disorder and may serve as biomarkers for diagnosis and screening of the disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Immunology
Rachel E. Crossland, Jean Norden, Sakhila Ghimire, Mateja Kralj Juric, Kim F. Pearce, Clare Lendrem, Matthew Collin, Eva Mischak-Weissinger, Ernst Holler, Hildegard T. Greinix, Anne M. Dickinson
Summary: The study found that miR-155 and miR-146a were upregulated in gastrointestinal and skin tissue samples of aGvHD patients, and their expression levels in serum and urine samples were also associated with the risk of developing aGvHD. These results support the potential of miR-155 and miR-146a as biomarkers for aGvHD, but further investigation is needed to understand their role in generalized inflammation and specific pathophysiology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Junhua Li, Bulin Baila, Tian Xiang Xu, Jiang Song, Su Rina, Ji Wu, Tegexibaiyin Wang
Summary: Colorectal cancer (CRC) is one of the most common gastrointestinal cancers in the world, including China, and its incidence is increasing. Recent research has shown that certain miRNAs are differentially expressed in cancer tissues and are closely associated with the prognosis of CRC.
ANALYTICAL CELLULAR PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Amir Bayat, Mohammad Raad, Alireza Sharafshah, Mohammad Ahmadvand, Hesam Aminian
Summary: This study found that the transcription level of miR-195-5p is significantly downregulated in colorectal cancer patients, and low transcription level is related to clinical characteristics of the tumor and shorter overall survival of the patients.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Oncology
Xiulin Jiang, Yixiao Yuan, Lin Tang, Juan Wang, Dahang Zhang, William C. Cho, Lincan Duan
Summary: The expression of miRNA-30a-5p is significantly decreased in LUAD and is associated with clinical outcomes and immune cell infiltration. Furthermore, miRNA-30a-5p has been found to inhibit cell proliferation and migration in LUAD.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Dennis Gerloff, Stefanie Kewitz-Hempel, Gerd Hause, Jovine Ehrenreich, Linda Golle, Tim Kingreen, Cord Sunderkoetter
Summary: Extracellular vesicles (EVs) play an important role in intercellular communication, influencing the function and phenotype of different cell types within the tumor microenvironment and promoting tumor progression. This study identified miRNAs enriched in both melanoma cells and melanoma cell-derived EVs, and showed that these miRNAs were also elevated in serum-derived EVs of patients with metastatic melanoma, suggesting their potential as prognostic or diagnostic liquid biopsy markers in melanoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu-Jen Chen, Chia-Tien Hsu, Shang-Feng Tsai, Cheng-Hsu Chen
Summary: Chronic allograft dysfunction (CAD) is a major condition affecting long-term kidney graft survival. In this study, the correlation between plasma miR-21 and the severity of CAD was investigated. RNA sequencing was performed and differentially expressed miRNAs in CAD were identified. MiR-21-5p, miR-20a-5p, and miR-101-3p were found to be associated with the TGF-beta pathway and CAD. These findings may lead to the development of early prediction miRNA biomarkers and therapeutic tools for CAD in the field of kidney transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jovana Despotovic, Aleksandar Bogdanovic, Sandra Dragicevic, Danijel Galun, Zoran Krivokapic, Aleksandra Nikolic
Summary: This study found that the expression pattern of tumoral and circulating miR-93-5p is associated with liver metastasis in colorectal cancer patients, but not with therapy response or one-year recurrence-free survival. However, high miR-93-5p serum levels are significantly associated with early disease recurrence.
