Review
Biochemistry & Molecular Biology
Melissa Garcia-Caballero, Liliana Sokol, Anne Cuypers, Peter Carmeliet
Summary: The dynamic crosstalk between different components of the tumor microenvironment plays a critical role in cancer progression and metastasis. Angiogenesis is crucial for tumor growth, but abnormal blood vessels can lead to hypoxia and acidosis in the tumor microenvironment. Cancer and stromal cells can alter their metabolism to meet high energy demands and promote tumor proliferation. Recent studies have shown that the metabolism of tumor endothelial cells is reprogrammed and targeting these metabolic pathways can affect blood vessel formation. Therefore, metabolic antiangiogenic therapies combined with immunotherapies offer a clinical opportunity for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Yuan Gu, Maximilian A. Becker, Luisa Mueller, Katharina Reuss, Frederik Umlauf, Tianci Tang, Michael D. Menger, Matthias W. Laschke
Summary: Tumor endothelial cells (TECs) are crucial for tumor angiogenesis, growth and metastasis, and small non-coding microRNAs (miRNAs) play a significant role in regulating TEC function and blood vessel formation. This review provides an overview of the regulatory mechanisms and effects of endothelial miRNAs, highlighting their involvement in fundamental angiogenesis-related signaling pathways. Targeting endothelial miRNAs represents a potential strategy for anti-angiogenic cancer therapy, but further research is needed to understand their networks and develop specific delivery technologies.
Article
Oncology
Zhihao Wang, Shuxin Zhang, Junhong Li, Yunbo Yuan, Siliang Chen, Mingrong Zuo, Wenhao Li, Wentao Feng, Mina Chen, Yanhui Liu
Summary: This study found that the expression of lactate metabolism genes in glioma patients is associated with prognosis and influences the activity of immune cells in the tumor microenvironment. This may serve as a potential biomarker for predicting the response of gliomas to immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Jing Liang, Shouqi Wang, Guowei Zhang, Baoyu He, Qingli Bie, Bin Zhang
Summary: Studying the differences, heterogeneity, and interaction of tumor-specific endothelial cells (TECs) with the tumor microenvironment is crucial for developing specific anti-tumor angiogenesis therapies.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anna Maria Reuss, Dominik Groos, Michael Buchfelder, Nicolai Savaskan
Summary: Malignant glioma is a fatal disease with a poor prognosis, characterized by adaptations to hypoxia, glycolytic and angiogenic switch leading to more aggressive and malignant behavior. The acidic tumor microenvironment and metabolic communication between cancer cells enhance invasiveness. The study also highlights the functional consequences of the glycolytic switch on glioma malignancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Wa Du, Lu Ren, Milton H. Hamblin, Yanbo Fan
Summary: The process of angiogenesis, involving the formation of new blood vessels from existing ones, is critical in various physiological and pathological conditions. Endothelial cell metabolism, particularly glycolysis, has been shown to play a significant role in angiogenesis, with various regulators identified to modulate this process. Understanding the metabolic regulation in endothelial cells could lead to potential therapeutic strategies for angiogenesis-related diseases.
Review
Medicine, Research & Experimental
Ali Baradaran, Zahra Asadzadeh, Nima Hemmat, Amir Baghbanzadeh, Mahdi Abdoli Shadbad, Neda Khosravi, Afshin Derakhshani, Hajar Alemohammad, Mina Afrashteh Nour, Hossein Safarpour, Nicola Silvestris, Oronzo Brunetti, Behzad Baradaran
Summary: TAMs play important roles in the tumor microenvironment, contributing to tumor development, chemoresistance, immune evasion, and metastasis. The interaction between TAMs and tumoral endothelial cells has a significant impact on tumor angiogenesis and immune evasion. Therefore, targeting TAMs and their interaction could be a promising strategy for improving cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Genetics & Heredity
Tianhao Hu, Yutao Wang, Xiaoliang Wang, Run Wang, Yifu Song, Li Zhang, Sheng Han
Summary: In this study, a comprehensive analysis of angiogenesis-related genes (ARGs) in glioma was conducted, resulting in the establishment of a 14-gene risk signature that independently predicted the clinical outcomes of patients and was associated with the tumor immune microenvironment.
