Review
Biochemistry & Molecular Biology
Gyorgy Trencsenyi, Kata Nora Enyedi, Gabor Mezo, Gabor Halmos, Zita Kepes
Summary: Angiogenesis plays a key role in tumor progression and metastasis. Targeting angiogenesis using specific vectors has gained attention from researchers. The high expression of angiogenesis-associated aminopeptidase N (APN/CD13) on the surface of activated endothelial cells and various tumor cells makes it a promising target for cancer imaging and therapy. Radiolabeled NGR peptides, which selectively bind to APN/CD13, have been investigated for non-invasive, real-time imaging of APN/CD13 overexpressing malignancies.Various radioisotopes, such as Ga-68, Cu-64, (99)mTc, Lu-177, Re-188, and Bi-213, have been used for labeling tumor vasculature homing NGR sequences in preclinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Uwe Lendeckel, Farzaneh Karimi, Ruba Al Abdulla, Carmen Wolke
Summary: APN/CD13 is expressed in various cells/tissues and is associated with diverse physiological functions. Increased expression or activity of APN/CD13 has been described in various tumors, and is usually associated with reduced survival. The mechanisms of APN/CD13-mediated cellular effects have been largely determined.
Review
Chemistry, Multidisciplinary
Shuai Lv, Yufei Liu, Changheng Xie, Chenyang Xue, Shi Du, Jing Yao
Summary: Tumor angiogenesis and cancer stem cells are two major features of solid tumors that have critical roles in tumor progression, metastasis, and recurrence. There is evidence of a close association between cancer stem cells and tumor vasculature, where cancer stem cells promote tumor angiogenesis and the highly vascularized tumor microenvironment further maintains their growth, forming a vicious circle to promote tumor development. This review highlights the crosstalk between tumor vasculature and cancer stem cells, with emphasis on small-molecule compounds and associated biological signaling pathways. Disrupting the cancer stem cells-angiogenesis vicious circle by linking tumor vessels to cancer stem cells is of utmost importance, and more precise treatment regimens targeting tumor vasculature and cancer stem cells are expected to improve future tumor treatments.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biochemistry & Molecular Biology
Uwe Lendeckel, Carmen Wolke
Summary: Cancer stem cells are a subset of cells with tumor-initiating and treatment-resistant abilities, and their stemness is maintained by low levels of reactive oxygen species, resulting in resistance to chemotherapy and radiotherapy.
Review
Cell Biology
Fengkai Li, Jiahui Xu, Suling Liu
Summary: Cancer stem cells play crucial roles in tumor-associated angiogenesis, contributing to tumor progression and metastasis through various pathways. Understanding these mechanisms is essential for developing more efficient therapeutic approaches for cancer treatment.
Article
Medicine, Research & Experimental
Ruifeng Pei, Le Zhao, Yiren Ding, Zhan Su, Deqiang Li, Shuo Zhu, Lu Xu, Wei Zhao, Wuyuan Zhou
Summary: This study reveals the promoting effect of HOTAIR in radioresistance of liver cancer stem cells (LCSCs). Mechanistically, HOTAIR recruits LSD1 to the MAPK1 promoter region, reduces the level of H3K9me2, and elevates ERK2 (MAPK1) expression. The JMJD6-BRD4 complex positively regulates HOTAIR transcription, ERK2 (MAPK1) expression, and maintains the stemness of LCSCs, ultimately promoting their radioresistance.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Shiming He, Chunyan Zhao, Hongyu Tao, Weijin Sheng, Ruijuan Gao, Xiujun Liu, Yongsu Zhen
Summary: This study evaluated the anti-tumor efficacy of Fv-LDP-D3 and its antibody-drug conjugate Fv-LDP-D3-AE against esophageal cancer. Both Fv-LDP-D3 and Fv-LDP-D3-AE exhibited high binding affinity for EGFR-overexpressing esophageal cancer cells and demonstrated potent cytotoxicity, inhibiting cell proliferation, inducing apoptosis, and causing DNA damage. In animal models, both compounds significantly inhibited the growth of esophageal cancer xenografts. These results suggest that Fv-LDP-D3 and Fv-LDP-D3-AE have promising potential for targeted therapy against esophageal cancer.
Article
Oncology
Chengjin Ai, Yu Zhou, Kunming Pu, Yi Yang, Yingying Zhou
Summary: This study found that neurite outgrowth inhibitor A (Nogo-A) plays an important role in regulating U87MG-CSCs via the Nogo-A/NgR signaling pathway, with different roles compared to parental cancer cells.
Review
Pharmacology & Pharmacy
Adriana G. Quiroz-Reyes, Paulina Delgado-Gonzalez, Jose Francisco Islas, Juan Luis Delgado Gallegos, Javier Humberto Martinez Garza, Elsa N. Garza-Trevino
Summary: TRAIL is a promising strategy for tumor elimination, but cancer stem cells can easily develop evasion mechanisms for TRAIL-induced apoptosis.