Article
Oncology
An Huang, Jingyi Shi, Zhuang Sun, Yong Yang, Zhaoya Gao, Jin Gu
Summary: Researchers constructed a prognostic signature based on ten hub genes using RNA sequencing data from TCGA datasets. Patients in the high-risk group had significantly worse overall survival. ENTR1 was identified as a prognostic marker for MAC, with its expression positively correlated with cell stemness and CD8+ T cell infiltration, and negatively associated with stromal scores. Immunohistochemistry validation confirmed higher expression of ENTR1 in MAC tissues.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Oriana Maria Maurel, Sebastiano Alfio Torrisi, Cristina Barbagallo, Michele Purrello, Salvatore Salomone, Filippo Drago, Marco Ragusa, Gian Marco Leggio
Summary: Our study found that the expression of miRNAs in different brain areas is associated with susceptibility/resilience to PTSD. Changes in specific miRNAs may influence the transcription levels of FKBP5 and BDNF, and show a linear correlation with stress-induced behavioral phenotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Maria-Alexandra Papadimitriou, Konstantina Panoutsopoulou, Katerina-Marina Pilala, Andreas Scorilas, Margaritis Avgeris
Summary: Methylation of DNA/RNA and proteins is crucial for cellular homeostasis and development, and disrupted methylation imprinting is strongly associated with human pathologies, especially cancer. Recent evidence has shown that miRNAs play a significant role in regulating cellular methylation profiles during cancer onset and progression. Epi-miRNAs are a novel subclass of miRNAs that have potential clinical utility in cancer diagnostics and personalized therapeutics.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Article
Biotechnology & Applied Microbiology
Olga Martzoukou, Sotiris Amillis, Panayiotis D. D. Glekas, Dimitra Breyanni, Margaritis Avgeris, Andreas Scorilas, Dimitris Kekos, Michalis Pachnos, George Mavridis, Diomi Mamma, Dimitris G. G. Hatzinikolaou
Summary: In this study, an advanced biocatalyst with three genetic modifications was constructed, which showed high biodesulfurization activities and could be produced in a simple and low-cost medium without the need for antibiotics. Transcript level quantification confirmed the effects of genetic engineering approaches on the mRNA ratios of recombinant strains and revealed a gene-specific differential increase in mRNA levels. These findings can potentially pave the way for economically viable biodesulfurization processes through further strain and process optimization.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Medical Laboratory Technology
Maria-Alexandra Papadimitriou, Panagiotis Levis, Georgios Kotronopoulos, Konstantinos Stravodimos, Margaritis Avgeris, Andreas Scorilas
Summary: This study evaluated the clinical utility of preoperative serum cell-free DNA (cfDNA) in risk stratification and prognosis of bladder cancer patients. The results showed that elevated preoperative cfDNA levels were associated with disease progression and metastasis, and were strongly correlated with short-term metastasis and poor prognosis of muscle-invasive bladder cancer (MIBC) patients.
CLINICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Despoina D. Gianniou, Aimilia D. Sklirou, Maria-Alexandra Papadimitriou, Katerina-Marina Pilala, Konstantinos Stravodimos, Margaritis Avgeris, Andreas Scorilas, Ioannis P. Trougakos
Summary: This study investigated the expression and role of HSPB2 and HSPB3 genes in bladder cancer patients and bladder cancer cells. The results showed increased expression levels of HSPB2 and HSPB3 genes and proteins in high-grade bladder cancer cells. In clinical samples, the expression levels of HSPB2 and HSPB3 genes were significantly downregulated in bladder tumors but showed an upregulation trend in muscle-invasive and high-grade tumors. These findings suggest that HSPB2 and HSPB3 have a pro-survival role in advanced bladder cancer and can be targeted as novel molecular markers for treatment optimization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Environmental Sciences
Aikaterini Galani, Athina Markou, Lampros Dimitrakopoulos, Aikaterini Kontou, Marios Kostakis, Vasileios Kapes, Marios A. Diamantopoulos, Panagiotis G. Adamopoulos, Margaritis Avgeris, Evi Lianidou, Andreas Scorilas, Dimitrios Paraskevis, Sotirios Tsiodras, Meletios-Athanasios Dimopoulos, Nikolaos Thomaidis
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Aikaterini Galani, Athina Markou, Lampros Dimitrakopoulos, Aikaterini Kontou, Marios Kostakis, Vasileios Kapes, Marios A. Diamantopoulos, Panagiotis G. Adamopoulos, Margaritis Avgeris, Evi Lianidou, Andreas Scorilas, Dimitrios Paraskevis, Sotirios Tsiodras, Meletios-Athanasios Dimopoulos, Nikolaos Thomaidis