FRONTIERS IN GENETICS
(2022)
Review
Cell Biology
Qixin Duan, Shuang Zhang, Yang Wang, Dongming Lu, Yingming Sun, Yongyang Wu
Summary: The Warburg effect refers to the hyperactive glycolysis in tumor cells that provides energy for rapid growth and proliferation even under sufficient oxygen. Proton-coupled monocarboxylate transporters (MCTs) play a crucial role in the metabolic reprogramming and survival of tumor cells, as well as tumor angiogenesis, immune suppression, multidrug resistance, migration and metastasis, ferroptosis resistance, and autophagy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Neurosciences
Xu Guo, Rui Sui, Haozhe Piao
Summary: This review summarizes the role of exosomes released by glioma cells in the tumor microenvironment, including mediating intercellular communication, inducing macrophage polarization, and inhibiting immune cell activity. Exosomes play a crucial regulatory role in the development and immune evasion of glioma.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biotechnology & Applied Microbiology
Hyukjun Choi, Mirae Yeo, Yujin Kang, Hyo Jeong Kim, Seong Guk Park, Eunjung Jang, Sung Ho Park, Eunhee Kim, Sebyung Kang
Summary: The aggressive proliferation of tumor cells often requires increased glucose uptake and excessive anaerobic glycolysis, leading to the massive production and secretion of lactate to form a unique tumor microenvironment (TME).
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Chunrong Yang, Yujie Li, Yuchen Yang, Qiankun Ni, Zeyu Zhang, Yi Chai, Jinghong Li
Summary: This study demonstrates the potential of enhancing the efficacy of immunotherapy for glioma by targeting and modulating the tumor microenvironment. The researchers designed a nanomedicine that silenced SOCS1 and triggered a strong antitumor immune response, inhibiting tumor growth.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Arianna Filippelli, Cinzia Del Gaudio, Vittoria Simonis, Valerio Ciccone, Andrea Spini, Sandra Donnini
Summary: Platelets play an important role in the tumor microenvironment and are closely related to angiogenesis. Although there is abundant evidence supporting their involvement in tumor angiogenesis, it remains unclear whether the number, volume, content, and localization of platelets have clinical relevance. More molecular and quantitative data are needed to translate the findings from preclinical studies into the clinical setting, and to correlate platelet biology with angiogenesis for personalized cancer therapy and clinical prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Bo Li, Fang Wang, Nan Wang, Kuiyuan Hou, Jianyang Du
Summary: Angiogenesis in immunosuppressed low-grade gliomas is driven by m6A modification regulators and plays a role in mediating immunosuppression. This study investigated the relevance and mechanism of angiogenesis-related genes and m6A regulators, providing insights for the diagnosis and treatment of low-grade gliomas.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Tzu-Yin Lin, Chi-Hwa Yang, Hsiao-Chin Chou, Chun-Mei Cheng, Ya-Wen Liu, Jiz-Yuh Wang, Li-Rung Huang, Shih-Feng Tsai, Shiu-Feng Huang, Yi-Rong Chen
Summary: This study identified CLEC11A as a novel factor in tumor angiogenesis, with endothelial trophic and tumor-promoting activities. CLEC11A was over-expressed in lung cancer cells with EGFR mutation and in lung adenocarcinoma tissues. It enhanced angiogenesis triggered by VEGF-A or basic FGF and increased tumorigenic ability in mouse models. CLEC11A exhibited chemotactic ability towards endothelial cells and increased levels of active integrin beta 1 in these cells.
Article
Cell Biology
Julieta Afonso, Andreia Barbosa, Paula Roberta Aguiar Pastrez, Murilo Bonatelli, Ricardo Filipe Alves da Costa, Celine Pinheiro, Adhemar Longatto-Filho, Fatima Baltazar
Summary: Glycolytic activity is associated with poor clinicopathological profile in esophageal cancer patients. MCT4 and CAIX positivity independently predict a worse prognosis. Further studies are needed to assess the predictive value of these biomarkers in treatment response and explore the impact of MCT1/4 targeting and HKII expression and function.
Article
Oncology
Julieta Afonso, Celine Goncalves, Marta Costa, Debora Ferreira, Lucio Santos, Adhemar Longatto-Filho, Fatima Baltazar
Summary: Glycolysis-related proteins are associated with bladder cancer aggressiveness and poor prognosis. The HK2 inhibitor 2-deoxy-D-glucose can inhibit glycolysis, reduce bladder cancer cell invasion, and increase sensitivity to cisplatin.