Article
Biotechnology & Applied Microbiology
Adrienn Kis, Noemi Denes, Judit P. Szabo, Viktoria Arato, Livia Beke, Orsolya Matolay, Kata Nora Enyedi, Gabor Mehes, Gabor Mezo, Peter Bai, Istvan Kertesz, Gyorgy Trencsenyi
Summary: The study showed that bestatin treatment effectively inhibited tumor growth and reduced Ga-68-NODAGA-c(NGR) uptake in both HT1080 and B16-F10 tumor models, while actinonin led to higher radio-tracer accumulation in HT1080 tumors but lower accumulation in B16-F10 melanoma tumors. The Ga-68-NODAGA-c(NGR) radiotracer is a useful tool for monitoring the efficacy of APN/CD13 inhibition-based anticancer therapies.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Cell Biology
Ganping Wang, Yarong Dai, Kang Li, Maosheng Cheng, Gan Xiong, Xiaochen Wang, Shuang Chen, Zhi Chen, Jianwen Chen, Xiuyun Xu, Rong-song Ling, Liang Peng, Demeng Chen
Summary: The study demonstrates that Mettl3-mediated m(6)A modification is crucial for the activation of TEK-VEGF-A-mediated tumor progression and angiogenesis in bladder cancer. Experimental results using transgenic mouse models and bladder cancer stem cell populations showed that depletion of Mettl3 inhibits tumor oncogenesis and progression in bladder cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jiangying Cao, Chunlong Zhao, Hang Dong, Qifu Xu, Yingjie Zhang
Summary: A new series of pyrazoline-based derivatives were synthesized, among which compound 2k showed promising APN inhibitory activity and effectively prevented pulmonary metastasis of H22 hepatoma cells in vivo, indicating its potential as an anti-tumor agent.
Review
Oncology
Surendar Aravindhan, Sura Salman Ejam, Methaq Hadi Lafta, Alexander Markov, Alexei Valerievich Yumashev, Majid Ahmadi
Summary: The interaction between the tumor microenvironment and tumor cells plays a crucial role in tumor progression, with mesenchymal stem cells (MSCs) being key players in modulating the tumor microenvironment and influencing the fate of tumor cells. MSCs exhibit dual functions in the tumor microenvironment, either promoting tumorigenicity or inhibiting tumor growth. Their ability to release mediators such as exosomes and migrate to tumor sites facilitates efficient drug delivery and targeting of migrating tumor cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Mans Kadefors, Sara Rolandsson Enes, Emma Ahrman, Barbora Michalikova, Anna Lofdahl, Goran Dellgren, Stefan Scheding, Gunilla Westergren-Thorsson
Summary: Mesenchymal cells in the lung play crucial roles in tissue regeneration and repair, with dysregulation potentially leading to tissue remodeling in lung diseases. Two populations of CD105(+)CD90(+) mesenchymal cells, distinguished by their expression of CD13, show differences in clonogenic and proliferative capacity, with CD105(+)CD90(+)CD13(+) cells being more potent. Adventitial fibroblast subset is identified as the origin of these clonogenic mesenchymal cells in human lung through transcriptomic and spatial analysis.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Furkan Yigitbilek, Sabena M. Conley, Hui Tang, Ishran M. Saadiq, Kyra L. Jordan, Lilach O. Lerman, Timucin Taner
Summary: MSCs from liver and adipose tissue showed similar proliferation and migration properties, but had differences in immunomodulatory and pro-angiogenic abilities. Selecting cell-based therapy according to the specific characteristics of different cell sources may be important for treating certain diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yan-Bo Zheng, Jian-Hua Gong, Xiu-Jun Liu, Shu-Ying Wu, Yi Li, Xian-Dong Xu, Bo-Yang Shang, Jin-Ming Zhou, Zhi-Ling Zhu, Shu-Yi Si, Yong-Su Zhen
SCIENTIFIC REPORTS
(2016)
Article
Medicine, Research & Experimental
Yan-bo Zheng, Bo-yang Shang, Yi Li, Yong-su Zhen
BIOMEDICINE & PHARMACOTHERAPY
(2013)
Article
Multidisciplinary Sciences
Xiu-Jun Liu, Yan-Bo Zheng, Yi Li, Shu-Ying Wu, Yong-Su Zhen
Article
Oncology
Jian-Hua Gong, Yan-Bo Zheng, Meng-Ran Zhang, Yue-Xuan Wang, Si-Qi Yang, Rui-Hai Wang, Qing-Fang Miao, Xiu-Jun Liu, Yong-Su Zhen
CANCER BIOLOGY & THERAPY
(2020)
Article
Cell Biology
Yan-Bo Zheng, Jian-Hua Gong, Yong-Su Zhen
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Qi Zhao, Yanbo Zheng, Xing Lv, Jianhua Gong, Lijun Yang
Summary: IMB5036, a novel pyridazinone compound, exhibits potent cytotoxicity against pancreatic cancer cells by inducing necroptosis, leading to inhibiting tumor growth.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Oncology
Xing Lv, Qi Zhao, Yanqun Dong, Lijun Yang, Jianhua Gong, Yanbo Zheng, Tao Yang
Summary: In this study, a small-molecule compound called IMB5036 exhibited potent antitumor activity against hepatocellular carcinoma (HCC). It induced apoptosis and inhibited cell motility in HCC cells. IMB5036 also regulated the expression of E-cadherin, N-cadherin, and Tau protein. Furthermore, in vivo experiments demonstrated that IMB5036 significantly inhibited the growth of HCC xenografts. These findings suggest that IMB5036 may be a promising therapeutic candidate for HCC patients.
INVESTIGATIONAL NEW DRUGS
(2022)
Article
Pharmacology & Pharmacy
Yan-Bo Zheng, Yan-Qun Dong, Shu-Yi Si, Yong-Su Zhen, Jian-Hua Gong
Summary: IMB5476, a novel nitrobenzoate microtubule inhibitor, exhibits increased aqueous solubility. It disrupts microtubule networks in cells, causing cell cycle arrest and inducing cell death through mitotic catastrophe and apoptosis. IMB5476 also inhibits angiogenesis and overcomes multidrug resistance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)