Summary: Wastewater analysis is an attractive alternative for quantifying and profiling the variants of SARS-CoV-2. RT-qPCR assays can monitor infection dynamics, while NGS provides evidence for the presence of existing or emerging variants. The study reports the infection dynamics in Attica since June 1st, 2021, and monitors omicron and delta variants using novel Nested-Seq and RT-PCR methods.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Maria Papasavva, Styliana Amvrosiou, Katerina-Marina Pilala, Konstantinos Soureas, Panayiota Christodoulou, Yuan Ji, Konstantinos Stravodimos, Damo Xu, Andreas Scorilas, Margaritis Avgeris, Maria-Ioanna Christodoulou
Summary: Cellular and molecular immune components, including interleukin-37 (IL-37) and its receptor SIGIRR, play a crucial role in the development and progression of bladder urothelial carcinoma (BLCA). IL-37 levels are associated with tumor development and longer overall survival in BLCA patients. Mutations in SIGIRR are related to increased infiltration of regulatory T cells and dendritic cells in the tumor. These findings suggest that IL-37 and SIGIRR could be potential prognostic and diagnostic markers for BLCA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Paraskevi Karousi, Christos K. Kontos, Panagiota Papakotsi, Ioannis K. Kostakis, Alexios-Leandros Skaltsounis, Andreas Scorilas
Summary: This study found that oleuropein and oleocanthal can inhibit the proliferation of triple-negative breast cancer (TNBC) cells and significantly alter the expression profile of TNBC cells. These compounds may have therapeutic benefits for TNBC through their effects on multiple pathways associated with TNBC.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Review
Biochemistry & Molecular Biology
Konstantinos Soureas, Maria-Alexandra Papadimitriou, Konstantina Panoutsopoulou, Katerina-Marina Pilala, Andreas Scorilas, Margaritis Avgeris
Summary: This passage emphasizes the role of regulatory non-coding RNAs in cancer quiescence and highlights their impact on treatment resistance and modern cancer therapeutics.
TRENDS IN MOLECULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Panagiotis G. Adamopoulos, Konstantina Athanasopoulou, Glykeria N. Daneva, Andreas Scorilas
Summary: Recent advances in molecular biology have allowed for the identification of post-transcriptional marks on RNAs, leading to the emerging field of epitranscriptomics. Over 170 RNA modifications have been reported, playing crucial roles in RNA biogenesis, stability, and accuracy of transcription and translation. Dysfunctions in the enzymes responsible for RNA modifications can lead to human diseases and cancer. This review focuses on the landscape of epitranscriptomics in human RNAs, describing the most common modifications and their functional and regulatory roles, as well as their involvement in cellular homeostasis and disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Katerina Katsaraki, Christos K. Kontos, Gerasimos Ardavanis-Loukeris, Alexandros A. Tzovaras, Diamantis C. Sideris, Andreas Scorilas
Summary: This study investigates the regulatory effect of proteasome inhibitors (PIs) on miRNA expression in breast cancer (BrCa) cell lines. The results show a high heterogeneity in miRNA levels among different cell lines and different treatment durations. Three miRNAs (miR-1-3p, miR-421-3p, and miR-765-3p) are identified as potential key players in BrCa. Various biological processes, molecular functions, and pathways are predicted to be affected.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tasneem Abaza, Mostafa K. Abd El-Aziz, Kerolos Ashraf Daniel, Paraskevi Karousi, Maria Papatsirou, Sherif Ashraf Fahmy, Nadia M. Hamdy, Christos K. Kontos, Rana A. Youness
Summary: Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options and high recurrence rates. Recently, immunotherapeutic agents such as immune checkpoint inhibitors (ICIs) and circular RNAs (circRNAs) have shown promise in HCC treatment. CircRNAs can influence the tumor immune microenvironment and may impact the effectiveness of ICIs. Therefore, circRNAs have the potential to serve as biomarkers for diagnosis, prognosis, and targeted therapy in HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Paraskevi Karousi, Martina Samiotaki, Manousos Makridakis, Jerome Zoidakis, Diamantis C. Sideris, Andreas Scorilas, Thomas Carell, Christos K. Kontos
Summary: This study investigates the role of 3'-tRF-Cys(GCA) in gene expression regulation in HEK-293 cells and finds that it can regulate gene expression by affecting multiple cellular pathways. Additionally, the study identifies the direct interaction between 3'-tRF-Cys(GCA) and thymopoietin and its modulation of the protein's levels.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)