Article
Biochemistry & Molecular Biology
Esther Clavero, Jose Manuel Sanchez-Maldonado, Angelica Macauda, Rob Ter Horst, Belem Sampaio-Marques, Artur Jurczyszyn, Alyssa Clay-Gilmour, Angelika Stein, Michelle A. T. Hildebrandt, Niels Weinhold, Gabriele Buda, Ramon Garcia-Sanz, Waldemar Tomczak, Ulla Vogel, Andres Jerez, Daria Zawirska, Marzena Watek, Jonathan N. Hofmann, Stefano Landi, John J. Spinelli, Aleksandra Butrym, Abhishek Kumar, Joaquin Martinez-Lopez, Sara Galimberti, Maria Eugenia Sarasquete, Edyta Subocz, Elzbieta Iskierka-Jazdzewska, Graham G. Giles, Malwina Rybicka-Ramos, Marcin Kruszewski, Niels Abildgaard, Francisco Garcia Verdejo, Pedro Sanchez Rovira, Miguel Inacio da Silva Filho, Katalin Kadar, Malgorzata Razny, Wendy Cozen, Matteo Pelosini, Manuel Jurado, Parveen Bhatti, Marek Dudzinski, Agnieszka Druzd-Sitek, Enrico Orciuolo, Yang Li, Aaron D. Norman, Jan Maciej Zaucha, Rui Manuel Reis, Miroslaw Markiewicz, Juan Jose Rodriguez Sevilla, Vibeke Andersen, Krzysztof Jamroziak, Kari Hemminki, Sonja I. Berndt, Vicent Rajkumar, Grzegorz Mazur, Shaji K. Kumar, Paula Ludovico, Arnon Nagler, Stephen J. Chanock, Charles Dumontet, Mitchell J. Machiela, Judit Varkonyi, Nicola J. Camp, Elad Ziv, Annette Juul Vangsted, Elizabeth E. Brown, Daniele Campa, Celine M. Vachon, Mihai G. Netea, Federico Canzian, Asta Foersti, Juan Sainz
Summary: By conducting a meta-analysis on the germline genetic data of 234 autophagy-related genes from three independent study populations, we investigated the influence of autophagy-related variants on the risk of Multiple Myeloma (MM) and examined the functional mechanisms behind the observed associations. We identified SNPs within the six CD46, IKBKE, PARK2, ULK4, ATG5, and CDKN2A loci associated with MM risk and found that their effect on disease risk was mediated by specific subsets of immune cells, as well as vitamin D3-, MCP-2-, and IL20-dependent mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lorena R. Sousa, Ana Gabriela S. Oliveira, Antonio Arantes, Joao Gabriel M. Junqueira, Gerso P. Alexandre, Vanessa G. P. Severino, Rui Manuel Reis, Bonglee Kim, Rosy I. M. A. Ribeiro
Summary: This study investigated the effects of four fractions of hexane and ethyl acetate extract of Annona coriacea Mart. against GBM cell lines. The fractions showed selective cytotoxicity to GBM cells compared to TMZ, and also inhibited cell migration, MMP-2 activity, and induced necroptosis-like morphological changes. These findings suggest that the fractions of A. coriacea Mart. should be further studied for potential GBM treatment.
Article
Oncology
Rhafaela Lima Causin, Andre Van Helvoort Lengert, Izabela Natalia Faria Gomes, Ana Julia Aguiar De Freitas, Marcela Nunes Rosa, Ricardo Dos Reis, Rui Manuel Reis, Marcia Maria Chiquitelli Marques
Summary: miR-130a-3p is overexpressed in cervical cancer cells and plays a significant role in the development of cervical cancer. Inhibiting miR-130a-3p can significantly reduce the proliferation, migration, and invasion of cervical cancer cells. miR-130a-3p may regulate the biological functions of cervical cancer cells by directly targeting the DLL1 gene. Therefore, miR-130a-3p may serve as a biomarker for determining cervical cancer progression.
Article
Cell Biology
Rodrigo de Oliveira Cavagna, Icaro Alves Pinto, Flavia Escremim de Paula, Gustavo Noriz Berardinelli, Debora Sant'Anna, Iara Santana, Vinicius Duval Da Silva, Eduardo Caetano Albino da Silva, Jose Elias Miziara, Josiane Mourao, Augusto Antoniazzi, Alexandre Jacinto, Pedro De Marchi, Miguel Angel Molina, Leticia Ferro Leal, Rui Manuel Reis
Summary: TP53 mutations are common in Brazilian lung adenocarcinomas, especially in lung adenocarcinomas with a prevalence of 60.4%. Disruptive and truncating mutations in TP53 gene are associated with younger age, African ancestry, and shorter overall survival.
Article
Nutrition & Dietetics
Ana Fernandes, Ana Oliveira, Ana Luisa Carvalho, Raquel Soares, Pedro Barata
Summary: This study found a significant reduction in the relative abundance of Faecalibacterium prausnitzii in the gut microbiota of differentiated thyroid cancer patients compared to controls. The study also showed that radioiodine therapy resulted in an increase in the relative and absolute abundances of this bacterium in most patients.
Article
Cell Biology
Rita Silva-Pedrosa, Jonas Campos, Aline Marie Fernandes, Miguel Silva, Carla Calcada, Ana Marote, Olga Martinho, Maria Isabel Veiga, Ligia R. Rodrigues, Antonio Jose Salgado, Pedro Eduardo Ferreira
Summary: Neural injuries in cerebral malaria patients are a major cause of morbidity and mortality. This study proposes an in vitro system using cellular approaches to study human cerebral malaria. By analyzing gene expression profiles in human brain microvascular endothelial cells (HBMEC) activated by Plasmodium falciparum parasites, specific molecular alterations similar to the blood-brain barrier in cerebral malaria were identified. The impact of HBMEC-P. falciparum-activated secretomes on human brain organoids was evaluated to gain a deeper understanding of the physiological mechanisms underlying cerebral malaria.
Review
Biochemistry & Molecular Biology
Magda Fonseca, Mubashar Rehman, Raquel Soares, Pedro Fonte
Summary: Excessive UV radiation exposure leads to skin cancer due to oxidative burst and sunburn. However, the effectiveness of approved sunscreens is questionable due to insufficient UV photoprotection and their negative impact on ecosystems and human health. Therefore, finding UV filters with strong antioxidant activity and improved performance is urgently needed. Recent research focuses on using nanosized natural molecules in sunscreens as they can enhance overall sunscreen efficacy, retention, and reduce toxicity. Future clinical investigation is required to validate these findings.
Article
Medicine, Research & Experimental
Felipe Antonio de Oliveira Garcia, Adriane Feijo Evangelista, Bruna Minniti Mancano, Daniel Antunes Moreno, Gustavo Noriz Berardinelli, Flavia Escremim de Paula, Augusto Perazzolo Antoniazzi, Carlos Almeida Junior, Ismael Lombardi, Iara Santana, Gustavo Ramos Teixeira, Caio Evangelista Costa, Rui Manuel Reis
Summary: Choroid plexus tumors are rare intracranial neoplasms and account for less than 1% of all brain tumors but 20% of first-year pediatric brain tumors. The somatic driver alterations of these tumors are poorly understood. This study performed whole-exome sequencing on two cases of lateral ventricle tumors and identified genetic variants and copy-number alterations. The findings suggest the absence of recurrent somatic mutations in these tumors and call for further studies to better understand their biology.
COLD SPRING HARBOR MOLECULAR CASE STUDIES
(2023)
Article
Biotechnology & Applied Microbiology
Mariana de Oliveira Klein, Luiza Flavia Veiga Francisco, Izabela Natalia Faria Gomes, Sergio Serrano, Rui M. Reis, Henrique C. S. Silveira
Summary: This study analyzed the cytotoxicity and genotoxicity of anticancer drugs and their metabolites in aquatic ecosystems. The results showed that these compounds induced cytotoxic and genotoxic effects in cells at concentrations found in the environment. These findings provide valuable insights for the development of public policies to minimize potential environmental contamination.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2023)
Article
Plant Sciences
Ana Gabriela Silva Oliveira, Marina Andrade Rocha, Lucas Santos de Azevedo, Aline Thaynara de Moura Coelho, Rafael Cesar Russo Chagas, Helio Batista Santos, Ralph Gruppi Thome, Peter Samuel, Evelyn Wolfram, Bonglee Kim, Rui Manuel Reis, Rosy Iara Maciel Azambuja Ribeiro
Summary: This study investigated the constituents and antitumor potential of Tapirira guianensis in glioblastoma. The results showed that T. guianensis extracts have potential antitumor effects and can reduce tumor size and induce blood vessel shrinkage.
Article
Oncology
Carla Luis, Fernando Schmitt, Rute Fernandes, Nuno Coimbra, Joana Rigor, Paula Dias, Dina Leitao, Ruben Fernandes, Raquel Soares
Summary: This study investigated the expression of enzymes involved in glycolysis and gluconeogenesis in breast cancer, and found significant differences based on molecular subtype and body mass index. These differences were closely related to hormonal receptor and HER2 status, as well as pathological stage and histological grade. Obesity appeared to attenuate these differences, but adipocyte deposition and inflammatory infiltration did not affect the differences. Additionally, obesity-related conditions such as diabetes, hypertension, and dyslipidemia influenced the expression of certain enzymes.
Article
Oncology
Florinda A. Santos, Rui Manuel Reis, Lucas C. Barroti, Allan A. L. Pereira, Marcus M. Matsushita, Ana Carolina de Carvalho, Jose Guilherme Datorre, Gustavo N. Berardinelli, Raphael L. C. Araujo
Summary: This retrospective cohort study evaluated the overall survival (OS), RAS, BRAF, and MSI frequencies in refractory mCRC patients treated with cetuximab. The study identified BRAF V600E, KRAS, and NRAS gene mutations, as well as MSI status, in pre-treated patients. The study found that BRAF, NRAS mutations, and MSI-High status were associated with shorter OS, while tumour laterality remained an independent prognostic factor.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)